Thomas Hankemeier

Thomas Hankemeier

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Thomas Hankemeier

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Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.

Cell Rep 2019 Nov;29(7):1767-1777.e8

School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Division of Microbiology, National University of Galway, Galway, Ireland; APC Microbiome Ireland, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856723PMC
November 2019

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro.

J Vis Exp 2019 Nov 6(153). Epub 2019 Nov 6.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center.

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http://dx.doi.org/10.3791/59678DOI Listing
November 2019

Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

J Pharmacol Exp Ther 2019 Oct 1;371(1):15-24. Epub 2019 Aug 1.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (R.C.v.W., E.H.J.K., V.K., T.K., A.C.H., T.H., P.H.v.d.G.) and Animal Sciences and Health, Institute of Biology Leiden (A.O., H.P.S.), Leiden University, Leiden, The Netherlands; and Certara QSP, Canterbury, United Kingdom (P.H.v.d.G.)

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http://dx.doi.org/10.1124/jpet.119.260299DOI Listing
October 2019

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.

CPT Pharmacometrics Syst Pharmacol 2019 Oct 15. Epub 2019 Oct 15.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12469DOI Listing
October 2019

Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species.

Metabolites 2019 Oct 11;9(10). Epub 2019 Oct 11.

Leibniz Institute of Plant Biochemistry, Bioinformatics and Scientific Data, Weinberg 3, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/metabo9100222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835487PMC
October 2019

Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics.

Electrophoresis 2019 09 2;40(18-19):2309-2320. Epub 2019 May 2.

Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1002/elps.201900126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767474PMC
September 2019

CE-MS for anionic metabolic profiling: An overview of methodological developments.

Electrophoresis 2019 09 4;40(18-19):2349-2359. Epub 2019 Jun 4.

Biomedical Microscale Analytics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.201900115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771621PMC
September 2019

Integration of three-phase microelectroextraction sample preparation into capillary electrophoresis.

J Chromatogr A 2019 Sep 26:460570. Epub 2019 Sep 26.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2300 RA Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.chroma.2019.460570DOI Listing
September 2019

Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biomass-Limited Samples.

Methods Mol Biol 2019 ;1972:165-172

Biomedical Microscale Analytics, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-9213-3_11DOI Listing
August 2019

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum.

Sci Rep 2019 Aug 26;9(1):12370. Epub 2019 Aug 26.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-48876-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710273PMC
August 2019

LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

J Chromatogr A 2019 Jul 31:460413. Epub 2019 Jul 31.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.460413DOI Listing
July 2019

Plasma lipid profiling of tissue-specific insulin resistance in human obesity.

Int J Obes (Lond) 2019 05 21;43(5):989-998. Epub 2018 Sep 21.

Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://www.nature.com/articles/s41366-018-0189-8
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http://dx.doi.org/10.1038/s41366-018-0189-8DOI Listing
May 2019

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

J Ind Microbiol Biotechnol 2019 Mar 7;46(3-4):483-492. Epub 2019 Feb 7.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10295-019-02140-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403205PMC
March 2019

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Alzheimers Dement 2019 Feb 15;15(2):232-244. Epub 2018 Oct 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454538PMC
February 2019

Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain.

CPT Pharmacometrics Syst Pharmacol 2019 Feb 24;8(2):107-117. Epub 2019 Jan 24.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389346PMC
February 2019

Automated microfluidic cell culture of stem cell derived dopaminergic neurons.

Sci Rep 2019 Feb 11;9(1):1796. Epub 2019 Feb 11.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1038/s41598-018-34828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370836PMC
February 2019

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Sci Rep 2019 Feb 15;9(1):2149. Epub 2019 Feb 15.

Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-019-38530-w
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http://dx.doi.org/10.1038/s41598-019-38530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609PMC
February 2019

Role of amino acids in rheumatoid arthritis studied by metabolomics.

Int J Rheum Dis 2019 Jan 22;22(1):38-46. Epub 2017 Mar 22.

Analytical BioSciences, LACDR, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/1756-185X.13062DOI Listing
January 2019

Utility of sheathless capillary electrophoresis-mass spectrometry for metabolic profiling of limited sample amounts.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 6;1105:10-14. Epub 2018 Dec 6.

Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.12.004DOI Listing
January 2019

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

AAPS J 2018 12 18;21(1):11. Epub 2018 Dec 18.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Room number 0.2.11, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-018-0278-6DOI Listing
December 2018

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

J Bacteriol 2018 10 24;200(20). Epub 2018 Sep 24.

Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands

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http://jb.asm.org/lookup/doi/10.1128/JB.00290-18
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http://dx.doi.org/10.1128/JB.00290-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153666PMC
October 2018

Global testing of shifts in metabolic phenotype.

