Publications by authors named "Thomas Meissner"

166 Publications

Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes.

Eur J Immunol 2021 Oct 8. Epub 2021 Oct 8.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany.

The important role of IL-7 in the generation of self-reactive T-cells in autoimmune diseases is well established. Recent studies on autoimmunity-associated genetic polymorphisms indicated that differential IL-7 receptor (IL-7R) expression of monocytes may play a role in the underlying pathogenesis. The relevance of IL-7-mediated monocyte functions in type 1 diabetes remains elusive. In the present study, we characterized monocyte phenotype and IL-7-mediated effects in children with type 1 diabetes and healthy controls with multicolor flow cytometry and t-distributed Stochastic Neighbor-Embedded (t-SNE)-analyses. IL-7R expression of monocytes rapidly increased in vitro and was boosted through LPS. In the presence of IL-7, we detected lower monocyte IL-7R expression in type 1 diabetes patients as compared to healthy controls. This difference was most evident for the subset of nonclassical monocytes, which increased after IL-7 stimulation. t-SNE analyses revealed IL-7-dependent differences in monocyte subset distribution and expression of activation and maturation markers (i.e., HLA-DR, CD80, CD86, CD40). Notably, monocyte CD40 expression increased considerably by IL-7 and CD40/IL-7R co-expression differed between patients and controls. This study shows the unique effects of IL-7 on monocyte phenotype and functions. Lower IL-7R expression on IL-7-induced CD40 monocytes and impaired IL-7 response characterize monocytes from patients with type 1 diabetes.
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http://dx.doi.org/10.1002/eji.202149229DOI Listing
October 2021

Efficacy of Motivational Interviewing to Improve Utilization of Mental Health Services Among Youths With Chronic Medical Conditions: A Cluster Randomized Clinical Trial.

JAMA Netw Open 2021 Oct 1;4(10):e2127622. Epub 2021 Oct 1.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Heinrich-Heine-University, Düsseldorf, Germany.

Importance: Despite the high prevalence of anxiety and depression in youths with chronic medical conditions (CMCs), physicians encounter substantial barriers in motivating these patients to access mental health care services.

Objective: To determine the efficacy of motivational interviewing (MI) training for pediatricians in increasing youths' use of mental health care.

Design, Setting, And Participants: The COACH-MI (Chronic Conditions in Adolescents: Implementation and Evaluation of Patient-Centered Collaborative Healthcare-Motivational Interviewing) study was a single-center cluster randomized clinical trial at the University Children's Hospital specialized outpatient clinics in Düsseldorf, Germany. Treating pediatricians were cluster randomized to a 2-day MI workshop or treatment as usual (TAU). Patient recruitment and MI conversations occurred between April 2018 and May 2020 with 6-month follow-up and 1-year rescreening. Participants were youths aged 12 to 20 years with CMCs and comorbid symptoms of anxiety and depression; they were advised by their MI-trained or untrained physicians to access psychological counseling services. Statistical analysis was performed from October 2020 to April 2021.

Interventions: MI physicians were trained through a 2-day, certified MI training course; they recommended use of mental health care services during routine clinical appointments.

Main Outcomes And Measures: The primary outcome of uptake of mental health care services within the 6-month follow-up was analyzed using a logistic mixed model, adjusted for the data's cluster structure. Uptake of mental health services was defined as making at least 1 appointment by the 6-month follow-up.

Results: Among 164 youths with CMCs and conspicuous anxiety or depression screening, 97 (59%) were female, 94 (57%) had MI, and 70 (43%) had TAU; the mean (SD) age was 15.2 (1.9) years. Compared with patients receiving TAU, the difference in mental health care use at 6 months among patients whose physicians had undergone MI training was not statistically significant (odds ratio [OR], 1.96; 95% CI, 0.98-3.92; P = .06). The effect was moderated by the subjective burden of disease (F2,158 = 3.42; P = .04). Counseling with an MI-trained physician also led to lower anxiety symptom scores at 1-year rescreening (F1,130 = 4.11; P = .045). MI training was associated with longer conversations between patients and physicians (30.3 [16.7] minutes vs 16.8 [12.5] minutes; P < .001), and conversation length significantly influenced uptake rates across conditions (OR, 1.03; 95% CI, 1.01-1.06; P = .005).

