Publications by authors named "Thomas Roberts"

100Publications

Application of CRISPR-Cas9-Mediated Genome Editing for the Treatment of Myotonic Dystrophy Type 1.

Mol Ther 2020 Oct 14. Epub 2020 Oct 14.

Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UK; MDUK Oxford Neuromuscular Centre, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.10.005DOI Listing
October 2020

Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss.

J Pathol 2020 Nov 9. Epub 2020 Nov 9.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/path.5587DOI Listing
November 2020

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle.

Biomaterials 2021 Jan 5;266:120435. Epub 2020 Oct 5.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK; Department of Paediatrics, University of Oxford, Oxford, UK; MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.120435DOI Listing
January 2021

Auroral ionospheric plasma flow extraction using subsonic retarding potential analyzers.

Rev Sci Instrum 2020 Sep;91(9):094503

SRI International, Menlo Park, California 94025, USA.

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http://dx.doi.org/10.1063/1.5144498DOI Listing
September 2020

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas.

Cell Rep 2020 Sep;32(13):108196

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571617PMC
September 2020

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.

Proc Natl Acad Sci U S A 2020 09 14;117(39):24427-24433. Epub 2020 Sep 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.2000060117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533832PMC
September 2020

Advances in oligonucleotide drug delivery.

Nat Rev Drug Discov 2020 10 11;19(10):673-694. Epub 2020 Aug 11.

Department of Paediatrics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41573-020-0075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419031PMC
October 2020

The time course of calf muscle fluid volume during prolonged running.

Physiol Rep 2020 05;8(9):e14414

Department of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.14814/phy2.14414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202985PMC
May 2020

Loading Rate Has Little Influence on Tendon Fascicle Mechanics.

Front Physiol 2020 24;11:255. Epub 2020 Mar 24.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, United States.

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http://dx.doi.org/10.3389/fphys.2020.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105874PMC
March 2020

Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).

Magn Reson Med 2020 09 14;84(3):1543-1551. Epub 2020 Feb 14.

Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1002/mrm.28207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317745PMC
September 2020

Internal fluid pressure influences muscle contractile force.

Proc Natl Acad Sci U S A 2020 01 26;117(3):1772-1778. Epub 2019 Dec 26.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912.

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http://dx.doi.org/10.1073/pnas.1914433117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983394PMC
January 2020

The need for speed: functional specializations of locomotor and feeding muscles in lizards.

J Exp Biol 2020 01 27;223(Pt 2). Epub 2020 Jan 27.

Department of Ecology and Evolutionary Biology, Brown University, Box G-B205, Providence, RI 02912, USA.

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http://dx.doi.org/10.1242/jeb.213397DOI Listing
January 2020

Diversity of extracellular matrix morphology in vertebrate skeletal muscle.

J Morphol 2020 02 16;281(2):160-169. Epub 2019 Dec 16.

Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island.

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http://dx.doi.org/10.1002/jmor.21088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137673PMC
February 2020

Combination of KRAS gene silencing and PI3K inhibition for ovarian cancer treatment.

J Control Release 2020 02 12;318:98-108. Epub 2019 Dec 12.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056267PMC
February 2020

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities.

Biomolecules 2019 11 7;9(11). Epub 2019 Nov 7.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/biom9110713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921025PMC
November 2019

The Multi-Scale, Three-Dimensional Nature of Skeletal Muscle Contraction.

Physiology (Bethesda) 2019 11;34(6):402-408

Department of Ecology and Evolutionary Biology, University of California-Irvine, Irvine, California.

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http://dx.doi.org/10.1152/physiol.00023.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002870PMC
November 2019

Passive muscle tension increases in proportion to intramuscular fluid volume.

J Exp Biol 2019 10 31;222(Pt 21). Epub 2019 Oct 31.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1242/jeb.209668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857584PMC
October 2019

Potential Therapies Using Myogenic Stem Cells Combined with Bio-Engineering Approaches for Treatment of Muscular Dystrophies.

Cells 2019 09 11;8(9). Epub 2019 Sep 11.

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan.