Metabolomics 2018 10 4;14(10):139. Epub 2018 Oct 4.

Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1435-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208751PMC
October 2018

The influence of neuronal electrical activity on the mammalian central clock metabolome.

Metabolomics 2018 09 17;14(10):122. Epub 2018 Sep 17.

Department of Cellular and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1423-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153692PMC
September 2018

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Anal Chim Acta 2018 Aug 3;1020:62-75. Epub 2018 Mar 3.

Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183029
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http://dx.doi.org/10.1016/j.aca.2018.02.055DOI Listing
August 2018

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Obesity (Silver Spring) 2018 08 1;26(8):1332-1337. Epub 2018 Aug 1.

Department of Medicine, Division of Endocrinology Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/oby.22245DOI Listing
August 2018

Fusing metabolomics data sets with heterogeneous measurement errors.

PLoS One 2018 26;13(4):e0195939. Epub 2018 Apr 26.

Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919515PMC
July 2018

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Anal Bioanal Chem 2018 Apr 2;410(10):2551-2568. Epub 2018 Mar 2.

Department of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s00216-018-0912-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857282PMC
April 2018

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Sci Rep 2018 02 27;8(1):3688. Epub 2018 Feb 27.

LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Sylviusweg72, 2333BE, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-22074-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829193PMC
February 2018

Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

Oncotarget 2018 Jan 11;9(2):2028-2034. Epub 2017 Dec 11.

Leiden Academic Centre for Drug Research, Faculty of Mathematics and Natural Sciences, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.23175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788618PMC
January 2018

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Eur J Pharm Sci 2017 Nov 11;109S:S15-S21. Epub 2017 May 11.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.018DOI Listing
November 2017

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Eur J Pharm Sci 2017 Nov 12;109S:S32-S38. Epub 2017 May 12.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.027DOI Listing
November 2017

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Diabetes 2017 11 28;66(11):2915-2926. Epub 2017 Aug 28.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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http://dx.doi.org/10.2337/db17-0199DOI Listing
November 2017

Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission.

J Photochem Photobiol B 2017 Oct 7;175:291-296. Epub 2017 Sep 7.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.09.002DOI Listing
October 2017

Blood-based metabolic signatures in Alzheimer's disease.

Alzheimers Dement (Amst) 2017 6;8:196-207. Epub 2017 Sep 6.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607205PMC
September 2017

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Sci Rep 2017 08 8;7(1):7558. Epub 2017 Aug 8.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-07980-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548787PMC
August 2017

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

PLoS One 2016 9;11(6):e0157035. Epub 2016 Jun 9.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900660PMC
July 2017

Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism.

Sci Rep 2017 04 27;7(1):1229. Epub 2017 Apr 27.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-01229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430737PMC
April 2017

Feasibility of ultra-performance liquid chromatography-ion mobility-time-of-flight mass spectrometry in analyzing oxysterols.

J Chromatogr A 2017 Mar 18;1487:147-152. Epub 2017 Jan 18.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.01.039DOI Listing
March 2017

Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response.

J Photochem Photobiol B 2017 Mar 22;168:1-11. Epub 2017 Jan 22.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300, RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands; SU BioMedicine, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Changchun University of Chinese Medicine, No. 1035, Boshuo Rd, Jingyue Economic Development District, Changchun 130117, China.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.01.018DOI Listing
March 2017

Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis.

J Photochem Photobiol B 2017 Mar 3;168:98-106. Epub 2017 Feb 3.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.12.036DOI Listing
March 2017

Next-generation capillary electrophoresis-mass spectrometry approaches in metabolomics.

Curr Opin Biotechnol 2017 02 22;43:1-7. Epub 2016 Jul 22.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2016.07.002DOI Listing
February 2017

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis.

Cephalalgia 2017 Jan 30;37(1):49-63. Epub 2016 Sep 30.

1 Department of Neurology, Leiden University Medical Centre, the Netherlands.

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http://dx.doi.org/10.1177/0333102415625614DOI Listing
January 2017

Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine.

J Photochem Photobiol B 2017 Jan 17;166:86-93. Epub 2016 Nov 17.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands; SU BioMedicine, Utrechtseweg 48, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.11.013DOI Listing
January 2017

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Zebrafish 2016 12 15;13(6):504-510. Epub 2016 Sep 15.

1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/zeb.2016.1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745PMC
December 2016

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Metabolomics 2017 19;13(1). Epub 2016 Dec 19.

Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-016-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165030PMC
December 2016

A novel method for serum lipoprotein profiling using high performance capillary isotachophoresis.

