Thomas Langer

Thomas Langer

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The mitochondrial intermembrane space-facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism.

Mol Biol Cell 2019 Oct 4;30(21):2681-2694. Epub 2019 Sep 4.

Interfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1091/mbc.E19-03-0166DOI Listing
October 2019

Walter Neupert (1939-2019), a pioneer of mitochondrial biogenesis and morphology.

EMBO J 2019 Sep 16;38(17):e103100. Epub 2019 Aug 16.

Zellbiologie, Universität Kaiserslautern, Kaiserslautern, Germany.

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http://dx.doi.org/10.15252/embj.2019103100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717888PMC
September 2019

The Good and the Bad of Mitochondrial Breakups.

Trends Cell Biol 2019 Sep 5. Epub 2019 Sep 5.

Max Planck Institute for Biology of Ageing, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2019.08.003DOI Listing
September 2019

Short-term Physiologic Consequences of Regional Pulmonary Vascular Occlusion in Pigs.

Anesthesiology 2019 Aug;131(2):336-343

From the Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy (T.L., V.C., S.B., T.M., A.Z., A.P.) the Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (T.L., A.S., T.M., A.Z., A.P.).

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http://Insights.ovid.com/crossref?an=00000542-900000000-9659
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http://dx.doi.org/10.1097/ALN.0000000000002735DOI Listing
August 2019

Mitochondrial Proteolysis and Metabolic Control.

Cold Spring Harb Perspect Biol 2019 Jul 1;11(7). Epub 2019 Jul 1.

Department of Mitochondrial Proteostasis, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

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http://dx.doi.org/10.1101/cshperspect.a033936DOI Listing
July 2019

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Cell 2019 May;177(6):1536-1552.e23

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193050
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http://dx.doi.org/10.1016/j.cell.2019.05.008DOI Listing
May 2019

Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.

Nat Commun 2019 03 8;10(1):1130. Epub 2019 Mar 8.

Max-Planck-Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931, Cologne, Germany.

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http://dx.doi.org/10.1038/s41467-019-09089-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408443PMC
March 2019

Leitlinienreport der S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus.

Z Gastroenterol 2019 03 12;57(3):e103-e119. Epub 2019 Mar 12.

Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, Berlin.

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http://dx.doi.org/10.1055/a-0833-6106DOI Listing
March 2019

Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial.

J Clin Anesth 2019 Feb 20;52:111-118. Epub 2018 Sep 20.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1016/j.jclinane.2018.09.021DOI Listing
February 2019

Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines.

J Am Chem Soc 2019 Feb 18;141(8):3356-3360. Epub 2019 Feb 18.

School of Chemistry , University of Bristol , Bristol , BS8 1TS , United Kingdom.

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http://dx.doi.org/10.1021/jacs.8b12689DOI Listing
February 2019

A fully automated three-step protein purification procedure for up to five samples using the NGC chromatography system.

Protein Expr Purif 2019 01 10;153:1-6. Epub 2018 Aug 10.

Sanofi-Aventis Deutschland GmbH, R&D Biologics Research, Building H811, Industriepark Höchst, 65926, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2018.08.003DOI Listing
January 2019

Ventilatory and integrated physiological responses to chronic hypercapnia in goats.

J Physiol 2018 11 14;596(22):5343-5363. Epub 2018 Oct 14.

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1113/JP276666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235946PMC
November 2018

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Cell 2018 11;175(5):1321-1335.e20

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541012PMC
November 2018

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer.