Conclusions And Relevance: In this study, use of MI in specialized pediatric consultations did not increase the use of mental health care services among youths with CMCs but did lead to longer patient-physician conversations and lower anxiety scores at 1 year. Additional research is required to determine whether varying scope and duration of MI training for physicians could encourage youths with CMCs to seek counseling and thus improve integrated care models.

Trial Registration: German Trials Registry: DRKS00014043.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.27622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486984PMC
October 2021

Warnung vor heftiger Influenza-Saison.

Authors:
Thomas Meißner

Pneumo News 2021 10;13(4):46-47. Epub 2021 Sep 10.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s15033-021-2735-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420839PMC
September 2021

Biologika gegen schweres instabiles Asthma.

Authors:
Thomas Meißner

CME (Berl) 2021 24;18(7-8):6-7. Epub 2021 Aug 24.

Häusliche Pflege Meißner & Walter GmbH, Alt Biesdorf 71 a, 12683 Berlin, Germany.

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http://dx.doi.org/10.1007/s11298-021-2083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370781PMC
August 2021

Kaftrio - Dreifachkombi bei Cystischer Fibrose : CFTR-Modulator.

Authors:
Thomas Meißner

MMW Fortschr Med 2021 Aug;163(14):65

Redaktionsbüro Meißner, Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s15006-021-0193-0DOI Listing
August 2021

Comirnaty - erstes zugelassenes mRNA-Vakzin : SARS-CoV-2-Pandemie.

Authors:
Thomas Meißner

MMW Fortschr Med 2021 Aug;163(14):64

Redaktionsbüro Meißner, Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s15006-021-0196-xDOI Listing
August 2021

Arrest of root caries with an adjuvant chlorhexidine-fluoride varnish over a 12-months observation period: a QLF-analyzed, placebo-controlled, randomized, clinical trial (RCT).

Odontology 2021 Jul 13. Epub 2021 Jul 13.

Department of CariologyEndodontology and Periodontology, University Leipzig, Liebigstr. 12, 04103, Leipzig, Germany.

This study aimed at evaluating the effectiveness of an adjuvant chlorhexidine-fluoride varnish (Cervitec F) for prevention and arrest of root caries on elderly participants using quantitative light-induced fluorescence (QLF). 23 participants with two or three non-cavitated root carious lesions were included and assigned to three groups of different varnishes (CF: Cervitec F, P: placebo, DP: Duraphate). Agents were applied once to root surface at baseline and in follow-up after 3, 6 and 9 months. The lesions were assessed clinically and with QLF. QLF-images were analyzed regarding fluorescence loss (ΔF), lesion volume (ΔQ) and bacterial activity (ΔR) before (t), after 14 days (t), 6- (t) and 12-months (t). CF showed a significant difference between t and t: ∆F (- 12.51 [15.41] vs. - 7.80 [16.72], p = 0.012), ∆Q (- 2339.97 (20,898.30) vs. - 751.82 (5725.35), p < 0.001), ∆R (23.80 [41.70] vs. 7.07 [37.50], p = 0.006). Independently of the varnish application, preventive care seems positively influence the root caries progress. Although within CF group the strongest effect was observed, no superiority of a specific varnish application was confirmed over a 12-months QLF observation period. Extra topical fluoride can help remineralise dentin lesions and QLF can be used as a measurement method to determine changes in the dentin lesions.
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http://dx.doi.org/10.1007/s10266-021-00637-wDOI Listing
July 2021

Acceptability of small-sized oblong tablets in comparison to syrup and mini-tablets in infants and toddlers: A randomized controlled trial.

Eur J Pharm Biopharm 2021 Sep 19;166:126-134. Epub 2021 Jun 19.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

Objective: There is limited evidence for the acceptability of various drug formulations holding the potential to improve medicines administration to children. Suitable formulations need to meet the requirements of pediatric patients. Previous studies have demonstrated the acceptance of mini-tablets. Oblong tablets may carry more active ingredient content per unit than mini-tablets and could be an important alternative when the drug substance requires administration of higher doses. The primary objective was to demonstrate non-inferiority of acceptability of oblong tablets in comparison to 3 ml glucose syrup in children aged 1 to 5 years. Secondary objectives were investigation of acceptability, swallowability and palatability of mini-tablets, oblong tablets and glucose syrup in children between 1 and 5 years.

