Thomas Ratajczak

Thomas Ratajczak

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Thomas Ratajczak

Thomas Ratajczak

Publications by authors named "Thomas Ratajczak"

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28Publications

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The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor.

J Cell Physiol 2018 Jan 5;233(1):38-56. Epub 2017 Jun 5.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/jcp.25957DOI Listing
January 2018

The Changing Presentation of Paget's Disease of Bone in Australia, A High Prevalence Region.

Calcif Tissue Int 2017 12 7;101(6):564-569. Epub 2017 Sep 7.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.

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http://dx.doi.org/10.1007/s00223-017-0312-1DOI Listing
December 2017

Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease.

Authors:
Thomas Ratajczak

Curr Mol Pharmacol 2015 ;9(1):66-95

Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands WA 6009, Australia.

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http://dx.doi.org/10.2174/1874467208666150519113639DOI Listing
October 2016

Bafilomycin A1 Attenuates Osteoclast Acidification and Formation, Accompanied by Increased Levels of SQSTM1/p62 Protein.

J Cell Biochem 2016 Jun 26;117(6):1464-70. Epub 2015 Nov 26.

Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

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http://dx.doi.org/10.1002/jcb.25442DOI Listing
June 2016

Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.

Clin Biochem Rev 2015 May;36(2):31-52

Laboratory for Molecular Endocrinology, Harry Perkins Institute of Medical Research and the UWA Centre for Medical Research, The University of Western Australia, Nedlands WA 6009, Australia; ; Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands WA 6009, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504154PMC
May 2015

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Endocr Rev 2013 Aug 23;34(4):501-24. Epub 2013 Apr 23.

Department of Endocrinology and Diabetes, Level 1, C Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1210/er.2012-1034DOI Listing
August 2013

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones.

Mol Endocrinol 2013 Jul 17;27(7):1020-35. Epub 2013 May 17.

Laboratory for Molecular Endocrinology, Western Australian Institute forMedical Research and the UWA Centre for Medical Research, The University of Western Australia, Australia.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2012-1023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415241PMC
July 2013

The role of the calcium-sensing receptor in human disease.

Clin Biochem 2012 Aug 5;45(12):943-53. Epub 2012 Apr 5.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1016/j.clinbiochem.2012.03.034DOI Listing
August 2012

The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling.

Biochem J 2012 Feb;441(3):995-1006

‡Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia.

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http://biochemj.org/lookup/doi/10.1042/BJ20111277
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http://dx.doi.org/10.1042/BJ20111277DOI Listing
February 2012

Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling.

Biochem Biophys Res Commun 2011 Sep 6;412(4):584-9. Epub 2011 Aug 6.

Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Nedlands, Western Australia 6009, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1101377
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http://dx.doi.org/10.1016/j.bbrc.2011.07.132DOI Listing
September 2011

Versatile TPR domains accommodate different modes of target protein recognition and function.

Cell Stress Chaperones 2011 Jul 9;16(4):353-67. Epub 2010 Dec 9.

Centre for Medical Research, The University of Western Australia, Nedlands, WA.

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http://dx.doi.org/10.1007/s12192-010-0248-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118826PMC
July 2011

The calcium-sensing receptor: a molecular perspective.

Endocr Rev 2011 Feb 20;32(1):3-30. Epub 2010 Aug 20.

Department of Endocrinology and Diabetes, First Floor, C Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia.

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http://edrv.endojournals.org/content/32/1/3.full.pdf
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http://press.endocrine.org/doi/abs/10.1210/er.2009-0043
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http://dx.doi.org/10.1210/er.2009-0043DOI Listing
February 2011

Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.

J Cell Physiol 2009 Aug;220(2):450-9

Molecular Orthopaedic Laboratory, Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/jcp.21787DOI Listing
August 2009

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

J Bone Miner Res 2009 Jul;24(7):1216-23

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Nedlands, Australia.

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http://dx.doi.org/10.1359/jbmr.090214DOI Listing
July 2009

Cyclophilin 40: an Hsp90-cochaperone associated with apo-steroid receptors.

Int J Biochem Cell Biol 2009 Aug-Sep;41(8-9):1652-5. Epub 2009 Mar 24.

Centre for Medical Research, The University of Western Australia, Nedlands, WA, Australia.

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http://dx.doi.org/10.1016/j.biocel.2009.03.006DOI Listing
June 2009

A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

J Bone Miner Res 2006 Jul;21(7):1136-45

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, University of Western Australia, Nedlands.

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http://dx.doi.org/10.1359/jbmr.060405DOI Listing
July 2006

Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia.

Clin Endocrinol (Oxf) 2006 May;64(5):580-7

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1111/j.1365-2265.2006.02512.xDOI Listing
May 2006

The chaperone function of cyclophilin 40 maps to a cleft between the prolyl isomerase and tetratricopeptide repeat domains.

FEBS Lett 2006 May 24;580(11):2761-8. Epub 2006 Apr 24.

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, The University of Western Australia, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1016/j.febslet.2006.04.039DOI Listing
May 2006

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.

J Biol Chem 2006 Mar 17;281(11):7161-71. Epub 2006 Jan 17.

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, Queen Elizabeth II Medical Centre, The University of Western Australia, Hospital Avenue, Nedlands, WA 6009, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M512406200
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http://dx.doi.org/10.1074/jbc.M512406200DOI Listing
March 2006

A novel homozygous deletion in the calcium-sensing receptor ligand-binding domain associated with neonatal severe hyperparathyroidism.

J Pediatr Endocrinol Metab 2006 Jan;19(1):93-100

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Australia.

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http://dx.doi.org/10.1515/jpem.2006.19.1.93DOI Listing
January 2006

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.

Cell Stress Chaperones 2004 ;9(2):167-81

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065296PMC
http://dx.doi.org/10.1379/csc-26r.1DOI Listing
February 2005

Functional deletion of the calcium-sensing receptor in a case of neonatal severe hyperparathyroidism.

J Clin Endocrinol Metab 2004 Aug;89(8):3721-30

UWA Centre for Medical Research, the University of Western Australia, Nedlands, Western Australia 6009.

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http://dx.doi.org/10.1210/jc.2003-031653DOI Listing
August 2004

Immunophilin chaperones in steroid receptor signalling.

Curr Top Med Chem 2003 ;3(12):1348-57

Centre for Medical Research, the University of Western Australia, Nedlands, WA 6009, Australia. tomr@ cyllene.uwa.edu.au

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http://dx.doi.org/10.2174/1568026033451934DOI Listing
October 2003

A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90.

J Biol Chem 2002 Oct 26;277(43):40799-809. Epub 2002 Jul 26.

Western Australian Institute for Medical Research, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1074/jbc.M207097200DOI Listing
October 2002