Publications by authors named "Thomas Powles"

100Publications

Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Nivolumab plus Cabozantinib Joins Immune Checkpoint Inhibition Combination Therapies for Treatment-naïve Metastatic Clear-Cell Renal Cell Carcinoma.

Eur Urol 2020 Dec 20. Epub 2020 Dec 20.

The Royal Free London NHS Foundation Trust, London, UK; UCL Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Electronic address:

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December 2020

Rationale and Outcomes for Neoadjuvant Immunotherapy in Urothelial Carcinoma of the Bladder.

Eur Urol Oncol 2020 Dec 8;3(6):728-738. Epub 2020 Nov 8.

Experimental Cancer Medicine Centre Barts Cancer Institute, Queen Mary University of London, St Bartholomew's Hospital, London, UK.

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December 2020

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.

N Engl J Med 2020 09 18;383(13):1218-1230. Epub 2020 Sep 18.

From Barts Cancer Institute, Experimental Cancer Medicine Centre, Queen Mary University of London, St. Bartholomew's Hospital, London (T.P.); Sungkyunkwan University Samsung Medical Center, Seoul, South Korea (S.H.P.); Centre Jean Bernard Clinique Victor Hugo, Le Mans (E.V.), and Gustave Roussy, INSERM Unité 981, Université Paris-Saclay, Villejuif (Y.L.) - both in France; the Medical Oncology Unit, Azienda Ospedaliera S. Maria, Terni (C.C.), and Pfizer, Milan (C.F., A.P.) - both in Italy; the Department of Medical Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain (B.P.V.); the Department of Clinical Medicine, Macquarie University, Sydney (H.G.); the Division of Oncology, Department of Medicine, University General Hospital of Patras, Patras, Greece (H.K.); the Institute for Oncology and Radiology of Serbia, Belgrade (S.R.); the Department of Medical Oncology, Algemeen Ziekenhuis Klina, Brasschaat, Belgium (W.D.); Patient Area Pelvic Cancer, Theme Cancer, Karolinska University Hospital, and the Department of Oncology-Pathology, Karolinska Institute, Solna, Sweden (A.U.); Princess Margaret Cancer Centre, University Health Network, Toronto (S.S.S.); the Department of Urology, Yamagata University Faculty of Medicine, Yamagata, Japan (N.T.); the State Institution of Healthcare Regional Clinical Oncology Dispensary, Omsk, Russia (E.K.); the Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York (C.N.S.); the Department of Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston (J.B.), and Pfizer, Cambridge (R.L., J.W.) - both in Massachusetts; Inova Schar Cancer Institute, Fairfax, VA (J.B.A.-C.); Yale Cancer Center, New Haven (D.P.P.), and Pfizer, Groton (B.H.) - both in Connecticut; Pfizer, La Jolla, CA (C.D., J.A.B.-H.); Pfizer, Porto Salvo, Portugal (N.C.); and the Department of Medicine, Division of Oncology, University of Washington, and the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle (P.G.).

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September 2020

Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.

Eur Urol 2020 Aug 12. Epub 2020 Aug 12.

Beth Israel Deaconess Medical Center and PSMAR-IMIM Research Lab, Harvard Medical School, Boston, MA, USA. Electronic address:

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August 2020

Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors.

Eur Urol 2020 Aug 26;78(2):276-280. Epub 2020 May 26.

Barts Cancer Centre, Queen Mary University of London, London, UK. Electronic address:

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August 2020

Immune checkpoint inhibition in urothelial carcinoma.

Lancet 2020 05;395(10236):1522-1523

Centre for Experimental Cancer Medicine, Barts Cancer Centre, London EC1A 7BE, UK. Electronic address:

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May 2020

Advice Regarding Systemic Therapy in Patients with Urological Cancers During the COVID-19 Pandemic.

Eur Urol 2020 06 17;77(6):667-668. Epub 2020 Apr 17.

Barts Cancer Institute, Queen Mary University of London, London, UK. Electronic address:

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June 2020

Treatment Choices for Front-line Metastatic Clear Cell Renal Cancer.

Authors:
Thomas Powles

Eur Urol 2020 04 28;77(4):454-456. Epub 2020 Jan 28.

Department of Medical Oncology, The Royal Free Hospital, London, UK; Bart Cancer Centre, London, UK. Electronic address:

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April 2020

Deferred Cytoreductive Nephrectomy Following Presurgical Vascular Endothelial Growth Factor Receptor-targeted Therapy in Patients with Primary Metastatic Clear Cell Renal Cell Carcinoma: A Pooled Analysis of Prospective Trial Data.

Eur Urol Oncol 2020 04 16;3(2):168-173. Epub 2020 Jan 16.

Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, UCL Division of Surgical and Interventional Science, London, UK. Electronic address:

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April 2020

The evolving role of PD-L1 testing in patients with metastatic urothelial carcinoma.

Cancer Treat Rev 2020 Jan 11;82:101925. Epub 2019 Nov 11.

PSMAR-IMIM Research Institute in Barcelona and Harvard Medical School, Boston, MA, USA. Electronic address:

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January 2020

Cytoreductive nephrectomy in the current treatment algorithm.

