Publications by authors named "Thomas Helm"

62 Publications

Consider drug induced pemphigus before establishing a diagnosis of paraneoplastic pemphigus (PNP).

Int Immunopharmacol 2021 Oct 18;99:107967. Epub 2021 Jul 18.

The Hershey Medical Center Department of Dermatology, Hershey, PA, United States.

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http://dx.doi.org/10.1016/j.intimp.2021.107967DOI Listing
October 2021

Melanoma arising in a persistent nevus: Melanoma where 'pseudomelanoma' is expected.

JAAD Case Rep 2021 Jun 3;12:5-7. Epub 2021 Apr 3.

Department of Dermatology, Hershey Medical Center, Hershey, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2021.03.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102720PMC
June 2021

Note to dermatopathologists: When it comes to moderately atypical nevi, leave the treatment plan to clinicians.

J Am Acad Dermatol 2019 06 15;80(6):e169. Epub 2019 Jan 15.

Department of Dermatology, Penn State Hershey Medical Center, Hershey, Pennsylvania; Department of Pathology, Penn State Hershey Medical Center, Hershey, Pennsylvania.

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http://dx.doi.org/10.1016/j.jaad.2018.12.063DOI Listing
June 2019

Eroded plaque on the lower lip.

Cutis 2017 Jul;100(1):E1-E3

Buffalo Medical Group, New York, and the Department of Dermatology, State University of New York at Buffalo, USA.

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July 2017

Partial biopsies and persistent nevi: Communicate clearly and proceed with caution.

J Am Acad Dermatol 2017 09;77(3):e83

Department of Dermatology, Penn State Hershey Medical Center, Hershey, Pennsylvania; Department of Pathology, Penn State Hershey Medical Center, Hershey, Pennsylvania.

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http://dx.doi.org/10.1016/j.jaad.2017.04.1139DOI Listing
September 2017

Spitz Nevus Intermingling With Hemangioma, Angiomatoid Spitz Nevus, Angiotropism, and Vascular Co-option Viewed With Differing Availability Heuristics.

Am J Dermatopathol 2018 06;40(6):465-467

Department of Dermatology, Buffalo Medical Group, Williamsville, NY Mr. Klaus Helm is now with the Departments of Dermatology and Pathology, Penn State Health Hershey Medical Center, Hershey, PA.

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http://dx.doi.org/10.1097/DAD.0000000000000870DOI Listing
June 2018

Mohs micrographic surgery and secondary intention healing of a plantar melanoma in-situ.

Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.

University at Buffalo, Jacobs School of Medicine, Department of Dermatology, Buffalo, New York.

This report details an acral melanoma in-situ on theright plantar foot that was successfully treated withMohs micrographic surgery and secondary intentionwound healing.
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February 2017

Immunomodulation, alemtuzumab associated dermatitis and the histology of drug-induced exanthems.

J Cutan Pathol 2017 04 6;44(4):405-406. Epub 2017 Feb 6.

Departments of Dermatology and Allergy, Buffalo Medical Group, Williamsville, New York.

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http://dx.doi.org/10.1111/cup.12888DOI Listing
April 2017

Mitotic figures and the evolving staging of melanoma.

Authors:
Thomas N Helm

J Cutan Pathol 2017 04 14;44(4):358-359. Epub 2017 Feb 14.

Jacobs School of Medicine, State University of New York at Buffalo, Williamsville, New York.

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http://dx.doi.org/10.1111/cup.12913DOI Listing
April 2017

Firm plaques and nodules over the body.

Cutis 2015 Jun;95(6):E21-3

Buffalo Medical Group, Department of Dermatopathology, 6225 Sheridan Dr, Ste 208, Bldg B, Williamsville, NY 14221, USA.

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June 2015

Friable nodule on the back.

Cutis 2015 Mar;95(3):E8-11

325 Essjay Rd, Williamsville, NY 14221, USA.

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March 2015

Localized argyria with pseudo-ochronosis.

Cutis 2015 Jan;95(1):20, 29-31

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January 2015

Microvessel density, lymphovascular density, and lymphovascular invasion in primary cutaneous melanoma-correlation with histopathologic prognosticators and BRAF status.

Hum Pathol 2015 Feb 26;46(2):304-12. Epub 2014 Nov 26.

Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118. Electronic address:

The relationship between microvessel density (MVD), lymphovascular density (LVD), and lymphovascular invasion (LVI) in primary cutaneous melanoma (PCM) remains unclear. Given this, a total of 102 PCMs were assessed for MVD (vascular endothelial growth factor receptor 2 and Endocan), LVD (D2-40), and LVI (immunostaining with D2-40/S-100 and hematoxylin and eosin); tumoral S-100A13, vascular endothelial growth factor receptor 2, and Endocan; and BRAF status. LVD was associated with MVD (P = .01). MVD was higher in PCMs with depth greater than or equal to 2 mm and ulceration (P = .04, .05), whereas LVD was higher in PCMs with depth greater than or equal to 2 mm and mitoses (P = .03, .02). After adjusting for MVD and LVD, only ulceration was associated with LVI (P < .02). A BRAF mutation was seen in 30.4% cases, and when present, both LVD and host response (P = .0008 and .04, respectively) were significantly associated with MVD. Immunostaining with S-100A13 was noted in 99% of cases and a significant association noted only with ulceration (P = .05). Immunostaining increased LVI positivity (46.5% versus 4.9% by hematoxylin and eosin, P < .0001). MVD and LVD are not associated with LVI, appear to be closely related with each other, and are associated with select markers of poor prognosticative value. The association between a host response and LVD and MVD in PCMs with a BRAF mutation suggests that they exhibit potential for strategizing immunotherapies.
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http://dx.doi.org/10.1016/j.humpath.2014.11.006DOI Listing
February 2015

Rapidly enlarging noduloulcerative lesions. Lues maligna.

Cutis 2014 Sep;94(3):E20-2

1314 N Macomb St, Monroe, MI 48162, USA.

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September 2014

Breslow thickness determined with the use of immunohistochemical techniques could provide misleading information when used with prognostic models based on data obtained by conventional means.

Am J Dermatopathol 2014 Sep;36(9):757

*State University of New York, Buffalo, NY †Hershey Medical Center of the Penn State University.

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http://dx.doi.org/10.1097/DAD.0b013e318293f3dcDOI Listing
September 2014

What is your diagnosis? Calciphylaxis.

Cutis 2014 Jul;94(1):12, 26-8

131 Biomedical Education Building, Buffalo, NY 14214, USA.

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July 2014

Addressing overdiagnosis and overtreatment in cancer.

Lancet Oncol 2014 Jul;15(8):e307

American Society for Mohs Surgery, Huntington Beach, CA, USA.

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http://dx.doi.org/10.1016/S1470-2045(14)70295-5DOI Listing
July 2014

Wells syndrome.

Cutis 2014 Jan;93(1):17, 38-9

SUNY Upstate Medical School, 4 Fiore Cir, Latham, NY 12110, USA.

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January 2014

Superficial plantar fibromatosis.

Cutis 2013 Nov;92(5):220, 225, 226

Dermatopathology Laboratory, 6255 Sheridan Dr, Building B, Ste 208, Williamsville, NY 14221, USA.

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November 2013

An infant with atrophic and wrinkled abdominal skin.

JAMA Dermatol 2014 Feb;150(2):197-8

Department of Dermatology, State University of New York at Buffalo, Buffalo.

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http://dx.doi.org/10.1001/jamadermatol.2013.5721DOI Listing
February 2014

The presentation, pathology, and current management strategies of cutaneous metastasis.

N Am J Med Sci 2013 Sep;5(9):499-504

Department of Dermatology, Roswell Park Cancer Institute, University at Buffalo, Buffalo, New York, USA.

Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on skin metastasis regarding recent trends in clinical presentation and diagnosis of the most common cutaneous lesions. An extensive literature review was conducted using PubMed from May 26, 2011 to July 16, 2013 relating cutaneous metastases. Articles chosen for reference were queried with the following prompts: "Cutaneous metastases", "clinical presentation", "histological features", and "immunohistochemistry". Further searches included "treatment" and "management" options for "metastatic breast", "metastatic colorectal", "metastatic melanoma", "metastatic lung", and "hematologic cancers." We also reviewed the literature on the current management of melanoma as a model for all cutaneous metastatic disease. Our own clinical findings are presented and compared to the literature. Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses. Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions. We review these notable findings and developments regarding skin metastases for the general dermatologist.
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http://dx.doi.org/10.4103/1947-2714.118918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818821PMC
September 2013

What is your diagnosis? Hansen disease (leprosy).