Authors:
Achim Wöckel Jasmin Festl Tanja Stüber Katharina Brust Mathias Krockenberger Peter U Heuschmann Steffi Jírů-Hillmann Ute-Susann Albert Wilfried Budach Markus Follmann Wolfgang Janni Ina Kopp Rolf Kreienberg Thorsten Kühn Thomas Langer Monika Nothacker Anton Scharl Ingrid Schreer Hartmut Link Jutta Engel Tanja Fehm Joachim Weis Anja Welt Anke Steckelberg Petra Feyer Klaus König Andrea Hahne Traudl Baumgartner Hans H Kreipe Wolfram Trudo Knoefel Michael Denkinger Sara Brucker Diana Lüftner Christian Kubisch Christina Gerlach Annette Lebeau Friederike Siedentopf Cordula Petersen Hans Helge Bartsch Rüdiger Schulz-Wendtland Markus Hahn Volker Hanf Markus Müller-Schimpfle Ulla Henscher Renza Roncarati Alexander Katalinic Christoph Heitmann Christoph Honegger Kerstin Paradies Vesna Bjelic-Radisic Friedrich Degenhardt Frederik Wenz Oliver Rick Dieter Hölzel Matthias Zaiss Gudrun Kemper Volker Budach Carsten Denkert Bernd Gerber Hans Tesch Susanne Hirsmüller Hans-Peter Sinn Jürgen Dunst Karsten Münstedt Ulrich Bick Eva Fallenberg Reina Tholen Roswita Hung Freerk Baumann Matthias W Beckmann Jens Blohmer Peter Fasching Michael P Lux Nadia Harbeck Peyman Hadji Hans Hauner Sylvia Heywang-Köbrunner Jens Huober Jutta Hübner Christian Jackisch Sibylle Loibl Hans-Jürgen Lück Gunter von Minckwitz Volker Möbus Volkmar Müller Ute Nöthlings Marcus Schmidt Rita Schmutzler Andreas Schneeweiss Florian Schütz Elmar Stickeler Christoph Thomssen Michael Untch Simone Wesselmann Arno Bücker Andreas Buck Stephanie Stangl

Geburtshilfe Frauenheilkd 2018 Nov 26;78(11):1056-1088. Epub 2018 Nov 26.

Institut für Klinische Epidemiologie und Biometrie (IKE-B), Universität Würzburg, Würzburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0646-4630
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http://dx.doi.org/10.1055/a-0646-4630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261741PMC
November 2018

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) - Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities.

Geburtshilfe Frauenheilkd 2018 Nov 26;78(11):1089-1109. Epub 2018 Nov 26.

Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1055/a-0715-2964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261739PMC
November 2018

The signalling conformation of the insulin receptor ectodomain.

Nat Commun 2018 10 24;9(1):4420. Epub 2018 Oct 24.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3015, Australia.

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http://www.nature.com/articles/s41467-018-06826-6
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http://dx.doi.org/10.1038/s41467-018-06826-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200814PMC
October 2018

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer.

Geburtshilfe Frauenheilkd 2018 Oct 19;78(10):949-971. Epub 2018 Oct 19.

Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0713-1218
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http://dx.doi.org/10.1055/a-0713-1218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195426PMC
October 2018

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer.

Geburtshilfe Frauenheilkd 2018 Oct 19;78(10):927-948. Epub 2018 Oct 19.

Universitätsfrauenklinik Würzburg, Universität Würzburg, Würzburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0646-4522
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http://dx.doi.org/10.1055/a-0646-4522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202580PMC
October 2018

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates.

Angew Chem Int Ed Engl 2018 04 22;57(18):5124-5128. Epub 2018 Mar 22.

School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.

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http://dx.doi.org/10.1002/anie.201801109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969259PMC
April 2018

Complete Genome Sequence of a New Ruminococcaceae Bacterium Isolated from Anaerobic Biomass Hydrolysis.

Genome Announc 2018 Apr 5;6(14). Epub 2018 Apr 5.

Department of Bioengineering, Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB), Potsdam, Germany

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http://dx.doi.org/10.1128/genomeA.00030-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887030PMC
April 2018

m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration.

Cell Res 2018 Mar 16;28(3):296-306. Epub 2018 Feb 16.

Max Planck Institute for Biology of Aging, Cologne, Germany.

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http://dx.doi.org/10.1038/cr.2018.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835776PMC
March 2018

PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.

EMBO J 2018 02 4;37(4). Epub 2018 Jan 4.

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/embj.201797909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813258PMC
February 2018

Proteiniborus indolifex sp. nov., isolated from a thermophilic industrial-scale biogas plant.

