Thomas Krucker

Thomas Krucker

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Thomas Krucker

Thomas Krucker

Publications by authors named "Thomas Krucker"

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Enabling drug discovery and development through single-cell imaging.

Expert Opin Drug Discov 2019 Feb 24;14(2):115-125. Epub 2018 Dec 24.

d Alliance Management and Partnering , Novartis Institutes for BioMedical Research Inc ., Emeryville , CA , USA.

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http://dx.doi.org/10.1080/17460441.2019.1559147DOI Listing
February 2019

Advances and challenges in bacterial compound accumulation assays for drug discovery.

Curr Opin Chem Biol 2018 06 24;44:9-15. Epub 2018 May 24.

Infectious Diseases Area, Novartis Institutes for BioMedical Research, Emeryville, CA 94608, USA.

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http://dx.doi.org/10.1016/j.cbpa.2018.05.005DOI Listing
June 2018

Assessing Antibiotic Permeability of Gram-Negative Bacteria via Nanofluidics.

ACS Nano 2017 07 16;11(7):6959-6967. Epub 2017 Jun 16.

Novartis Institutes for Biomedical Research , Emeryville, California 94608, United States.

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http://dx.doi.org/10.1021/acsnano.7b02267DOI Listing
July 2017

Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C-Secondary Ion Mass Spectrometry.

Anal Chem 2017 05 15;89(9):5050-5057. Epub 2017 Apr 15.

Department of Chemistry, Pennsylvania State University , University Park, Pennsylvania 16802, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415874PMC
May 2017

Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin.

Proteins 2014 Nov 21;82(11):2998-3012. Epub 2014 Aug 21.

Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, 02139.

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http://dx.doi.org/10.1002/prot.24659DOI Listing
November 2014

Temporal variations of skin pigmentation in C57BL/6 mice affect optical bioluminescence quantitation.

Mol Imaging Biol 2011 Dec;13(6):1114-23

Global Imaging Group, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1007/s11307-010-0440-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210941PMC
December 2011

Optical imaging for the new grammar of drug discovery.

Philos Trans A Math Phys Eng Sci 2011 Nov;369(1955):4651-65

Global Imaging Group, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1098/rsta.2011.0300DOI Listing
November 2011

Gender variations in the optical properties of skin in murine animal models.

J Biomed Opt 2011 Jan-Feb;16(1):011008

Boston University, Department of Biomedical Engineering, Boston, Massachusetts 02215, USA.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.3525565DOI Listing
May 2011

Hybrid FMT-CT imaging of amyloid-beta plaques in a murine Alzheimer's disease model.

Neuroimage 2009 Feb 7;44(4):1304-11. Epub 2008 Nov 7.

Laboratory for Bio-optics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2008.10.038DOI Listing
February 2009

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse.

Neurobiol Dis 2008 Dec 15;32(3):391-401. Epub 2008 Aug 15.

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.nbd.2008.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740935PMC
December 2008

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.

Proc Natl Acad Sci U S A 2008 Mar 27;105(9):3587-92. Epub 2008 Feb 27.

Department of Zoology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1073/pnas.0709788105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265182PMC
March 2008

Technical considerations in longitudinal multispectral small animal molecular imaging.

J Biomed Opt 2007 Sep-Oct;12(5):051601

Northeastern University, Department of Physics, 360 Huntington Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1117/1.2799188DOI Listing
January 2008

Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling.

Brain Res 2007 Oct 26;1172:1-9. Epub 2007 Jul 26.

Novartis Institutes for BioMedical Research, Inc. Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.07.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094008PMC
October 2007

Effects of lipopolysaccharide on 56Fe-particle radiation-induced impairment of synaptic plasticity in the mouse hippocampus.

Radiat Res 2007 Oct;168(4):462-70

Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA.

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http://dx.doi.org/10.1667/RR1038.1DOI Listing
October 2007

Hierarchical microimaging for multiscale analysis of large vascular networks.

Neuroimage 2006 Aug 11;32(2):626-36. Epub 2006 May 11.

Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.neuroimage.2006.03.043DOI Listing
August 2006

New polyurethane-based material for vascular corrosion casting with improved physical and imaging characteristics.

Microsc Res Tech 2006 Feb;69(2):138-47

Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/jemt.20263DOI Listing
February 2006

Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability.

Neurobiol Aging 2004 Aug;25(7):955-62

CVN-12, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2003.10.008DOI Listing
August 2004

Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices.

J Neuroimmunol 2004 May;150(1-2):37-47

Department of Neuropharmacology, CVN-12, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2004.01.011DOI Listing
May 2004

Mice lacking 5-HT receptors show specific impairments in contextual learning.

Eur J Neurosci 2004 Apr;19(7):1913-22

Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://doi.wiley.com/10.1111/j.1460-9568.2004.03288.x
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http://dx.doi.org/10.1111/j.1460-9568.2004.03288.xDOI Listing
April 2004

Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.

J Neurosci 2003 Sep;23(24):8453-9

Discovery Technologies Center, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740368PMC
September 2003