Thomas Klingebiel

Thomas Klingebiel

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Thomas Klingebiel

Publications by authors named "Thomas Klingebiel"

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Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells.

Cancer Lett 2019 Nov 26;465:1-11. Epub 2019 Aug 26.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, 60528, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.08.012DOI Listing
November 2019

The Impact of Local Control in the Treatment of Children with Advanced Infantile and Adult-Type Fibrosarcoma: Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS).

J Pediatr Surg 2019 Nov 9. Epub 2019 Nov 9.

Klinikum Stuttgart - Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany; Children's Hospital, Department of Pediatric Hematology and Oncology, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2019.10.051DOI Listing
November 2019

Treatment and outcome of the patients with rhabdomyosarcoma of the biliary tree: Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS).

BMC Cancer 2019 Oct 14;19(1):945. Epub 2019 Oct 14.

Department of Pediatric Surgery and Pediatric Urology, University Children's Hospital Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1186/s12885-019-6172-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791000PMC
October 2019

Adoptive cellular immunotherapy for refractory childhood cancers: a single center experience.

Oncotarget 2019 Oct 22;10(58):6138-6151. Epub 2019 Oct 22.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescent Medicine, University Hospital Frankfurt, JW Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.18632/oncotarget.27242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817438PMC
October 2019

Treatment and outcome of patients with thoracic tumors of the Ewing sarcoma family: A report from the Cooperative Weichteilsarkom Studiengruppe CWS-81, -86, -91, -96, and -2002P trials.

Pediatr Blood Cancer 2019 Aug;66 Suppl 3:e27884

Klinikum Stuttgart - Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany.

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http://dx.doi.org/10.1002/pbc.27884DOI Listing
August 2019

Clearance of Hematologic Malignancies by Allogeneic Cytokine-Induced Killer Cell or Donor Lymphocyte Infusions.

Biol Blood Marrow Transplant 2019 Jul 13;25(7):1281-1292. Epub 2019 Mar 13.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.03.004DOI Listing
July 2019

Extended Dosing Regimens for Fungal Prophylaxis.

Clin Microbiol Rev 2019 06 15;32(3). Epub 2019 May 15.

Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children's Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1128/CMR.00010-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589864PMC
June 2019

Treatment and outcome of patients with thoracic tumors of the Ewing sarcoma family: A report from the Cooperative Weichteilsarkom Studiengruppe CWS-81, -86, -91, -96, and -2002P trials.

Pediatr Blood Cancer 2019 03 12;66(3):e27537. Epub 2018 Nov 12.

Klinikum Stuttgart - Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany.

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http://doi.wiley.com/10.1002/pbc.27537
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http://dx.doi.org/10.1002/pbc.27537DOI Listing
March 2019

Mobilized peripheral blood stem cell apheresis via Hickman catheter in pediatric patients.

Transfusion 2019 03 4;59(3):1061-1068. Epub 2019 Jan 4.

Department for Children and Adolescents, Division for Pediatric Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/trf.15113DOI Listing
March 2019

Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets.

Sci Rep 2019 Feb 11;9(1):1774. Epub 2019 Feb 11.

University Hospital for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.

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http://www.nature.com/articles/s41598-019-38517-7
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http://dx.doi.org/10.1038/s41598-019-38517-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370815PMC
February 2019

Alveolar soft-part sarcoma: Primary metastatic disease and metastatic relapse occurring during long-term follow-up: Treatment results of four Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry.

Pediatr Blood Cancer 2018 12 19;65(12):e27405. Epub 2018 Aug 19.

Klinikum Stuttgart-Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend-und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany.

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http://doi.wiley.com/10.1002/pbc.27405
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http://dx.doi.org/10.1002/pbc.27405DOI Listing
December 2018

Impact of Whole Lung Irradiation on Survival Outcome in Patients With Lung Relapsed Ewing Sarcoma.

Int J Radiat Oncol Biol Phys 2018 11 3;102(3):584-592. Epub 2018 Jul 3.

