Thomas Lion

Thomas Lion

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Thomas Lion

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Adenovirus persistence, reactivation, and clinical management.

Authors:
Thomas Lion

FEBS Lett 2019 Aug 14. Epub 2019 Aug 14.

St.Anna Children's Cancer Research Institute (CCRI), Department of Pediatrics, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1002/1873-3468.13576DOI Listing
August 2019

Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges.

J Hematol Oncol 2019 Apr 23;12(1):39. Epub 2019 Apr 23.

Children's Cancer Research Institute (CCRI) and Medical University of Vienna, Vienna, Austria.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-019-0729-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480772PMC
April 2019

A kinase profile-adapted drug combination elicits synergistic cooperative effects on leukemic cells carrying BCR-ABL1 in Ph+ CML.

Leuk Res 2019 Mar 28;78:36-44. Epub 2018 Dec 28.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2018.12.013DOI Listing
March 2019

Diagnostic Parameters of Adenoviremia in Pediatric Stem Cell Transplant Recipients.

Front Microbiol 2019 22;10:414. Epub 2019 Feb 22.

Molecular Microbiology, Children's Cancer Research Institute, Vienna, Austria.

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00414
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http://dx.doi.org/10.3389/fmicb.2019.00414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396503PMC
February 2019

Intestinal Adenovirus Shedding Before Allogeneic Stem Cell Transplantation Is a Risk Factor for Invasive Infection Post-transplant.

EBioMedicine 2018 Feb 9;28:114-119. Epub 2018 Jan 9.

Children's Cancer Research Institute, Zimmermannplatz 10, 1090 Vienna, Austria; Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835548PMC
February 2018

Prerequisites for Control of Contamination in Fungal Diagnosis.

Methods Mol Biol 2017 ;1508:249-255

Children's Cancer Research Institute (CCRI), St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-4939-6515-1_13DOI Listing
January 2018

Broad-Spectrum Molecular Detection of Fungal Nucleic Acids by PCR-Based Amplification Techniques.

Methods Mol Biol 2017 ;1508:257-266

Children's Cancer Research Institute (CCRI), St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-4939-6515-1_14DOI Listing
January 2018

BCR-ABL1 compound mutants display differential and dose-dependent responses to ponatinib.

Haematologica 2018 01 5;103(1):e10-e12. Epub 2017 Oct 5.

Children's Cancer Research Institute, and Department of Pediatrics, Medical University of Vienna, Austria

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http://dx.doi.org/10.3324/haematol.2017.176347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777206PMC
January 2018

Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells.

J Steroid Biochem Mol Biol 2017 01 9;165(Pt B):356-362. Epub 2016 Aug 9.

Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705058PMC
January 2017

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

Authors:
Christian Dittrich Michael Kosty Svetlana Jezdic Doug Pyle Rossana Berardi Jonas Bergh Nagi El-Saghir Jean-Pierre Lotz Pia Österlund Nicholas Pavlidis Gunta Purkalne Ahmad Awada Susana Banerjee Smita Bhatia Jan Bogaerts Jan Buckner Fatima Cardoso Paolo Casali Edward Chu Julia Lee Close Bertrand Coiffier Roisin Connolly Sarah Coupland Luigi De Petris Maria De Santis Elisabeth G E de Vries Don S Dizon Jennifer Duff Linda R Duska Alexandru Eniu Marc Ernstoff Enriqueta Felip Martin F Fey Jill Gilbert Nicolas Girard Andor W J M Glaudemans Priya K Gopalan Axel Grothey Stephen M Hahn Diana Hanna Christian Herold Jørn Herrstedt Krisztian Homicsko Dennie V Jones Lorenz Jost Ulrich Keilholz Saad Khan Alexander Kiss Claus-Henning Köhne Rainer Kunstfeld Heinz-Josef Lenz Stuart Lichtman Lisa Licitra Thomas Lion Saskia Litière Lifang Liu Patrick J Loehrer Merry Jennifer Markham Ben Markman Marius Mayerhoefer Johannes G Meran Olivier Michielin Elizabeth Charlotte Moser Giannis Mountzios Timothy Moynihan Torsten Nielsen Yuichiro Ohe Kjell Öberg Antonio Palumbo Fedro Alessandro Peccatori Michael Pfeilstöcker Chandrajit Raut Scot C Remick Mark Robson Piotr Rutkowski Roberto Salgado Lidia Schapira Eva Schernhammer Martin Schlumberger Hans-Joachim Schmoll Lowell Schnipper Cristiana Sessa Charles L Shapiro Julie Steele Cora N Sternberg Friedrich Stiefel Florian Strasser Roger Stupp Richard Sullivan Josep Tabernero Luzia Travado Marcel Verheij Emile Voest Everett Vokes Jamie Von Roenn Jeffrey S Weber Hans Wildiers Yosef Yarden

ESMO Open 2016 29;1(5):e000097. Epub 2016 Sep 29.

Department of General Medical Oncology , University Hospitals Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1136/esmoopen-2016-000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070299PMC
September 2016

Modified pan-adenovirus real-time PCR assay based on genome analysis of seventy HAdV types.