Methods: An open, randomized, single dose two-way cross-over design in two parallel study arms was applied. 280 children were stratified to one of five age groups and randomized to receiving one oblong tablet (2.5 × 6 mm) in comparison either to 3 ml glucose syrup or to three mini-tablets (2 × 2 mm). Acceptability and swallowability were assessed according to pre-defined evaluation criteria. The application of the formulations was video documented to evaluate the palatability.

Results: As primary objective, non-inferiority was observed regarding acceptability of the oblong tablet compared to syrup in all age groups (84.4% vs 80.1%, difference 4,29% points with 95% CI of -3.00%,11.57%). For swallowability, superiority of the oblong tablet compared to syrup could be shown (74.5% vs. 53.2%, difference 21.26% points, 95% CI of 11.29%, 31.23%). Regarding palatability, <10% of children demonstrated unpleasant reaction after intake of the oblong tablet or mini-tablets as graded by both raters, however, in contrast up to 40% of children after intake of syrup.

Conclusion: Oblong tablets are a promising, safe alternative to liquid drug formulations and administration of multiple mini-tablets in children.
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http://dx.doi.org/10.1016/j.ejpb.2021.06.007DOI Listing
September 2021

Verbesserte Asthmakontrolle per Smartphone-App.

Authors:
Thomas Meißner

Pneumo News 2021 25;13(3):48. Epub 2021 Jun 25.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s15033-021-2724-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204617PMC
June 2021

Pneumologen: Weaning-Regelungen dringend erforderlich.

Authors:
Thomas Meißner

Pneumo News 2021 25;13(3):47. Epub 2021 Jun 25.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s15033-021-2725-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204596PMC
June 2021

CD5-expressing CD8 T-cell subsets differ between children with type 1 diabetes and controls.

Immunol Cell Biol 2021 Nov 18;99(10):1077-1084. Epub 2021 Jul 18.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany.

Different lymphocyte subsets are involved in autoimmune pathogenesis of type 1 diabetes (T1D). Previous studies suggested a role of CD5-expressing T and B cells including rare unconventional lymphocytes with combined T- and B-cell features [dual expressing (DE) cells]. We performed algorithm-supported multiparameter flow cytometry and quantitative PCR to investigate immune cell subsets and DE cells in children with T1D (n = 20) and matched controls (n = 20). Comparisons of conventional immune cells detected increased proportions of CD3 T cells in T1D patients, whereas CD19 B-cell proportions were comparable to controls. Self-organizing maps for flow cytometry analyses (FlowSOM) showed highly similar CD5-expressing B-cell subsets and no differences for DE cells were detected between the study groups by flow cytometry or specific quantitative PCR. Notably, differences in CD8 T cells were indicated by FlowSOM and similarity-based t-distributed stochastic neighbor embedding (tSNE) analyses. Study group comparisons confirmed significantly reduced CD8 T-cell proportions with moderate or low CD5 expression in T1D patients. Finally, in vitro experiments showed stable CD5 expression differences of CD8 T cells after T-cell activation, cytokine stimulation and culture. We observed differences of T-cell coreceptor CD5 expression in T1D patients with potential relevance for immune regulation of CD8 T-cell activation.
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http://dx.doi.org/10.1111/imcb.12488DOI Listing
November 2021

Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.

Cell Chem Biol 2021 10 11;28(10):1474-1488.e7. Epub 2021 Jun 11.

Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Center of Competence for Innovative Diabetes Therapy (KomIT), German Diabetes Center (DDZ), 40225 Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabetes mellitus (T2DM). Pancreatic islets are among the peripheral tissues that positively respond to DXM, and anti-diabetic effects of DXM were observed in two placebo-controlled, randomized clinical trials in humans with T2DM. Since these effects were associated with central side effects, we here developed chemical derivatives of DXM that pass the blood-brain barrier to a significantly lower extent than the original drug. We show that basic nitrogen-containing residues block central adverse events of DXM without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death. These results show how to chemically modify DXM, and possibly other morphinans, as to exclude central side effects, while targeting peripheral tissues, such as pancreatic islets.
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http://dx.doi.org/10.1016/j.chembiol.2021.05.011DOI Listing
October 2021

Multiorganvirus: Eine Bestandsaufnahme.

Authors:
Thomas Meißner

CME (Berl) 2021 21;18(5):41. Epub 2021 May 21.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s11298-021-2037-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097126PMC
May 2021

Rassismus in klinischer Forschung.

Authors:
Thomas Meißner

HNO Nachr 2021 22;51(2):10-13. Epub 2021 Apr 22.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s00060-021-7496-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042628PMC
April 2021

Consensus statements on the information to deliver after a febrile seizure.

Eur J Pediatr 2021 Sep 17;180(9):2993-2999. Epub 2021 Apr 17.

APHP. Service de Neurologie Pédiatrique, Hôpital Robert Debré, Paris, France.

Febrile seizures (FS) are usually self-limiting and cause no morbidity. Nevertheless they represent very traumatic events for families. There is a need to identify key messages that reassure carers and help to prevent inappropriate, anxiety-driven behaviors associated with "fever phobia." No recommendations have been proposed to date regarding the content of such messages. Using a Delphi process, we have established a consensus regarding the information to be shared with families following a FS. Twenty physicians (child neurologists and pediatricians) from five European countries participated in a three-step Delphi process between May 2018 and October 2019. In the first step, each expert was asked to give 10 to 15 free statements about FS. In the second and third steps, statements were scored and selected according to the expert ranking of importance. A list of key messages for families has emerged from this process, which offer reassurance about FS based on epidemiology, underlying mechanisms, and the emergency management of FS should they recur. Interestingly, there was a high level of agreement between child neurologists and general pediatricians.Conclusion: We propose key messages to be communicated with families in the post-FS clinic setting. What is Known: • Febrile seizures (FS) are traumatic events for families. • No guidelines exist on what information to share with parents following a FS. What is New: • A Delphi process involving child neurologists and pediatricians provides consensual statement about information to deliver after a febrile seizure. • We propose key messages to be communicated with families in the post-FS clinic setting.
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http://dx.doi.org/10.1007/s00431-021-04067-2DOI Listing
September 2021

Challenges in management of transient hyperinsulinism - a retrospective analysis of 36 severely affected children.

J Pediatr Endocrinol Metab 2021 Jul 16;34(7):867-875. Epub 2021 Apr 16.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Objectives: Transient hyperinsulinism (THI) is a hypoglycemia disorder which resolves spontaneously within the first weeks or months of life. The pathomechanism of THI is not elucidated yet; however, it is known that perinatal stress predisposes for THI. We aimed to characterize the clinical phenotype and treatment of children with THI, and to identify options for improved management.

Methods: A retrospective analysis of 36 children with THI treated at the University Children's Hospital Düsseldorf between 2007 and 2019 was performed.

Results: All children had risk factors for neonatal hypoglycemia or indicators of perinatal stress. Eighty three percent were diagnosed with hypoglycemia on day of life (DOL)1. None of the six diagnosed later had routine blood glucose screening and showed significantly lower blood glucose levels at the time of first blood glucose measurement compared to the children diagnosed on DOL1. Ninety seven percent of all children received intravenous glucose, 42% received continuous glucagon and 81% were started on diazoxide. Diazoxide withdrawal and subsequent fasting tests lacked standardization and were based on clinical experience. Three patients had a subsequent episode of hypoglycemia, after fasting studies only demonstrated "clinical" remission without proving the ability to ketogenesis.

Conclusions: Any kind of perinatal stress might pose a risk to develop THI, and postnatal monitoring for hypoglycemia still needs to be improved. Diazoxide is effective in children with THI; however, further studies are needed to guide the development of criteria and procedures for the initiation and discontinuation of treatment. Furthermore, establishing consensus diagnostic criteria/definitions for THI would improve comparability between studies.
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http://dx.doi.org/10.1515/jpem-2020-0639DOI Listing
July 2021

Dschingis Khan: Schwarzer Tod eines Kriegers.

