Thomas S Kupper

Thomas S Kupper

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Thomas S Kupper

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Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem.

Clin Cancer Res 2019 Dec 15;25(24):7272-7274. Epub 2019 Oct 15.

Department of Dermatology, Brigham and Women's Hospital, and Dana Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-2742DOI Listing
December 2019

T cells and the skin: from protective immunity to inflammatory skin disorders.

Nat Rev Immunol 2019 Aug;19(8):490-502

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41577-019-0162-3
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http://dx.doi.org/10.1038/s41577-019-0162-3DOI Listing
August 2019

Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Nature 2019 May;569(7758):E12

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1207-2DOI Listing
May 2019

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Nature 2019 02 6;566(7743):259-263. Epub 2019 Feb 6.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-019-0928-6
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http://dx.doi.org/10.1038/s41586-019-0928-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640140PMC
February 2019

Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells.

Front Immunol 2018 18;9:1347. Epub 2018 Jun 18.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01347
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http://dx.doi.org/10.3389/fimmu.2018.01347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016524PMC
June 2018

High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides.

Sci Transl Med 2018 05;10(440)

Department of Dermatology, Brigham and Women's Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.aar5894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366329PMC
May 2018

Medical Scribes in an Academic Dermatology Practice.

JAMA Dermatol 2018 01;154(1):101-103

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamadermatol.2017.3658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833578PMC
January 2018

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing αβ T cell clones.

J Clin Invest 2017 Nov 25;127(11):4031-4041. Epub 2017 Sep 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI93396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663366PMC
November 2017

Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia.

Pediatr Dermatol 2017 Mar 26;34(2):197-198. Epub 2016 Dec 26.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/pde.13056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483175PMC
March 2017

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

Nature 2017 03 20;543(7644):252-256. Epub 2017 Feb 20.

Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature21379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509051PMC
March 2017

Aprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature.

BMC Cancer 2017 03 16;17(1):200. Epub 2017 Mar 16.

Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12885-017-3194-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356405PMC
March 2017

Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab).

J Cutan Pathol 2016 Nov 9;43(11):989-993. Epub 2016 Sep 9.

Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/cup.12800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507594PMC
November 2016

Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis.

Am J Emerg Med 2016 Aug 26;34(8):1645-52. Epub 2016 May 26.

Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07356757163019
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http://dx.doi.org/10.1016/j.ajem.2016.05.064DOI Listing
August 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.

Nat Commun 2016 05 10;7:11514. Epub 2016 May 10.

Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.

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http://dx.doi.org/10.1038/ncomms11514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866325PMC
May 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Research Techniques Made Simple: Techniques to Assess Cell Proliferation.

J Invest Dermatol 2016 Jan;136(1):e1-e7

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2015.11.020DOI Listing
January 2016

Palliative Therapy for Recalcitrant Cutaneous T-Cell Lymphoma of the Hands and Feet With Low-Dose, High Dose-Rate Brachytherapy.

JAMA Dermatol 2015 Dec;151(12):1354-1357

Harvard Medical School, Boston, Massachusetts3Center for Cutaneous Oncology, Dana Farber Cancer Institute, Boston, Massachusetts4Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamadermatol.2015.3028DOI Listing
December 2015

Humanized Mice in Dermatology Research.

J Invest Dermatol 2015 Dec;135(12):e39-e43

1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.393DOI Listing
December 2015

ABCB5 Identifies Immunoregulatory Dermal Cells.

Cell Rep 2015 Sep 28;12(10):1564-74. Epub 2015 Aug 28.

Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA; Transplantation Research Center, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA; School of Medical Sciences, Edith Cowan University, Joondalup, WA 6027, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565759PMC
September 2015

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.

Cell 2015 Sep;162(6):1242-56

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700833PMC
September 2015

The emerging role of resident memory T cells in protective immunity and inflammatory disease.

Nat Med 2015 Jul 29;21(7):688-97. Epub 2015 Jun 29.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640452PMC
July 2015

The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL).

Clin Cancer Res 2015 Jun 16;21(12):2820-9. Epub 2015 Mar 16.

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470792PMC
June 2015

Common clonal origin of central and resident memory T cells following skin immunization.

Nat Med 2015 Jun 11;21(6):647-53. Epub 2015 May 11.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632197PMC
June 2015

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.

