Thomas Ioerger

Thomas Ioerger

UNVERIFIED PROFILE

Are you Thomas Ioerger?   Register this Author

Register author
Thomas Ioerger

Thomas Ioerger

Publications by authors named "Thomas Ioerger"

Are you Thomas Ioerger?   Register this Author

100Publications

2758Reads

26Profile Views

Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2019 Oct 23;63(10). Epub 2019 Sep 23.

Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01006-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761525PMC
October 2019

3--Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2019 Sep 23;63(9). Epub 2019 Aug 23.

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Dusseldorf, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00136-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709504PMC
September 2019

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Sci Rep 2019 Aug 6;9(1):11394. Epub 2019 Aug 6.

NTNU Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Clinical and Molecular Medicine, Trondheim, 7491, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-47905-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684656PMC
August 2019

Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase.

Cell Rep 2019 May;27(8):2468-2479.e3

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183200
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.12.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538288PMC
May 2019

Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

Org Biomol Chem 2019 Mar;17(12):3267-3274

Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77842-3012, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9ob00204aDOI Listing
March 2019

Design criteria for minimalist mimics of protein-protein interface segments.

Org Biomol Chem 2019 01;17(4):908-915

Department of Chemistry and Laboratory For Molecular Simulation, Texas A & M University, Box 30012, College Station, TX 77842-3012, USA.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C8OB02901F
Publisher Site
http://dx.doi.org/10.1039/c8ob02901fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344279PMC
January 2019

A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex.

Microbes Infect 2019 Apr - May;21(3-4):154-162. Epub 2018 Nov 13.

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitaetsstr. 1, 40225, Duesseldorf, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12864579183016
Publisher Site
http://dx.doi.org/10.1016/j.micinf.2018.10.006DOI Listing
November 2018

A statistical method to identify recombination in bacterial genomes based on SNP incompatibility.

BMC Bioinformatics 2018 Nov 22;19(1):450. Epub 2018 Nov 22.

Department of Computer Science & Engineering, Texas A&M University, College Station, TX 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-018-2456-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251179PMC
November 2018

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

J Chem Inf Model 2018 10 12;58(10):2085-2091. Epub 2018 Sep 12.

Department of Chemistry , Texas A&M University , P.O. Box 30012, College Station , Texas 77842 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.8b00417DOI Listing
October 2018

Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

Chembiochem 2018 08 10;19(15):1590-1594. Epub 2018 Jun 10.

Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708-0346, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201800124DOI Listing
August 2018

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

PLoS Pathog 2018 03 5;14(3):e1006939. Epub 2018 Mar 5.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854444PMC
March 2018

Altered Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

Front Microbiol 2018 19;9:494. Epub 2018 Mar 19.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.00494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867343PMC
March 2018

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis.

ACS Infect Dis 2018 02 16;4(2):123-134. Epub 2017 Nov 16.

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf , Universitätsstraße 1, 40225 Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsinfecdis.7b00055DOI Listing
February 2018

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2018 01 7;108:96-98. Epub 2017 Nov 7.

TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854369PMC
January 2018

Susceptibility of Mycobacterium tuberculosis Cytochrome Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome .

Antimicrob Agents Chemother 2017 10 22;61(10). Epub 2017 Sep 22.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Cape Town, South Africa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01338-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610507PMC
October 2017

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis .

Antimicrob Agents Chemother 2017 09 24;61(9). Epub 2017 Aug 24.

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01205-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571309PMC
September 2017

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Nat Commun 2017 09 19;8(1):588. Epub 2017 Sep 19.

African Health Research Institute (AHRI), Nelson R. Mandela School of Medicine, K-RITH Tower Building, Level 3, 719 Umbilo Road, Durban, 4001, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-00721-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605632PMC
September 2017

Statistical analysis of genetic interactions in Tn-Seq data.

Nucleic Acids Res 2017 Jun;45(11):e93

Department of Computer Science, Texas A&M University, College Station, TX 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkx128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499643PMC
June 2017

Introduction to selected papers from the 8th International Conference on Bioinformatics and Computational Biology (BICOB 2016).

J Bioinform Comput Biol 2017 06 1;15(3):1702002. Epub 2017 Jun 1.

3 Department of Computer Science, University of Houston Clear Lake, Houston, TX 77058, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0219720017020024DOI Listing
June 2017

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in .

