Thomas J Broekelmann

Thomas J Broekelmann

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Thomas J Broekelmann

Thomas J Broekelmann

Publications by authors named "Thomas J Broekelmann"

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Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1.

J Biol Chem 2020 Jan 27. Epub 2020 Jan 27.

Cell Biology and Physiology, Washington University School of Medicine, United States.

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http://dx.doi.org/10.1074/jbc.RA119.010540DOI Listing
January 2020

Measurement of elastin, collagen, and total protein levels in tissues.

Methods Cell Biol 2018 6;143:133-146. Epub 2017 Nov 6.

Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0091679X173012
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http://dx.doi.org/10.1016/bs.mcb.2017.08.008DOI Listing
November 2018

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.

Matrix Biol 2018 10 7;71-72:100-111. Epub 2018 Mar 7.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128786PMC
October 2018

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

Sci Adv 2017 May 3;3(5):e1602532. Epub 2017 May 3.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/sciadv.1602532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415335PMC
May 2017

Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.

Am J Physiol Heart Circ Physiol 2015 Sep 31;309(5):H1008-16. Epub 2015 Jul 31.

Departments of Pediatrics Washington University School of Medicine, St. Louis, Missouri; and

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http://dx.doi.org/10.1152/ajpheart.00288.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591401PMC
September 2015

Zap70 inhibits Syk-mediated osteoclast function.

J Cell Biochem 2013 Aug;114(8):1871-8

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/jcb.24531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977572PMC
August 2013

Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.

J Biol Chem 2013 Feb 7;288(8):5268-77. Epub 2013 Jan 7.

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.446054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581369PMC
February 2013

Paxillin contracts the osteoclast cytoskeleton.

J Bone Miner Res 2012 Dec;27(12):2490-500

Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/jbmr.1706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494816PMC
December 2012

Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.

J Cell Biochem 2012 Jan;113(1):93-9

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/jcb.23331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245339PMC
January 2012

Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.

J Biol Chem 2011 Dec 2;286(52):44926-36. Epub 2011 Nov 2.

Departments of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M111.274779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248007PMC
December 2011

Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.

J Biol Chem 2011 Apr 14;286(15):13574-82. Epub 2011 Feb 14.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.192088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075703PMC
April 2011

Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.

J Biol Chem 2010 Nov 16;285(48):37396-404. Epub 2010 Sep 16.

Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.126789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988345PMC
November 2010

Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts.

J Cell Sci 2010 Sep;123(Pt 17):2955-63

Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jcs.069872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923570PMC
September 2010

Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.

Matrix Biol 2008 Sep 17;27(7):631-9. Epub 2008 Jun 17.

Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.matbio.2008.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586719PMC
September 2008

Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.

J Biol Chem 2008 Sep 14;283(37):25533-43. Epub 2008 Jul 14.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M709962200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533084PMC
September 2008

Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.

J Biol Chem 2008 Apr 4;283(15):9513-22. Epub 2008 Jan 4.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M706239200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442305PMC
April 2008

Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain.

J Biol Chem 2005 Dec 27;280(49):40939-47. Epub 2005 Sep 27.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M507309200DOI Listing
December 2005

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.

J Biol Chem 2005 Dec 26;280(52):42848-55. Epub 2005 Oct 26.

Institut de Biologie et Chimie des Protéines, CNRS/Université Lyon 1 UMR-5086, 7 passage du Vercors, 69367 Lyon Cedex 07, France.

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http://dx.doi.org/10.1074/jbc.M506832200DOI Listing
December 2005

Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2.

J Biol Chem 2004 May 24;279(22):23045-51. Epub 2004 Mar 24.

Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M402656200DOI Listing
May 2004

Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment.

Biochem J 2003 Oct;375(Pt 2):425-32

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://biochemj.org/lookup/doi/10.1042/bj20030649
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http://dx.doi.org/10.1042/BJ20030649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223679PMC
October 2003

A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis.

J Immunol 2003 Jul;171(1):398-406

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.171.1.398DOI Listing
July 2003

Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms.

J Biol Chem 2002 Mar 16;277(13):11050-7. Epub 2002 Jan 16.

Department of Cell Biology and Physiology and the Division of Pulmonary and Critical Care Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110347200DOI Listing
March 2002

Processing of type II procollagen amino propeptide by matrix metalloproteinases.

J Biol Chem 2002 Jan 8;277(3):2193-201. Epub 2001 Nov 8.

Department of Orthopaedic Surgery, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M105485200
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http://dx.doi.org/10.1074/jbc.M105485200DOI Listing
January 2002