J Clin Virol 2016 07 4;80:60-1. Epub 2016 May 4.

Children's Cancer Research Institute, Zimmermannplatz 10, 1090 Vienna, Austria; Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2016.05.001DOI Listing
July 2016

DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia.

Eur J Clin Invest 2014 Dec;44(12):1239-45

Division of Haematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/eci.12368DOI Listing
December 2014

Combined immunodeficiency evolving into predominant CD4+ lymphopenia caused by somatic chimerism in JAK3.

J Clin Immunol 2014 Nov 10;34(8):941-53. Epub 2014 Sep 10.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, A-1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s10875-014-0088-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220108PMC
November 2014

Post-transplant monitoring of chimerism by lineage-specific analysis.

Methods Mol Biol 2014 ;1109:271-91

Children's Cancer Research Institute (CCRI), Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-4614-9437-9_14DOI Listing
September 2014

High-quality DNA from fingernails for genetic analysis.

J Mol Diagn 2014 Jul 30;16(4):459-66. Epub 2014 Apr 30.

Children's Cancer Research Institute, Vienna, Austria; Labdia Labordiagnostik GmbH, Vienna, Austria; Department of Pediatrics, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.02.004DOI Listing
July 2014

Adenovirus infections in immunocompetent and immunocompromised patients.

Authors:
Thomas Lion

Clin Microbiol Rev 2014 Jul;27(3):441-62

Children's Cancer Research Institute and Medical University Vienna, Vienna, Austria

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http://dx.doi.org/10.1128/CMR.00116-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135893PMC
July 2014

First-in-man clinical results with good manufacturing practice (GMP)-compliant polypeptide-expanded adenovirus-specific T cells after haploidentical hematopoietic stem cell transplantation.

J Immunother 2014 May;37(4):245-9

Departments of *Clinical Cell Biology and FACS Core Unit †Quality Management ∥Molecular Microbiology, Children´s Cancer Research Institute (CCRI) ‡St. Anna Children´s Hospital #Department of Stem Cell Transplantation, St. Anna Children´s Hospital Departments of §Pediatrics ¶Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria **Institute of Pathology, Charité Unversitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

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http://dx.doi.org/10.1097/CJI.0000000000000034DOI Listing
May 2014

Induction of sustained deep molecular response in a patient with chronic-phase T315I-mutated chronic myeloid leukemia with interferon-α monotherapy.

Leuk Lymphoma 2014 Apr 25;55(4):934-7. Epub 2013 Jul 25.

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital , Helsinki , Finland.

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http://dx.doi.org/10.3109/10428194.2013.812788DOI Listing
April 2014

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA.

Exp Hematol 2014 Apr 6;42(4):282-293.e4. Epub 2014 Jan 6.

Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria; Ludwig Boltzmann Cluster Oncology, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2013.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338611PMC
April 2014

Screening for adenoviruses in haematological neoplasia: High prevalence in mantle cell lymphoma.

Eur J Cancer 2014 Feb 15;50(3):622-7. Epub 2013 Nov 15.

Children's Cancer Research Institute, Vienna, Austria; Department of Pediatrics, Medical University Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.10.013DOI Listing
February 2014

[Current diagnostic requirements in chronic myeloid leukemia].

Wien Med Wochenschr 2013 Nov 1;163(21-22):477-94. Epub 2013 Oct 1.

LabDia Labordiagnostik/St.Anna Kinderkrebsforschung, Zimmermannplatz 8, 1090, Wien, Österreich,

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http://dx.doi.org/10.1007/s10354-013-0239-8DOI Listing
November 2013

Diagnosis and treatment of adenovirus infection in immunocompromised patients.

Expert Rev Anti Infect Ther 2013 Oct 27;11(10):1017-28. Epub 2013 Sep 27.

St Anna Children's Hospital, Stem cell transplantation, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1586/14787210.2013.836964DOI Listing
October 2013

Stem cell transplantation after reduced-intensity conditioning for sickle cell disease.

Eur J Haematol 2013 Apr 26;90(4):308-12. Epub 2013 Feb 26.

Department of Paediatrics, St. Anna Children's Hospital, Medical University, Kinderspitalgasse 6, Vienna, Austria.

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http://dx.doi.org/10.1111/ejh.12082DOI Listing
April 2013

An adenoviral vector-based expression and delivery system for the inhibition of wild-type adenovirus replication by artificial microRNAs.

Antiviral Res 2013 Jan 2;97(1):10-23. Epub 2012 Nov 2.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Department of Pediatrics, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.antiviral.2012.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552158PMC
January 2013

Osmosis in a minimal model system.

J Chem Phys 2012 Dec;137(24):244911

SUPA, School of Physics and Astronomy, University of Edinburgh, James Clerk Maxwell Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JZ, United Kingdom.

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http://dx.doi.org/10.1063/1.4770271DOI Listing
December 2012

Computing the local pressure in molecular dynamics simulations.

J Phys Condens Matter 2012 Jul 27;24(28):284133. Epub 2012 Jun 27.

SUPA, School of Physics and Astronomy, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, UK.