Pediatrics III, Hematology/ Oncology, West German Cancer Center and German Cancer Research Center, University Hospital Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.06.032DOI Listing
November 2018

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008.

J Clin Oncol 2018 Sep 6:JCO2018782516. Epub 2018 Sep 6.

Jeremy Whelan, University College Hospital; Ian Judson, Institute of Cancer Research, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Bruce Morland, Birmingham Children's Hospital; Keith Wheatley, University of Birmingham, Birmingham; Ian Lewis, Leeds Community Healthcare National Health Service Trust, Leeds; Alan Craft, Newcastle University, Newcastle upon Tyne, United Kingdom; Marie-Cecile Le Deley and Cyril Lervat, Centre Oscar Lambret, Lille; Gwénaël Le Teuff, Nathalie Gaspar, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Jean-Yves Blay, Centre Léon Bérard; Perrine Marec-Berard, Institute of Pediatric Onco-Haematology, Lyon; Marie-Pierre Castex, Centre Hospitalier Universitaire de Toulouse, Toulouse; Jean-Claude Gentet, Centre Hospitalier Universitaire La Timone, Marseille; Marta Jimenez, Unicancer; Valerie Laurence and Jean Michon, Institut Curie, Paris; France; Uta Dirksen, Sebastian Bauer, Andreas Ranft, University Hospital Essen, Essen; Susanne Amler, Institut für Biometrie und Klinische Forschung; Wolfgang Hartmann and Heribert Juergens, Universitätsklinikum, Münster, Münster; Stefan Bielack, Klinikum Stuttgart, Stuttgart; Stefan Burdach, Comprehensive Cancer Center, München; Dagmar Dilloo, University-Clinic Bonn, Bonn; Angelika Eggert, Charité University; Peter Reichardt, HELIOS Klinikum Berlin-Buch, Berlin; Wolf-Achim Hassenpflug, University Medical Center Hamburg-Eppendorf, Hamburg; Thomas Klingebiel, Childrens University Hospital, Frankfurt; Udo Kontny, University Medical Center Aachen, Aachen; Michael Paulussen, Children's and Adolescents' Hospital, Datteln; Germany; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Hans Gelderblom, Leiden University Medical Center, Leiden; Hendrik van den Berg, University of Amsterdam, Amsterdam, the Netherlands; Lars Hjorth, Skane University Hospital, Lund, Sweden; Jarmila Kruseova, Faculty Hospital Motol Prague, Prague, Czech Republic; Ruth Ladenstein, St Anna Children's Hospital and Children's Cancer Research Institute, Vienna, Austria; Sandrine Marreaud, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.2516
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http://dx.doi.org/10.1200/JCO.2018.78.2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209090PMC
September 2018

Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells.

Cancer Lett 2018 08 24;429:19-28. Epub 2018 Apr 24.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, 60528, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.04.025DOI Listing
August 2018

Haploidentical allogeneic hematopoietic stem cell transplantation in patients with high-risk soft tissue sarcomas: results of a single-center prospective trial.

Bone Marrow Transplant 2018 07 24;53(7):891-894. Epub 2018 Jan 24.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1038/s41409-018-0088-6DOI Listing
July 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Radical Surgery Improves Survival in Patients with Stage 4 Neuroblastoma.

World J Surg 2018 06;42(6):1877-1884

Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00268-017-4340-9DOI Listing
June 2018

Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe.

Pediatr Blood Cancer 2018 06 26;65(6):e27012. Epub 2018 Feb 26.

Pediatrics 5 (Oncology, Hematology, and Immunology), Stuttgart Cancer Center, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany.

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http://doi.wiley.com/10.1002/pbc.27012
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http://dx.doi.org/10.1002/pbc.27012DOI Listing
June 2018

Epstein-Barr virus-specific cytokine-induced killer cells for treatment of Epstein-Barr virus-related malignant lymphoma.

