Thomas R Webb

Thomas R Webb

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Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors.

Circ Genom Precis Med 2019 Jan;12(1):e002196

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N., F.Y.L., M.N., S.Y., T.R.W., N.J.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196
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http://dx.doi.org/10.1161/CIRCGEN.118.002196DOI Listing
January 2019

Improving the Efficiency of the Drug Development by Expanding the Scope of the Role of Medicinal Chemists in Drug Discovery.

Authors:
Thomas R Webb

ACS Med Chem Lett 2018 Dec 29;9(12):1153-1155. Epub 2018 Nov 29.

SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295863PMC
December 2018

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping.

RNA 2018 08 29;24(8):1056-1066. Epub 2018 May 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1261/rna.065383.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049506PMC
August 2018

Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6.

Biomark Insights 2017 12;12:1177271917730557. Epub 2017 Sep 12.

University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1177/1177271917730557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598794PMC
September 2017

USP39 Deubiquitinase Is Essential for Oncogene-driven Cancer.

J Biol Chem 2017 03 1;292(10):4164-4175. Epub 2017 Feb 1.

From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain,

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http://dx.doi.org/10.1074/jbc.M116.762757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354494PMC
March 2017

Erratum to "A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore" [Bioorg. Med. Chem. Lett. 27 (2017) 406-412].

Bioorg Med Chem Lett 2017 03 16;27(6):1488-1489. Epub 2017 Feb 16.

Division of Biosciences, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X173012
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http://dx.doi.org/10.1016/j.bmcl.2017.02.009DOI Listing
March 2017

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.

Bioorg Med Chem Lett 2017 02 24;27(3):406-412. Epub 2016 Dec 24.

Division of Biosciences, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.12.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295499PMC
February 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Authors:
Nathan O Stitziel Kathleen E Stirrups Nicholas G D Masca Jeanette Erdmann Paola G Ferrario Inke R König Peter E Weeke Thomas R Webb Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Stavroula Kanoni Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenberg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Piera A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian M Shaffer Nour Eddine El-Mokhtari Andre Franke Omri Gottesman Stefanie Heilmann Christian Hengstenberg Per Hoffman Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Martina Müller-Nurasyid Majid Nikpay Oliviero Olivieri Louis-Philippe Lemieux Perreault Alaa AlQarawi Neil R Robertson Karen O Akinsanya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Aldi T Kraja Chunyu Liu George B Ehret Christopher Newton-Cheh Daniel I Chasman Rajiv Chowdhury Marco Ferrario Ian Ford J Wouter Jukema Frank Kee Kari Kuulasmaa Børge G Nordestgaard Markus Perola Danish Saleheen Naveed Sattar Praveen Surendran David Tregouet Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Sekkar Kathiresan Panos Deloukas Nilesh J Samani Heribert Schunkert

N Engl J Med 2016 03 2;374(12):1134-44. Epub 2016 Mar 2.

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http://dx.doi.org/10.1056/NEJMoa1507652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850838PMC
March 2016

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2207-17. Epub 2015 Aug 20.

