Thomas Keller

Thomas Keller

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Thomas Keller

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Neutron Larmor diffraction on powder samples.

Authors:
Thomas Keller Piotr Fabrykiewicz Radosław Przeniosło Izabela Sosnowska Bernhard Keimer

J Appl Crystallogr 2020 Feb 1;53(Pt 1):88-98. Epub 2020 Feb 1.

Max Planck Institute for Solid State Research, Stuttgart, Germany.

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http://dx.doi.org/10.1107/S160057671901611XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998774PMC
February 2020

Initiating Low-Value Inhaled Corticosteroids in an Inception Cohort with COPD.

Authors:
Laura J Spece Lucas M Donovan Matthew F Griffith Thomas Keller Laura C Feemster Nicholas L Smith David H Au

Ann Am Thorac Soc 2020 Jan 3. Epub 2020 Jan 3.

University of Washington, Division of Pulmonary and Critical Care Medicine, Seatlle, Washington, United States.

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http://dx.doi.org/10.1513/AnnalsATS.201911-854OCDOI Listing
January 2020

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Authors:
Jacek Kwiatkowski Boping Liu Shermaine Pang Nur Huda Binte Ahmad Gang Wang Anders Poulsen Haiyan Yang Yong Rui Poh Doris Hui Ying Tee Esther Ong Priya Retna Nurul Dinie Perlyn Kwek John Liang Kuan Wee Vithya Manoharan Choon Bing Low Peck Gee Seah Vishal Pendharkar Kanda Sangthongpitag Joma Joy Nithya Baburajendran Anna Elisabet Jansson Kassoum Nacro Jeffrey Hill Thomas H Keller Alvin W Hung

J Med Chem 2020 Jan 7;63(2):621-637. Epub 2020 Jan 7.

Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01582DOI Listing
January 2020

Electronic Cigarette Use and Chronic Respiratory Symptoms Among United States Adults.

Authors:
Shewit P Giovanni Thomas L Keller Alexander D Bryant Noel S Weiss Alyson J Littman

Am J Respir Crit Care Med 2020 Jan 10. Epub 2020 Jan 10.

University of Washington, 7284, Seattle, Washington, United States.

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http://dx.doi.org/10.1164/rccm.201907-1460LEDOI Listing
January 2020

Rational Design of Thiolated Polyenes as Trifunctional Raman Reporter Molecules in SERS Nanotags for Cytokine Detection in a Lateral Flow Assay.

Authors:
Thomas Keller Svetlana Brem Vi Tran Oliver Sritharan Daniel Schäfer Sebastian Schlücker

J Biophotonics 2020 Jan 19:e201960126. Epub 2020 Jan 19.

Department of Chemistry, University of Duisburg-Essen, Universitaetsstr. 5, 45141 Essen, Germany, Center for Nanointegration Duisburg-Essen (CENIDE), and Zentrum für Medizinische Biotechnologie (ZMB).

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http://dx.doi.org/10.1002/jbio.201960126DOI Listing
January 2020

Probing biological mechanisms with chemical tools.

Authors:
Congbao Kang Thomas H Keller

Pharmacol Res 2020 Jan 18;153:104656. Epub 2020 Jan 18.

Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos, #05-01, 138670, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.104656DOI Listing
January 2020

Facing the large variety of life-limiting conditions in children.

Authors:
Jessica I Hoell Hannah Weber Jens Warfsmann Laura Trocan Gabriele Gagnon Mareike Danneberg Stefan Balzer Thomas Keller Gisela Janßen Michaela Kuhlen

Eur J Pediatr 2019 Dec 17;178(12):1893-1902. Epub 2019 Oct 17.

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, University of Duesseldorf, Duesseldorf, Germany.

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http://dx.doi.org/10.1007/s00431-019-03467-9DOI Listing
December 2019

How youth mentoring relationships end and why it matters: a mixed-methods, multi-informant study.

Authors:
Renée Spencer Thomas E Keller Meghan Perry Alison L Drew Hyuny Clark-Shim John Paul Horn Miriam Miranda-Díaz Martha J McCormack

Ann N Y Acad Sci 2019 Dec 23. Epub 2019 Dec 23.

School of Social Work, Portland State University, Portland, Oregon.

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http://dx.doi.org/10.1111/nyas.14290DOI Listing
December 2019

Influence of program staff on quality of relationships in a community-based youth mentoring program.

Authors:
Thomas E Keller David L DuBois

Ann N Y Acad Sci 2019 Dec 23. Epub 2019 Dec 23.

Community Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1111/nyas.14289DOI Listing
December 2019

Gas-Induced Segregation in Pt-Rh Alloy Nanoparticles Observed by In Situ Bragg Coherent Diffraction Imaging.

Authors:
Tomoya Kawaguchi Thomas F Keller Henning Runge Luca Gelisio Christoph Seitz Young Yong Kim Evan R Maxey Wonsuk Cha Andrew Ulvestad Stephan O Hruszkewycz Ross Harder Ivan A Vartanyants Andreas Stierle Hoydoo You

Phys Rev Lett 2019 Dec;123(24):246001

Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.

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http://dx.doi.org/10.1103/PhysRevLett.123.246001DOI Listing
December 2019

Radiosynthesis and Preclinical Evaluation of an α-Adrenoceptor Tracer Candidate, 6-[F]Fluoro-marsanidine.

Authors:
Anna Krzyczmonik Thomas Keller Francisco R López-Picón Sarita Forsback Anna K Kirjavainen Jatta S Takkinen Aleksandra Wasilewska Mika Scheinin Merja Haaparanta-Solin Franciszek Sączewski Olof Solin

Mol Imaging Biol 2019 10;21(5):879-887

Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1007/s11307-019-01317-6DOI Listing
October 2019

Solution blow spinning of polymer/nanocomposite micro-/nanofibers with tunable diameters and morphologies using a gas dynamic virtual nozzle.

Authors:
Ramakrishna Vasireddi Joscha Kruse Mohammad Vakili Satishkumar Kulkarni Thomas F Keller Diana C F Monteiro Martin Trebbin

Sci Rep 2019 Oct 4;9(1):14297. Epub 2019 Oct 4.

Department of Chemistry, The State University of New York, University at Buffalo, 760 Natural Sciences Complex, Buffalo, New York, 14260-3000, USA.

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http://www.nature.com/articles/s41598-019-50477-6
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http://dx.doi.org/10.1038/s41598-019-50477-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778068PMC
October 2019

Malawian children with uncomplicated and cerebral malaria have decreased activated Vγ9Vδ2 γδ T cells which increase in convalescence.

Authors:
Visopo Harawa Madi Njie Thomas Keller Kami Kim Anthony Jaworowski Karl Seydel Stephen J Rogerson Wilson Mandala

PLoS One 2019 10;14(10):e0223410. Epub 2019 Oct 10.