Cytotherapy 2018 06 10;20(6):839-850. Epub 2018 May 10.

University Hospital Frankfurt, Goethe University, Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jcyt.2018.04.005DOI Listing
June 2018

Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

Pediatr Blood Cancer 2018 05 5;65(5):e26943. Epub 2018 Jan 5.

Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, and Immunology), Klinikum Stuttgart-Olgahospital, Stuttgart, Germany.

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http://dx.doi.org/10.1002/pbc.26943DOI Listing
May 2018

Treatment and outcome of patients with localized intrathoracic and chest wall rhabdomyosarcoma: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

J Cancer Res Clin Oncol 2018 May 20;144(5):925-934. Epub 2018 Feb 20.

Klinikum Stuttgart, Zentrum für Kinder-, Jugend-und Frauenmedizin, Olgahospital, Pediatrics 5 (Pediatric Oncology Hematology and Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00432-018-2603-yDOI Listing
May 2018

Crizotinib in ALK inflammatory myofibroblastic tumors-Current experience and future perspectives.

Pediatr Blood Cancer 2018 04 29;65(4). Epub 2017 Dec 29.

Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/pbc.26920DOI Listing
April 2018

Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma.

Cancer Res 2018 04 30;78(8):1935-1947. Epub 2018 Jan 30.

Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1860DOI Listing
April 2018

Paratesticular alveolar rhabdomyosarcomas do not harbor typical translocations: a distinct entity with favorable prognosis?

Virchows Arch 2018 Mar 21;472(3):441-449. Epub 2018 Feb 21.

Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart Cancer Center, Klinikum Stuttgart-Olgahospital, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00428-018-2311-7DOI Listing
March 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

[Fertility Preservation in Prepubertal und Pubertal Children and Adolescents].

Klin Padiatr 2018 Feb 8. Epub 2018 Feb 8.

Gynäkologische Endokrinologie und Reproduktionsmedizin, Inselspital Universitätsspital Bern, Schweiz.

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http://dx.doi.org/10.1055/s-0044-100396DOI Listing
February 2018

The prognostic value of early radiographic response in children and adolescents with embryonal rhabdomyosarcoma stage IV, metastases confined to the lungs: A report from the Cooperative Weichteilsarkom Studiengruppe (CWS).

Pediatr Blood Cancer 2017 Oct 17;64(10). Epub 2017 Mar 17.

Olgahospital, Pediatrics 5 (Pediatric Oncology, Hematology, Immunology), Zentrum für Kinder-, Jugend- und Frauenmedizin, Klinikum Stuttgart, Stuttgart, Germany.

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http://dx.doi.org/10.1002/pbc.26510DOI Listing
October 2017

Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children.

Oncotarget 2017 Sep 2;8(39):66137-66153. Epub 2017 Aug 2.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.18632/oncotarget.19821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630399PMC
September 2017

Tunneled central venous catheters in children with malignant and chronic diseases: A comparison of open vs. percutaneous implantation.

J Pediatr Surg 2017 May 30;52(5):810-812. Epub 2017 Jan 30.

Department of Pediatric Surgery and Pediatric Urology, University Hospital, Goethe-University Frankfurt/M., Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jpedsurg.2017.01.045DOI Listing
May 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Generation and flow cytometric quality control of clinical-scale TCRαβ/CD19-depleted grafts.

Cytometry B Clin Cytom 2017 03 14;92(2):126-135. Epub 2015 Dec 14.

Clinic for Pediatric and Adolescent Medicine, University Hospital, Frankfurt, Germany.

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http://doi.wiley.com/10.1002/cyto.b.21328
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http://dx.doi.org/10.1002/cyto.b.21328DOI Listing
March 2017

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

Leuk Lymphoma 2017 03 28;58(3):718-721. Epub 2016 Nov 28.

e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1207765DOI Listing
March 2017

The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells.

Front Immunol 2017 7;8:202. Epub 2017 Mar 7.