Int J Syst Evol Microbiol 2018 Jan 25. Epub 2018 Jan 25.

Department of Bioengineering, Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB), D-14469 Potsdam, Germany.

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http://dx.doi.org/10.1099/ijsem.0.002591DOI Listing
January 2018

S3-Leitlinie – Kolorektales Karzinom.

Z Gastroenterol 2017 12 6;55(12):1344-1498. Epub 2017 Dec 6.

St. Joseph-Stift Bremen, Medizinische Klinik, Bremen.

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http://dx.doi.org/10.1055/s-0043-121106DOI Listing
December 2017

Electron Microscopy as a Tool for Assessment of Anticoagulation Strategies During Extracorporeal Life Support: The Proof Is on the Membrane.

ASAIO J 2016 Sep-Oct;62(5):525-32

From the *The Geneva Foundation, Tacoma, Washington; †US Army Institute of Surgical Research (USAISR), Ft. Sam Houston, Texas; ‡Tri-Service Research Laboratory, San Antonio, Texas; ¶University of Texas San Antonio Health Sciences Center, San Antonio, Texas; and §Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy.

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http://dx.doi.org/10.1097/MAT.0000000000000394DOI Listing
November 2017

Expression and purification of the extracellular domains of human glycoprotein VI (GPVI) and the receptor for advanced glycation end products (RAGE) from Rattus norvegicus in Leishmania tarentolae.

Prep Biochem Biotechnol 2017 Nov 31;47(10):1008-1015. Epub 2017 Aug 31.

a R&D Biologics Research, Sanofi-Aventis Deutschland GmbH , Frankfurt am Main , Germany.

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http://dx.doi.org/10.1080/10826068.2017.1365252DOI Listing
November 2017

Intravenous fluid therapy for hospitalized and critically ill children: rationale, available drugs and possible side effects.

Anaesthesiol Intensive Ther 2018 18;50(1):49-58. Epub 2017 Nov 18.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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http://dx.doi.org/10.5603/AIT.a2017.0058DOI Listing
November 2017

The completely annotated genome and comparative genomics of the Peptoniphilaceae bacterium str. ING2-D1G, a novel acidogenic bacterium isolated from a mesophilic biogas reactor.

J Biotechnol 2017 Sep 6;257:178-186. Epub 2017 Jun 6.

Center for Biotechnology (CeBiTec), Genome Research of Industrial Microorganisms, Bielefeld University, Universitätsstr. 27, 33615 Bielefeld, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2017.05.027DOI Listing
September 2017

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

Biochem Biophys Res Commun 2017 09 15;491(2):416-422. Epub 2017 Jul 15.

Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X173143
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http://dx.doi.org/10.1016/j.bbrc.2017.07.087DOI Listing
September 2017

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.

Mol Cell 2017 Aug 14;67(3):471-483.e7. Epub 2017 Jul 14.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.013DOI Listing
August 2017

Do we really need postoperative ICU management after elective surgery? No, not any more!

Intensive Care Med 2017 07 18;43(7):1037-1038. Epub 2017 May 18.

Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.

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http://dx.doi.org/10.1007/s00134-017-4814-0DOI Listing
July 2017

Prohibitins.

Curr Biol 2017 Jul;27(13):R629-R631

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.04.030DOI Listing
July 2017

Spontaneous breathing: a double-edged sword to handle with care.

Ann Transl Med 2017 Jul;5(14):292

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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http://dx.doi.org/10.21037/atm.2017.06.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537122PMC
July 2017

Effects on breathing of agonists to μ-opioid or GABA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

Respir Physiol Neurobiol 2017 05 27;239:10-25. Epub 2017 Jan 27.

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, United States; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, United States; Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53226, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15699048163016
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http://dx.doi.org/10.1016/j.resp.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996971PMC
May 2017

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Nat Cell Biol 2017 04 13;19(4):318-328. Epub 2017 Mar 13.

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne 50931, Germany.

