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Merck & Company, Inc., Kenilworth, New Jersey (N.A.D., S.P.W., Y.C., H.Z., D.G.M., T.P.R., D.G.J., D.M.E., D.E.K., S.P.F.), and Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio (T.K.)