University Hospital Frankfurt, Department for Children and Adolescents Medicine, Division of Stem Cell Transplantation and Immunology, Goethe University, Frankfurt, Germany; LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339542PMC
March 2017

The impact of local control in the treatment of type II/III pleuropulmonary blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS).

J Surg Oncol 2017 Feb 19;115(2):164-172. Epub 2017 Jan 19.

Klinikum Stuttgart, Zentrum für Kinder-, Jugend- und Frauenmedizin, Olgahospital, Pediatrics 5 (Pediatric Oncology, Hematology, Immunology), Stuttgart, Germany.

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http://dx.doi.org/10.1002/jso.24416DOI Listing
February 2017

[On the way to becoming an MD (Dr. med.): What kind of support do doctoral students need? Part 1: Survey and development of a program].

Z Evid Fortbild Qual Gesundhwes 2016 12;110-111:69-76. Epub 2016 Jan 12.

Johann Wolfgang Goethe-Universität Frankfurt/Main, Institut für Allgemeinmedizin, Deutschland.

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http://dx.doi.org/10.1016/j.zefq.2015.12.004DOI Listing
January 2017

[On the way to becoming an MD (Dr. med.): What kind of support do doctoral students need? Part 2: Establishing the program].

Z Evid Fortbild Qual Gesundhwes 2016 8;110-111:77-84. Epub 2016 Jan 8.

Johann Wolfgang Goethe-Universität Frankfurt/Main, Dekanat des Fachbereichs Medizin, Deutschland. Electronic address:

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http://dx.doi.org/10.1016/j.zefq.2015.12.003DOI Listing
January 2017

Pre-Emptive Immunotherapy for Clearance of Molecular Disease in Childhood Acute Lymphoblastic Leukemia after Transplantation.

Biol Blood Marrow Transplant 2017 01 11;23(1):87-95. Epub 2016 Oct 11.

University Hospital Frankfurt/Main, Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Goethe-University Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2016.10.006DOI Listing
January 2017

Computed tomography-guided biopsies in children: accuracy, efficiency and dose usage.

Ital J Pediatr 2017 Jan 6;43(1). Epub 2017 Jan 6.

Institute for Diagnostic and Interventional Radiology, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1186/s13052-016-0319-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217564PMC
January 2017

A novel homozygous mutation in UNC13D presenting as Epstein-Barr-virus-associated lymphoproliferative disease at 9 years of age.

Leuk Lymphoma 2016 12 28;57(12):2949-2951. Epub 2016 Apr 28.

a Pediatric Oncology, Hematology and Clinical Immunology , Heinrich Heine University Medical Center , Düsseldorf , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1177724DOI Listing
December 2016

Specific phenotype and function of CD56-expressing innate immune cell subsets in human thymus.

J Leukoc Biol 2016 12 28;100(6):1297-1310. Epub 2016 Jun 28.

Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander Universität Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany;

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http://dx.doi.org/10.1189/jlb.1A0116-038RDOI Listing
December 2016

Synovial Sarcoma Recurrence in Children and Young Adults.

Ann Surg Oncol 2016 12 8;23(Suppl 5):618-626. Epub 2016 Sep 8.

Pediatrics 5 (Oncology, Hematology, Immunology), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany.

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http://dx.doi.org/10.1245/s10434-016-5535-2DOI Listing
December 2016

Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study.

Pediatr Transplant 2016 Dec 13;20(8):1132-1136. Epub 2016 Oct 13.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1111/petr.12831DOI Listing
December 2016

Cytotoxic potential of IL-15-activated cytokine-induced killer cells against human neuroblastoma cells.

Pediatr Blood Cancer 2016 12 19;63(12):2230-2239. Epub 2016 Jul 19.

