Thomas S Rush

Thomas S Rush

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Thomas S Rush

Thomas S Rush

Publications by authors named "Thomas S Rush"

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Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.

Comb Chem High Throughput Screen 2010 Jan;13(1):16-26

Drug Design and Optimization, Boston, MA 02115, USA.

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http://dx.doi.org/10.2174/138620710790218186DOI Listing
January 2010

3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.

Bioorg Med Chem Lett 2009 Aug 9;19(16):4546-50. Epub 2009 Jul 9.

Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.008DOI Listing
August 2009

Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.

Mol Endocrinol 2009 Feb 18;23(2):157-68. Epub 2008 Dec 18.

Oregon National Primate Research Center/Oregon Health Sciences University, Beaverton, Oregon 97006, USA.

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http://dx.doi.org/10.1210/me.2008-0384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646616PMC
February 2009

Functional, biophysical, and structural bases for antibacterial activity of tigecycline.

Antimicrob Agents Chemother 2006 Jun;50(6):2156-66

Department of Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA.

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http://dx.doi.org/10.1128/AAC.01499-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479133PMC
June 2006

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

Bioorg Med Chem Lett 2006 Jan 3;16(2):311-6. Epub 2005 Nov 3.

Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.001DOI Listing
January 2006

Structure-based identification of the binding site for the hemiasterlin analogue HTI-286 on tubulin.

Biochemistry 2005 Dec;44(48):15871-9

Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA.

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http://dx.doi.org/10.1021/bi051268bDOI Listing
December 2005

Synthesis and SAR of highly selective MMP-13 inhibitors.

Bioorg Med Chem Lett 2005 Nov;15(22):4961-6

Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.001DOI Listing
November 2005

Identification of potent and selective MMP-13 inhibitors.

Bioorg Med Chem Lett 2005 Sep;15(18):4105-9

Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.06.019DOI Listing
September 2005

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.

J Med Chem 2005 Mar;48(5):1489-95

Department of Chemical & Screening Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1021/jm040163oDOI Listing
March 2005

The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors.

Curr Top Med Chem 2004 ;4(12):1311-27

Structural Biology & Computational Chemistry, Department of Chemical & Screening Sciences, Wyeth Research, 87 Cambridge Park Dr. Cambridge, MA, 02140, USA.

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http://dx.doi.org/10.2174/1568026043387999DOI Listing
January 2005

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

Org Biomol Chem 2003 Dec 29;1(23):4138-40. Epub 2003 Oct 29.

Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA.

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http://dx.doi.org/10.1039/b312016cDOI Listing
December 2003

IR spectra of cytochrome c denatured with deuterated guanidine hydrochloride show increase in beta sheet.

Biopolymers 2003 ;72(3):193-204

Department of Chemistry, University of Montana, Missoula, MT 59812, USA.

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http://dx.doi.org/10.1002/bip.10337DOI Listing
June 2003

FeNO structure in distal pocket mutants of myoglobin based on resonance Raman spectroscopy.

Biochemistry 2003 May;42(17):4896-903

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1021/bi026395bDOI Listing
May 2003

The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein.

J Biol Chem 2003 Apr 27;278(14):12522-9. Epub 2003 Jan 27.

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA.

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http://dx.doi.org/10.1074/jbc.M211599200DOI Listing
April 2003

Impact of mobility on structure-based drug design for the MMPs.

J Am Chem Soc 2002 Oct;124(43):12658-9

Department of Biological Chemistry Wyeth Research, 87 Cambridge Park Dr., Massachusetts 02140, USA.

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http://dx.doi.org/10.1021/ja027391xDOI Listing
October 2002