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http://dx.doi.org/10.3390/cells8091066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769835PMC
September 2019

Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.

Oncogene 2020 01 28;39(1):50-63. Epub 2019 Aug 28.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1038/s41388-019-0953-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937212PMC
January 2020

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress.

Sci Rep 2019 07 17;9(1):10332. Epub 2019 Jul 17.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70210, Kuopio, Finland.

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http://dx.doi.org/10.1038/s41598-019-46841-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637125PMC
July 2019

Molecular Profiling Establishes Genetic Features Predictive of the Efficacy of the p110β Inhibitor KIN-193.

Cancer Res 2019 09 10;79(17):4524-4531. Epub 2019 Jul 10.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726497PMC
September 2019

Some Challenges of Playing with Power: Does Complex Energy Flow Constrain Neuromuscular Performance?

Authors:
Thomas J Roberts

Integr Comp Biol 2019 12;59(6):1619-1628

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1093/icb/icz108DOI Listing
December 2019

Mango Seed Kernel Fat as a Cocoa Butter Substitute Suitable for the Tropics.

J Food Sci 2019 Jun 22;84(6):1315-1321. Epub 2019 May 22.

Plant Breeding Inst., Sydney Inst. of Agriculture, Univ. of Sydney, NSW, 2006, Australia.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1750-3841.14
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http://dx.doi.org/10.1111/1750-3841.14614DOI Listing
June 2019

Evidence of a tunable biological spring: elastic energy storage in aponeuroses varies with transverse strain in vivo.

Proc Biol Sci 2019 04;286(1900):20182764

4 Department of Ecology and Evolutionary Biology, Brown University , Providence, RI 02912 , USA.

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http://dx.doi.org/10.1098/rspb.2018.2764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501694PMC
April 2019

Carotenoid complement of rust spores: Variation among species and pathotype.

Phytochemistry 2019 May 2;161:139-148. Epub 2019 Mar 2.

Plant Breeding Institute, Sydney Institute of Agriculture, University of Sydney, NSW, 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2019.02.007DOI Listing
May 2019

Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B-cell neoplasms.

Br J Haematol 2019 04 25;185(2):261-265. Epub 2019 Jan 25.

Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1111/bjh.15762DOI Listing
April 2019

Salinity tolerance in Australian wild Oryza species varies widely and matches that observed in O. sativa.

Rice (N Y) 2018 Dec 22;11(1):66. Epub 2018 Dec 22.

Department of Biological Sciences, Macquarie University, Sydney, Australia.

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http://dx.doi.org/10.1186/s12284-018-0257-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303227PMC
December 2018

Release of fascial compartment boundaries reduces muscle force output.

J Appl Physiol (1985) 2019 03 13;126(3):593-598. Epub 2018 Dec 13.

Department of Ecology and Evolutionary Biology, Brown University , Providence, Rhode Island.

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http://dx.doi.org/10.1152/japplphysiol.00330.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459388PMC
March 2019

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366450PMC
December 2018

Evaluation of Repurposing Archetypal Preventive Radiological/Nuclear Detectors for the Consequence Management Mission.

Health Phys 2019 01;116(1):4-17

DHS HS-STEM Summer Internship Program, Oak Ridge Institute for Science and Education, P.O. Box 117, Oak Ridge, TN 37831.

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http://dx.doi.org/10.1097/HP.0000000000000940DOI Listing
January 2019

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells.

iScience 2018 Nov 18;9:149-160. Epub 2018 Oct 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183017
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http://dx.doi.org/10.1016/j.isci.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215964PMC
November 2018

Targeted Profiling of RNA Translation.

Curr Protoc Mol Biol 2019 01 22;125(1):e71. Epub 2018 Oct 22.

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326074PMC
January 2019

Integrated and efficient diffusion-relaxometry using ZEBRA.

Sci Rep 2018 10 11;8(1):15138. Epub 2018 Oct 11.

Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.

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http://www.nature.com/articles/s41598-018-33463-2
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http://dx.doi.org/10.1038/s41598-018-33463-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181938PMC
October 2018

Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9325-E9332. Epub 2018 Sep 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1805782115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176620PMC
October 2018

Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD.

