Thomas Longerich

Thomas Longerich

UNVERIFIED PROFILE

Are you Thomas Longerich?   Register this Author

Register author
Thomas Longerich

Thomas Longerich

Publications by authors named "Thomas Longerich"

Are you Thomas Longerich?   Register this Author

100Publications

3799Reads

17Profile Views

ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.

Gastroenterology 2019 11 27;157(5):1352-1367.e13. Epub 2019 Jul 27.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, Shanghai, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2019.07.036DOI Listing
November 2019

Susceptibility based multiparametric quantification of liver disease: Non-invasive evaluation of steatosis and iron overload.

Magn Reson Imaging 2019 11 16;63:114-122. Epub 2019 Aug 16.

German Cancer Research Center (DKFZ), Department of Radiology, D-69120 Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2019.08.016DOI Listing
November 2019

Impact of interventions and tumor stage on health-related quality of life in patients with hepatocellular carcinoma.

J Cancer Res Clin Oncol 2019 Nov 19;145(11):2761-2769. Epub 2019 Aug 19.

Department of Internal Medicine IV, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-03005-yDOI Listing
November 2019

Emerging Role of the Pathologist in Precision Medicine for HCC.

Dig Dis Sci 2019 04;64(4):928-933

Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05548-zDOI Listing
April 2019

Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver.

Z Gastroenterol 2019 Jan 14;57(1):57-60. Epub 2019 Jan 14.

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0755-2478DOI Listing
January 2019

A microfluidics platform for combinatorial drug screening on cancer biopsies.

Nat Commun 2018 06 22;9(1):2434. Epub 2018 Jun 22.

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, 69117, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-04919-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015045PMC
June 2018

Non-invasive diagnosis of hepatocellular carcinoma revisited.

Gut 2018 05 12;67(5):991-993. Epub 2017 Sep 12.

Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2017-314981DOI Listing
May 2018

Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI.

Cancer Imaging 2018 Mar 1;18(1). Epub 2018 Mar 1.

Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, INF 110, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40644-018-0143-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831838PMC
March 2018

De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells.

Oncol Rep 2017 Nov 20;38(5):2697-2704. Epub 2017 Sep 20.

Department of General and Transplant Surgery, University Hospital Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2017.5980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780022PMC
November 2017

Targeting CCl -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice.

Hepatology 2017 10 26;66(4):1242-1257. Epub 2017 Aug 26.

Department of Internal Medicine III, RWTH Aachen University, Aachen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29275DOI Listing
October 2017

Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.

J Hepatol 2017 10 29;67(4):749-757. Epub 2017 Jun 29.

Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2017.06.020DOI Listing
October 2017

Sensitive and non-invasive assessment of hepatocellular iron using a novel room-temperature susceptometer.

J Hepatol 2017 09 5;67(3):535-542. Epub 2017 May 5.

Dept. of Medicine, Salem Medical Center and Center for Alcohol Research and Liver Disease, University of Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2017.04.019DOI Listing
September 2017

Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-κB activation.

Oncotarget 2017 Aug 28;8(34):56095-56109. Epub 2016 Jul 28.

Department of Medicine and University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593547PMC
August 2017

Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin.

EMBO Mol Med 2017 06;9(6):741-749

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201607222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452049PMC
June 2017

Successful ablation of lymph nodes using irreversible electroporation (IRE) in a porcine survival model.

Langenbecks Arch Surg 2017 May 4;402(3):465-473. Epub 2017 Apr 4.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-017-1579-4DOI Listing
May 2017

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.

Cancer Cell 2017 01 22;31(1):94-109. Epub 2016 Dec 22.

Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.11.009DOI Listing
January 2017

Dysregulation of the epigenetic regulator SETDB1 in liver carcinogenesis-more than one way to skin a cat.

Authors:
Thomas Longerich

Chin Clin Oncol 2016 Dec 1;5(6):72. Epub 2016 Apr 1.

Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany. Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/cco.2016.03.18DOI Listing
December 2016

Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the variant I148M.

World J Hepatol 2016 Dec;8(35):1547-1556

Vanessa Rausch, Teresa Peccerella, Helmut-Karl Seitz, Sebastian Mueller, Salem Medical Center and Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.wjgnet.com/1948-5182/full/v8/i35/1547.htm
Publisher Site
http://dx.doi.org/10.4254/wjh.v8.i35.1547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165268PMC
December 2016

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.

Cancer Cell 2016 10;30(4):533-547

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.09.003DOI Listing
October 2016

Evaluation of the modified HTK solution in pancreas transplantation-An experimental model.

Asian J Surg 2016 Apr 26;39(2):66-73. Epub 2015 Jul 26.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.asjsur.2015.03.017DOI Listing
April 2016

Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants.

Biomed Res Int 2015 9;2015:383791. Epub 2015 Jul 9.

Institute of Pathology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2015/383791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512561PMC
April 2016

Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma.

