Thomas Hielscher

Thomas Hielscher

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Thomas Hielscher

Publications by authors named "Thomas Hielscher"

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How to evaluate agreement between quantitative measurements.

Radiother Oncol 2019 Dec 25;141:321-326. Epub 2019 Sep 25.

Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.radonc.2019.09.004DOI Listing
December 2019

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.

Nat Microbiol 2019 Nov 4. Epub 2019 Nov 4.

Schaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41564-019-0594-3DOI Listing
November 2019

Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.

Leukemia 2019 Nov 11. Epub 2019 Nov 11.

Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41375-019-0634-2DOI Listing
November 2019

cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma.

J Neurooncol 2019 Nov 28. Epub 2019 Nov 28.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03348-zDOI Listing
November 2019

Susceptibility-weighted imaging in malignant melanoma brain metastasis.

J Magn Reson Imaging 2019 Oct 21;50(4):1251-1259. Epub 2019 Feb 21.

Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jmri.26692DOI Listing
October 2019

The effect of gender-specific invitation letters on utilization of colorectal cancer screening.

Z Gastroenterol 2019 Sep 16;57(9):1051-1058. Epub 2019 Sep 16.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1055/a-0958-2874DOI Listing
September 2019

Salvage therapy versus upfront autologous stem cell transplantation in multiple myeloma patients with progressive disease after first-line induction therapy.

Leuk Lymphoma 2019 Aug 19:1-10. Epub 2019 Aug 19.

Department of Hematology, Oncology and Rheumatology, University Hospital of Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.1080/10428194.2019.1646905DOI Listing
August 2019

Marginal variable screening for survival endpoints.

Biom J 2019 Aug 26. Epub 2019 Aug 26.

Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/bimj.201800269DOI Listing
August 2019

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin.

Carcinogenesis 2019 Jul;40(6):715-723

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/carcin/bgz059DOI Listing
July 2019

Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.

Mol Cell Biol 2019 Jul 27;39(14). Epub 2019 Jun 27.

Schaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany

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http://dx.doi.org/10.1128/MCB.00553-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597885PMC
July 2019

Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses.

J Invest Dermatol 2019 Jul 2. Epub 2019 Jul 2.

Department of Pediatrics, University of Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.06.134DOI Listing
July 2019

Micronucleus formation in human cancer cells is biased by chromosome size.

Genes Chromosomes Cancer 2019 06 17;58(6):392-395. Epub 2019 Jan 17.

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22707DOI Listing
June 2019

SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia.

Leukemia 2019 03 15;33(3):795-799. Epub 2018 Oct 15.

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

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http://www.nature.com/articles/s41375-018-0287-6
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http://dx.doi.org/10.1038/s41375-018-0287-6DOI Listing
March 2019

Cytogenetic abnormalities in monoclonal gammopathy of undetermined significance.

Leukemia 2018 12 6;32(12):2717-2719. Epub 2018 Jul 6.

Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0202-1DOI Listing
December 2018

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.

Int J Radiat Oncol Biol Phys 2018 12 31;102(5):1472-1480. Epub 2018 Jul 31.

Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.2004DOI Listing
December 2018

Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 16;5(5):e480. Epub 2018 Jul 16.

Department of Neuroradiology (K.K.-J., D.S., M.B., M.O.B.), University Hospital Heidelberg, Im Neuenheimer Feld 400; Neurology Clinic (B.W., R.D., W.W.), University Hospital Heidelberg, Im Neuenheimer Feld 400; Division of Biostatistics (T.H.), German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280; and Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Consortium, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053940PMC
September 2018

Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas.

Eur J Nucl Med Mol Imaging 2018 07 7;45(9):1573-1584. Epub 2018 May 7.

Division of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00259-018-4009-0DOI Listing
July 2018

Toward an integrated map of genetic interactions in cancer cells.

Mol Syst Biol 2018 02 21;14(2):e7656. Epub 2018 Feb 21.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820685PMC
http://dx.doi.org/10.15252/msb.20177656DOI Listing
February 2018

Invitation letters increase participation in colorectal cancer screening - results from an observational study.

Z Gastroenterol 2017 Dec 6;55(12):1307-1312. Epub 2017 Dec 6.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1055/s-0043-121347DOI Listing
December 2017

Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.

Oncotarget 2017 Dec 24;8(65):109201-109216. Epub 2017 Nov 24.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.22648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752514PMC
December 2017

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.

Int J Colorectal Dis 2017 Apr 28;32(4):575-582. Epub 2016 Nov 28.

Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Universitätsmedizin Mannheim, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00384-016-2717-0DOI Listing
April 2017

Risk Factors for Local Recurrence of Large, Flat Colorectal Polyps after Endoscopic Mucosal Resection.

Digestion 2016 7;93(4):311-7. Epub 2016 Jun 7.

Divisions of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1159/000446364DOI Listing
March 2017

Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.

Cell Death Dis 2017 03 2;8(3):e2635. Epub 2017 Mar 2.

Department of Pediatric Hematology, Oncology and SCT, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, Berlin 13353, Germany.

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http://dx.doi.org/10.1038/cddis.2017.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386552PMC
March 2017

Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients.

J Neurol 2017 Feb 1;264(2):341-349. Epub 2016 Dec 1.

Department of Neuroradiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00415-016-8353-3DOI Listing
February 2017

Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.

Am J Hematol 2016 Nov 3;91(11):E473-E477. Epub 2016 Sep 3.

Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ajh.24533DOI Listing
November 2016

Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism.

Int J Cancer 2016 10 7;139(8):1776-87. Epub 2016 Jul 7.