From the Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany (I.B., B.R., J.E.); DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany (I.B., B.R., J.E.); University Heart Center Lübeck, Lübeck, Germany (I.B., B.R., J.E.); Departments of Medicine (M.C., A.J.L.) and Integrative Biology and Physiology (Y.Z., X.Y.), University of California, Los Angeles; Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (B.V., L.Z., H.S.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA (A.D.J.); Unité Mixte de Recherche en Santé (UMR_S) 1166, Institut National pour la Santé et la Recherche Médicale (INSERM), Paris, France (V.C., D.-A.T.); UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), Paris, France (V.C., D.-A.T.); Institute for Cardiometabolism and Nutrition (ICAN), Paris, France (V.C., D.-A.T.); Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Cardiovascular Biomedical Research Unit, BHF Cardiovascular Research Centre, Leicester, United Kingdom (T.R.W., S.E.H., N.J.S.); Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (H.F.A., J.L.M.B.); and Department of Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, CA (E.J.T.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583353PMC
October 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:
Majid Nikpay Anuj Goel Hong-Hee Won Leanne M Hall Christina Willenborg Stavroula Kanoni Danish Saleheen Theodosios Kyriakou Christopher P Nelson Jemma C Hopewell Thomas R Webb Lingyao Zeng Abbas Dehghan Maris Alver Sebastian M Armasu Kirsi Auro Andrew Bjonnes Daniel I Chasman Shufeng Chen Ian Ford Nora Franceschini Christian Gieger Christopher Grace Stefan Gustafsson Jie Huang Shih-Jen Hwang Yun Kyoung Kim Marcus E Kleber King Wai Lau Xiangfeng Lu Yingchang Lu Leo-Pekka Lyytikäinen Evelin Mihailov Alanna C Morrison Natalia Pervjakova Liming Qu Lynda M Rose Elias Salfati Richa Saxena Markus Scholz Albert V Smith Emmi Tikkanen Andre Uitterlinden Xueli Yang Weihua Zhang Wei Zhao Mariza de Andrade Paul S de Vries Natalie R van Zuydam Sonia S Anand Lars Bertram Frank Beutner George Dedoussis Philippe Frossard Dominique Gauguier Alison H Goodall Omri Gottesman Marc Haber Bok-Ghee Han Jianfeng Huang Shapour Jalilzadeh Thorsten Kessler Inke R König Lars Lannfelt Wolfgang Lieb Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Patrik K Magnusson Nadeem H Mallick Narinder Mehra Thomas Meitinger Fazal-Ur-Rehman Memon Andrew P Morris Markku S Nieminen Nancy L Pedersen Annette Peters Loukianos S Rallidis Asif Rasheed Maria Samuel Svati H Shah Juha Sinisalo Kathleen E Stirrups Stella Trompet Laiyuan Wang Khan S Zaman Diego Ardissino Eric Boerwinkle Ingrid B Borecki Erwin P Bottinger Julie E Buring John C Chambers Rory Collins L Adrienne Cupples John Danesh Ilja Demuth Roberto Elosua Stephen E Epstein Tõnu Esko Mary F Feitosa Oscar H Franco Maria Grazia Franzosi Christopher B Granger Dongfeng Gu Vilmundur Gudnason Alistair S Hall Anders Hamsten Tamara B Harris Stanley L Hazen Christian Hengstenberg Albert Hofman Erik Ingelsson Carlos Iribarren J Wouter Jukema Pekka J Karhunen Bong-Jo Kim Jaspal S Kooner Iftikhar J Kullo Terho Lehtimäki Ruth J F Loos Olle Melander Andres Metspalu Winfried März Colin N Palmer Markus Perola Thomas Quertermous Daniel J Rader Paul M Ridker Samuli Ripatti Robert Roberts Veikko Salomaa Dharambir K Sanghera Stephen M Schwartz Udo Seedorf Alexandre F Stewart David J Stott Joachim Thiery Pierre A Zalloua Christopher J O'Donnell Muredach P Reilly Themistocles L Assimes John R Thompson Jeanette Erdmann Robert Clarke Hugh Watkins Sekar Kathiresan Ruth McPherson Panos Deloukas Heribert Schunkert Nilesh J Samani Martin Farrall

Nat Genet 2015 Oct 7;47(10):1121-1130. Epub 2015 Sep 7.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895PMC
October 2015

Recent advances in computer-aided drug design as applied to anti-influenza drug discovery.

Curr Top Med Chem 2014 ;14(16):1875-89

Department of Chemical Biology, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.

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June 2015

HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia.

Retrovirology 2014 Dec 18;11:119. Epub 2014 Dec 18.

Université de Lyon 1, CNRS UMR5239, Oncovirologie et Biothérapies, Laboratoire de Biologie Moléculaire de la Cellule, Faculté de Médecine Lyon Sud, Pierre Bénite, France.

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http://dx.doi.org/10.1186/s12977-014-0119-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293115PMC
December 2014

Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel.

PLoS Negl Trop Dis 2014 Oct 16;8(10):e3265. Epub 2014 Oct 16.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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https://dx.plos.org/10.1371/journal.pntd.0003265
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http://dx.doi.org/10.1371/journal.pntd.0003265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199547PMC
October 2014

Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel.

Bioorg Med Chem Lett 2014 Jun 13;24(11):2469-72. Epub 2014 Apr 13.

Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055354PMC
June 2014

Sudemycin E influences alternative splicing and changes chromatin modifications.

Nucleic Acids Res 2014 Apr 11;42(8):4947-61. Epub 2014 Mar 11.

Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone, Lexington, KY 40536, USA, Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA and GenoSplice Technology, Hôpital Saint-Louis, Av Claude Vellefaux, 75010 Paris, France.

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http://dx.doi.org/10.1093/nar/gku151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005683PMC
April 2014

Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.

ACS Chem Biol 2014 Mar 30;9(3):643-8. Epub 2013 Dec 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , 262 Danny Thomas PI, MS 1000, Memphis, Tennessee 38105, United States.

