Publications by authors named "Thomas Pietschmann"

100Publications

Correction for Haid et al., "Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System".

J Virol 2020 Jul 1;94(14). Epub 2020 Jul 1.

Division of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

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http://dx.doi.org/10.1128/JVI.01690-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343214PMC
July 2020

Controlled Functional Zonation of Hepatocytes by Engineering of Wnt Signaling.

ACS Synth Biol 2020 07 6;9(7):1638-1649. Epub 2020 Jul 6.

Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1021/acssynbio.9b00435DOI Listing
July 2020

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.

PLoS Pathog 2020 06 15;16(6):e1008554. Epub 2020 Jun 15.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1008554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316345PMC
June 2020

Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells.

Med Microbiol Immunol 2020 Aug 22;209(4):499-514. Epub 2020 Apr 22.

Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Feodor-Lynen-Straße 7, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00430-020-00675-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176029PMC
August 2020

C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.

J Hepatol 2020 Sep 12;73(3):549-558. Epub 2020 Apr 12.

Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; Faculty of Medicine, Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.03.047DOI Listing
September 2020

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry.

Antiviral Res 2020 05 18;177:104774. Epub 2020 Mar 18.

Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany; German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2020.104774DOI Listing
May 2020

Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus.

Gut 2020 Sep 29;69(9):1659-1666. Epub 2020 Feb 29.

Institute of Experimental Virology, Twincore, Hannover, Germany

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http://dx.doi.org/10.1136/gutjnl-2019-319354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456736PMC
September 2020

Protecting-Group-Mediated Diastereoselective Synthesis of C4'-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus.

J Org Chem 2020 Mar 26;85(6):4267-4278. Epub 2020 Feb 26.

Technische Universität Braunschweig, Institute for Organic Chemistry, Hagenring 30, 38106 Braunschweig, Germany.

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http://dx.doi.org/10.1021/acs.joc.9b03425DOI Listing
March 2020

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones.

ACS Omega 2019 Mar 5;4(3):4871-4887. Epub 2019 Mar 5.

Université de Strasbourg, Université de Haute-Alsace, CNRS, LIMA, UMR 7042, Equipe Chimie Bioorganique et Médicinale, ECPM, 25 Rue Becquerel, 67000 Strasbourg, France.

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http://dx.doi.org/10.1021/acsomega.8b03332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648324PMC
March 2019

Synthesis of 4'/5'-Spirocyclopropanated Uridine and d-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus.

Org Lett 2019 09 21;21(17):6966-6971. Epub 2019 Aug 21.

Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.

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http://dx.doi.org/10.1021/acs.orglett.9b02555DOI Listing
September 2019

Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion.

Cold Spring Harb Perspect Med 2020 02 3;10(2). Epub 2020 Feb 3.

TWINCORE, Center for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.

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http://dx.doi.org/10.1101/cshperspect.a036830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996445PMC
February 2020

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit.

Cells 2019 03 12;8(3). Epub 2019 Mar 12.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), 30625 Hannover, Germany.

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http://dx.doi.org/10.3390/cells8030233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468556PMC
March 2019

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors.

J Hepatol 2019 06 13;70(6):1082-1092. Epub 2019 Feb 13.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Str. 7, 30625 Hannover, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.01.033DOI Listing
June 2019

Hepatitis C Virus.

Trends Microbiol 2019 04 29;27(4):379-380. Epub 2019 Jan 29.

Division of Experimental Virology, Twincore Center for Experimental and Clinical Infection Research, Feodor-Lynen-Straße 7-9, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.tim.2019.01.001DOI Listing
April 2019

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

J Hepatol 2019 04 13;70(4):593-602. Epub 2018 Nov 13.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183252
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http://dx.doi.org/10.1016/j.jhep.2018.11.003DOI Listing
April 2019

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.

PLoS Pathog 2018 07 19;14(7):e1007111. Epub 2018 Jul 19.

Insitute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1007111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053247PMC
July 2018

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells.

Viruses 2018 04 20;10(4). Epub 2018 Apr 20.

Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.

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http://dx.doi.org/10.3390/v10040207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923501PMC
April 2018

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry.

Antiviral Res 2017 11 18;147:19-28. Epub 2017 Sep 18.

Institute of Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.09.006DOI Listing
November 2017

Hepatitis C Virus Strain-Dependent Usage of Apolipoprotein E Modulates Assembly Efficiency and Specific Infectivity of Secreted Virions.

J Virol 2017 09 24;91(18). Epub 2017 Aug 24.

Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hanover, Germany

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http://dx.doi.org/10.1128/JVI.00422-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571276PMC
September 2017

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

J Hepatol 2017 09 22;67(3):480-489. Epub 2017 Apr 22.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.04.010DOI Listing
September 2017

Immune protection against reinfection with nonprimate hepacivirus.

Proc Natl Acad Sci U S A 2017 03 8;114(12):E2430-E2439. Epub 2017 Mar 8.

Institute for Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, Medical School Hannover (MHH)-Helmholtz Centre for Infection Research (HZI), 30625 Hannover, Germany;

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http://dx.doi.org/10.1073/pnas.1619380114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373355PMC
March 2017

Protein Interactions during the Flavivirus and Hepacivirus Life Cycle.