Biomedical Sciences Department, College of Medicine, University of Malawi, Blantyre, Malawi.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223410PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786631PMC
October 2019

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Authors:
Jothi Anantharajan Hengbo Zhou Lingdi Zhang Taylor Hotz Melanie Y Vincent Melanie A Blevins Anna E Jansson John Wee Liang Kuan Elizabeth Yihui Ng Yee Khoon Yeo Nithya Baburajendran Grace Lin Alvin W Hung Joma Joy Samarjit Patnaik Juan Marugan Pratyaydipta Rudra Debashis Ghosh Jeffrey Hill Thomas H Keller Rui Zhao Heide L Ford CongBao Kang

Mol Cancer Ther 2019 09 8;18(9):1484-1496. Epub 2019 Jul 8.

Experimental Drug Discovery Centre, A*STAR, Singapore, Singapore.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726557PMC
September 2019

A versatile nanoreactor for complementary in situ X-ray and electron microscopy studies in catalysis and materials science.

Authors:
Yakub Fam Thomas L Sheppard Johannes Becher Dennis Scherhaufer Heinz Lambach Satishkumar Kulkarni Thomas F Keller Arne Wittstock Felix Wittwer Martin Seyrich Dennis Brueckner Maik Kahnt Xiaogang Yang Andreas Schropp Andreas Stierle Christian G Schroer Jan Dierk Grunwaldt

J Synchrotron Radiat 2019 Sep 27;26(Pt 5):1769-1781. Epub 2019 Aug 27.

Institute for Chemical Technology and Polymer Chemistry, Karlsruhe Institute of Technology, Engesserstraße 20, Karlsruhe, Baden Württemberg 76131, Germany.

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http://dx.doi.org/10.1107/S160057751900660XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732905PMC
September 2019

A Novel Algorithm to Identify Predictors of Treatment Response: Tapentadol Monotherapy or Tapentadol/Pregabalin Combination Therapy in Chronic Low Back Pain?

Authors:
Jan C Otto Julia Forstenpointner Juliane Sachau Philipp Hüllemann Martin Hukauf Thomas Keller Janne Gierthmühlen Ralf Baron

Front Neurol 2019 13;10:979. Epub 2019 Sep 13.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.3389/fneur.2019.00979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753214PMC
September 2019

Association between rapid weather changes and incidence of chiefly cardiovascular complaints in the emergency department.

Authors:
Torben Ostendorf Michael Bernhard Thomas Hartwig Markus Voigt Thomas Keller Michael Stumvoll André Gries

Am J Emerg Med 2019 Sep 11. Epub 2019 Sep 11.

Emergency Department, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ajem.2019.158440DOI Listing
September 2019

Cortical Cell Diameter Is Key To Energy Costs of Root Growth in Wheat.

Authors:
Tino Colombi Anke Marianne Herrmann Pernilla Vallenback Thomas Keller

Plant Physiol 2019 08 13;180(4):2049-2060. Epub 2019 May 13.

Department of Soil and Environment, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.

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http://dx.doi.org/10.1104/pp.19.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670075PMC
August 2019

Effectiveness of a homeopathic complex medicine in infantile colic: A randomized multicenter study.

Authors:
Christa Raak Peter Krueger Petra Klement Sabine De Jaegere Stephan Weber Thomas Keller Lydia Ilyenko David Martin Thomas Ostermann

Complement Ther Med 2019 Aug 1;45:136-141. Epub 2019 Jun 1.

Chair of Research Methodology and Statistics in Psychology, Witten/Herdecke University, Witten, Germany.

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http://dx.doi.org/10.1016/j.ctim.2019.05.026DOI Listing
August 2019

Correction to "Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3".

Authors:
Chuhui Huang Si Si Liew Grace R Lin Anders Poulsen Melgious J Y Ang Brian C S Chia Sin Yin Chew Zekui P Kwek John L K Wee Esther H Ong Priya Retna Nithya Baburajendran Rong Li Weixuan Yu Xiaoying Koh-Stenta Anna Ngo Sravanthy Manesh Justina Fulwood Zhiyuan Ke Hwa Hwa Chung Sugunavathi Sepramaniam Xin Hui Chew Nurul Dinie May Ann Lee Yun Shan Chew Choon Bing Low Vishal Pendharkar Vithya Manoharan Susmitha Vuddagiri Kanda Sangthongpitag Joma Joy Alex Matter Jeffrey Hill Thomas H Keller Klement Foo

ACS Med Chem Lett 2019 Aug 9;10(8):1240. Epub 2019 Jul 9.

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https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00278
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http://dx.doi.org/10.1021/acsmedchemlett.9b00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691561PMC
August 2019

Agricultural intensification reduces microbial network complexity and the abundance of keystone taxa in roots.

Authors:
Samiran Banerjee Florian Walder Lucie Büchi Marcel Meyer Alain Y Held Andreas Gattinger Thomas Keller Raphael Charles Marcel G A van der Heijden

ISME J 2019 07 8;13(7):1722-1736. Epub 2019 Mar 8.

Agroscope, Department of Agroecology & Environment, Reckenholzstrasse 191, 8046, Zürich, Switzerland.

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http://dx.doi.org/10.1038/s41396-019-0383-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591126PMC
July 2019

Measurement of Fractional Exhaled Nitric Oxide: Comparison of Three Different Analysers.

Authors:
Stephanie Korn Maike Wilk Stefanie Voigt Stephan Weber Thomas Keller Roland Buhl

Respiration 2020 9;99(1):1-8. Epub 2019 Jul 9.

Department of Pulmonary, Mainz University Hospital, Mainz, Germany.

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http://dx.doi.org/10.1159/000500727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979424PMC
July 2019

Novel synthetic opioids - toxicological aspects and analysis.

Authors:
Inês Tabarra Sofia Soares Tiago Rosado Joana Gonçalves Ângelo Luís Sara Malaca Mário Barroso Thomas Keller José Restolho Eugenia Gallardo

Forensic Sci Res 2019 3;4(2):111-140. Epub 2019 Jul 3.

Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal.

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http://dx.doi.org/10.1080/20961790.2019.1588933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609355PMC
July 2019

Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.

Authors:
Mark Laible Kerstin Hartmann Claudia Gürtler Tobias Anzeneder Ralph Wirtz Stephan Weber Thomas Keller Ugur Sahin Martin Rees Annette Ramaswamy

BMC Cancer 2019 Jul 15;19(1):694. Epub 2019 Jul 15.

Institut für Pathologie, Universitätsklinikum Giessen und Marburg, Baldingerstraße, 35043, Marburg, Germany.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5890-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631550PMC
July 2019

Iron Hack - A symposium/hackathon focused on porphyrias, Friedreich's ataxia, and other rare iron-related diseases.