Cutis 2013 Oct;92(4):168, 187-9

Buffalo Medical Group, PC, 6255 Sheridan Dr, Ste 208, Williamsville, NY 14221, USA.

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October 2013

A rapidly growing crusted nodule on the lip.

Cleve Clin J Med 2013 Apr;80(4):222-4

Department of Dermatopathology, Buffalo Medical Group, 6225 Sheridan Drive, Suite 208, Building B, Williamsville, NY 14221, USA.

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http://dx.doi.org/10.3949/ccjm.80a.12050DOI Listing
April 2013

Patterns of skin metastases: a review of 25 years' experience at a single cancer center.

Int J Dermatol 2014 Jan 22;53(1):56-60. Epub 2013 Feb 22.

Department of Dermatology, University at Buffalo, Roswell Park Cancer Institute, Buffalo, NY, USA.

Background: Skin metastases can be defined as the spread of a tumor from its site of primary origin to the skin. Skin metastasis may be the first sign of advanced cancer or an indicator of cancer recurrence.

Objectives: To review patient data of 401 skin metastases available from our institution and compare this information to previously published studies.

Methods: Patient data from the Cancer Registry at RPCI database was reviewed for skin metastasis using vendor software. We included all cases of carcinoma, melanoma, sarcomas, and hematologic malignancies entered during a 25-year period from January 4, 1985, to March 1, 2010. Data identifying the relationship of tumor incidence, morphology, and skin metastasis was reviewed. A total of 401 patients who had skin metastases at the time of cancer diagnosis or had skin metastases as a recurrent site were included in this study. Extensive literature review was conducted using PubMed for articles relating to skin metastases and its clinical presentation and histological features.

Results: Breast cancer was the most common cancer to metastasize to the skin (32.7% of all skin metastases seen) followed by bronchus and lung (13.2%), skin (melanoma; 9.5%), lymph nodes (7.5%), oral cavity/pharynx/larynx (6.2%), blood and bone marrow (5.5%), and colorectal (4.2%). The most common histological types of tumors were identified as adenocarcinoma (infiltrating ductal carcinoma [22.7%]), lobular carcinoma (4.7%), and non-adenocarcinoma (squamous cell carcinoma [12.2%] and malignant melanoma [5.2%]).

Conclusions: This is the largest review of skin metastases in the United States in the past 25 years. We found the primary cancers that metastasize to the skin have changed in frequency from previous studies. Our data are helpful in indicating which cancers have the strongest predilection for skin metastasis. Identification of these cancers can help both the clinician and patient detect early signs of metastases, which may allow for earlier diagnosis, implementation of therapy, and possible prolonged survival.
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http://dx.doi.org/10.1111/j.1365-4632.2012.05635.xDOI Listing
January 2014

Clinical stage of Merkel cell carcinoma and survival are not associated with Breslow thickness of biopsied tumor.

Dermatol Surg 2012 Aug 27;38(8):1351-6. Epub 2012 Mar 27.

Massachusetts General Hospital, Department of Dermatology, Boston, Massachusetts, USA.

Background: Merkel cell carcinoma (MCC) is an aggressive malignancy that often presents on the skin with concurrent metastatic disease.

Objective: To determine whether Breslow thickness of biopsied MCC correlates with clinical disease stage.

Materials And Methods: We performed a retrospective review of clinical data and histopathology specimens from 34 individuals with MCC treated at the Roswell Park Cancer Institute for whom complete clinical information and histopathology specimens were available.

Results: There was no correlation between Breslow thickness of biopsied MCC on the head and neck or body and clinical stage of disease, progression-free survival, or overall survival. Hence, thin MCCs should not be taken to represent lesions with less-aggressive clinical behavior.

Conclusion: Our findings validate the current practice of staging all newly diagnosed MCC, irrespective of size or Breslow thickness.
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http://dx.doi.org/10.1111/j.1524-4725.2012.02398.xDOI Listing
August 2012

Canine melanoma: a comparison with human pigmented epithelioid melanocytoma.

Int J Dermatol 2011 Dec;50(12):1542-5

State University of New York at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1111/j.1365-4632.2011.04965.xDOI Listing
December 2011

What is your diagnosis? Tinea nigra.

Cutis 2011 May;87(5):229, 232

Buffalo Medical Group, New York, USA.

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May 2011
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