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http://pubs.acs.org/doi/10.1021/cb400695j
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http://dx.doi.org/10.1021/cb400695jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962696PMC
March 2014

Optimization of antitumor modulators of pre-mRNA splicing.

J Med Chem 2013 Dec 11;56(24):10033-44. Epub 2013 Dec 11.

Department of Chemical Biology and Therapeutics, ‡Preclinical PK Shared Resource, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105-2794, United States.

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http://dx.doi.org/10.1021/jm401370hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932738PMC
December 2013

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

Drug Discov Today 2013 Jan 3;18(1-2):43-9. Epub 2012 Aug 3.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.drudis.2012.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596818PMC
January 2013

Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.

ACS Chem Biol 2012 Mar 19;7(3):526-34. Epub 2012 Jan 19.

Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

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http://dx.doi.org/10.1021/cb200439zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960075PMC
March 2012

Radiosynthesis of antitumor spliceosome modulators.

Appl Radiat Isot 2011 Sep 16;69(9):1231-4. Epub 2011 Apr 16.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096980431100217
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http://dx.doi.org/10.1016/j.apradiso.2011.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105125PMC
September 2011

Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.

Bioorg Med Chem Lett 2011 Aug 12;21(15):4592-6. Epub 2011 Jun 12.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X110074
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http://dx.doi.org/10.1016/j.bmcl.2011.05.103DOI Listing
August 2011

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

ACS Chem Biol 2011 Jun 7;6(6):582-9. Epub 2011 Mar 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

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http://dx.doi.org/10.1021/cb100356kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113647PMC
June 2011

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.

Medchemcomm 2011 Jan;2(9):904-908

Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, U.S.A. ; Tel: 901 595 3928.

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http://dx.doi.org/10.1039/C1MD00040CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171832PMC
January 2011

Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.

J Med Chem 2010 Dec 24;53(24):8709-15. Epub 2010 Nov 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm101101qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022373PMC
December 2010

Efficient synthesis of pyrazolopyrimidine libraries.

J Comb Chem 2010 Nov 30;12(6):807-9. Epub 2010 Aug 30.

Department of Chemical Biology & Therapeutics, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/cc1001204DOI Listing
November 2010

2-Substituted-4,5-dihydroxypyrimidine-6-carboxamide antiviral targeted libraries.

J Comb Chem 2009 Nov-Dec;11(6):1100-4

Department of Chemical Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/cc900111uDOI Listing
February 2010

Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel.

FASEB J 2010 Jan 2;24(1):128-35. Epub 2009 Sep 2.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1096/fj.09-137091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797036PMC
January 2010

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

J Med Chem 2009 Nov;52(22):6979-90

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, MS 1000, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm901215mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801547PMC
November 2009

Combinatorial synthesis and biological evaluation of peptide-binding GPCR-targeted library.

Bioorg Chem 2009 Jun 19;37(3):90-5. Epub 2009 Apr 19.

Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S004520680900018
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http://dx.doi.org/10.1016/j.bioorg.2009.04.001DOI Listing
June 2009

Design and synthesis of a novel tyrosine kinase inhibitor template.

Bioorg Med Chem 2009 May 27;17(9):3308-16. Epub 2009 Mar 27.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN 38105-3678, United States.

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http://dx.doi.org/10.1016/j.bmc.2009.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696309PMC
May 2009

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Expert Rev Anticancer Ther 2009 Mar;9(3):331-56

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, 332 North Lauderdale Street, Mail Stop 1000, Memphis, TN 38105, USA.

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http://www.tandfonline.com/doi/full/10.1586/14737140.9.3.331
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http://dx.doi.org/10.1586/14737140.9.3.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780428PMC
March 2009

Antitumor compounds based on a natural product consensus pharmacophore.

J Med Chem 2008 Oct 13;51(19):6220-4. Epub 2008 Sep 13.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm8006195
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701350PMC
October 2008

Generation of new synthetic scaffolds using framework libraries selected and refined via medicinal chemist synthetic expertise.

J Chem Inf Model 2008 Apr 13;48(4):882-8. Epub 2008 Mar 13.

ChemBridge Research Labs., Inc., ChemBridge Corporation, 16981 Via Tazon, San Diego, California 92127, USA.

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http://pubs.acs.org/doi/abs/10.1021/ci7001928
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April 2008

Pulmonary toxicity screening studies in male rats with M5 respirable fibers and particulates.

Inhal Toxicol 2007 Sep;19(11):951-63

DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA.

