Thomas J Urban

Thomas J Urban

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Thomas J Urban

Thomas J Urban

Publications by authors named "Thomas J Urban"

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An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis.

Scand J Gastroenterol 2017 Nov 4;52(11):1263-1269. Epub 2017 Aug 4.

a Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/00365521.2017.1359664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773288PMC
November 2017

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury.

Clin Gastroenterol Hepatol 2017 01 14;15(1):103-112.e2. Epub 2016 Jun 14.

Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370577PMC
January 2017

Variant Inosine Triphosphatase Phenotypes Are Associated With Increased Ribavirin Triphosphate Levels.

J Clin Pharmacol 2017 01 4;57(1):118-124. Epub 2016 Aug 4.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1002/jcph.783DOI Listing
January 2017

Reply.

Clin Gastroenterol Hepatol 2016 12 19;14(12):1845-1846. Epub 2016 Aug 19.

Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.cgh.2016.08.011DOI Listing
December 2016

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.

Pharmacogenet Genomics 2016 May;26(5):218-24

Departments of aSystems Biology bBiomedical Informatics cThe Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York dUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina eTarget Sciences, GSK, King of Prussia, Pennsylvania, USA fInstitute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel gDrug Commission of the German Medical Association (DCGMA), Berlin, Germany hInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne iNational Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, UK jDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The National University Hospital of Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1097/FPC.0000000000000209DOI Listing
May 2016

IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance.

Sci Rep 2015 Nov 4;5:16037. Epub 2015 Nov 4.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham NC, 27710, USA.

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http://www.nature.com/articles/srep16037
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http://dx.doi.org/10.1038/srep16037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631997PMC
November 2015

Clinical application of whole-genome sequencing in patients with primary immunodeficiency.

J Allergy Clin Immunol 2015 Aug 14;136(2):476-9.e6. Epub 2015 May 14.

Center for Human Genome Variation, Duke University School of Medicine, Durham, NC; Institute for Genomic Medicine, Columbia University Medical Center, New York, NY.

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https://www.uab.edu/medicine/rheumatology/images/TH_-_Mousal
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http://linkinghub.elsevier.com/retrieve/pii/S009167491500428
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http://dx.doi.org/10.1016/j.jaci.2015.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037571PMC
August 2015

Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury.

BMC Med 2015 Aug 19;13:196. Epub 2015 Aug 19.

Department of Internal Medicine III and IZKF, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, D-52074, Aachen, Germany.

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http://dx.doi.org/10.1186/s12916-015-0418-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545365PMC
August 2015

Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors.

Drug Metab Dispos 2015 May 3;43(5):725-34. Epub 2015 Mar 3.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)

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http://dx.doi.org/10.1124/dmd.114.062539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407708PMC
May 2015

Population pharmacokinetic modeling of plasma and intracellular ribavirin concentrations in patients with chronic hepatitis C virus infection.

Antimicrob Agents Chemother 2015 Apr 2;59(4):2179-88. Epub 2015 Feb 2.

University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Aurora, Colorado, USA

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http://dx.doi.org/10.1128/AAC.04618-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356818PMC
April 2015

Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden.

Virology 2015 Feb 9;476:334-340. Epub 2015 Jan 9.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, NC 27710, USA; Center for Human Genome Variation, Duke University Medical Center, NC 27710, USA; Center for RNA Biology, Duke University Medical Center, NC 27710, USA.

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http://dx.doi.org/10.1016/j.virol.2014.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494652PMC
February 2015

Genetic basis of drug-induced liver injury: present and future.

Semin Liver Dis 2014 May 31;34(2):123-33. Epub 2014 May 31.

National Institute for Health Research Nottingham Digestive Diseases Biomedical research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1055/s-0034-1375954DOI Listing
May 2014

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

Drug Metab Dispos 2014 Apr 23;42(4):665-74. Epub 2013 Oct 23.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.K., B.C.F., I.N., K.Y., K.L.R.B.), and Biostatistics Department, School of Public Health (P.W.St.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacy, Uppsala University, Uppsala, Sweden (I.N.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.); and Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (P.W.Sw.).

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http://dx.doi.org/10.1124/dmd.113.054304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965904PMC
April 2014

Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS.

PLoS Pathog 2013 1;9(8):e1003424. Epub 2013 Aug 1.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of

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http://dx.doi.org/10.1371/journal.ppat.1003424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731241PMC
March 2014

Pharmacogenetics at 50: genomic personalization comes of age.

Sci Transl Med 2014 Jan;6(220):220ps1

Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005237DOI Listing
January 2014

Whole-genome sequencing in pharmacogenetics.

Authors:
Thomas J Urban

Pharmacogenomics 2013 Mar;14(4):345-8

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http://dx.doi.org/10.2217/pgs.12.211DOI Listing
March 2013

Impact of the Interaction between 3'-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes.

Front Genet 2012 21;3:248. Epub 2012 Nov 21.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University West Lafayette, IN, USA.

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http://dx.doi.org/10.3389/fgene.2012.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502871PMC
November 2012

Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium.

Am J Hum Genet 2012 Sep 30;91(3):422-34. Epub 2012 Aug 30.

Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511993PMC
September 2012

Genetic and environmental correlates of topiramate-induced cognitive impairment.

Epilepsia 2012 Jan 16;53(1):e5-8. Epub 2011 Nov 16.

Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2011.03322.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253145PMC
January 2012

Race, ethnicity, ancestry, and pharmacogenetics.

Authors:
Thomas J Urban

Mt Sinai J Med 2010 Mar-Apr;77(2):133-9

Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1002/msj.20168DOI Listing
June 2011

Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function.

Gastroenterology 2011 Apr 1;140(4):1314-21. Epub 2011 Jan 1.

Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.12.038DOI Listing
April 2011

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

Nature 2009 Sep 16;461(7262):399-401. Epub 2009 Aug 16.

Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1038/nature08309DOI Listing
September 2009

Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.

Mol Pharmacol 2008 Apr 23;73(4):1151-8. Epub 2008 Jan 23.

Department of Biopharmaceutical Sciences, 1550 4th Street, RH584, Box 2911, University of California, San Francisco, CA 94158-2911, USA.

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http://dx.doi.org/10.1124/mol.107.043117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698938PMC
April 2008

WGAViewer: software for genomic annotation of whole genome association studies.

Genome Res 2008 Apr 6;18(4):640-3. Epub 2008 Feb 6.

Center for Population Genomics & Pharmacogenetics, Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1101/gr.071571.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279251PMC
April 2008

Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).

Mol Pharmacol 2006 Nov 24;70(5):1602-11. Epub 2006 Aug 24.

Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143-2911, USA.

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http://dx.doi.org/10.1124/mol.106.028126DOI Listing
November 2006

Functional genomics of membrane transporters in human populations.

Genome Res 2006 Feb 14;16(2):223-30. Epub 2005 Dec 14.

Department of Biopharmaceutical Sciences, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1101/gr.4356206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361718PMC
February 2006

Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.

J Pharm Sci 2006 Jan;95(1):25-36

Department of Biopharmaceutical Sciences, University of California San Francisco, USA.

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http://dx.doi.org/10.1002/jps.20536DOI Listing
January 2006

Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.

Mol Pharmacol 2004 Mar;65(3):512-9

Department of Biopharmaceutical Sciences, University of California-San Francisco, San Francisco, CA 94143-0446, USA.

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http://dx.doi.org/10.1124/mol.65.3.512DOI Listing
March 2004