Sci Transl Med 2015 Mar;7(279):279ra39

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Dana-Farber/Brigham and Women's Cancer Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425193PMC
March 2015

Inhibiting Janus kinases to treat alopecia areata.

Nat Med 2014 Sep;20(9):989-90

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3685DOI Listing
September 2014

Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission.

JAMA Dermatol 2014 Jul;150(7):776-9

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamadermatol.2013.10099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092049PMC
July 2014

Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.

Clin Cancer Res 2014 Jul 21;20(14):3799-808. Epub 2014 May 21.

Authors' Affiliations: Division of Dermatology, McGill University Health Centre, Montréal;

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863442PMC
July 2014

Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis.

Oncotarget 2014 Jun;5(12):4418-25

Molecular Medicine Lab and Chieng Genomics Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147334PMC
http://dx.doi.org/10.18632/oncotarget.2031DOI Listing
June 2014

Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus.

J Invest Dermatol 2014 Mar 14;134(3):686-694. Epub 2013 Oct 14.

Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945525PMC
March 2014

CXCR4 pathway associated with family history of melanoma.

Cancer Causes Control 2014 Jan 25;25(1):125-32. Epub 2013 Oct 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 45 Francis St, 221L, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s10552-013-0315-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100594PMC
January 2014

CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.

J Immunol 2013 Sep 9;191(6):3119-27. Epub 2013 Aug 9.

Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.1200938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784989PMC
September 2013

Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.

J Am Acad Dermatol 2013 Jul 26;69(1):61-5. Epub 2013 Feb 26.

Department of Dermatology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.jaad.2012.12.975DOI Listing
July 2013

Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma.

PLoS One 2012 4;7(9):e44455. Epub 2012 Sep 4.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044455PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433438PMC
January 2013

Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

Nat Med 2012 Aug 8;18(8):1248-53. Epub 2012 Jul 8.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518666PMC
August 2012

Disruption of TNF-α/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection.

J Invest Dermatol 2012 May 9;132(5):1425-34. Epub 2012 Feb 9.

Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153575
Publisher Site
http://dx.doi.org/10.1038/jid.2011.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326195PMC
May 2012

Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells.

Immunity 2012 May 3;36(5):873-84. Epub 2012 May 3.

Department of Dermatology/Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716276PMC
May 2012

Old and new: recent innovations in vaccine biology and skin T cells.

Authors:
Thomas S Kupper

J Invest Dermatol 2012 Mar 12;132(3 Pt 2):829-34. Epub 2012 Jan 12.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02493, USA.

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http://dx.doi.org/10.1038/jid.2011.400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644944PMC
March 2012

Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.

Nature 2012 Feb 29;483(7388):227-31. Epub 2012 Feb 29.

Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature10851
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http://dx.doi.org/10.1038/nature10851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437663PMC
February 2012

Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.

J Clin Invest 2011 Dec 14;121(12):4838-49. Epub 2011 Nov 14.

Department of Dermatology, Cutaneous Oncology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI41769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225985PMC
December 2011

Interleukin-16 as a marker of Sézary syndrome onset and stage.

J Clin Immunol 2011 Feb 28;31(1):39-50. Epub 2010 Sep 28.

Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1007/s10875-010-9464-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863446PMC
February 2011

High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.

Blood 2011 Feb 9;117(6):1966-76. Epub 2010 Dec 9.

Department of Dermatology, Brigham and Women's Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2010-05-287664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056643PMC
February 2011

Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity.

PLoS One 2011 Jan 26;6(1):e16245. Epub 2011 Jan 26.

Department of Dermatology, Brigham and Women's Hospital, Harvard Skin Disease Research Center, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027667PMC
January 2011

Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma.

Arch Dermatol Res 2010 Aug 29;302(6):453-9. Epub 2010 Jan 29.

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00403-009-1023-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892560PMC
August 2010

Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors.

Blood 2010 Aug 18;116(5):767-71. Epub 2010 May 18.

Department of Dermatology, Brigham and Women's Hospital/Harvard, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2009-11-251926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918332PMC
August 2010

Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma.

Clin Cancer Res 2010 Apr 16;16(7):2106-14. Epub 2010 Mar 16.

Division of Dermatology, McGill University Health Centre, Montréal, Quebec, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-2879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853253PMC
April 2010

Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.