Mol Cell Proteomics 2017 04 11;16(4 suppl 1):S75-S91. Epub 2017 Jan 11.

From the Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1074/mcp.R116.065649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393392PMC
April 2017

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy.

Antiviral Res 2017 Mar 3;139:129-137. Epub 2017 Jan 3.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, A joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Str. 7, 30625, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292934PMC
March 2017

Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases.

J Virol 2017 Jan 3;91(2). Epub 2017 Jan 3.

Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany, and German Centre for Infection Research, Hannover-Braunschweig, Germany

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http://dx.doi.org/10.1128/JVI.01914-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215334PMC
January 2017

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites.

Cell Host Microbe 2016 Oct;20(4):443-457

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.09.003DOI Listing
October 2016

Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.

J Virol 2016 Dec 14;90(23):10670-10681. Epub 2016 Nov 14.

Institute for Experimental Virology, Centre for Experimental and Clinical Infection Research, TWINCORE, Hanover, Germany

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http://dx.doi.org/10.1128/JVI.01634-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110154PMC
December 2016

Apolipoprotein E polymorphisms and their protective effect on hepatitis E virus replication.

Hepatology 2016 12 30;64(6):2274-2276. Epub 2016 Sep 30.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research GmbH; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1002/hep.28788DOI Listing
December 2016

Hepatitis C virus plays hide and seek with neutralizing antibodies.

Hepatology 2016 12 25;64(6):1840-1842. Epub 2016 Aug 25.

Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1002/hep.28760DOI Listing
December 2016

Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner.

PLoS Pathog 2016 07 6;12(7):e1005736. Epub 2016 Jul 6.

Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1005736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934921PMC
July 2016

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production.

PLoS Pathog 2016 04 28;12(4):e1005568. Epub 2016 Apr 28.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1005568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849665PMC
April 2016

Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication.

Antimicrob Agents Chemother 2016 Apr 25;60(4):2132-9. Epub 2016 Mar 25.

Institute for Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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http://dx.doi.org/10.1128/AAC.02427-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808167PMC
April 2016

Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System.

J Virol 2015 Dec 30;90(6):3065-73. Epub 2015 Dec 30.

Division of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

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http://dx.doi.org/10.1128/JVI.03074-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810627PMC
December 2015

Cell culture-derived HCV cannot infect synovial fibroblasts.

Sci Rep 2015 Dec 8;5:18043. Epub 2015 Dec 8.

TWINCORE, Center for Experimental and Clinical Infection Research, Institute of Experimental Virology, Hannover, Germany.

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http://dx.doi.org/10.1038/srep18043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672287PMC
December 2015

Decoding protein networks during virus entry by quantitative proteomics.

Virus Res 2016 06 10;218:25-39. Epub 2015 Sep 10.

Insitute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, A joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30652 Hannover, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914609PMC
June 2016

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.

PLoS One 2015 30;10(7):e0134529. Epub 2015 Jul 30.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520612PMC
May 2016

Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry.

Cell Rep 2015 Aug 23;12(5):864-78. Epub 2015 Jul 23.

Insitute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30165 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836839PMC
August 2015

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design.

Viruses 2015 Jul 17;7(7):3995-4046. Epub 2015 Jul 17.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centrefor Infection Research (HZI), Hannover D-30625, Germany.

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http://dx.doi.org/10.3390/v7072809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517138PMC
July 2015

Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells.

J Virol 2015 Mar 31;89(6):3200-8. Epub 2014 Dec 31.

Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany

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http://dx.doi.org/10.1128/JVI.03229-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337522PMC
March 2015

Mechanisms of methods for hepatitis C virus inactivation.

Appl Environ Microbiol 2015 Mar 19;81(5):1616-21. Epub 2014 Dec 19.

Institute of Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, Hanover, Germany

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http://dx.doi.org/10.1128/AEM.03580-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325173PMC
March 2015

Role of hypervariable region 1 for the interplay of hepatitis C virus with entry factors and lipoproteins.

J Virol 2014 Nov 20;88(21):12644-55. Epub 2014 Aug 20.

Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Medical School Hannover (MHH) and Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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http://dx.doi.org/10.1128/JVI.01145-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248924PMC
November 2014

Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region.

Antiviral Res 2014 Oct 22;110:52-9. Epub 2014 Jul 22.

Divison of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Str. 7, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2014.07.009DOI Listing
October 2014

The HCV life cycle: in vitro tissue culture systems and therapeutic targets.

Dig Dis 2014 14;32(5):525-37. Epub 2014 Jul 14.

TWINCORE - Institute of Experimental Virology, Centre for Experimental and Clinical Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1159/000360830DOI Listing
March 2015

Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles.

Hepatology 2014 Aug 24;60(2):508-20. Epub 2014 Jun 24.

Institute for Experimental Virology, Twincore, and Hannover Medical School Hannover, Germany, and Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1002/hep.27190DOI Listing
August 2014

Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virion.

Viruses 2014 Mar 11;6(3):1149-87. Epub 2014 Mar 11.

