Publications by authors named "Thomas Kukar"

33Publications

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.

Adv Exp Med Biol 2021 ;1281:219-242

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

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January 2021

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.

Neurobiol Dis 2020 Dec 18;146:105085. Epub 2020 Sep 18.

Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Neurology, Emory University, School of Medicine, Atlanta, GA, United States of America. Electronic address:

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December 2020

Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.

Neuron 2020 07 5;107(2):292-305.e6. Epub 2020 May 5.

Department of Cell Biology, Emory University, Atlanta, GA 30322, USA; Laboratory for Translational Cell Biology, Emory University, Atlanta, GA 30322, USA; Wallace H. Coulter Graduate Program in Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA; Department of Neurology, Emory University, Atlanta, GA 30322, USA. Electronic address:

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July 2020

Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity.

Protein Sci 2017 Sep 22;26(9):1759-1772. Epub 2017 Jun 22.

Department of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, Mississippi, 39406.

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September 2017

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

J Neurosci 2014 Jun;34(23):7802-13

Department of Pharmacology, Center for Neurodegenerative Disease, Department of Neurology, Emory University, School of Medicine, Atlanta, Georgia 30322,

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June 2014

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.

Biochemistry 2014 Apr 20;53(12):1947-57. Epub 2014 Mar 20.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, and McKnight Brain Institute, College of Medicine, University of Florida , Gainesville, Florida 32603, United States.

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April 2014

Steroids as γ-secretase modulators.

FASEB J 2013 Sep 28;27(9):3775-85. Epub 2013 May 28.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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September 2013

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

J Biol Chem 2011 Nov 25;286(46):39794-803. Epub 2011 Aug 25.

Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA.

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November 2011

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Biochemistry 2009 Nov;48(46):10894-904

Laboratory for Neurodegenerative Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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November 2009

Medicine. Avoiding unintended toxicity.

Science 2009 May;324(5927):603-4

Mayo Clinic, College of Medicine, Department of Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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May 2009

Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

Curr Top Med Chem 2008 ;8(1):47-53

Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.

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March 2008

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.

FASEB J 2006 Aug;20(10):1671-9

Department of Neuroscience, Mayo Clinic Jacksonville, Mayo Clinic College of Medicine, 4500 San Pablo Rd., Jacksonville, Florida 32224, USA.

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August 2006

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

J Neurochem 2006 Jan 21;96(2):355-65. Epub 2005 Nov 21.

Emmy Noether Research Group, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.

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January 2006

Structural insights and functional implications of choline acetyltransferase.

J Struct Biol 2004 Nov;148(2):226-35

Department of Biochemistry and Molecular Biology, McKnight Brain Institute and University of Florida, Gainesville, FL 32610, USA.

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November 2004

Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.

J Struct Biol 2004 Jun;146(3):416-24

Biochemistry and Molecular Biology, University of Florida and The McKnight Brain Institute, 1600 Archer Rd., Gainesville, FL 32610, USA.

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June 2004

Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.

Acta Crystallogr D Biol Crystallogr 2004 Feb 23;60(Pt 2):374-5. Epub 2004 Jan 23.

Department of Medicinal Chemistry, McKnight Brain Institute and University of Florida, Gainesville, Florida 32610, USA.

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February 2004

Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.

J Biol Chem 2003 Apr 31;278(15):13159-65. Epub 2003 Jan 31.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.

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April 2003

Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.

Acta Crystallogr D Biol Crystallogr 2002 Jul 20;58(Pt 7):1193-4. Epub 2002 Jun 20.

Department of Medicinal Chemistry, McKnight Brain Institute and University of Florida, Gainesville 32610, USA.

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July 2002

Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins.

Anal Biochem 2002 Jul;306(1):50-4

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.

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July 2002