DKFZ Junior Group Brain Tumor Translational Targets, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.30234DOI Listing
October 2016

Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma.

J Neurooncol 2016 09 15;129(3):533-539. Epub 2016 Jul 15.

Neurology Clinic & National Center for Tumor Disease, University of Heidelberg and German Cancer Research Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-016-2206-xDOI Listing
September 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

Molecular driver alterations and their clinical relevance in cancer of unknown primary site.

Oncotarget 2016 Jul;7(28):44322-44329

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.10035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190099PMC
July 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1.

Viruses 2016 05 19;8(5). Epub 2016 May 19.

Research Program Infection, Inflammation and Cancer, Division of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/v8050138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885093PMC
May 2016

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
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http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

Transcriptional profiling of dendritic cells matured in different osmolarities.

Genom Data 2016 Mar 26;7:64-6. Epub 2015 Nov 26.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany; Institute of Pathology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.gdata.2015.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778600PMC
March 2016

The chemokines CCR1 and CCRL2 have a role in colorectal cancer liver metastasis.

Tumour Biol 2016 Feb 18;37(2):2461-71. Epub 2015 Sep 18.

Toxicology and Chemotherapy Unit, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s13277-015-4089-4DOI Listing
February 2016

The renal microenvironment modifies dendritic cell phenotype.

Kidney Int 2016 Jan 4;89(1):82-94. Epub 2016 Jan 4.

Department of Cellular and Molecular Pathology, Heidelberg, Germany; Institute of Pathology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1038/ki.2015.292DOI Listing
January 2016

Frequent co-occurrence of high-grade dysplasia in large flat colonic polyps (>20 mm) and synchronous polyps.

BMC Gastroenterol 2015 Jul 10;15:82. Epub 2015 Jul 10.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

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http://dx.doi.org/10.1186/s12876-015-0312-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498525PMC
July 2015

Metastasis-related processes show various degrees of activation in different stages of pancreatic cancer rat liver metastasis.

Oncol Res Treat 2014 11;37(9):464-70. Epub 2014 Jul 11.

Toxicology and Chemotherapy Unit, G401, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000365496DOI Listing
May 2015

Appearance of monoclonal plasma cell diseases in whole-body magnetic resonance imaging and correlation with parameters of disease activity.

Int J Cancer 2014 Nov 17;135(10):2380-6. Epub 2014 Apr 17.

Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany; Department of Radiology, German Cancer Research Center (dkfz), Heidelberg, Germany.

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http://doi.wiley.com/10.1002/ijc.28877
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http://dx.doi.org/10.1002/ijc.28877DOI Listing
November 2014

Riproximin's activity depends on gene expression and sensitizes PDAC cells to TRAIL.

Cancer Biol Ther 2014 Sep 11;15(9):1185-97. Epub 2014 Jun 11.

Toxicology and Chemotherapy Unit; German Cancer Research Center (DKFZ); Heidelberg, Germany.

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http://dx.doi.org/10.4161/cbt.29503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128861PMC
September 2014

Patients with cancer of unknown primary: a retrospective analysis of 223 patients with adenocarcinoma or undifferentiated carcinoma.

Dtsch Arztebl Int 2014 Jul;111(27-28):481-7

Department of Internal Medicine V: Hematology, Oncology and Rheumatology, Heidelberg University Hospital.

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http://dx.doi.org/10.3238/arztebl.2014.0481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187410PMC
July 2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1904DOI Listing
May 2014

Cell competition is a tumour suppressor mechanism in the thymus.

Nature 2014 May 14;509(7501):465-70. Epub 2014 May 14.

Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13317DOI Listing
May 2014

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis.

Int J Cancer 2014 Feb 2;134(3):703-16. Epub 2013 Sep 2.

Division of Tumor Virology, Program Infection and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, Heidelberg, Germany; Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.28386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232887PMC
February 2014

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):409-14. Epub 2013 Dec 23.

German Cancer Consortium, Clinical Cooperation Units Neurooncology and Neuropathology, Helmholtz Group Experimental Neuroimmunology, Small Animal Imaging Facility, Biostatistics, and Functional Proteome Analysis, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1314469111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890826PMC
January 2014

Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load.

J Clin Oncol 2013 Dec 21;31(34):4325-32. Epub 2013 Oct 21.

Kai Neben, Anna Jauch, Jens Hillengass, Nicola Lehners, Martin Granzow, Marc S. Raab, and Anthony D. Ho, University of Heidelberg; Thomas Hielscher, German Cancer Research Center; and Anja Seckinger, Hartmut Goldschmidt, and Dirk Hose,University of Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2012.48.4923DOI Listing
December 2013

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma.

Childs Nerv Syst 2013 Aug 16;29(8):1253-62. Epub 2013 May 16.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00381-013-2142-4DOI Listing
August 2013

Epigenetic Silencing of DKK3 in medulloblastoma.

Int J Mol Sci 2013 Apr 8;14(4):7492-505. Epub 2013 Apr 8.

Department of Experimental Medicine (DIMES), University of Genoa-IRCCS A.O.U. San Martino-IST National Cancer Research Institute, Genoa 16132, Italy.

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http://dx.doi.org/10.3390/ijms14047492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645699PMC
April 2013

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.08.024DOI Listing
October 2012

A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR.

Epigenetics 2012 Jul 1;7(7):772-80. Epub 2012 Jul 1.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://www.tandfonline.com/doi/abs/10.4161/epi.20299
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http://dx.doi.org/10.4161/epi.20299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414395PMC
July 2012