Authors:
Gloria C Ferreira Jenna Oberstaller Renée Fonseca Thomas E Keller Swamy Rakesh Adapa Justin Gibbons Chengqi Wang Xiaoming Liu Chang Li Minh Pham Guy W Dayhoff Ii Linh M Duong Luis Tañón Reyes Luciano Enrique Laratelli Douglas Franz Segun Fatumo Atm Golam Bari Audrey Freischel Lindsey Fiedler Omkar Dokur Krishna Sharma Deborah Cragun Ben Busby Rays H Y Jiang

F1000Res 2019 19;8:1135. Epub 2019 Jul 19.

Global and Planetary Health, College of Public Health, University of South Florida, USF Genomics Program, 3720 Spectrum Blvd, Tampa, FL, 33612, USA.

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http://dx.doi.org/10.12688/f1000research.19140.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894363PMC
July 2019

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Authors:
Chuhui Huang Si Si Liew Grace R Lin Anders Poulsen Melgious J Y Ang Brian C S Chia Sin Yin Chew Zekui P Kwek John L K Wee Esther H Ong Priya Retna Nithya Baburajendran Rong Li Weixuan Yu Xiaoying Koh-Stenta Anna Ngo Sravanthy Manesh Justina Fulwood Zhiyuan Ke Hwa Hwa Chung Sugunavathi Sepramaniam Xin Hui Chew Nurul Dinie May Ann Lee Yun Shan Chew Choon Bing Low Vishal Pendharkar Vithya Manoharan Susmitha Vuddagiri Kanda Sangthongpitag Joma Joy Alex Matter Jeffrey Hill Thomas H Keller Klement Foo

ACS Med Chem Lett 2019 Jun 23;10(6):978-984. Epub 2019 May 23.

Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580565PMC
June 2019

Radiosynthesis of the norepinephrine transporter tracer [ F]NS12137 via copper-mediated F-labelling.

Authors:
Salla Lahdenpohja Thomas Keller Johan Rajander Anna K Kirjavainen

J Labelled Comp Radiopharm 2019 05 2;62(6):259-264. Epub 2019 Jun 2.

Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1002/jlcr.3717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619244PMC
May 2019

Comparison of high and low molar activity TSPO tracer [F]F-DPA in a mouse model of Alzheimer's disease.

Authors:
Thomas Keller Francisco R López-Picón Anna Krzyczmonik Sarita Forsback Jatta S Takkinen Johan Rajander Simo Teperi Frédéric Dollé Juha O Rinne Merja Haaparanta-Solin Olof Solin

J Cereb Blood Flow Metab 2019 May 29:271678X19853117. Epub 2019 May 29.

1 Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland.

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http://dx.doi.org/10.1177/0271678X19853117DOI Listing
May 2019

Periodic Co/Nb pseudo spin valve for cryogenic memory.

Authors:
Nikolay Klenov Yury Khaydukov Sergey Bakurskiy Roman Morari Igor Soloviev Vladimir Boian Thomas Keller Mikhail Kupriyanov Anatoli Sidorenko Bernhard Keimer

Beilstein J Nanotechnol 2019 9;10:833-839. Epub 2019 Apr 9.

Max-Planck-Institut für Festkörperforschung, Heisenbergstraße 1, D-70569 Stuttgart, Germany.

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http://dx.doi.org/10.3762/bjnano.10.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466729PMC
April 2019

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Authors:
Jacek Kwiatkowski Nithya Baburajendran Anders Poulsen Boping Liu Doris Hui Ying Tee Yun Xuan Wong Zhi Ying Poh Esther Hq Ong Nurul Dinie Joseph Cherian Anna Elisabet Jansson Jeffrey Hill Thomas H Keller Alvin W Hung

ACS Med Chem Lett 2019 Mar 15;10(3):318-323. Epub 2019 Feb 15.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (ASTAR), 11 Biopolis Way, Helios #03-10/11, Singapore 138667, Singapore.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421525PMC
March 2019

Translation and Validation of the German New Knee Society Scoring System.

Authors:
Mahmut Enes Kayaalp Thomas Keller Wolfgang Fitz Giles R Scuderi Roland Becker

Clin Orthop Relat Res 2019 02;477(2):383-393

M. E. Kayaalp, Department of Orthopaedics and Traumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey T. Keller , StatConsult GmbH, Magdeburg, Germany W. Fitz, Brigham and Women's Hospital, Boston, MA, USA G. R. Scuderi, Northwell Orthopedic Institute, New York, NY, USA M. E. Kayaalp, R. Becker, Department of Orthopaedics and Traumatology, University Hospital Brandenburg, Medical School Brandenburg Theodor Fontane, Brandenburg an der Havel, Germany.

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http://dx.doi.org/10.1097/CORR.0000000000000555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370076PMC
February 2019

[F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease.

Authors:
Thomas Keller Francisco R López-Picón Anna Krzyczmonik Sarita Forsback Anna K Kirjavainen Jatta S Takkinen Obada Alzghool Johan Rajander Simo Teperi Fanny Cacheux Annelaure Damont Frédéric Dollé Juha O Rinne Olof Solin Merja Haaparanta-Solin

Nucl Med Biol 2018 12 26;67:1-9. Epub 2018 Sep 26.

PET Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, Finland; MediCity Research Laboratory, University of Turku, Finland.

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http://dx.doi.org/10.1016/j.nucmedbio.2018.09.001DOI Listing
December 2018

Clinical Manifestation of Acute, Subacute, and Chronic Low Back Pain in Different Age Groups: Low Back Pain in 35,446 Patients.

Authors:
Philipp Hüllemann Thomas Keller Maria Kabelitz Janne Gierthmühlen Rainer Freynhagen Thomas Tölle Julia Forstenpointner Ralf Baron

Pain Pract 2018 11 23;18(8):1011-1023. Epub 2018 Jun 23.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1111/papr.12704DOI Listing
November 2018

Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning.

Authors:
Nicole Gruenheit Katie Parkinson Christopher A Brimson Satoshi Kuwana Edward J Johnson Koki Nagayama Jack Llewellyn William M Salvidge Balint Stewart Thomas Keller Wouter van Zon Simon L Cotter Christopher R L Thompson

Dev Cell 2018 11 25;47(4):494-508.e4. Epub 2018 Oct 25.

Centre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK; Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251973PMC
November 2018

Assessing Support Network Stability With Transition-Age Foster Youth: Measuring Change Over Time.

Authors:
Jennifer E Blakeslee Thomas E Keller

Res Soc Work Pract 2018 Oct 16;28(7):857-868. Epub 2016 Nov 16.

School of Social Work, Portland State University, Portland, OR, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380507PMC
October 2018

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.