Mol Ther Nucleic Acids 2018 Dec 17;13:1-15. Epub 2018 Aug 17.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140421PMC
December 2018

Evidence of inflated exclusive breastfeeding estimates from a clinical trial in Bangladesh.

Int Breastfeed J 2018 22;13:39. Epub 2018 Aug 22.

2Department of Medicine, Stanford University School of Medicine, Stanford, USA.

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http://dx.doi.org/10.1186/s13006-018-0179-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106757PMC
August 2018

Waddle and shuffle: gait alterations associated with domestication in turkeys.

J Exp Biol 2018 08 13;221(Pt 15). Epub 2018 Aug 13.

Ecology and Evolutionary Biology, Brown University, Providence, RI 02906, USA.

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http://jeb.biologists.org/lookup/doi/10.1242/jeb.180687
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http://dx.doi.org/10.1242/jeb.180687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104819PMC
August 2018

A conditional silencing suppression system for transient expression.

Sci Rep 2018 06 21;8(1):9426. Epub 2018 Jun 21.

School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.

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http://www.nature.com/articles/s41598-018-27778-3
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http://dx.doi.org/10.1038/s41598-018-27778-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013485PMC
June 2018

Fortification of durum wheat semolina with detoxified matri () flour to improve the nutritional properties of pasta.

J Food Sci Technol 2018 Jun 19;55(6):2114-2121. Epub 2018 Mar 19.

4Plant Breeding Institute, Sydney Institute of Agriculture, University of Sydney, Sydney, NSW 2006 Australia.

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http://link.springer.com/10.1007/s13197-018-3126-x
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http://dx.doi.org/10.1007/s13197-018-3126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976595PMC
June 2018

Structural Determinants of Muscle Gearing During Dynamic Contractions.

Integr Comp Biol 2018 08;58(2):207-218

Department of Ecology and Evolutionary Biology, Brown University, 171 Meeting St, Box GB204, Providence, RI 02912, USA.

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https://academic.oup.com/icb/article/58/2/207/5034471
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http://dx.doi.org/10.1093/icb/icy054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104701PMC
August 2018

Bluegill sunfish use high power outputs from axial muscles to generate powerful suction-feeding strikes.

J Exp Biol 2018 06 5;221(Pt 11). Epub 2018 Jun 5.

Dept. of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1242/jeb.178160DOI Listing
June 2018

Oridonin inhibits aberrant AKT activation in breast cancer.

Oncotarget 2018 May 1;9(35):23878-23889. Epub 2018 Feb 1.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.18632/oncotarget.24378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963618PMC
May 2018

Aponeurosis influences the relationship between muscle gearing and force.

J Appl Physiol (1985) 2018 08 24;125(2):513-519. Epub 2018 May 24.

Department of Ecology and Evolutionary Biology, Brown University , Providence, Rhode Island.

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https://www.physiology.org/doi/10.1152/japplphysiol.00151.20
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http://dx.doi.org/10.1152/japplphysiol.00151.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139511PMC
August 2018

Patterns of musculoskeletal growth and dimensional changes associated with selection and developmental plasticity in domestic and wild strain turkeys.

Ecol Evol 2018 03 19;8(6):3229-3239. Epub 2018 Feb 19.

Department of Ecology and Evolutionary Biology Brown University Providence RI 02912 USA.

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http://dx.doi.org/10.1002/ece3.3881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869219PMC
March 2018

Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer.

J Clin Oncol 2018 05 8;36(13):1339-1342. Epub 2018 Mar 8.

Johann S. Bergholz, Thomas M. Roberts, and Jean J. Zhao, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.77.0891
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http://dx.doi.org/10.1200/JCO.2017.77.0891DOI Listing
May 2018

Skeletal muscle mechanics, energetics and plasticity.

J Neuroeng Rehabil 2017 10 23;14(1):108. Epub 2017 Oct 23.

University of Calgary, Faculty of Kinesiology, Calgary, Canada.

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http://dx.doi.org/10.1186/s12984-017-0318-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651624PMC
October 2017

Effects of Sorghum Malting on Colour, Major Classes of Phenolics and Individual Anthocyanins.