PLoS One 2014 16;9(10):e110591. Epub 2014 Oct 16.

National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany; Department of Gastroenterology, Diabetology and Rheumatology, Internal Medicine II, Marien-Hospital, Wesel, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199737PMC
December 2015

A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma.

Cancer Lett 2015 Dec 21;369(2):396-404. Epub 2015 Sep 21.

Division of Signal Transduction and Growth Control, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.09.005DOI Listing
December 2015

Outcome after a liver resection of benign lesions.

HPB (Oxford) 2015 Nov 3;17(11):994-1000. Epub 2015 Sep 3.

Department of General and Transplant Surgery, University Hospital Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hpb.12496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605338PMC
November 2015

Irreversible electroporation of the pancreas is feasible and safe in a porcine survival model.

Pancreas 2015 Jul;44(5):791-8

From the *Department of General, Visceral, and Transplantation Surgery, †Department of Diagnostic and Interventional Radiology, ‡Institute of Pathology, and §Department of Anesthesiology, University of Heidelberg, Heidelberg; and ‖Department of General, Visceral, and Transplantation Surgery LMU, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00006676-201507000-000
Publisher Site
http://dx.doi.org/10.1097/MPA.0000000000000331DOI Listing
July 2015

DNAJB1-PRKACA is specific for fibrolamellar carcinoma.

Mod Pathol 2015 Jun 20;28(6):822-9. Epub 2015 Feb 20.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/modpathol.2015.4DOI Listing
June 2015

Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9.

Int J Cancer 2015 May 13;136(10):2458-63. Epub 2014 Nov 13.

Division of Signal Transduction and Growth Control, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.29282DOI Listing
May 2015

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage.

EMBO Mol Med 2015 Mar;7(3):332-8

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201404246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364949PMC
March 2015

Protumorigenic role of Timeless in hepatocellular carcinoma.

Int J Oncol 2015 Feb 14;46(2):597-606. Epub 2014 Nov 14.

Institute of Pathology, University Hospital Heidelberg, D-69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2014.2751DOI Listing
February 2015

The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases.

Langenbecks Arch Surg 2014 Dec 9;399(8):1001-9. Epub 2014 Aug 9.

Department of General and Transplant Surgery, Ruprecht-Karls-University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-014-1237-zDOI Listing
December 2014

CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes.

World J Gastroenterol 2014 Dec;20(45):17049-64

Toni Urbanik, Bruno Christian Koehler, Laura Wolpert, Christin Elßner, Anna-Lena Scherr, Nicole Kautz, Stefan Welte, Dirk Jäger, Henning Schulze-Bergkamen, National Center for Tumor Diseases, Department of Medical Oncology, University Clinic of Heidelberg, 69120 Heidelberg, Baden-Wuerrtemberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v20.i45.17049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258573PMC
December 2014

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med 2014 Oct 14;20(10):1138-46. Epub 2014 Sep 14.

1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587571PMC
October 2014

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Cell 2014 Jul;158(3):579-92

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221237PMC
July 2014

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.

Hepatology 2014 May 1;59(5):1900-11. Epub 2014 Apr 1.

Helmholtz-University-Group "Molecular RNA Biology & Cancer," German Cancer Research Center DKFZ & Institute of Pathology, University Hospital Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hep.26997
Publisher Site
http://dx.doi.org/10.1002/hep.26997DOI Listing
May 2014

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.

Eur J Immunol 2014 Apr 16;44(4):1213-24. Epub 2014 Jan 16.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201343794DOI Listing
April 2014

Factors predictive of survival after stapler hepatectomy of hepatocellular carcinoma: a multivariate, single-center analysis.

Anticancer Res 2014 Feb;34(2):767-76

Department of General and Transplant Surgery, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
February 2014

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).

Hepatology 2013 Nov 7;58(5):1703-12. Epub 2013 Aug 7.

Helmholtz-University-Group "Molecular RNA Biology & Cancer," German Cancer Research Center DKFZ & Institute of Pathology, University Hospital Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26537DOI Listing
November 2013

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival.

Liver Int 2013 Oct 21;33(9):1428-40. Epub 2013 Jul 21.

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.12262DOI Listing
October 2013

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.

Hepatology 2013 Sep 7;58(3):1143-52. Epub 2013 Aug 7.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26412DOI Listing
September 2013

Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.

J Hepatol 2012 Nov 21;57(5):995-1003. Epub 2012 Jun 21.

National Center for Tumor Diseases, Department of Medical Oncology, University Clinic of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2012.06.017DOI Listing
November 2012

Transitions between flat epithelial atypia and low-grade ductal carcinoma in situ of the breast.

Am J Surg Pathol 2012 Aug;36(8):1247-52

Institute of Pathology, Heidelberg University, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0b013e31825f9d6aDOI Listing
August 2012