Authors:
Soo Yei Ho Weiling Wang Fui Mee Ng Yun Xuan Wong Zhi Ying Poh Sum Wai Eldwin Tan Shi Hua Ang Si Si Liew Yin Sze Joyner Wong Yvonne Tan Anders Poulsen Vishal Pendharkar Kanda Sangthongpitag John Manchester Gregory Basarab Jeffrey Hill Thomas H Keller Joseph Cherian

Eur J Med Chem 2018 Sep 11;157:610-621. Epub 2018 Aug 11.

Experimental Therapeutics Centre, 13 Biopolis Way, Nanos 13866, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.025DOI Listing
September 2018

Local orthorhombic lattice distortions in the paramagnetic tetragonal phase of superconducting NaFeNiAs.

Authors:
Weiyi Wang Yu Song Chongde Cao Kuo-Feng Tseng Thomas Keller Yu Li L W Harriger Wei Tian Songxue Chi Rong Yu Andriy H Nevidomskyy Pengcheng Dai

Nat Commun 2018 08 7;9(1):3128. Epub 2018 Aug 7.

Department of Physics and Astronomy, Rice University, Houston, TX, 77005, USA.

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http://dx.doi.org/10.1038/s41467-018-05529-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081486PMC
August 2018

A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intra-operative arterial hypotension: the 'HYPOTENS' study design and rationale.

Authors:
Leopold Eberhart Götz Geldner Susanne Huljic Kerstin Marggraf Thomas Keller Tilo Koch Peter Kranke

Curr Med Res Opin 2018 06 28;34(6):953-961. Epub 2018 Feb 28.

f Department of Anaesthesia and Critical Care , University Hospital Würzburg , Würzburg , Germany.

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http://dx.doi.org/10.1080/03007995.2018.1438379DOI Listing
June 2018

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Authors:
Yan Li Shuang Liu Elizabeth Yihui Ng Rong Li Anders Poulsen Jeffrey Hill Ajaybabu V Pobbati Alvin W Hung Wanjin Hong Thomas H Keller CongBao Kang

Biochem J 2018 06 26;475(12):2043-2055. Epub 2018 Jun 26.

Experimental Therapeutics Centre, A*STAR, 31 Biopolis Way, #3-01, Singapore 138669

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http://dx.doi.org/10.1042/BCJ20180225DOI Listing
June 2018

Feedbacks between soil penetration resistance, root architecture and water uptake limit water accessibility and crop growth - A vicious circle.

Authors:
Tino Colombi Lorena Chagas Torres Achim Walter Thomas Keller

Sci Total Environ 2018 Jun 19;626:1026-1035. Epub 2018 Feb 19.

Swedish University of Agricultural Sciences, Department of Soil and Environment, Uppsala, Sweden; Agroscope, Department of Agroecology and Environment, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.scitotenv.2018.01.129DOI Listing
June 2018

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Authors:
Jacek Kwiatkowski Boping Liu Doris Hui Ying Tee Guoying Chen Nur Huda Binte Ahmad Yun Xuan Wong Zhi Ying Poh Shi Hua Ang Eldwin Sum Wai Tan Esther Hq Ong Nurul Dinie Anders Poulsen Vishal Pendharkar Kanda Sangthongpitag May Ann Lee Sugunavathi Sepramaniam Soo Yei Ho Joseph Cherian Jeffrey Hill Thomas H Keller Alvin W Hung

J Med Chem 2018 05 4;61(10):4386-4396. Epub 2018 May 4.

Experimental Therapeutics Centre , Agency for Science, Technology and Research (A*STAR) , 11 Biopolis Way, Helios #03-10/11 , Singapore 138667 , Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00060DOI Listing
May 2018

"I really wanted her to have a Big Sister": Caregiver perspectives on mentoring for early adolescent girls.

Authors:
Thomas E Keller Bahia Overton Julia M Pryce Johanna E Barry Andrew Sutherland David L DuBois

Child Youth Serv Rev 2018 May 19;88:308-315. Epub 2018 Mar 19.

Institute for Health Research and Policy, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608.

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http://dx.doi.org/10.1016/j.childyouth.2018.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185733PMC
May 2018

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Authors:
Yan Li Zhenzhen Zhang Wint Wint Phoo Ying Ru Loh Rong Li Hai Yan Yang Anna E Jansson Jeffrey Hill Thomas H Keller Kassoum Nacro Dahai Luo CongBao Kang

Structure 2018 04 8;26(4):555-564.e3. Epub 2018 Mar 8.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183004
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http://dx.doi.org/10.1016/j.str.2018.02.005DOI Listing
April 2018

IFCC Working Group Recommendations for Assessing Commutability Part 1: General Experimental Design.

Authors:
W Greg Miller Heinz Schimmel Robert Rej Neil Greenberg Ferruccio Ceriotti Chris Burns Jeffrey R Budd Cas Weykamp Vincent Delatour Göran Nilsson Finlay MacKenzie Mauro Panteghini Thomas Keller Johanna E Camara Ingrid Zegers Hubert W Vesper

Clin Chem 2018 03 18;64(3):447-454. Epub 2018 Jan 18.

Centers for Disease Control and Prevention, Atlanta, GA.

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http://dx.doi.org/10.1373/clinchem.2017.277525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832613PMC
March 2018

IFCC Working Group Recommendations for Assessing Commutability Part 3: Using the Calibration Effectiveness of a Reference Material.

Authors:
Jeffrey R Budd Cas Weykamp Robert Rej Finlay MacKenzie Ferruccio Ceriotti Neil Greenberg Johanna E Camara Heinz Schimmel Hubert W Vesper Thomas Keller Vincent Delatour Mauro Panteghini Chris Burns W Greg Miller

Clin Chem 2018 03 18;64(3):465-474. Epub 2018 Jan 18.

Department of Pathology, Virginia Commonwealth University, Richmond, VA.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2017.277
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http://dx.doi.org/10.1373/clinchem.2017.277558DOI Listing
March 2018

IFCC Working Group Recommendations for Assessing Commutability Part 2: Using the Difference in Bias between a Reference Material and Clinical Samples.

Authors:
Göran Nilsson Jeffrey R Budd Neil Greenberg Vincent Delatour Robert Rej Mauro Panteghini Ferruccio Ceriotti Heinz Schimmel Cas Weykamp Thomas Keller Johanna E Camara Chris Burns Hubert W Vesper Finlay MacKenzie W Greg Miller

Clin Chem 2018 03 18;64(3):455-464. Epub 2018 Jan 18.

Department of Pathology, Virginia Commonwealth University, Richmond, VA.

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http://dx.doi.org/10.1373/clinchem.2017.277541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835923PMC
March 2018

Radial Growth of Self-Catalyzed GaAs Nanowires and the Evolution of the Liquid Ga-Droplet Studied by Time-Resolved in Situ X-ray Diffraction.

Authors:
Philipp Schroth Julian Jakob Ludwig Feigl Seyed Mohammad Mostafavi Kashani Jonas Vogel Jörg Strempfer Thomas F Keller Ullrich Pietsch Tilo Baumbach

Nano Lett 2018 01 28;18(1):101-108. Epub 2017 Dec 28.

Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology , Kaiserstraße 12, D-76131 Karlsruhe, Germany.

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http://dx.doi.org/10.1021/acs.nanolett.7b03486DOI Listing
January 2018

Sensory symptom profiles differ between trigeminal and thoracolumbar postherpetic neuralgia.

Authors:
Stefanie Rehm Moritz Groβkopf Maria Kabelitz Thomas Keller Rainer Freynhagen Thomas R Tölle Ralf Baron

Pain Rep 2018 Jan 6;3(1):e636. Epub 2018 Feb 6.

Sektion Neurologische Schmerzforschung und -therapie, Klinik für Neurologie Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1097/PR9.0000000000000636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802323PMC
January 2018

The effect of a dynamic PCL brace on patellofemoral compartment pressures in PCL-and PCL/PLC-deficient knees.

Authors:
Tyler Welch Thomas Keller Ruben Maldonado Melodie Metzger Karen Mohr Ronald Kvitne

J Exp Orthop 2017 Dec 31;4(1):10. Epub 2017 Mar 31.

Kerlan Jobe Orthopaedic Clinic, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s40634-017-0085-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374082PMC
December 2017

BUILD EXITO: a multi-level intervention to support diversity in health-focused research.

Authors:
Dawn M Richardson Thomas E Keller De' Sha S Wolf Adrienne Zell Cynthia Morris Carlos J Crespo

BMC Proc 2017 4;11(Suppl 12):19. Epub 2017 Dec 4.

1School of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR 97207 USA.

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https://bmcproc.biomedcentral.com/articles/10.1186/s12919-01
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http://dx.doi.org/10.1186/s12919-017-0080-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773881PMC
December 2017

A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters.

Authors:
Sascha Lutz Eloisa Lopez-Calle Pamela Espindola Christoph Boehm Thorsten Brueckner Juergen Spinke Moritz Marcinowski Thomas Keller Armin Tgetgel Nicolas Herbert Thomas Fischer Erik Beiersdorf

Analyst 2017 Nov;142(22):4206-4214

Roche Diagnostics GmbH, Sandhofer Str. 116, 68305 Mannheim, Germany.

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http://xlink.rsc.org/?DOI=C7AN00547D
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http://dx.doi.org/10.1039/c7an00547dDOI Listing
November 2017

Radiosynthesis and Preclinical Evaluation of [F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats.

Authors:
Thomas Keller Anna Krzyczmonik Sarita Forsback Francisco R López Picón Anna K Kirjavainen Jatta Takkinen Johan Rajander Fanny Cacheux Annelaure Damont Frédéric Dollé Juha O Rinne Merja Haaparanta-Solin Olof Solin

Mol Imaging Biol 2017 Oct;19(5):736-745

Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1007/s11307-016-1040-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574958PMC
October 2017

A new immunochemistry platform for a guideline-compliant cardiac troponin T assay at the point of care: proof of principle.

Authors:
Eloisa Lopez-Calle Pamela Espindola Juergen Spinke Sascha Lutz Alfons Nichtl Armin Tgetgel Nicolas Herbert Moritz Marcinowski Juergen Klepp Thomas Fischer Thorsten Brueckner Christoph Boehm Thomas Keller

Clin Chem Lab Med 2017 Oct;55(11):1798-1804

.

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http://dx.doi.org/10.1515/cclm-2016-1078DOI Listing
October 2017

Zika Virus Protease: An Antiviral Drug Target.

Authors:
CongBao Kang Thomas H Keller Dahai Luo

Trends Microbiol 2017 10 5;25(10):797-808. Epub 2017 Aug 5.

Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2017.07.001DOI Listing
October 2017

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor.

Authors:
Yan Li Hui Qi Ng Anna Ngo Shuang Liu Yih Wan Tan Perlyn Zekui Kwek Alvin W Hung Joma Joy Jeffrey Hill Thomas H Keller CongBao Kang

Biomol NMR Assign 2017 Oct 14;11(2):225-229. Epub 2017 Aug 14.

Experimental Therapeutics Centre, Agency for Science, Technology and Research, 31 Biopolis Way Nanos, #03-01, Singapore, 138669, Singapore.

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http://dx.doi.org/10.1007/s12104-017-9753-8DOI Listing
October 2017

Investigation of the Integration of Supports for Youth Thriving Into a Community-Based Mentoring Program.

Authors:
David L DuBois Thomas E Keller

Child Dev 2017 09 19;88(5):1480-1491. Epub 2017 Jun 19.

Portland State University.

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http://dx.doi.org/10.1111/cdev.12887DOI Listing
September 2017

Developing Fine-Grained Actigraphies for Rheumatoid Arthritis Patients from a Single Accelerometer Using Machine Learning.

Authors:
Javier Andreu-Perez Luis Garcia-Gancedo Jonathan McKinnell Anniek Van der Drift Adam Powell Valentin Hamy Thomas Keller Guang-Zhong Yang

Sensors (Basel) 2017 Sep 14;17(9). Epub 2017 Sep 14.

The Hamlyn Centre, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.3390/s17092113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620953PMC
September 2017

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal F-FDG and F-DPA-714 PET imaging.

Authors:
Jatta S Takkinen Francisco R López-Picón Rana Al Majidi Olli Eskola Anna Krzyczmonik Thomas Keller Eliisa Löyttyniemi Olof Solin Juha O Rinne Merja Haaparanta-Solin

J Cereb Blood Flow Metab 2017 Aug 1;37(8):2870-2882. Epub 2016 Jan 1.

1 MediCity Research Laboratory, University of Turku, Turku, Finland.

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http://journals.sagepub.com/doi/10.1177/0271678X16677990
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http://dx.doi.org/10.1177/0271678X16677990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536795PMC
August 2017

Root Tip Shape Governs Root Elongation Rate under Increased Soil Strength.

Authors:
Tino Colombi Norbert Kirchgessner Achim Walter Thomas Keller

Plant Physiol 2017 Aug 9;174(4):2289-2301. Epub 2017 Jun 9.

Agroscope, Department of Agroecology and Environment, Zurich 8046, Switzerland.

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http://dx.doi.org/10.1104/pp.17.00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543947PMC
August 2017

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Authors:
Soo Yei Ho Jenefer Alam Duraiswamy Athisayamani Jeyaraj Weiling Wang Grace Ruiting Lin Shi Hua Ang Eldwin Sum Wai Tan May Ann Lee Zhiyuan Ke Babita Madan David M Virshup Li Jun Ding Vithya Manoharan Yun Shan Chew Choon Bing Low Vishal Pendharkar Kanda Sangthongpitag Jeffrey Hill Thomas H Keller Anders Poulsen

J Med Chem 2017 08 20;60(15):6678-6692. Epub 2017 Jul 20.