Proc Natl Acad Sci U S A 2010 Apr 5;107(16):7443-8. Epub 2010 Apr 5.

Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0912943107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867765PMC
April 2010

Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.

Nat Med 2010 Feb 17;16(2):224-7. Epub 2010 Jan 17.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Harvard Skin Disease Research Center, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nm.2078
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http://dx.doi.org/10.1038/nm.2078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070948PMC
February 2010

Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin.

J Invest Dermatol 2009 Nov 11;129(11):2676-85. Epub 2009 Jun 11.

Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/jid.2009.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841955PMC
November 2009

Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology.

Clin Dermatol 2008 Sep-Oct;26(5):554-61

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0738081X0700267
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http://dx.doi.org/10.1016/j.clindermatol.2007.11.007DOI Listing
January 2009

Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.

J Allergy Clin Immunol 2008 Jan 1;121(1):148-157.e3. Epub 2007 Oct 1.

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566300PMC
January 2008

Identification of cells initiating human melanomas.

Nature 2008 Jan;451(7176):345-9

Transplantation Research Center, Children's Hospital Boston and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature06489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660705PMC
January 2008

T-cell distribution and adhesion receptor expression in metastatic melanoma.

Clin Cancer Res 2007 May;13(9):2549-56

Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2450DOI Listing
May 2007

IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.

Blood 2007 Jan 12;109(1):194-202. Epub 2006 Sep 12.

Department of Dermatology, Brigham and Women's Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2006-02-002873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785078PMC
January 2007

The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.

J Immunol 2006 Oct;177(7):4488-94

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.177.7.4488DOI Listing
October 2006

Dynamic programming of CD8+ T cell trafficking after live viral immunization.

Immunity 2006 Sep;25(3):511-20

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.06.019DOI Listing
September 2006

Misbehaving macrophages in the pathogenesis of psoriasis.

J Clin Invest 2006 Aug;116(8):2084-7

Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI29441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523394PMC
August 2006

A novel method for the isolation of skin resident T cells from normal and diseased human skin.

J Invest Dermatol 2006 May;126(5):1059-70

Department of Dermatology, Brigham and Women's Hospital and the Harvard Skin Disease Research Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.jid.5700199DOI Listing
May 2006

The vast majority of CLA+ T cells are resident in normal skin.

J Immunol 2006 Apr;176(7):4431-9

Department of Dermatology, Brigham and Women's Hospital and Harvard Skin Disease Research Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.176.7.4431DOI Listing
April 2006

CD43 is a ligand for E-selectin on CLA+ human T cells.

Blood 2006 Feb 3;107(4):1421-6. Epub 2005 Nov 3.

Department of Dermatology, Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2005-05-2112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895405PMC
February 2006

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.

Clin Cancer Res 2006 Jan;12(2):376-82

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1777DOI Listing
January 2006

Activation of neutrophils in cutaneous T-cell lymphoma.

Clin Cancer Res 2005 Dec;11(23):8243-9

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://clincancerres.aacrjournals.org/content/11/23/8243.ful
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http://dx.doi.org/10.1158/1078-0432.CCR-05-1434DOI Listing
December 2005

Basic fibroblast growth factor treatment for skin ulcerations in scleroderma.

Cutis 2005 Dec;76(6):373-6

Department of Dermatology, Mie University, Graduate School of Medicine, Japan.

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December 2005

Human skin cells support thymus-independent T cell development.

J Clin Invest 2005 Nov 13;115(11):3239-49. Epub 2005 Oct 13.

Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI24731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253623PMC
November 2005

Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma.

Clin Cancer Res 2005 Aug;11(16):5748-55

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 023115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2514DOI Listing
August 2005

Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.

J Virol 2005 Jun;79(12):7363-70

Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Suite 672, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/JVI.79.12.7363-7370.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143660PMC
June 2005

Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes.

J Invest Dermatol 2005 Jun;124(6):1267-74

Dermatology Section, Division of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1111/j.0022-202X.2005.23684.xDOI Listing
June 2005

Aggressive cutaneous T-cell lymphomas after TNFalpha blockade.

J Am Acad Dermatol 2004 Oct;51(4):660-2

Department of Dermatology at Harvard Medical School, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jaad.2004.03.047DOI Listing
October 2004