Molecules 2017 Oct 12;22(10). Epub 2017 Oct 12.

Plant Breeding Institute, Sydney Institute of Agriculture, University of Sydney, Sydney, NSW 2006, Australia.

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http://www.mdpi.com/1420-3049/22/10/1713
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http://dx.doi.org/10.3390/molecules22101713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151653PMC
October 2017

Biomarker Potential of Extracellular miRNAs in Duchenne Muscular Dystrophy.

Trends Mol Med 2017 11 5;23(11):989-1001. Epub 2017 Oct 5.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.09.002DOI Listing
November 2017

3-D range of motion envelopes reveal interacting degrees of freedom in avian hind limb joints.

J Anat 2017 Dec 18;231(6):906-920. Epub 2017 Aug 18.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1111/joa.12680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696129PMC
December 2017

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

Sci Rep 2017 07 21;7(1):6153. Epub 2017 Jul 21.

Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41598-017-06483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522382PMC
July 2017

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.

Cell Rep 2017 07;20(3):549-557

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173088
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http://dx.doi.org/10.1016/j.celrep.2017.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704918PMC
July 2017

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7095-7100. Epub 2017 Jun 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1704706114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502636PMC
July 2017

Epigenetic regulation of RTK signaling.

J Mol Med (Berl) 2017 08 6;95(8):791-798. Epub 2017 Jun 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://link.springer.com/10.1007/s00109-017-1546-0
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http://dx.doi.org/10.1007/s00109-017-1546-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663182PMC
August 2017

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development.

Nat Biotechnol 2017 06 1;35(6):551-560. Epub 2017 May 1.

Department of Systems Biology, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.3854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569300PMC
June 2017

The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 14;1868(1):123-131. Epub 2017 Mar 14.

Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548615PMC
August 2017

Speed-dependent modulation of wing muscle recruitment intensity and kinematics in two bat species.

J Exp Biol 2017 05 24;220(Pt 10):1820-1829. Epub 2017 Feb 24.

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1242/jeb.144550DOI Listing
May 2017

Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro.

Protein Sci 2017 03 23;26(3):600-610. Epub 2017 Feb 23.

Departments of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO.

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http://dx.doi.org/10.1002/pro.3110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326571PMC
March 2017

Peanut protein extraction conditions strongly influence yield of allergens Ara h 1 and 2 and sensitivity of immunoassays.

Food Chem 2017 Apr 14;221:335-344. Epub 2016 Oct 14.

Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia; Plant Breeding Institute, Faculty of Agriculture and Environment, University of Sydney, Sydney, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03088146163168
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http://dx.doi.org/10.1016/j.foodchem.2016.10.063DOI Listing
April 2017

Turning ASCO Members Into Conquer Cancer Foundation Donors.

J Oncol Pract 2017 01 22;13(1):1-3. Epub 2016 Nov 22.

Conquer Cancer Foundation, Alexandria, VA.

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http://ascopubs.org/doi/10.1200/JOP.2016.018440
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http://dx.doi.org/10.1200/JOP.2016.018440DOI Listing
January 2017

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss.

Elife 2016 10 4;5. Epub 2016 Oct 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States.

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http://dx.doi.org/10.7554/eLife.17635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050018PMC
October 2016

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell Discov 2016 20;2:16030. Epub 2016 Sep 20.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029543PMC
September 2016

Time Matters: Antibiotic Timing in Sepsis and Septic Shock.

Crit Care Med 2016 10;44(10):e1016-7

Emergency Department, King's College Hospital, King's Health Partners, London, United Kingdom;Health e-Research Centre, Farr Institute, University of Manchester, Manchester, United Kingdom;Emergency Department, King's College Hospital, King's Health Partners, London, United Kingdom;Heart of England NHS Foundation Trust, Birmingham, United Kingdom;Emergency Department, Derriford Hospital & University of Plymouth, Plymouth, United Kingdom;Emergency Department, King's College Hospital, King's Health Partners, London, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000001968DOI Listing
October 2016