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http://dx.doi.org/10.1038/ncb3488DOI Listing
April 2017

Intramitochondrial phospholipid trafficking.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Jan 16;1862(1):81-89. Epub 2016 Aug 16.

Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.08.006DOI Listing
January 2017

Extremely high transpulmonary pressure in a spontaneously breathing patient with early severe ARDS on ECMO.

Intensive Care Med 2016 Dec 11;42(12):2101-2103. Epub 2016 Aug 11.

Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.

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http://dx.doi.org/10.1007/s00134-016-4470-9DOI Listing
December 2016

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

EMBO Rep 2016 12 13;17(12):1844-1856. Epub 2016 Oct 13.

Institute for Genetics Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and University of Cologne, Cologne, Germany

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http://embor.embopress.org/lookup/doi/10.15252/embr.20164269
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http://dx.doi.org/10.15252/embr.201642698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283581PMC
December 2016

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.

PLoS Genet 2016 Dec 2;12(12):e1006463. Epub 2016 Dec 2.

Institute for Genetics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1006463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135034PMC
December 2016

Intravenous balanced solutions: from physiology to clinical evidence.

Anaesthesiol Intensive Ther 2015 20;47 Spec No:s78-88. Epub 2015 Nov 20.

Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.5603/AIT.a2015.0079DOI Listing
October 2016

Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.

J Med Genet 2016 10 12;53(10):690-6. Epub 2016 May 12.

The Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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http://jmg.bmj.com/content/early/2016/05/12/jmedgenet-2016-1
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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2016-103922
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http://dx.doi.org/10.1136/jmedgenet-2016-103922DOI Listing
October 2016

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.

Mol Cell 2016 10 15;64(1):148-162. Epub 2016 Sep 15.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Max Planck Institute for Biology of Aging, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.08.020DOI Listing
October 2016

[The German Guideline Program in Oncology (GGPO): A central core of an evidence-based, patient-centered interdisciplinary oncology?].

Z Evid Fortbild Qual Gesundhwes 2015 26;109(6):437-44. Epub 2015 Sep 26.

Deutsche Krebsgesellschaft e. V., Berlin, Deutschland.

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https://linkinghub.elsevier.com/retrieve/pii/S18659217150018
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http://dx.doi.org/10.1016/j.zefq.2015.09.007DOI Listing
September 2016

Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides.

Angew Chem Int Ed Engl 2016 09 27;55(37):11198-11202. Epub 2016 Jul 27.

School of Chemistry, University of Bristol, Bristol, BS8 1TS, United Kingdom.

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http://dx.doi.org/10.1002/anie.201605152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010782PMC
September 2016

Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.

Toxicol Lett 2016 Jul 10;255:43-6. Epub 2016 May 10.

Dipartimento di Anestesia, Rianimazione ed Emergenza-Urgenza, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi, Milan, Italy.

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http://dx.doi.org/10.1016/j.toxlet.2016.05.010DOI Listing
July 2016

OPA1 processing in cell death and disease - the long and short of it.

J Cell Sci 2016 06 17;129(12):2297-306. Epub 2016 May 17.

Institute of Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany

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http://dx.doi.org/10.1242/jcs.159186DOI Listing
June 2016

MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria.

J Cell Biol 2016 06 30;213(5):525-34. Epub 2016 May 30.

Institute of Genetics, University of Cologne, 50931 Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany

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http://dx.doi.org/10.1083/jcb.201602007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896057PMC
June 2016

"Awake" extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering.

Crit Care 2016 06 30;20(1):150. Epub 2016 Jun 30.

Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.

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http://dx.doi.org/10.1186/s13054-016-1329-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928342PMC
June 2016

Understanding the role of the cerebrospinal fluid in acid-base disorders.

Intensive Care Med 2016 Mar 23;42(3):436-439. Epub 2015 Sep 23.

Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.

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http://dx.doi.org/10.1007/s00134-015-4059-8DOI Listing
March 2016

Description of sp. nov., sp. nov. and gen. nov., sp. nov., isolated from mesophilic laboratory-scale biogas reactors, and emended description of the genus .