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http://stacks.iop.org/0953-8984/24/i=28/a=284133?key=crossre
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http://dx.doi.org/10.1088/0953-8984/24/28/284133DOI Listing
July 2012

Nilotinib as frontline and second-line therapy in chronic myeloid leukemia: open questions.

Crit Rev Oncol Hematol 2012 Jun 7;82(3):370-7. Epub 2011 Sep 7.

Department of Internal Medicine I, Division of Haematology & Haemostaseology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.critrevonc.2011.08.002DOI Listing
June 2012

Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery.

Antiviral Res 2012 Jun 10;94(3):195-207. Epub 2012 Apr 10.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Department of Pediatrics, Medical University of Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S01663542120007
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http://dx.doi.org/10.1016/j.antiviral.2012.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370646PMC
June 2012

Molecular diagnosis and management of viral infections in hematopoietic stem cell transplant recipients.

Mol Diagn Ther 2012 Apr;16(2):63-77

Department of Pediatric Stem Cell Transplantation, St. Anna Childrens Hospital, Medical University of Vienna, Vienna, Austria.

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http://link.springer.com/content/pdf/10.1007/BF03256431.pdf
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http://dx.doi.org/10.2165/11631490-000000000-00000DOI Listing
April 2012

Targeted expression of herpes simplex virus thymidine kinase in adenovirus-infected cells reduces virus titers upon treatment with ganciclovir in vitro.

J Gene Med 2012 Jan;14(1):3-19

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Department of Pediatrics, Medical University of Vienna, Austria.

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http://doi.wiley.com/10.1002/jgm.1638
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http://dx.doi.org/10.1002/jgm.1638DOI Listing
January 2012

Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.

Am J Pathol 2008 Jan 28;172(1):203-14. Epub 2007 Dec 28.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.2353/ajpath.2008.061263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189624PMC
January 2008

Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children.

Haematologica 2007 Nov;92(11):1561-4

Department of Hematology and Oncology, St. Anna Children's Hospital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.11239DOI Listing
November 2007

Detection of impending graft rejection and relapse by lineage-specific chimerism analysis.

Authors:
Thomas Lion

Methods Mol Med 2007 ;134:197-216

Children's Cancer Institute, St. Anna Children's Hospital, Vienna, Austria.

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October 2007

The Pan-AC assay: a single-reaction real-time PCR test for quantitative detection of a broad range of Aspergillus and Candida species.

J Med Microbiol 2007 Sep;56(Pt 9):1167-73

Division of Molecular Microbiology and Development of Genetic Diagnostics, Children's Cancer Research Institute, A-1090 Vienna, Austria.

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http://jmm.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.47212-0DOI Listing
September 2007

Investigation of adenovirus occurrence in pediatric tumor entities.

J Virol 2007 Jul 9;81(14):7629-35. Epub 2007 May 9.

Division of Molecular Microbiology and Development of Genetic Diagnostics, St. Anna Kinderkrebsforschung, Children's Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1128/JVI.00355-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933336PMC
July 2007

Typing of human adenoviruses in specimens from immunosuppressed patients by PCR-fragment length analysis and real-time quantitative PCR.

J Clin Microbiol 2006 Aug;44(8):2808-15

Division of Molecular Microbiology and Development of Genetic Diagnostics, Children's Cancer Research Institute, A-1090 Vienna, Austria.

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http://jcm.asm.org/cgi/doi/10.1128/JCM.00048-06
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http://dx.doi.org/10.1128/JCM.00048-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594637PMC
August 2006

Visualization of episomal and integrated Epstein-Barr virus DNA by fiber fluorescence in situ hybridization.

Int J Cancer 2006 Apr;118(7):1603-8

Children's Cancer Research Institute, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://doi.wiley.com/10.1002/ijc.21498
Publisher Site
http://dx.doi.org/10.1002/ijc.21498DOI Listing
April 2006

Chimerism analysis following nonmyeloablative stem cell transplantation.

Methods Mol Med 2006 ;125:275-95

Children's Cancer Research Institute, Vienna, Austria.

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April 2006

In vitro and in vivo T-cell depletion with myeloablative or reduced-intensity conditioning in pediatric hematopoietic stem cell transplantation.

Haematologica 2005 Oct;90(10):1405-14

St. Anna Children's Hospital and Children's Cancer Research Institute (CCRI) Kinderspitalgasse 6, A-1090 Wien, Austria.

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October 2005

Philadelphia chromosome-positive mature B-cell (Burkitt cell) leukaemia.

Br J Haematol 2002 Aug;118(2):559-62

Children's Cancer Research Institute, St. Anna Children's Hospital, Kinderspitalgasse 6, 1090 Vienna, Austria.

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http://dx.doi.org/10.1046/j.1365-2141.2001.03598.xDOI Listing
August 2002

Genetic changes of two Wilms tumors with anaplasia and a review of the literature suggesting a marker profile for therapy resistance.

Cancer Genet Cytogenet 2002 Jun;135(2):128-38

Children's Cancer Research Institute (CCRI), St. Anna Children's Hospital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/s0165-4608(01)00647-1DOI Listing
June 2002