Publications by authors named "Thomas Lengauer"

221Publications

Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.

Authors:
Michael Scherer Petr V Nazarov Reka Toth Shashwat Sahay Tony Kaoma Valentin Maurer Nikita Vedeneev Christoph Plass Thomas Lengauer Jörn Walter Pavlo Lutsik

Nat Protoc 2020 10 25;15(10):3240-3263. Epub 2020 Sep 25.

Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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October 2020

Quantitative comparison of within-sample heterogeneity scores for DNA methylation data.

Authors:
Michael Scherer Almut Nebel Andre Franke Jörn Walter Thomas Lengauer Christoph Bock Fabian Müller Markus List

Nucleic Acids Res 2020 05;48(8):e46

Big Data in BioMedicine Group, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.

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May 2020

Corrigendum to: Family-joining: A fast distance-based method for constructing generally labeled trees.

Authors:
Prabhav Kalaghatgi Nico Pfeifer Thomas Lengauer

Mol Biol Evol 2020 06;37(6):1845

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June 2020

Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey.

Authors:
Andrea De Luca Patrizio Pezzotti Charles Boucher Matthias Döring Francesca Incardona Rolf Kaiser Thomas Lengauer Nico Pfeifer Eugen Schülter Anne-Mieke Vandamme Maurizio Zazzi Anna Maria Geretti

PLoS One 2019 21;14(11):e0225381. Epub 2019 Nov 21.

Institute of Infection and Global Health, University of Liverpool, Liverpool, England, United Kingdom.

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March 2020

Unique and assay specific features of NOMe-, ATAC- and DNase I-seq data.

Authors:
Karl J V Nordström Florian Schmidt Nina Gasparoni Abdulrahman Salhab Gilles Gasparoni Kathrin Kattler Fabian Müller Peter Ebert Ivan G Costa Nico Pfeifer Thomas Lengauer Marcel H Schulz Jörn Walter

Nucleic Acids Res 2019 11;47(20):10580-10596

Department of Genetics, Saarland University, 66123 Saarbrücken, Germany.

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November 2019

Soluble immune markers in the different phases of chronic hepatitis B virus infection.

Authors:
Steffen B Wiegand Bastian Beggel Anika Wranke Elmira Aliabadi Jerzy Jaroszewicz Cheng-Jian Xu Yang Li Michael P Manns Thomas Lengauer Heiner Wedemeyer Anke R M Kraft Christine S Falk Markus Cornberg

Sci Rep 2019 10 1;9(1):14118. Epub 2019 Oct 1.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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October 2019

Failure of Dolutegravir First-Line ART with Selection of Virus Carrying R263K and G118R.

Authors:
Nadine Lübke Björn Jensen Falk Hüttig Torsten Feldt Andreas Walker Alexander Thielen Martin Däumer Martin Obermeier Rolf Kaiser Elena Knops Eva Heger Saleta Sierra Mark Oette Thomas Lengauer Jörg Timm Dieter Häussinger

N Engl J Med 2019 08;381(9):887-889

Heinrich Heine University Hospital, Düsseldorf, Germany.

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August 2019

Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants.

Authors:
Nadezhda T Doncheva Francisco S Domingues David R McGivern Tetsuro Shimakami Stefan Zeuzem Thomas Lengauer Christian M Lange Mario Albrecht Christoph Welsch

J Mol Biol 2019 05 30;431(12):2354-2368. Epub 2019 Apr 30.

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrücken, Germany; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt a.M., Germany. Electronic address:

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May 2019

RnBeads 2.0: comprehensive analysis of DNA methylation data.

Authors:
Fabian Müller Michael Scherer Yassen Assenov Pavlo Lutsik Jörn Walter Thomas Lengauer Christoph Bock

Genome Biol 2019 03 14;20(1):55. Epub 2019 Mar 14.

Max Planck Institute for Informatics, Saarland Informatics Campus, 66123, Saarbrücken, Germany.

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March 2019

Relative Principal Components Analysis: Application to Analyzing Biomolecular Conformational Changes.

Authors:
Mazen Ahmad Volkhard Helms Olga V Kalinina Thomas Lengauer

J Chem Theory Comput 2019 Apr 6;15(4):2166-2178. Epub 2019 Mar 6.

Computational Biology Research Group , Max Planck Institute for Informatics , Saarland Informatics Campus, Campus E1 4 , 66123 Saarbrücken , Germany.

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April 2019

Integrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters.