Authors:
Thomas Meißner

CME (Berl) 2021 20;18(4):34-35. Epub 2021 Apr 20.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Germany.

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http://dx.doi.org/10.1007/s11298-021-1974-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034042PMC
April 2021

Neue Empfehlungen zur Colitis-Therapie.

Authors:
Thomas Meißner

MMW Fortschr Med 2021 Mar;163(5):24-25

Redaktionsbüro Meißner, Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s15006-021-9694-0DOI Listing
March 2021

Clinical management and knowledge of neonatal hypoglycaemia in Germany: A national survey of midwives and nurses.

J Paediatr Child Health 2021 06 8;57(6):854-859. Epub 2021 Mar 8.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital Duesseldorf, Duesseldorf, Germany.

Aim: Despite being a common metabolic condition, the detection and care of neonatal hypoglycaemia in Germany largely depends on the infant's health-care provider, rather than a national protocol. Therefore, this study aimed to evaluate midwives' and nurses' knowledge and management of neonatal hypoglycaemia and to determine the need for national guidelines.

Methods: An anonymous online survey was developed and completed by 127 perinatal nurses and midwives. Descriptive statistics, Mann-Whitney-U, χ and Fisher's exact tests were used to summarise and analyse the results.

Results: In total, 82% of respondents indicated using guidelines but routine blood glucose screening for neonates at risk for hypoglycaemia was rarely reported (44%). A blood glucose concentration of 2.5 mmol/L (45 mg/dL) was considered the treatment threshold by 52% of the respondents. However, the responses to clinical scenarios showed distinct differences regarding the management of neonatal hypoglycaemia. Finally, 49% of respondents reported insufficient knowledge regarding neonatal hypoglycaemia and 77% indicated that they would advocate the implication of enhanced national guidelines.

Conclusions: There is considerable variation in knowledge about the prevention, screening and management of neonatal hypoglycaemia among nurses and midwives in Germany. Enhanced guidelines and education of health-care professionals are urgently needed to provide the best possible care to all hypoglycaemic newborns.
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http://dx.doi.org/10.1111/jpc.15337DOI Listing
June 2021

Corona-Pandemie und Versorgungssicherheit.

Authors:
Thomas Meißner

Heilberufe 2021 5;73(3):40-41. Epub 2021 Mar 5.

Häusliche Pflege Meißner & Walter GmbH, Berlin, Germany.

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http://dx.doi.org/10.1007/s00058-021-1989-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919245PMC
March 2021

Corona-Pandemie: Jetzt hinschauen und lernen.

Authors:
Thomas Meißner

Heilberufe 2021 5;73(2):54-57. Epub 2021 Feb 5.

Häusliche Pflege Meißner & Walter GmbH, Berlin, Germany.

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http://dx.doi.org/10.1007/s00058-020-1955-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848240PMC
February 2021

Risk Factors for Adverse Neurodevelopment in Transient or Persistent Congenital Hyperinsulinism.

Front Endocrinol (Lausanne) 2020 30;11:580642. Epub 2020 Nov 30.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.

Objective: Aim was to identify hypotheses why adverse neurodevelopment still occurs in children with transient or persistent hyperinsulinism despite improvements in long-term treatment options during the last decades.

Material And Methods: A retrospective review of 87 children with transient (n=37) or persistent congenital hyperinsulinism (CHI) (n=50) was conducted at the University Children's Hospital Duesseldorf, Germany. Possible risk factors for neurodevelopmental sequelae due to hypoglycemia were analyzed with a focus on the first days after onset of disease.