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http://dx.doi.org/10.1080/08958370701515852 DOI Listing
September 2007

Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics.

Toxicol Sci 2007 Jan 9;95(1):270-80. Epub 2006 Oct 9.

DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA.

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http://dx.doi.org/10.1093/toxsci/kfl128DOI Listing
January 2007

Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties.

Toxicology 2007 Jan 10;230(1):90-104. Epub 2006 Nov 10.

DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA.

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January 2007

Polymer-supported synthesis of pyridone-focused libraries as inhibitors of anaplastic lymphoma kinase.

J Comb Chem 2006 May-Jun;8(3):401-9

Department of High Throughput Medicinal Chemistry, ChemBridge Research Laboratories, San Diego, California 92127, USA.

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August 2006

Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area.

Toxicol Sci 2006 May 22;91(1):227-36. Epub 2006 Feb 22.

DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA.

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May 2006

Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.

J Med Chem 2006 Feb;49(3):1006-15

ChemBridge Research Laboratories and ChemBridge Corporation, 16981 Via Tazon, Suites K and G, San Diego, CA 92127, USA.

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February 2006

Current directions in the evolution of compound libraries.

Authors:
Thomas R Webb

Curr Opin Drug Discov Devel 2005 May;8(3):303-8

ChemBridge Corporation and Chembridge Research Laboratories Inc, 16981 Via Tazon, San Diego, CA 92127, USA.

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May 2005

Bonding along a linear B...N...B triad.

J Org Chem 2004 Oct;69(20):6564-71

Department of Chemistry, Auburn University, Auburn, Alabama 36849-5312, USA.

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October 2004

Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor.

Bioorg Med Chem Lett 2004 Aug;14(15):3869-73

Department of Medicinal Chemistry and Department of Pharmacology, Neurocrine Bioscience, Inc., 10555 Science Center Drive, San Diego, CA 92121, USA.

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August 2004

Novel asymmetric approach to proline-derived spiro-beta-lactams.

J Org Chem 2004 Aug;69(17):5766-9

Department of Chemistry Research, ChemBridge Research Laboratories and ChemBridge Corporation, 16981 Via Tazon, San Diego, California 92127, USA.

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August 2004

Solid-phase synthesis of tetrahydro-1,4-benzodiazepine-2-one derivatives as a beta-turn peptidomimetic library.

J Comb Chem 2004 Mar-Apr;6(2):207-13

Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.

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http://dx.doi.org/10.1021/cc034039mDOI Listing
May 2004

Bis(fluoroformyl)trioxide, FC(O)OOOC(O)F.

Angew Chem Int Ed Engl 2004 May;43(21):2843-6

Fakultät 4, Anorganische Chemie, Gerhard-Mercator-Universität Duisburg, Lotharstrasse 1, 47057 Duisburg, Germany.

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http://dx.doi.org/10.1002/anie.200353369DOI Listing
May 2004

Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance.

Toxicology 2003 Nov;192(2-3):189-210

DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA.

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November 2003

Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors.

Bioorg Med Chem 2003 Nov;11(23):5059-68

ChemBridge Research Labs., LLC, 16981 Via Tazon, San Diego, CA 92127, USA.

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November 2003

Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.

Bioorg Med Chem Lett 2003 Oct;13(19):3375-9

Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 10555 Science Centre Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/s0960-894x(03)00684-xDOI Listing
October 2003

Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammation.

Inhal Toxicol 2003 Oct;15(12):1231-46

DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA.

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October 2003

Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors.

Bioorg Med Chem 2003 Jan;11(1):77-85

ChemBridge Corporation, 16981 Via Tazon, Suite G, San Diego, CA 92127, USA.

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January 2003

Sulfuranes Lacking Benzoannelation. Sulfuranes and Other Hypervalent Molecules Studied by (17)O-NMR.

J Org Chem 1999 Oct;64(22):8226-8235

Department of Chemistry, Auburn University, Auburn, Alabama 36849-5312.

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http://dx.doi.org/10.1021/jo9909608DOI Listing
October 1999

Crystal Structure, Electronic Structure, and Temperature-Dependent Raman Spectra of Tl[Ag(CN)(2)]: Evidence for Ligand-Unsupported Argentophilic Interactions.

Inorg Chem 1998 Mar;37(6):1380-1386

Department of Chemistry, University of Maine, Orono, Maine 04469, Department of Chemistry, Auburn University, Auburn, Alabama 36849, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831, and Angelo State University, San Angelo, Texas 76909.

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March 1998