Thomas Ketas

Thomas Ketas

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Thomas Ketas

Thomas Ketas

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Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers .

J Virol 2018 07 13;92(13). Epub 2018 Jun 13.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

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http://dx.doi.org/10.1128/JVI.00381-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002727PMC
July 2018

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

PLoS Pathog 2013 Sep 19;9(9):e1003618. Epub 2013 Sep 19.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1003618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777863PMC
September 2013

Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance.

Virology 2012 Jul 19;428(2):86-97. Epub 2012 Apr 19.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2012.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353024PMC
July 2012

Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array.

J Am Chem Soc 2012 May 23;134(17):7317-20. Epub 2012 Apr 23.

Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ja302428dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377471PMC
May 2012

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.

Proc Natl Acad Sci U S A 2011 Jul 20;108(27):11181-6. Epub 2011 Jun 20.

Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1103012108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131343PMC
July 2011

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.

Virology 2011 Apr 26;413(1):47-59. Epub 2011 Feb 26.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2010.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070043PMC
April 2011

Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.

Proc Natl Acad Sci U S A 2009 Sep 17;106(35):14751-6. Epub 2009 Aug 17.

Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.0902663106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736470PMC
September 2009

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities.

Virology 2009 May 20;387(2):296-302. Epub 2009 Mar 20.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.virol.2009.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674391PMC
May 2009

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency.

Proc Natl Acad Sci U S A 2009 Apr 18;106(14):5801-6. Epub 2009 Mar 18.

Merck Research Laboratories Peptide Center of Excellence and Department of Drug Metabolism, Istituto di Ricerche di Biologia Molecolare P. Angeletti, 00040 Pomezia, Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0901007106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667053PMC
April 2009

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

Proc Natl Acad Sci U S A 2009 Mar 16;106(13):5318-23. Epub 2009 Mar 16.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0811713106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664029PMC
March 2009

Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors.

Virology 2008 Aug 2;377(2):401-7. Epub 2008 Jun 2.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2008.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528836PMC
August 2008

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

Proc Natl Acad Sci U S A 2008 Jul 22;105(30):10531-6. Epub 2008 Jul 22.

Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA.

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http://dx.doi.org/10.1073/pnas.0802666105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492474PMC
July 2008

N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus.

Virology 2008 Mar 26;372(1):187-200. Epub 2007 Nov 26.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2007.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2317825PMC
March 2008

Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes.

Virology 2007 Aug 10;364(2):431-40. Epub 2007 Apr 10.

Dept of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2007.03.001DOI Listing
August 2007

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands.

Virology 2007 Aug 10;364(2):281-90. Epub 2007 Apr 10.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2007.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151978PMC
August 2007

HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry.

Virology 2007 Apr 12;361(1):212-28. Epub 2006 Dec 12.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2006.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892195PMC
April 2007

Protein design of a bacterially expressed HIV-1 gp41 fusion inhibitor.

Biochemistry 2007 Apr 20;46(14):4360-9. Epub 2007 Mar 20.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi7001289
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http://dx.doi.org/10.1021/bi7001289DOI Listing
April 2007

The prolonged culture of human immunodeficiency virus type 1 in primary lymphocytes increases its sensitivity to neutralization by soluble CD4.

Virology 2004 Mar;321(1):8-22

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2003.12.012DOI Listing
March 2004

Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types.

AIDS Res Hum Retroviruses 2003 Mar;19(3):177-86

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1089/088922203763315678DOI Listing
March 2003