Institute of Experimental Virology, Twincore, Center for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover and the Helmholtz Center for Infection Research, 30625 Hannover, Germany.

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http://dx.doi.org/10.3390/v6031149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970144PMC
March 2014

Natural reservoirs for homologs of hepatitis C virus.

Emerg Microbes Infect 2014 Mar 26;3(3):e21. Epub 2014 Mar 26.

Institute for Experimental Virology, Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research , Hannover 30625, Germany.

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http://dx.doi.org/10.1038/emi.2014.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974340PMC
March 2014

In sero veritas: what serum markers teach us about HCV infection of primary human hepatocytes.

Gut 2014 Sep 28;63(9):1375-7. Epub 2013 Nov 28.

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http://dx.doi.org/10.1136/gutjnl-2013-306111DOI Listing
September 2014

Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment.

J Virol 2013 Dec 2;87(24):13297-306. Epub 2013 Oct 2.

Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Medical School Hannover (MHH) and Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01708-13
Publisher Site
http://dx.doi.org/10.1128/JVI.01708-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838269PMC
December 2013

Inactivation of hepatitis C virus infectivity by human breast milk.

J Infect Dis 2013 Dec 24;208(12):1943-52. Epub 2013 Sep 24.

Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Str. 7, Hannover 30625, Germany.

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http://dx.doi.org/10.1093/infdis/jit519DOI Listing
December 2013

Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.

Gastroenterology 2013 Dec 21;145(6):1414-23.e1. Epub 2013 Aug 21.

Research Group Innate Immunity and Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1053/j.gastro.2013.08.037DOI Listing
December 2013

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.

Hepatology 2014 Jan 18;59(1):78-88. Epub 2013 Nov 18.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/hep.26626DOI Listing
January 2014

A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication.

Hepatology 2014 Feb 23;59(2):363-5. Epub 2013 Dec 23.

Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1002/hep.26621DOI Listing
February 2014

hepatitis c Virus p7 is critical for capsid assembly and envelopment.

PLoS Pathog 2013 2;9(5):e1003355. Epub 2013 May 2.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642076PMC
December 2013

Stability and transmission of hepatitis C virus in different anesthetic agents.

Am J Infect Control 2013 Oct 22;41(10):942-3. Epub 2013 Mar 22.

Division of Experimental Virology, Twincore, Center for Experimental and Clinical Infection Research, Hannover, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.ajic.2013.01.016DOI Listing
October 2013

Cell culture systems for hepatitis C virus.

Curr Top Microbiol Immunol 2013 ;369:17-48

Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1007/978-3-642-27340-7_2DOI Listing
August 2013

Hepatitis C virus NS5B polymerase primes innate immune signaling.

Hepatology 2013 Mar 21;57(3):1275-7. Epub 2013 Feb 21.

Institute of Experimental Virology Twincore-Center for Experimental and Clinical Infectious Disease Research Hannover, Germany.

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http://dx.doi.org/10.1002/hep.26201DOI Listing
March 2013

Opportunities and Risks of Host-targeting Antiviral Strategies for Hepatitis C.

Curr Hepat Rep 2013 4;12(4):200-213. Epub 2013 Oct 4.

TWINCORE - Centre for Experimental and Clinical Infection Research, Institute of Experimental Virology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.

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http://dx.doi.org/10.1007/s11901-013-0187-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089091PMC
October 2013

Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells.

J Virol 2013 Feb 21;87(3):1664-78. Epub 2012 Nov 21.

Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02782-12
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http://dx.doi.org/10.1128/JVI.02782-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554161PMC
February 2013

Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment.

J Infect Dis 2013 Jan 5;207(2):281-7. Epub 2012 Nov 5.

Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Medical School Hannover and Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1093/infdis/jis677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611766PMC
January 2013

Entry and replication of recombinant hepatitis C viruses in cell culture.

Methods 2013 Feb 23;59(2):233-48. Epub 2012 Sep 23.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; A Joint Venture Between The Medical School Hannover and The Helmholtz Centre for Infection Research, Feodor-Lynen-Straße 7-9, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.ymeth.2012.09.005DOI Listing
February 2013

High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

J Biol Chem 2012 Nov 10;287(46):39224-32. Epub 2012 Sep 10.

Research Group Directed Evolution, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1074/jbc.M112.393843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493962PMC
November 2012

Two pathogen reduction technologies--methylene blue plus light and shortwave ultraviolet light--effectively inactivate hepatitis C virus in blood products.

Transfusion 2013 May 21;53(5):1010-8. Epub 2012 Aug 21.

Division of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1111/j.1537-2995.2012.03858.xDOI Listing
May 2013

Anti-retroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro.

Antiviral Res 2012 Oct 24;96(1):51-8. Epub 2012 Jul 24.

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1016/j.antiviral.2012.07.005DOI Listing
October 2012

Two methods of heterokaryon formation to discover HCV restriction factors.

J Vis Exp 2012 Jul 16(65):e4029. Epub 2012 Jul 16.

Division of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research.

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http://dx.doi.org/10.3791/4029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476423PMC
July 2012