Experimental Therapeutics Centre , 31 Biopolis Way, No. 03-01 Nanos, 138669, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00662DOI Listing
August 2017

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

Authors:
Yan Li Wint Wint Phoo Ying Ru Loh Zhenzhen Zhang Elizabeth Yihui Ng Weiling Wang Thomas H Keller Dahai Luo CongBao Kang

FEBS Lett 2017 08 20;591(15):2338-2347. Epub 2017 Jul 20.

Experimental Therapeutics Centre Agency for Science Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1002/1873-3468.12741DOI Listing
August 2017

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Authors:
Yan Li Zhenzhen Zhang Wint Wint Phoo Ying Ru Loh Weiling Wang Shuang Liu Ming Wei Chen Alvin W Hung Thomas H Keller Dahai Luo CongBao Kang

Structure 2017 08 6;25(8):1242-1250.e3. Epub 2017 Jul 6.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.06.006DOI Listing
August 2017

Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial.

Authors:
Jürgen Palm Vasyl V Kishchuk Àngels Ulied Joaquin Perotti Fernández Sabine De Jaegere Miek C Jong Thomas Keller Anatolii Kosakovskyi Kira Kompaniiets Inga Mityuryayeva-Korniiko Sergiy M Pukhlik Zoia Tretiakevych Stephan Weber Karin Wienhold Petra Klement

Complement Ther Clin Pract 2017 Aug 22;28:181-191. Epub 2017 May 22.

Deutsche Homöopathie-Union, DHU-Arzneimittel GmbH & Co. KG, Karlsruhe, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17443881173015
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http://dx.doi.org/10.1016/j.ctcp.2017.05.005DOI Listing
August 2017

Peer mentoring for undergraduates in a research-focused diversity initiative.

Authors:
Thomas E Keller Kay Logan Jennifer Lindwall Caitlyn Beals

Metrop Univ 2017 24;28(3):50-66. Epub 2017 Aug 24.

Center for Interdisciplinary Mentoring Research, Portland State University, P.O. Box 751, Portland, OR 97207, Telephone: 503-725-9281.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796667PMC
http://dx.doi.org/10.18060/21542DOI Listing
August 2017

Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III.

Authors:
Thorsten Bach Patrick J Bastian Andreas Blana Angelika Kaminsky Stefan Keller Thomas Knoll Christoph Lang Soeren Promnitz Burkhard Ubrig Thomas Keller Bryan Qvick Maximilian Burger

World J Urol 2017 May 30;35(5):737-744. Epub 2016 Aug 30.

Klinik für Urologie, Universitätsklinikum Regensburg, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00345-016-1925-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397437PMC
May 2017

Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation.

Authors:
Isabel Mendizabal Jia Zeng Thomas E Keller Soojin V Yi

Nucleic Acids Res 2017 05;45(8):4390-4400

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1093/nar/gkx020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416765PMC
May 2017

An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®.

Authors:
Zsuzsanna Varga Annette Lebeau Hong Bu Arndt Hartmann Frederique Penault-Llorca Elena Guerini-Rocco Peter Schraml Fraser Symmans Robert Stoehr Xiaodong Teng Andreas Turzynski Reinhard von Wasielewski Claudia Gürtler Mark Laible Kornelia Schlombs Heikki Joensuu Thomas Keller Peter Sinn Ugur Sahin John Bartlett Giuseppe Viale

Breast Cancer Res 2017 05 11;19(1):55. Epub 2017 May 11.

European Institute of Oncology, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1186/s13058-017-0848-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426065PMC
May 2017

Vacuum ultraviolet photon-mediated production of [ F]F.

Authors:
Anna Krzyczmonik Thomas Keller Anna K Kirjavainen Sarita Forsback Olof Solin

J Labelled Comp Radiopharm 2017 04 15;60(4):186-193. Epub 2017 Mar 15.

Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1002/jlcr.3489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413832PMC
April 2017

High resolution neutron Larmor diffraction using superconducting magnetic Wollaston prisms.

Authors:
Fankang Li Hao Feng Alexander N Thaler Steven R Parnell William A Hamilton Lowell Crow Wencao Yang Amy B Jones Hongyu Bai Masaaki Matsuda David V Baxter Thomas Keller Jaime A Fernandez-Baca Roger Pynn

Sci Rep 2017 04 13;7(1):865. Epub 2017 Apr 13.

Instrument and Source Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.

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http://dx.doi.org/10.1038/s41598-017-00740-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429841PMC
April 2017

Pain Drawings Improve Subgrouping of Low Back Pain Patients.

Authors:
Philipp Hüllemann Thomas Keller Maria Kabelitz Rainer Freynhagen Thomas Tölle Ralf Baron

Pain Pract 2017 03 23;17(3):293-304. Epub 2016 Jun 23.

Sektion Neurologische Schmerzforschung und -therapie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1111/papr.12470DOI Listing
March 2017

Enhanced Magnetization of Cobalt Defect Clusters Embedded in TiO Films.

Authors:
David L Cortie Yury Khaydukov Thomas Keller David J Sprouster Jacob S Hughes James P Sullivan Xiaolin L Wang Anton P Le Brun Joel Bertinshaw Sara J Callori Robert Aughterson Michael James Peter J Evans Gerry Triani Frank Klose

ACS Appl Mater Interfaces 2017 Mar 3;9(10):8783-8795. Epub 2017 Mar 3.

Australian Nuclear Science and Technology Organization , Lucas Heights, New South Wales 2234, Australia.

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http://dx.doi.org/10.1021/acsami.6b15071DOI Listing
March 2017

Artificial macropores attract crop roots and enhance plant productivity on compacted soils.

Authors:
Tino Colombi Serge Braun Thomas Keller Achim Walter

Sci Total Environ 2017 Jan 4;574:1283-1293. Epub 2016 Oct 4.

Institute of Agricultural Sciences (IAS), ETH Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.scitotenv.2016.07.194DOI Listing
January 2017

Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.

Authors:
Shahul H Nilar Suresh B Lakshminarayana Ngai Ling Ma Thomas H Keller Francesca Blasco Paul W Smith

Curr Comput Aided Drug Des 2016 ;12(1):52-61

Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, 138670, Singapore.

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http://dx.doi.org/10.2174/1573409912999160112113539DOI Listing
December 2016

Neutron resonance spin echo with longitudinal DC fields.

Authors:
Maximilian Krautloher Jonas Kindervater Thomas Keller Wolfgang Häußler

Rev Sci Instrum 2016 Dec;87(12):125110

Physik-Department, Technische Universität München, D-85748 Garching, Germany.

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http://dx.doi.org/10.1063/1.4972395DOI Listing
December 2016

Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution.