Int J Syst Evol Microbiol 2016 Mar 15;66(3):1466-1475. Epub 2016 Jan 15.

1​Department of Bioengineering, Leibniz Institute for Agricultural Engineering Potsdam-Bornim, D-14469, Potsdam, Germany.

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http://dx.doi.org/10.1099/ijsem.0.000902DOI Listing
March 2016

Mitochondrial Dynamics and Metabolic Regulation.

Trends Endocrinol Metab 2016 Feb 2;27(2):105-117. Epub 2016 Jan 2.

Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Max-Planck-Institute for Biology of Aging, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.12.001DOI Listing
February 2016

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

J Cell Biol 2016 Jan;212(2):157-66

Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany Center for Molecular Medicine, University of Cologne, 50931 Cologne, Germany Max Planck Institute for Biology of Aging, 50931 Cologne, Germany

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http://dx.doi.org/10.1083/jcb.201507022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738383PMC
January 2016

Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment.

Intensive Care Med Exp 2015 Dec 11;3(1):55. Epub 2015 Jun 11.

Dipartimento di Fisiopatologica Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Via Francesco Sforza 35, 20122, Milan, Italy,

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http://dx.doi.org/10.1186/s40635-015-0055-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480350PMC
December 2015

Low-Dose Heparin Anticoagulation During Extracorporeal Life Support for Acute Respiratory Distress Syndrome in Conscious Sheep.

Shock 2015 Dec;44(6):560-8

*French Armed Forces Institute of Biomedical Research (IRBA), Paris, France †Division of Pediatric Critical Care, Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas ‡Department of Anesthesia, Intensive Care Medicine, Emergency and Urgency, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan, Italy §Coagulation and Blood Research ||Comprehensive Intensive Care Research, U.S. Army Institute of Surgical Research (USAISR), Ft. Sam Houston, Texas.

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http://dx.doi.org/10.1097/SHK.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851223PMC
December 2015

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

Science 2015 Dec;350(6265):aad0116

Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1126/science.aad0116DOI Listing
December 2015

Combined unilateral blockade of cholinergic, peptidergic, and serotonergic receptors in the ventral respiratory column does not affect breathing in awake or sleeping goats.

J Appl Physiol (1985) 2015 Aug 28;119(3):308-20. Epub 2015 May 28.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin

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http://dx.doi.org/10.1152/japplphysiol.00145.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526704PMC
August 2015

Albumin in critically ill patients: the ideal colloid?

Curr Opin Crit Care 2015 Aug;21(4):302-8

aDipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano bDipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1097/MCC.0000000000000223DOI Listing
August 2015

Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).

Mol Cell Endocrinol 2015 Jun 24;408:62-72. Epub 2015 Feb 24.

Department of Biological Chemistry at the Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.02.022DOI Listing
June 2015

New roles for mitochondrial proteases in health, ageing and disease.

Nat Rev Mol Cell Biol 2015 Jun 13;16(6):345-59. Epub 2015 May 13.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1038/nrm3984DOI Listing
June 2015

Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.

Mol Cell Biol 2015 May 16;35(10):1838-47. Epub 2015 Mar 16.

Microbiome and Disease Tolerance Centre, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1128/MCB.00047-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405640PMC
May 2015

A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.

Angew Chem Int Ed Engl 2015 May 15;54(22):6511-5. Epub 2015 Apr 15.

Abteilung für NMR-basierte Strukturbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen (Germany).

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http://dx.doi.org/10.1002/anie.201500671DOI Listing
May 2015

Electrolyte shifts across the artificial lung in patients on extracorporeal membrane oxygenation: interdependence between partial pressure of carbon dioxide and strong ion difference.

J Crit Care 2015 Feb 22;30(1):2-6. Epub 2014 Sep 22.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy; Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy.

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http://dx.doi.org/10.1016/j.jcrc.2014.09.013DOI Listing
February 2015

Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies.

Cell Rep 2015 Feb 13;10(6):843-853. Epub 2015 Feb 13.

Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.01.012DOI Listing
February 2015

Human illnesses and animal deaths associated with freshwater harmful algal blooms-Kansas.

Toxins (Basel) 2015 Jan 30;7(2):353-66. Epub 2015 Jan 30.

Kansas Department of Health and Environment, 1000 SW Jackson Street, Suite 075, Topeka, KS 66612, USA.

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http://www.mdpi.com/2072-6651/7/2/353
Publisher Site
http://dx.doi.org/10.3390/toxins7020353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344628PMC
January 2015

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

Cell Metab 2014 Jul 22;20(1):158-71. Epub 2014 May 22.

Institute for Genetics, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Max-Planck-Institute for Biology of Aging, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.04.016DOI Listing
July 2014

1,2-N-migration in a gold-catalysed synthesis of functionalised indenes by the 1,1-carboalkoxylation of ynamides.

Chemistry 2014 Jun 14;20(24):7262-6. Epub 2014 May 14.

School of Chemistry, University of Birmingham (UK), Fax: (+44) 121-4144403.

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http://dx.doi.org/10.1002/chem.201403040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204129PMC
June 2014

Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome.

Intensive Care Med 2014 May 20;40(5):691-9. Epub 2014 Mar 20.

Dipartimento di Anestesia, Rianimazione (Intensiva e Subintensiva) e Terapia del Dolore, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via F. Sforza 35, Milan, Italy,

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http://dx.doi.org/10.1007/s00134-014-3264-1DOI Listing
May 2014

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.

Cell Rep 2014 May 24;7(3):834-47. Epub 2014 Apr 24.

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON K1Y, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.051DOI Listing
May 2014

Extracorporeal gas exchange and spontaneous breathing for the treatment of acute respiratory distress syndrome: an alternative to mechanical ventilation?*.

Crit Care Med 2014 Mar;42(3):e211-20

1Comprehensive Intensive Care Research Task Area, United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX. 2Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy. 3National Research Council, National Academies, Washington, DC. 4School of Medicine, Università degli Studi di Milano, Milan, Italy. 5Department of Surgery, San Antonio Military Medical Center, San Antonio, TX. 6Uniformed Services University of the Health Sciences, Bethesda, MD. 7Dipartimento di Anestesia, Rianimazione (Intensiva e Sub-intensiva) e Terapia del Dolore, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.

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http://dx.doi.org/10.1097/CCM.0000000000000121DOI Listing
March 2014

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

EMBO J 2014 Mar 18;33(6):578-93. Epub 2014 Feb 18.

Institute for Genetics Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) Center for Molecular Medicine (CMMC) University of Cologne, Cologne, Germany.

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http://emboj.embopress.org/cgi/doi/10.1002/embj.201386474
Publisher Site
http://dx.doi.org/10.1002/embj.201386474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989652PMC
March 2014

Dynamic survey of mitochondria by ubiquitin.

EMBO Rep 2014 Mar 25;15(3):231-43. Epub 2014 Feb 25.

Institute for Genetics Centre for Molecular Medicine (CMMC) Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/embr.201338225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989689PMC
March 2014

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

J Cell Biol 2014 Mar 10;204(6):919-29. Epub 2014 Mar 10.

Institute for Genetics, Center for Molecular Medicine (CMMC), and 2 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

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http://dx.doi.org/10.1083/jcb.201308006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998800PMC
March 2014

StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation.

Mol Endocrinol 2014 Feb 1;28(2):208-24. Epub 2013 Jan 1.

Department of Biological Chemistry (A.B., S.P., J.O.) and Bio-Imaging Unit (N.M.-B.), The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; and Institute for Genetics (I.L., T.L.), Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.

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http://dx.doi.org/10.1210/me.2013-1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427954PMC
February 2014

Mitochondrial lipid transport at a glance.

J Cell Sci 2013 Dec 4;126(Pt 23):5317-23. Epub 2013 Nov 4.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine (CMMC), University of Cologne, 50674 Cologne, Germany.

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http://dx.doi.org/10.1242/jcs.134130DOI Listing
December 2013