Results: Median age at follow-up was 7 years (IQR 8). Adverse neurodevelopmental outcome was seen in 34.5% (n=30) of all CHI patients. Fifteen had mildly abnormal neurodevelopment and 15 had a severe hypoglycemic brain injury. In univariate analysis, mildly abnormal neurodevelopment was associated with the diagnosis of persistent CHI (odds ratio (OR) 8.3; p=0.004) and higher birth weight (mean difference 1049 g; p<0.001). Severe hypoglycemic brain injury was associated with the diagnosis of persistent CHI (OR 5.1; p=0.013), being born abroad (OR 18.3; p<0.001) or in a lower-level maternity hospital (OR 4.8; p=0.039), and of note history of hypoglycemic seizures (OR 13.0; p=<0.001), and a delay between first symptoms of hypoglycemia and first blood glucose measurement/initiation of treatment (OR 10.7; p<0.001). Children with severe hypoglycemic brain injury had lower recorded blood glucose (mean difference -8.34 mg/dl; p=0.022) and higher birth weight than children with normal development (mean difference 829 g; p=0.012). In multivariate binary logistic regression models, lowest blood glucose <20 mg/dl (OR 134.3; p=0.004), a delay between initial symptoms and first blood glucose measurement/initiation of treatment (OR 71.7; p=0.017) and hypoglycemic seizures (OR 12.9; p=0.008) were positively correlated with severe brain injury. Analysis showed that the odds for brain injury decreased by 15% (OR 0.85; p=0.035) if the blood glucose increased by one unit.

Conclusion: While some risk factors for adverse outcome in CHI are not influenceable, others like lowest recorded blood glucose values <20 mg/dl, hypoglycemic seizures, and insufficiently-or even untreated hypoglycemia can be avoided. Future guidelines for management of neonatal hypoglycemia should address this by ensuring early identification and immediate treatment with appropriate escalation steps.
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http://dx.doi.org/10.3389/fendo.2020.580642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793856PMC
June 2021

Im Hotspot: Corona und die ambulante Pflege.

Authors:
Thomas Meißner

Pflege Z 2020 20;73(12):17-19. Epub 2020 Nov 20.

Häusliche Pflege Meißner & Walter GmbH, Berlin, Germany.

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http://dx.doi.org/10.1007/s41906-020-0944-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670990PMC
November 2020

So funktioniert eine altersgerechte Schmerztherapie.

Authors:
Thomas Meißner

MMW Fortschr Med 2020 Nov;162(Suppl 3):20-21

Redaktionsbüro Meißner, Lassallestraße 42, 99086, Erfurt, Germany.

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http://dx.doi.org/10.1007/s15006-020-4503-8DOI Listing
November 2020

Probleme mit der Beantragung von Cannabinoiden in der Schmerztherapie : Praktische Tipps für Ärzte.

Authors:
Thomas Meißner

MMW Fortschr Med 2020 Sep;162(Suppl 8):34-36

, Lassallestraße 42, 99086, Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s15006-020-4371-2DOI Listing
September 2020

Akut- und Erhaltungstherapie ohne Präparatwechsel : Eosinophile Ösophagitis.

Authors:
Thomas Meißner

MMW Fortschr Med 2020 Oct;162(17):69-71

Redaktionsbüro Meißner, Lassallestraße 42, 99086, Erfurt, Germany.

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http://dx.doi.org/10.1007/s15006-020-4441-5DOI Listing
October 2020

Cannabis-Vollextrakte - was ist zu beachten? : Schmerztherapie.

Authors:
Thomas Meißner

MMW Fortschr Med 2020 Sep;162(16):71

Redaktionsbüro Meißner, Lassallestraße 42, 99086, Erfurt, Germany.

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http://dx.doi.org/10.1007/s15006-020-4387-7DOI Listing
September 2020

Plasma-Spende von Rekonvaleszenten als Therapie bei COVID-19: Studien laufen.

Authors:
Thomas Meißner

Pneumo News 2020 14;12(4):46. Epub 2020 Jul 14.

Alt Biesdorf 71 a, 12683 Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s15033-020-1878-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332845PMC
July 2020

Schwangere gut auf den Urlaub vorbereiten.

Authors:
Thomas Meißner

CME (Berl) 2020 19;17(7):40-43. Epub 2020 Aug 19.

Redaktionsbüro Meißner, Lassallestraße 42, 99086 Erfurt, Deutschland.

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http://dx.doi.org/10.1007/s11298-020-8011-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413830PMC
August 2020
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