Thomas M Roberts

Thomas M Roberts

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The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities.

Biomolecules 2019 Nov 7;9(11). Epub 2019 Nov 7.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/biom9110713DOI Listing
November 2019

Molecular Profiling Establishes Genetic Features Predictive of the Efficacy of the p110β Inhibitor KIN-193.

Cancer Res 2019 Sep 10;79(17):4524-4531. Epub 2019 Jul 10.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726497PMC
September 2019

Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.

Oncogene 2019 Aug 28. Epub 2019 Aug 28.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1038/s41388-019-0953-9DOI Listing
August 2019

Targeted Profiling of RNA Translation.

Curr Protoc Mol Biol 2019 01 22;125(1):e71. Epub 2018 Oct 22.

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326074PMC
January 2019

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366450PMC
December 2018

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells.

iScience 2018 Nov 18;9:149-160. Epub 2018 Oct 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183017
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http://dx.doi.org/10.1016/j.isci.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215964PMC
November 2018

Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9325-E9332. Epub 2018 Sep 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1805782115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176620PMC
October 2018

Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer.

J Clin Oncol 2018 05 8;36(13):1339-1342. Epub 2018 Mar 8.

Johann S. Bergholz, Thomas M. Roberts, and Jean J. Zhao, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.77.0891
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http://dx.doi.org/10.1200/JCO.2017.77.0891DOI Listing
May 2018

The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 14;1868(1):123-131. Epub 2017 Mar 14.

Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548615PMC
August 2017

Epigenetic regulation of RTK signaling.

J Mol Med (Berl) 2017 08 6;95(8):791-798. Epub 2017 Jun 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://link.springer.com/10.1007/s00109-017-1546-0
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http://dx.doi.org/10.1007/s00109-017-1546-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663182PMC
August 2017

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7095-7100. Epub 2017 Jun 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1704706114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502636PMC
July 2017

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.

Cell Rep 2017 07;20(3):549-557

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173088
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http://dx.doi.org/10.1016/j.celrep.2017.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704918PMC
July 2017

Tyrosine receptor kinase B is a drug target in astrocytomas.

Neuro Oncol 2017 01 10;19(1):22-30. Epub 2016 Jul 10.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (J.N., S.X., V.L., Y.S., P.B., R.B., T.M.R., C.D.S., R.A.S., J.J.Z.); Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts (J.N., S.X., V.L., T.M.R., J.J.Z.); Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts (S.H.R., R.B., K.L.L., W.C.H.); Broad Institute, Boston, Massachusetts (P.B., R.B., W.C.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., K.L.L.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.)

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http://dx.doi.org/10.1093/neuonc/now139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193024PMC
January 2017

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss.

Elife 2016 10 4;5. Epub 2016 Oct 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States.

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http://dx.doi.org/10.7554/eLife.17635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050018PMC
October 2016

Delivery strategies and potential targets for siRNA in major cancer types.

Adv Drug Deliv Rev 2016 09 31;104:2-15. Epub 2016 May 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.

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http://dx.doi.org/10.1016/j.addr.2016.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958528PMC
September 2016

Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.

Gynecol Oncol 2016 09 15;142(3):548-56. Epub 2016 Jul 15.

Cancer Institute, The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.07.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551048PMC
September 2016

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell Discov 2016 20;2:16030. Epub 2016 Sep 20.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029543PMC
September 2016

Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP.

J Virol 2016 08 27;90(16):7032-7045. Epub 2016 Jul 27.

Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/JVI.00417-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984622PMC
August 2016

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Cell Rep 2016 06 9;15(12):2692-704. Epub 2016 Jun 9.

Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094353PMC
June 2016

Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.

Oncotarget 2016 Mar;7(11):13153-66

Cancer Institute, The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China.

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http://dx.doi.org/10.18632/oncotarget.7549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914348PMC
March 2016

Correction for Hwang et al., Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

J Virol 2015 Jul;89(13):6971

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/JVI.00952-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468481PMC
July 2015

Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

J Virol 2014 Oct 13;88(20):12055-64. Epub 2014 Aug 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

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http://jvi.asm.org/content/88/20/12055.full.pdf
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http://jvi.asm.org/cgi/doi/10.1128/JVI.01399-14
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http://dx.doi.org/10.1128/JVI.01399-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178709PMC
October 2014

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

Curr Biol 2014 Oct 11;24(19):2274-80. Epub 2014 Sep 11.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA; Department of Pharmacology, Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190129PMC
October 2014

The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type.