Proc Natl Acad Sci U S A 2017 03 6;114(11):E2225-E2232. Epub 2017 Mar 6.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1617655114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358392PMC
March 2017

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.

J Clin Microbiol 2016 10 20;54(10):2498-502. Epub 2016 Jul 20.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035431PMC
http://dx.doi.org/10.1128/JCM.01196-16DOI Listing
October 2016

Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2016 08 22;60(8):4590-9. Epub 2016 Jul 22.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00753-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958187PMC
August 2016

Normalization of transposon-mutant library sequencing datasets to improve identification of conditionally essential genes.

J Bioinform Comput Biol 2016 06 14;14(3):1642004. Epub 2016 Jan 14.

1 Department of Computer Science, Texas A&M University, College Station, Texas 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S021972001642004XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654600PMC
June 2016

Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction.

Mol Genet Genomic Med 2016 May 4;4(3):322-43. Epub 2016 Mar 4.

Department of Biochemistry and Biophysics Texas A&M University College Station Texas 77843.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867566PMC
May 2016

Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum.

Antimicrob Agents Chemother 2016 Feb 16;60(2):735-43. Epub 2015 Nov 16.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01370-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750710PMC
February 2016

RNA sequencing for transcript 5'-end mapping in mycobacteria.

Methods Mol Biol 2015 ;1285:31-45

Department of Immunology and Infectious Diseases, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 20115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2450-9_3DOI Listing
December 2015

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

Tuberculosis (Edinb) 2015 Dec 19;95(6):689-694. Epub 2015 Oct 19.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2015.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667687PMC
December 2015

Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

J Bacteriol 2015 Dec 14;198(4):720-30. Epub 2015 Dec 14.

Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.00696-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751807PMC
December 2015

Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.

Methods Mol Biol 2015 ;1279:79-95

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2398-4_6DOI Listing
October 2015

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):13087-92. Epub 2015 Oct 5.

Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, MA 02115; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1514135112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620856PMC
October 2015

TRANSIT--A Software Tool for Himar1 TnSeq Analysis.

PLoS Comput Biol 2015 Oct 8;11(10):e1004401. Epub 2015 Oct 8.

Department of Computer Science, Texas A&M University, College Station, Texas, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1004401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598096PMC
October 2015

High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.

Stem Cells 2015 Aug 12;33(8):2509-22. Epub 2015 May 12.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1983DOI Listing
August 2015

A novel antimycobacterial compound acts as an intracellular iron chelator.

Antimicrob Agents Chemother 2015 Apr 2;59(4):2256-64. Epub 2015 Feb 2.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.05114-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356758PMC
April 2015

High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria.

PLoS One 2013 12;8(11):e77844. Epub 2013 Nov 12.

Emerging Health Technologies Platform, Council for Scientific and Industrial Research, Biosciences Unit, Pretoria, Gauteng, South Africa ; KwaZulu-Natal Research Institute for Tuberculosis and Human Immunodeficiency Virus, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827053PMC
September 2014

A multifaceted secondary structure mimic based on piperidine-piperidinones.

Angew Chem Int Ed Engl 2014 Apr 3;53(14):3594-8. Epub 2014 Mar 3.

Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77841-3012 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201400927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019009PMC
April 2014

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.

Nat Med 2014 Jan 15;20(1):75-9. Epub 2013 Dec 15.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947310PMC
January 2014

Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS).

Org Biomol Chem 2013 Nov 14;11(44):7789-801. Epub 2013 Oct 14.

Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77842, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3ob41848kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862180PMC
November 2013

A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data.

BMC Bioinformatics 2013 Oct 8;14:303. Epub 2013 Oct 8.

Department of Computer Science, Texas A&M University, College Station, TX 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2105-14-303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854130PMC
October 2013

Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.

MBio 2013 Sep 17;4(5):e00475-13. Epub 2013 Sep 17.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.00475-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781833PMC
September 2013

Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.

J Biol Chem 2013 Jun 26;288(25):18473-83. Epub 2013 Apr 26.

Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M113.466912
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.466912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689989PMC
June 2013

Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.

Bioinformatics 2013 Mar 29;29(6):695-703. Epub 2013 Jan 29.