Authors:
Isabel Mendizabal Lei Shi Thomas E Keller Genevieve Konopka Todd M Preuss Tzung-Fu Hsieh Enzhi Hu Zhe Zhang Bing Su Soojin V Yi

Mol Biol Evol 2016 11 25;33(11):2947-2959. Epub 2016 Aug 25.

School of Biological Sciences, Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA

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http://dx.doi.org/10.1093/molbev/msw176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062329PMC
November 2016

Collective epithelial cell sheet adhesion and migration on polyelectrolyte multilayers with uniform and gradients of compliance.

Authors:
Jessica S Martinez Joseph B Schlenoff Thomas C S Keller

Exp Cell Res 2016 08 9;346(1):17-29. Epub 2016 Jun 9.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967014PMC
August 2016

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

Authors:
Yan Li Ying Lei Wong Fui Mee Ng Boping Liu Yun Xuan Wong Zhi Ying Poh Shuang Liu Siew Wen Then Michelle Yueqi Lee Hui Qi Ng Qiwei Huang Alvin W Hung Joseph Cherian Jeffrey Hill Thomas H Keller CongBao Kang

J Biol Chem 2016 08 30;291(34):17743-53. Epub 2016 Jun 30.

From the Experimental Therapeutics Centre, Agency for Science, Technology, and Research (A*STAR), 31 Biopolis Way, Nanos, 03-01, Singapore 138669

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http://dx.doi.org/10.1074/jbc.M116.737429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016168PMC
August 2016

The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial.

Authors:
Robert van Haselen Manuela Thinesse-Mallwitz Vitaliy Maidannyk Stephen L Buskin Stephan Weber Thomas Keller Julia Burkart Petra Klement

Glob Pediatr Health 2016 4;3:2333794X16654851. Epub 2016 Jul 4.

Deutsche Homöopathie-Union, Karlsruhe, Germany.

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http://dx.doi.org/10.1177/2333794X16654851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959794PMC
August 2016

Effectiveness, safety and tolerability of a complex homeopathic medicinal product in the prevention of recurrent acute upper respiratory tract infections in children: a multicenter, open, comparative, randomized, controlled clinical trial.

Authors:
Miek C Jong Stephen L Buskin Lydia Ilyenko Irina Kholodova Julia Burkart Stephan Weber Thomas Keller Petra Klement

Multidiscip Respir Med 2016 16;11:19. Epub 2016 May 16.

Deutsche Homöopathie-Union, DHU-Arzneimittel GmbH & Co. KG, Karlsruhe, Germany.

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http://dx.doi.org/10.1186/s40248-016-0056-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868034PMC
May 2016

Different prognostic value of circulating and disseminated tumor cells in primary breast cancer: Influence of bisphosphonate intake?

Authors:
Sabine Kasimir-Bauer Katharina Reiter Bahriye Aktas Ann-Kathrin Bittner Stephan Weber Thomas Keller Rainer Kimmig Oliver Hoffmann

Sci Rep 2016 05 23;6:26355. Epub 2016 May 23.

Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.

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http://dx.doi.org/10.1038/srep26355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876469PMC
May 2016

A Comparative Randomized Controlled Clinical Trial on the Effectiveness, Safety, and Tolerability of a Homeopathic Medicinal Product in Children with Sleep Disorders and Restlessness.

Authors:
Miek C Jong Lydia Ilyenko Irina Kholodova Cynthia Verwer Julia Burkart Stephan Weber Thomas Keller Petra Klement

Evid Based Complement Alternat Med 2016 8;2016:9539030. Epub 2016 May 8.

Deutsche Homöopathie-Union, DHU-Arzneimittel GmbH & Co. KG, 76227 Karlsruhe, Germany.

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http://dx.doi.org/10.1155/2016/9539030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875989PMC
May 2016

Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display.

Authors:
Thomas Keller Romana Kalt Ingrid Raab Helga Schachner Corina Mayrhofer Dontscho Kerjaschki Brigitte Hantusch

PLoS One 2015 20;10(5):e0127169. Epub 2015 May 20.

Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127169PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439027PMC
April 2016

Evolutionary Transition of Promoter and Gene Body DNA Methylation across Invertebrate-Vertebrate Boundary.

Authors:
Thomas E Keller Priscilla Han Soojin V Yi

Mol Biol Evol 2016 Apr 29;33(4):1019-28. Epub 2015 Dec 29.

School of Biology, Georgia Institute of Technology

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http://dx.doi.org/10.1093/molbev/msv345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776710PMC
April 2016

The multivariate association between genomewide DNA methylation and climate across the range of Arabidopsis thaliana.

Authors:
Thomas E Keller Jesse R Lasky Soojin V Yi

Mol Ecol 2016 Apr 14;25(8):1823-37. Epub 2016 Mar 14.

School of Biology, Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

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http://dx.doi.org/10.1111/mec.13573DOI Listing
April 2016

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

Authors:
Joseph Cherian Kassoum Nacro Zhi Ying Poh Samantha Guo Duraiswamy A Jeyaraj Yun Xuan Wong Melvyn Ho Hai Yan Yang Joma Kanikadu Joy Zekui Perlyn Kwek Boping Liu John Liang Kuan Wee Esther H Q Ong Meng Ling Choong Anders Poulsen May Ann Lee Vishal Pendharkar Li Jun Ding Vithya Manoharan Yun Shan Chew Kanda Sangthongpitag Sharon Lim S Tiong Ong Jeffrey Hill Thomas H Keller

J Med Chem 2016 Apr 5;59(7):3063-78. Epub 2016 Apr 5.

Experimental Therapeutics Centre , 13 Biopolis Way, Nanos, Singapore 138669.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01712DOI Listing
April 2016

Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy.

Authors:
Sabine Kasimir-Bauer Ann-Kathrin Bittner Lisa König Katharina Reiter Thomas Keller Rainer Kimmig Oliver Hoffmann

Breast Cancer Res 2016 Feb 12;18(1):20. Epub 2016 Feb 12.

Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany.

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http://dx.doi.org/10.1186/s13058-016-0679-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751719PMC
February 2016

A Homeopathic Combination Preparation in the Treatment of Feverish Upper Respiratory Tract Infections: An International Randomized Controlled Trial.

Authors:
Manuela Thinesse-Mallwitz Vitaly Maydannik Thomas Keller Petra Klement

Forsch Komplementmed 2015 12;22(3):163-70. Epub 2015 May 12.

Private Practice, Munich, Germany.

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http://dx.doi.org/10.1159/000430762DOI Listing
December 2015

[Fatal skiing accidents: a forensic analysis taking the example of Salzburg].

Authors:
Sebastian N Kunz Thomas Keller Christina Grove Stefanie Lochner Fabio Monticelli

Arch Kriminol 2015 Jan-Feb;235(1-2):1-10

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December 2015

The use of porcupine inhibitors to target Wnt-driven cancers.