Ther Adv Med Oncol 2019 27;11:1758835919879026. Epub 2019 Sep 27.

Royal Free Hospital, Department of Urology, Renal Cancer Unit, University College London, Division of Surgical and Interventional Sciences, London, UK.

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September 2019

Molecular and histopathology directed therapy for advanced bladder cancer.

Nat Rev Urol 2019 08 9;16(8):465-483. Epub 2019 Jul 9.

Department of Oncology, University College London Hospital, London, UK.

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August 2019

Immune Checkpoint Blockade plus Axitinib for Renal-Cell Carcinoma. Reply.

N Engl J Med 2019 06;380(26):2582

Royal Free NHS Trust, London, United Kingdom.

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June 2019

Single-centre Experience of Patients with Metastatic Urothelial Cancer Treated with Chemotherapy Following Immune Checkpoint Inhibition.

Eur Urol Oncol 2019 Apr 9. Epub 2019 Apr 9.

Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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April 2019

Role of Checkpoint Inhibition in Localized Bladder Cancer.

Eur Urol Oncol 2018 08 30;1(3):190-198. Epub 2018 May 30.

Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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August 2018

Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches.

J Pathol 2019 10 24;249(2):151-165. Epub 2019 Jun 24.

Department of Urology, The First Affiliated Hospital and Academy of Medical Sciences, Zhengzhou University, Zhengzhou, PR China.

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October 2019

The adjuvant treatment of kidney cancer: a multidisciplinary outlook.

Nat Rev Nephrol 2019 07;15(7):423-433

Department of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.

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July 2019

European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update.

Eur Urol 2019 05 23;75(5):799-810. Epub 2019 Feb 23.

The Royal Free London NHS Foundation Trust, London, UK; UCL Division of Surgery and Interventional Science, London, UK; Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

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May 2019

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

N Engl J Med 2019 03 16;380(12):1116-1127. Epub 2019 Feb 16.

From the Cleveland Clinic Taussig Cancer Institute, Cleveland (B.I.R.); Fox Chase Cancer Center, Philadelphia (E.R.P.); Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine (V.S.) and Dnipropetrovsk Medical Academy (I.B.), Dnipro, Sumy State University, Sumy Regional Oncology Center, Sumy (I.V.), and Ivano-Frankivsk National Medical University, Ivano-Frankivsk (A.K.) - all in Ukraine; the Russian Scientific Center of Roentgen Radiology (R.G.), Central Clinical Hospital with Outpatient Clinic (D.N.), and Hertzen Moscow Cancer Research Institute (B.A.), Moscow; the Christie NHS Foundation Trust, Manchester (R.H.), and Barts Health and the Royal Free NHS Trusts, Barts Cancer Institute, and Queen Mary University of London, London (T.P.) - all in the United Kingdom; Centre Hospitalier Universitaire (CHU) de Québec and Université Laval, Quebec, QC (F.P.), and CHU de Montréal, Montreal (D.S.) - both in Canada; Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic (B.M.); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (S.J.A.); Centre Antoine Lacassagne, Université Côte d'Azur, Nice (D.B.), and Hôpitaux Universitaires de Lyon, Lyon (S. Tartas) - both in France; Military Institute of Medicine, Warsaw, Poland (C.S.); Rocky Mountain Cancer Center, Colorado Springs, CO (M.M.); Adelaide and Meath Hospital and University College Dublin, Dublin (R.S.M.); the Department of Urology, Eberhard-Karls University Tübingen, Tübingen, Germany (J.B.); Taipei Veterans General Hospital, Taipei, Taiwan (Y.-H.C.); Osaka City University Hospital, Osaka, Japan (S. Tamada); MSD China, Beijing (Q.S.); Merck, Kenilworth, NJ (R.F.P., M.C.); and Georgetown Lombardi Comprehensive Cancer Center, Washington, DC (M.B.A.).

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March 2019

Sunitinib Alone or after Nephrectomy in Renal Cancer.

N Engl J Med 2018 11;379(19):1877-8

Netherlands Cancer Institute, Amsterdam, the Netherlands

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November 2018

Novel Agents and Drug Development Needs in Advanced Clear Cell Renal Cancer.

J Clin Oncol 2018 Oct 29:JCO2018792655. Epub 2018 Oct 29.

Thomas Powles, Royal Free Hospital, and Queen Mary University of London, London, United Kingdom; and Brian Rini, Lerner College of Medicine, and Cleveland Clinic, Cleveland, OH.

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October 2018

Systemic Treatment of Metastatic Clear Cell Renal Cell Carcinoma in 2018: Current Paradigms, Use of Immunotherapy, and Future Directions.

Eur Urol 2019 01 13;75(1):100-110. Epub 2018 Oct 13.

The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Electronic address:

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January 2019

The Cancer Immunogram as a Framework for Personalized Immunotherapy in Urothelial Cancer.

Eur Urol 2019 03 28;75(3):435-444. Epub 2018 Sep 28.

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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March 2019