Department for Stem Cell Transplantation and Immunology, Clinic for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1002/pbc.26147DOI Listing
December 2016

Outcome, Treatment, and Treatment Failures in Patients Suffering Localized Embryonal Paratesticular Rhabdomyosarcoma: Results From the "Cooperative Weichteilsarkom Studiengruppe" Trials CWS-86, -91, -96, and -2002P.

Ann Surg 2016 Dec;264(6):1148-1155

*Department of Pediatric Surgery and Urology, University Children's Hospital, Tuebingen, Germany †Department of Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany ‡Department of Pediatric Hematology and Oncology, University Children's Hospital, Frankfurt/Main, Germany §Department of Pediatric Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany ¶Department of Radiotherapy, University Hospital, Muenster, Germany ||Department of Pediatric Hematology, Oncology and Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany.

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http://dx.doi.org/10.1097/SLA.0000000000001550DOI Listing
December 2016

Improvements in the Treatment of Patients Suffering from Bladder-Prostate Rhabdomyosarcoma: A Report from the CWS-2002P Trial.

Ann Surg Oncol 2016 11 7;23(12):4067-4072. Epub 2016 Jul 7.

Department of Pediatric Hematology/Oncology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany.

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http://dx.doi.org/10.1245/s10434-016-5391-0DOI Listing
November 2016

Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs.

Cancer Lett 2016 10 10;381(2):287-95. Epub 2016 Aug 10.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstr. 3a, 60528 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.07.007DOI Listing
October 2016

Optimization of individualized graft composition: CD3/CD19 depletion combined with CD34 selection for haploidentical transplantation.

Transfusion 2016 09 27;56(9):2336-45. Epub 2016 Jun 27.

Clinic for Pediatric and Adolescent Medicine, University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1111/trf.13694DOI Listing
September 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Lack of Effectiveness of Neutropenic Diet and Social Restrictions as Anti-Infective Measures in Children With Acute Myeloid Leukemia: An Analysis of the AML-BFM 2004 Trial.

J Clin Oncol 2016 08 6;34(23):2776-83. Epub 2016 Jun 6.

Lars Tramsen, Emilia Salzmann-Manrique, Konrad Bochennek, Thomas Klingebiel, and Thomas Lehrnbecher, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt; Dirk Reinhardt, Medical Center, University of Essen, Essen; Ursula Creutzig, Children's Hospital, Hannover Medical School, Hannover, Germany; and Lillian Sung, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2016.66.7881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019758PMC
August 2016

Primary Metastatic Synovial Sarcoma: Experience of the CWS Study Group.

Pediatr Blood Cancer 2016 07 22;63(7):1198-206. Epub 2016 Mar 22.

Pediatrics 5, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany.

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http://dx.doi.org/10.1002/pbc.25973DOI Listing
July 2016

In vitro migration and proliferation ("wound healing") potential of mesenchymal stromal cells generated from human CD271(+) bone marrow mononuclear cells.

J Transl Med 2015 Sep 25;13:315. Epub 2015 Sep 25.

Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Goethe University Hospital, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1186/s12967-015-0676-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582892PMC
September 2015

Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus.

Cytotherapy 2015 Aug 10;17(8):1139-51. Epub 2015 Jun 10.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt/Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2015.04.011DOI Listing
August 2015

Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.

Neoplasia 2015 Jun;17(6):481-9

Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany; German Cancer Consortium (DKTK) Heidelberg, Germany; German Cancer Research Center (DKFZ) Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150006
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http://dx.doi.org/10.1016/j.neo.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719005PMC
June 2015

Monitoring of minimal residual disease after allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia allows for the identification of impending relapse: results of the ALL-BFM-SCT 2003 trial.

J Clin Oncol 2015 Apr 20;33(11):1275-84. Epub 2015 Jan 20.