J Virol 2014 Sep 2;88(18):10673-9. Epub 2014 Jul 2.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

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http://jvi.asm.org/content/88/18/10673.full.pdf
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http://jvi.asm.org/cgi/doi/10.1128/JVI.01409-14
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http://dx.doi.org/10.1128/JVI.01409-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178865PMC
September 2014

KRAS and YAP1 converge to regulate EMT and tumor survival.

Cell 2014 Jul 19;158(1):171-84. Epub 2014 Jun 19.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110062PMC
July 2014

PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.

Proc Natl Acad Sci U S A 2014 Apr 15;111(17):6395-400. Epub 2014 Apr 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1323004111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035990PMC
April 2014

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

Cancer Discov 2013 Sep 10;3(9):1030-43. Epub 2013 Jul 10.

1Oncology Disease Area, 2Department of Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge; and 3Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0142DOI Listing
September 2013

Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm.

Int Rev Cell Mol Biol 2012 ;297:265-93

Department of Biological Science, Florida State University, Tallahassee, Florida, USA.

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http://dx.doi.org/10.1016/B978-0-12-394308-8.00007-8DOI Listing
December 2012

Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

J Virol 2011 Oct 10;85(20):10649-58. Epub 2011 Aug 10.

Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1128/JVI.05034-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187521PMC
October 2011

Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction.

Curr Biol 2011 Oct 13;21(20):1727-31. Epub 2011 Oct 13.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1016/j.cub.2011.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210573PMC
October 2011

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):E699-708. Epub 2011 Aug 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1108237108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174675PMC
September 2011

Targeting PI3K signaling as a therapeutic approach for colorectal cancer.

Gastroenterology 2011 Jul;141(1):50-61

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, and Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.05.010DOI Listing
July 2011

Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer.

Curr Top Microbiol Immunol 2010 ;347:55-77

Department of Cancer Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/82_2010_63DOI Listing
January 2011

Targeting the phosphoinositide 3-kinase pathway in cancer.

Nat Rev Drug Discov 2009 Aug;8(8):627-44

Department of Cancer Biology, Dana-Farber Cancer Institute, Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nrd2926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142564PMC
August 2009

Should individual PI3 kinase isoforms be targeted in cancer?

Curr Opin Cell Biol 2009 Apr 4;21(2):199-208. Epub 2009 Feb 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ceb.2008.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142565PMC
April 2009

Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.

Virology 2009 Feb 20;384(2):304-16. Epub 2008 Nov 20.

Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.virol.2008.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676342PMC
February 2009

Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.

J Virol 2009 Jan 15;83(1):117-27. Epub 2008 Oct 15.

Hillman Cancer Center, Research Pavilion Suite 1.8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1128/JVI.01515-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612341PMC
January 2009

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

Nature 2008 Aug 25;454(7205):776-9. Epub 2008 Jun 25.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature07091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750091PMC
August 2008

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.

PLoS Genet 2008 Aug 15;4(8):e1000152. Epub 2008 Aug 15.

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515337PMC
August 2008

The role of filament-packing dynamics in powering amoeboid cell motility.

Proc Natl Acad Sci U S A 2008 Apr 2;105(14):5390-5. Epub 2008 Apr 2.

Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1073/pnas.0708416105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291107PMC
April 2008

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.

Proc Natl Acad Sci U S A 2007 Nov 15;104(48):19011-6. Epub 2007 Nov 15.

Department of Biochemistry, Sackler School of Graduate Biomedical Sciences, School of Medicine, Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.1073/pnas.0706696104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141899PMC
November 2007

A histone H3 lysine 27 demethylase regulates animal posterior development.

Nature 2007 Oct 12;449(7163):689-94. Epub 2007 Sep 12.

Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature06192DOI Listing
October 2007

The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.

J Virol 2007 Jul 18;81(13):7069-76. Epub 2007 Apr 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/JVI.00115-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933267PMC
July 2007

Bub1: escapades in a cellular world.

Cell Cycle 2007 Jul 25;6(14):1699-704. Epub 2007 May 25.

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.4161/cc.6.14.4493DOI Listing
July 2007

A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris.

Mol Biol Cell 2007 May 7;18(5):1816-25. Epub 2007 Mar 7.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1091/mbc.e06-08-0741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855020PMC
May 2007

Surveillance mechanism linking Bub1 loss to the p53 pathway.

Proc Natl Acad Sci U S A 2007 May 8;104(20):8334-9. Epub 2007 May 8.

Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1073/pnas.0703164104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895950PMC
May 2007

Reconstitution in vitro of MSP-based filopodium extension in nematode sperm.

Cell Motil Cytoskeleton 2007 Apr;64(4):235-47

Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA.

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http://dx.doi.org/10.1002/cm.20177DOI Listing
April 2007

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

Cell 2007 Mar 22;128(6):1077-88. Epub 2007 Feb 22.

Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2007.02.017DOI Listing
March 2007

PI3 kinases in cancer: from oncogene artifact to leading cancer target.

Sci STKE 2006 Dec 12;2006(365):pe52. Epub 2006 Dec 12.

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/stke.3652006pe52DOI Listing
December 2006

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.

Proc Natl Acad Sci U S A 2006 Oct 23;103(44):16296-300. Epub 2006 Oct 23.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0607899103
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http://dx.doi.org/10.1073/pnas.0607899103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637576PMC
October 2006

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

J Biol Chem 2006 Aug 22;281(32):23003-12. Epub 2006 May 22.

Howard Hughes Medical Institute, Department of Cancer Immunology and AIDS, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M602648200
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http://dx.doi.org/10.1074/jbc.M602648200DOI Listing
August 2006

Human tumor mutants in the p110alpha subunit of PI3K.

Cell Cycle 2006 Apr 1;5(7):675-7. Epub 2006 Apr 1.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cc.5.7.2605DOI Listing
April 2006

Cytoskeleton dynamics powers nematode sperm motility.

Adv Protein Chem 2005 ;71:383-99

MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, England.

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http://dx.doi.org/10.1016/S0065-3233(04)71010-4DOI Listing
December 2005

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.

Proc Natl Acad Sci U S A 2005 Dec 8;102(51):18443-8. Epub 2005 Dec 8.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0508988102
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http://dx.doi.org/10.1073/pnas.0508988102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317954PMC
December 2005

Membrane insertion by anthrax protective antigen in cultured cells.

Mol Cell Biol 2005 Jul;25(13):5492-8

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave., Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1128/MCB.25.13.5492-5498.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156972PMC
July 2005

A genetic screen for candidate tumor suppressors identifies REST.

Cell 2005 Jun;121(6):837-48

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.03.033DOI Listing
June 2005

Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris.

Cell Motil Cytoskeleton 2005 Apr;60(4):191-9

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1002/cm.20058DOI Listing
April 2005

Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility.

J Mol Biol 2005 Apr;347(3):583-95

MRC Laboratory of Molecular Biology, Hills Rd., Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2005.01.054DOI Listing
April 2005

Major sperm protein.

Authors:
Thomas M Roberts

Curr Biol 2005 Mar;15(5):R153

Department of Biological Science, Florida State University, Tallahassee, Florida 32308, USA.

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http://dx.doi.org/10.1016/j.cub.2005.02.036DOI Listing
March 2005

Comment on "observation of optical precursors in water".

Authors:
Thomas M Roberts

Phys Rev Lett 2004 Dec 21;93(26 Pt 1):269401. Epub 2004 Dec 21.

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http://dx.doi.org/10.1103/PhysRevLett.93.269401DOI Listing
December 2004

The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling.

Proc Natl Acad Sci U S A 2004 Jul 6;101(28):10296-301. Epub 2004 Jul 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0403175101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478566PMC
July 2004

Functional genetics and experimental models of human cancer.

Trends Mol Med 2004 Jul;10(7):344-50

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147149140400127
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http://dx.doi.org/10.1016/j.molmed.2004.05.005DOI Listing
July 2004

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1.

Proc Natl Acad Sci U S A 2004 Jan 19;101(4):947-52. Epub 2004 Jan 19.

Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, Courtauld Building, 91 Riding House Street, London W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0308006100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327122PMC
January 2004

Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion.

Mol Biol Cell 2003 Dec 17;14(12):5082-8. Epub 2003 Oct 17.

Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA.

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http://dx.doi.org/10.1091/mbc.e03-04-0246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC284809PMC
December 2003

Retraction in amoeboid cell motility powered by cytoskeletal dynamics.

Science 2003 Nov;302(5649):1405-7

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1126/science.1089129DOI Listing
November 2003

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.

Proc Natl Acad Sci U S A 2003 Aug 24;100(16):9434-9. Epub 2003 Jul 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1432964100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170936PMC
August 2003

A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm.

J Cell Sci 2003 Jul 13;116(Pt 13):2655-63. Epub 2003 May 13.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1242/jcs.00469DOI Listing
July 2003

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.

Cancer Cell 2003 May;3(5):483-95

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(03)00088-6DOI Listing
May 2003

2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans.

J Mol Biol 2002 May;319(2):491-9

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/S0022-2836(02)00294-2DOI Listing
May 2002

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach.

Cancer Cell 2002 Apr;1(3):257-67

Department of Cancer Biology, Dana-Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00042-9DOI Listing
April 2002

DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.

J Biol Chem 2002 Mar 31;277(10):7962-9. Epub 2001 Dec 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M109149200DOI Listing
March 2002