Authors:
Fatemeh Behjati Ardakani Kathrin Kattler Karl Nordström Nina Gasparoni Gilles Gasparoni Sarah Fuchs Anupam Sinha Matthias Barann Peter Ebert Jonas Fischer Barbara Hutter Gideon Zipprich Charles D Imbusch Bärbel Felder Jürgen Eils Benedikt Brors Thomas Lengauer Thomas Manke Philip Rosenstiel Jörn Walter Marcel H Schulz

Epigenetics Chromatin 2018 11 10;11(1):66. Epub 2018 Nov 10.

Excellence Cluster for Multimodal Computing and Interaction, Saarland Informatics Campus, Saarland University, Campus E1 7, Saarbrücken, 66123, Germany.

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November 2018

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.

Authors:
Abdulrahman Salhab Karl Nordström Gilles Gasparoni Kathrin Kattler Peter Ebert Fidel Ramirez Laura Arrigoni Fabian Müller Julia K Polansky Cristina Cadenas Jan G Hengstler Thomas Lengauer Thomas Manke Jörn Walter

Genome Biol 2018 09 28;19(1):150. Epub 2018 Sep 28.

Department of Genetics, Saarland University, Campus Saarbrücken, Saarbrücken, 66123, Germany.

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September 2018

From hype to reality: data science enabling personalized medicine.

Authors:
Holger Fröhlich Rudi Balling Niko Beerenwinkel Oliver Kohlbacher Santosh Kumar Thomas Lengauer Marloes H Maathuis Yves Moreau Susan A Murphy Teresa M Przytycka Michael Rebhan Hannes Röst Andreas Schuppert Matthias Schwab Rainer Spang Daniel Stekhoven Jimeng Sun Andreas Weber Daniel Ziemek Blaz Zupan

BMC Med 2018 08 27;16(1):150. Epub 2018 Aug 27.

Faculty of Computer and Information Science, University of Ljubljana, Večna pot 113, SI-1000, Ljubljana, Slovenia.

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August 2018

geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data.

Authors:
Matthias Döring Joachim Büch Georg Friedrich Alejandro Pironti Prabhav Kalaghatgi Elena Knops Eva Heger Martin Obermeier Martin Däumer Alexander Thielen Rolf Kaiser Thomas Lengauer Nico Pfeifer

Nucleic Acids Res 2018 07;46(W1):W271-W277

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany.

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July 2018

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Authors:
Wei-Hung Pan Felix Sommer Maren Falk-Paulsen Thomas Ulas Philipp Best Antonella Fazio Priyadarshini Kachroo Anne Luzius Marlene Jentzsch Ateequr Rehman Fabian Müller Thomas Lengauer Jörn Walter Sven Künzel John F Baines Stefan Schreiber Andre Franke Joachim L Schultze Fredrik Bäckhed Philip Rosenstiel

Genome Med 2018 04 13;10(1):27. Epub 2018 Apr 13.

Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.

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April 2018

Results of the first international HIV-1 coreceptor proficiency panel test.

Authors:
Eva Heger Rolf Kaiser Elena Knops Maria Neumann-Fraune Eugen Schuelter Alejandro Pironti Thomas Lengauer Hauke Walter Saleta Sierra

J Clin Virol 2017 08 10;93:53-56. Epub 2017 Jun 10.

Institute of Virology, University of Cologne, 50935 Cologne, Germany.

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August 2017

Using drug exposure for predicting drug resistance - A data-driven genotypic interpretation tool.

Authors:
Alejandro Pironti Nico Pfeifer Hauke Walter Björn-Erik O Jensen Maurizio Zazzi Perpétua Gomes Rolf Kaiser Thomas Lengauer

PLoS One 2017 10;12(4):e0174992. Epub 2017 Apr 10.

Department of Computational Biology and Applied Algorithmics, Max-Planck-Institut für Informatik, Saarbrücken, Germany.

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August 2017

DeepBlueR: large-scale epigenomic analysis in R.

Authors:
Felipe Albrecht Markus List Christoph Bock Thomas Lengauer

Bioinformatics 2017 Jul;33(13):2063-2064

Max Planck Institute for Informatics.

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July 2017

Elucidating the energetic contributions to the binding free energy.

Authors:
Mazen Ahmad Volkhard Helms Olga V Kalinina Thomas Lengauer

J Chem Phys 2017 Jan;146(1):014105

Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus E1 4, 66123 Saarbrücken, Germany.

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January 2017

A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Authors:
Matthias Döring Pedro Borrego Joachim Büch Andreia Martins Georg Friedrich Ricardo Jorge Camacho Josef Eberle Rolf Kaiser Thomas Lengauer Nuno Taveira Nico Pfeifer

Retrovirology 2016 Dec 20;13(1):85. Epub 2016 Dec 20.

Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, Campus E 1 4, 66123, Saarbrücken, Germany.

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December 2016