Department of Computer Science, Texas A&M University, College Station, TX 77843, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btt043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597147PMC
March 2013

A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

Open Biol 2013 Feb 13;3(2):120175. Epub 2013 Feb 13.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, University of Cape Town, Observatory, Cape Town 7925, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.120175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603451PMC
February 2013

Exploring key orientations at protein-protein interfaces with small molecule probes.

J Am Chem Soc 2013 Jan 27;135(1):167-73. Epub 2012 Dec 27.

Department of Chemistry, Texas A & M University, Box 30012, College Station, Texas 77842, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja3067258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551583PMC
January 2013

Reannotation of translational start sites in the genome of Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2013 Jan 26;93(1):18-25. Epub 2012 Dec 26.

Department of Computer Science and Engineering, Texas A&M University, College Station, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2012.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582765PMC
January 2013

Global assessment of genomic regions required for growth in Mycobacterium tuberculosis.

PLoS Pathog 2012 Sep 27;8(9):e1002946. Epub 2012 Sep 27.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1002946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460630PMC
September 2012

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.

PLoS Pathog 2011 Sep 29;7(9):e1002251. Epub 2011 Sep 29.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1002251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182942PMC
September 2011

Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.

J Am Chem Soc 2011 Aug 22;133(32):12350-3. Epub 2011 Jul 22.

Department of Chemistry and Laboratory for Molecular Simulation, Texas A&M University, Box 30012, College Station, Texas 77842, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja2033734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154983PMC
August 2011

The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery.

Adv Protein Chem Struct Biol 2009 28;77:41-76. Epub 2009 Nov 28.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S187616230977003
Publisher Site
http://dx.doi.org/10.1016/S1876-1623(09)77003-8DOI Listing
November 2010

Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

Antimicrob Agents Chemother 2010 Sep 21;54(9):3776-82. Epub 2010 Jun 21.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00453-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935018PMC
September 2010

Structural genomics approach to drug discovery for Mycobacterium tuberculosis.

Curr Opin Microbiol 2009 Jun 28;12(3):318-25. Epub 2009 May 28.

Department of Computer Science and Engineering, Texas A&M University, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mib.2009.04.006DOI Listing
June 2009

Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.

Protein Sci 2008 Dec 24;17(12):2134-44. Epub 2008 Sep 24.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1110/ps.038125.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590921PMC
December 2008

Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.

J Med Chem 2008 Oct 9;51(19):5984-92. Epub 2008 Sep 9.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm800328v
Publisher Site
http://dx.doi.org/10.1021/jm800328vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610488PMC
October 2008

The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.

Acta Crystallogr D Biol Crystallogr 2008 Jun 14;64(Pt 6):627-35. Epub 2008 May 14.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444908007105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631106PMC
June 2008

Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.

Protein Sci 2008 Jan 27;17(1):159-70. Epub 2007 Nov 27.

Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843-2128, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1110/ps.073192208
Publisher Site
http://dx.doi.org/10.1110/ps.073192208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144582PMC
January 2008

Crystallographic protein model-building on the web.

Bioinformatics 2007 Feb 30;23(3):375-7. Epub 2006 Nov 30.

Department of Computer Science, Texas A&M University, 301 H.R. Bright Building, College Station, TX 77843-3112, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btl584DOI Listing
February 2007

Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building.

Acta Crystallogr D Biol Crystallogr 2006 Nov 18;62(Pt 11):1401-6. Epub 2006 Oct 18.

Texas A&M Center for Structural Biology, Institute for Biosciences and Technology, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444906034019DOI Listing
November 2006

Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.

Acta Crystallogr D Biol Crystallogr 2006 Sep 19;62(Pt 9):1012-21. Epub 2006 Aug 19.

Department of Computer Science, Texas A and M University, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444906023158DOI Listing
September 2006

Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography.

Proc IEEE Comput Syst Bioinform Conf 2004 :255-65

Department of Computer Science, Texas A&M University, USA.

View Article

Download full-text PDF

Source
July 2006

Determining relevant features to recognize electron density patterns in x-ray protein crystallography.

J Bioinform Comput Biol 2005 Jun;3(3):645-76

Department of Computer Science, Texas A&M University, 301 H.R. Bright Building, College Station TX 77843-3112, USA.

View Article

Download full-text PDF

Source
June 2005