Authors:
Soo Yei Ho Thomas H Keller

Bioorg Med Chem Lett 2015 Dec 23;25(23):5472-6. Epub 2015 Oct 23.

Experimental Therapeutics Centre, 31 Biopolis Way, #03-01 Nanos, Singapore 138669, Singapore.

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http://dx.doi.org/10.1016/j.bmcl.2015.10.032DOI Listing
December 2015

Organomediated Enantioselective (18)F Fluorination for PET Applications.

Authors:
Faye Buckingham Anna K Kirjavainen Sarita Forsback Anna Krzyczmonik Thomas Keller Ian M Newington Matthias Glaser Sajinder K Luthra Olof Solin Véronique Gouverneur

Angew Chem Int Ed Engl 2015 Nov 11;54(45):13366-9. Epub 2015 Sep 11.

University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA (UK).

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http://dx.doi.org/10.1002/anie.201506035DOI Listing
November 2015

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

Authors:
Yan Li Ying Lei Wong Fui Mee Ng Boping Liu Yun Xuan Wong Zhi Ying Poh Siew Wen Then Michelle Yueqi Lee Hui Qi Ng Alvin W Hung Joseph Cherian Jeffrey Hill Thomas H Keller CongBao Kang

Biochem Biophys Res Commun 2015 Nov 17;467(4):961-6. Epub 2015 Oct 17.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.036DOI Listing
November 2015

Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.

Authors:
CongBao Kang Yan Li Joseph Cherian Boping Liu Hui Qi Ng Michelle Yueqi Lee Nur Huda Binte Ahmad Zhi Ying Poh Yun Xuan Wong Qiwei Huang Ying Lei Wong Alvin W Hung Jeffrey Hill Thomas H Keller

Biophys J 2015 Nov;109(9):1969-77

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), Singapore. Electronic address:

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http://www.cell.com/biophysj/pdf/S0006-3495(15)01001-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000634951501001
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http://dx.doi.org/10.1016/j.bpj.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643325PMC
November 2015

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

Authors:
Yan Li Yun Xuan Wong Zhi Ying Poh Ying Lei Wong Michelle Yueqi Lee Hui Qi Ng Boping Liu Alvin W Hung Joseph Cherian Jeffrey Hill Thomas H Keller CongBao Kang

FEBS Lett 2015 Sep 10;589(19 Pt B):2683-9. Epub 2015 Aug 10.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.07.044DOI Listing
September 2015

Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

Authors:
Neil J Press Roger J Taylor Joseph D Fullerton Pamela Tranter Clive McCarthy Thomas H Keller Nicola Arnold David Beer Lyndon Brown Robert Cheung Julie Christie Alastair Denholm Sandra Haberthuer Julia D I Hatto Mark Keenan Mark K Mercer Helen Oakman Helene Sahri Andrew R Tuffnell Morris Tweed Alexandre Trifilieff

J Med Chem 2015 Sep 28;58(17):6747-52. Epub 2015 Aug 28.

Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00902DOI Listing
September 2015

Discovery and Optimization of a Porcupine Inhibitor.

Authors:
Athisayamani Jeyaraj Duraiswamy May Ann Lee Babita Madan Shi Hua Ang Eldwin Sum Wai Tan Wei Wen Vivien Cheong Zhiyuan Ke Vishal Pendharkar Li Jun Ding Yun Shan Chew Vithya Manoharan Kanda Sangthongpitag Jenefer Alam Anders Poulsen Soo Yei Ho David M Virshup Thomas H Keller

J Med Chem 2015 Aug 16;58(15):5889-99. Epub 2015 Jul 16.

†Experimental Therapeutics Centre, 31 Biopolis Way, No. 03-01 Nanos, 138669, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00507DOI Listing
August 2015

Application of Fragment-Based Drug Discovery against DNA Gyrase B.

Authors:
Guo-Ying Chen Fui Mee Ng Yih Wan Tan Anders Poulsen Weiguang Seetoh Grace Lin CongBao Kang Siew Wen Then Nur Huda Ahmad Ying Lei Wong Hui Qi Ng C S Brian Chia Qiu Ying Lau Jeffrey Hill Alvin W Hung Thomas H Keller

Chempluschem 2015 Aug 24;80(8):1250-1254. Epub 2015 Jun 24.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, Helios #03-10/11, Singapore 138667 (Singapore).

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http://dx.doi.org/10.1002/cplu.201500197DOI Listing
August 2015

Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design.

Authors:
Anders Poulsen Soo Yei Ho Weiling Wang Jenefer Alam Duraiswamy A Jeyaraj Shi Hua Ang Eldwin Sum Wai Tan Grace Ruiting Lin Vivien Wei Wen Cheong Zhiyuan Ke May Ann Lee Thomas H Keller

J Chem Inf Model 2015 Jul 15;55(7):1435-48. Epub 2015 Jun 15.

Experimental Therapeutics Centre, Agency for Science, Technology and Research, 31 Biopolis Way, Nanos Level 3, Singapore 138669.

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http://dx.doi.org/10.1021/acs.jcim.5b00159DOI Listing
July 2015

Discovery and Optimization of a Porcupine Inhibitor.

Authors:
Athisayamani Jeyaraj Duraiswamy May Ann Lee Babita Madan Shi Hua Ang Eldwin Sum Wai Tan Wei Wen Vivien Cheong Zhiyuan Ke Vishal Pendharkar Li Jun Ding Yun Shan Chew Vithya Manoharan Kanda Sangthongpitag Jenefer Alam Anders Poulsen Soo Yei Ho David M Virshup Thomas H Keller

J Med Chem 2015 Aug 16;58(15):5889-99. Epub 2015 Jul 16.

†Experimental Therapeutics Centre, 31 Biopolis Way, No. 03-01 Nanos, 138669, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00507DOI Listing
August 2015

Quasi-Spherical Cell Clusters Induced by a Polyelectrolyte Multilayer.

Authors:
Carlos J Arias Thomas C S Keller Joseph B Schlenoff

Langmuir 2015 Jun 2;31(23):6436-46. Epub 2015 Jun 2.

†Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, The Florida State University, Tallahassee, Florida 32306, United States.

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http://dx.doi.org/10.1021/acs.langmuir.5b00678DOI Listing
June 2015

Preclinical good laboratory practice-compliant safety study to evaluate biodistribution and tumorigenicity of a cartilage advanced therapy medicinal product (ATMP).

Authors:
Matthias Zscharnack Christoph Krause Gabriela Aust Christian Thümmler Frank Peinemann Thomas Keller Jeske J Smink Heidrun Holland Jeremy S Somerson Jens Knauer Ronny M Schulz Jörg Lehmann

J Transl Med 2015 May 20;13:160. Epub 2015 May 20.

Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

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http://dx.doi.org/10.1186/s12967-015-0517-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445304PMC
May 2015