Peter Bader, Hermann Kreyenberg, Emilia Salzmann-Manrique, Andre M. Willasch, and Thomas E. Klingebiel, University Hospital for Children and Adolescents, Frankfurt/Main; Arend von Stackelberg and Cornelia Eckert, Children's Hospital Charité, Berlin, Berlin; Roland Meisel, Heinrich-Heine-University, Düsseldorf; Daniel Stachel, University Hospital Erlangen, Erlangen; Martin Schrappe, Julia Alten, Andre Schrauder, Christian-Albrechts-University and Medical Center Schleswig-Holstein, Kiel; Ansgar Schulz, University Medical Center, Ulm; Peter Lang, University Children's Hospital, Tuebingen; Ingo Müller, University Medical Center Hamburg-Eppendorf, Hamburg; Michael H. Albert, University Children's Hospital, Munich, Germany; and Ulrike Poetschger and Christina Peters, St Anna Children's Hospital, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2014.58.4631DOI Listing
April 2015

Stem-cell transplantation in children with acute lymphoblastic leukemia: A prospective international multicenter trial comparing sibling donors with matched unrelated donors-The ALL-SCT-BFM-2003 trial.

J Clin Oncol 2015 Apr 9;33(11):1265-74. Epub 2015 Mar 9.

Christina Peters, Susanne Matthes-Martin, and Ulrike Poetschger, St Anna Children's Hospital, Vienna, Austria; Martin Schrappe, University Medical Center Schleswig-Holstein and Christian-Albrechts-University Kiel; André Schrauder, Kinderarztpraxis am Aalborgring, Kiel; Arend von Stackelberg and Wolfram Ebell, Charité-Children's Hospital Berlin, Berlin; Peter Bader and Thomas Klingebiel, Johann Wolfgang Goethe University, Frankfurt; Peter Lang, University Hospital Tübingen, Tübingen; Karl-Walter Sykora and Martin Zimmerman, Hannover Medical School, Hannover; Johanna Schrum, University Medical Center Hamburg-Eppendorf, Hamburg; Bernhard Kremens, University Hospital Essen, Essen; Karoline Ehlert, University Clinic Greifswald, Greifswald; Michael H. Albert, Dr. von Hauner University Children's Hospital, München; Roland Meisel, University Hospital Düsseldorf, Düsseldorf; Wolfgang Holter, Children's University Hospital Erlangen, Erlangen; Brigitte Strahm, University Hospital Freiburg, Freiburg; Bernd Gruhn, University Hospital Jena, Jena; Ansgar Schulz, University Hospital Ulm, Ulm; Wilhelm Woessmann, University Clinic Giessen, Giessen, Germany; and Tayfun Gungor, University Children's Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1200/JCO.2014.58.9747DOI Listing
April 2015

Osteosarcoma in patients with Rothmund-Thomson syndrome.

Pediatr Hematol Oncol 2015 Feb 31;32(1):32-40. Epub 2014 Dec 31.

1Cooperative Osteosarcoma Study Group (COSS), Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart-Olgahospital , Germany.

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http://dx.doi.org/10.3109/08880018.2014.987939DOI Listing
February 2015

Monitoring of hematopoietic chimerism after transplantation for pediatric myelodysplastic syndrome: real-time or conventional short tandem repeat PCR in peripheral blood or bone marrow?

Biol Blood Marrow Transplant 2014 Dec 31;20(12):1918-25. Epub 2014 Jul 31.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2014.07.030DOI Listing
December 2014

Challenges in the local treatment of large abdominal embryonal rhabdomyosarcoma.

Ann Surg Oncol 2014 Oct 22;21(11):3579-86. Epub 2014 Jul 22.

Pediatrics 5 (Oncology, Hematology, Immunology, Rheumatology, Gastroenterology and General Pedatrics), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany,

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http://dx.doi.org/10.1245/s10434-014-3551-7DOI Listing
October 2014

SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy.

Front Pediatr 2014 18;2:75. Epub 2014 Jul 18.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, University Hospital Frankfurt, Goethe University Frankfurt am Main , Frankfurt , Germany.

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http://dx.doi.org/10.3389/fped.2014.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103003PMC
August 2014