Anal Chim Acta 2016 Nov 5;944:57-69. Epub 2016 Oct 5.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Faculty of Science, Universiteit Leiden, Einsteinweg 55, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.aca.2016.09.038DOI Listing
November 2016

Tracking biochemical changes correlated with ultra-weak photon emission using metabolomics.

J Photochem Photobiol B 2016 Oct 25;163:237-45. Epub 2016 Aug 25.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine/Center for Photonics of Living Systems, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.08.030DOI Listing
October 2016

Sheathless Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biological Samples.

J Vis Exp 2016 10 1(116). Epub 2016 Oct 1.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University;

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http://dx.doi.org/10.3791/54535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092098PMC
October 2016

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Europace 2016 Sep 25;18(9):1383-90. Epub 2015 Oct 25.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Halsted 565, Baltimore, MD 21287, USA

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http://dx.doi.org/10.1093/europace/euv342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006959PMC
September 2016

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

Mediators Inflamm 2015 29;2015:543541. Epub 2015 Oct 29.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; Sino-Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; TNO Innovation for Life, P.O. Box 360, 3700 AJ Zeist, Netherlands.

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http://dx.doi.org/10.1155/2015/543541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641941PMC
September 2016

Delayed luminescence: an experimental protocol for Chinese herbal medicines.

Luminescence 2016 Sep 28;31(6):1220-8. Epub 2016 Jan 28.

Sino Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/bio.3094DOI Listing
September 2016

Effects of growth altitude on chemical constituents and delayed luminescence properties in medicinal rhubarb.

J Photochem Photobiol B 2016 Sep 11;162:24-33. Epub 2016 Jun 11.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, No. 6 Wangjing Zhonghuan South Street, Chaoyang District, Beijing 100102, China. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2016.06.018DOI Listing
September 2016

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Anal Bioanal Chem 2016 Sep 12;408(23):6307-19. Epub 2016 Jul 12.

Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-016-9742-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009176PMC
September 2016

Metabolomics enables precision medicine: "A White Paper, Community Perspective".

Metabolomics 2016;12(10):149. Epub 2016 Sep 2.

Psychiatry and Behavioral Sciences, Duke Internal Medicine and Duke Institute for Brain Sciences and Center for Applied Genomics and Precision Medicine, Duke University Medical Center, Box 3903, Durham, NC 27710 USA.

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http://dx.doi.org/10.1007/s11306-016-1094-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009152PMC
September 2016

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry.

Am J Med Genet B Neuropsychiatr Genet 2016 07 23;171(5):719-32. Epub 2016 Feb 23.

Department of Biological Psychology, VU Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.b.32435DOI Listing
July 2016

Bacterial surface layer proteins as a novel capillary coating material for capillary electrophoretic separations.

Anal Chim Acta 2016 Jun 8;923:89-100. Epub 2016 Apr 8.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Universiteit Leiden, Einsteinweg 55, 2300, RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.aca.2016.04.005DOI Listing
June 2016

Metabolic characterization of the natural progression of chronic hepatitis B.

Genome Med 2016 06 10;8(1):64. Epub 2016 Jun 10.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Wytemaweg 80, Room Na-1011, 3015, CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13073-016-0318-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902991PMC
June 2016

Electroextraction and electromembrane extraction: Advances in hyphenation to analytical techniques.

Electrophoresis 2016 05 31;37(9):1170-86. Epub 2016 Mar 31.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/elps.201500530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071742PMC
May 2016

Sheathless capillary electrophoresis-mass spectrometry for anionic metabolic profiling.

Electrophoresis 2016 Apr 15;37(7-8):1007-14. Epub 2015 Dec 15.

Leiden Academic Center for Drug Research, Division of Analytical Biosciences, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.201500435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064653PMC
April 2016

A Chinese literature overview on ultra-weak photon emission as promising technology for studying system-based diagnostics.

Complement Ther Med 2016 Apr 2;25:20-6. Epub 2016 Jan 2.

Sino Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Leiden University, LACDR, Department of Analytical Biosciences, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO Innovation for Life, P.O. Box 360, 3700 AJ, Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.ctim.2015.12.015DOI Listing
April 2016

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Dis Markers 2015 4;2015:857108. Epub 2015 Jun 4.

Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, Netherlands.

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http://dx.doi.org/10.1155/2015/857108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471382PMC
February 2016

Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Anal Bioanal Chem 2016 Jan 28;408(1):97-105. Epub 2015 Oct 28.

Merck and Co., Inc, Merck Research Laboratories, Kenilworth, NJ, 07033, USA.

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http://dx.doi.org/10.1007/s00216-015-9105-4DOI Listing
January 2016

Microfluidic 3D cell culture: from tools to tissue models.

Curr Opin Biotechnol 2015 Dec 19;35:118-26. Epub 2015 Jun 19.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2015.05.002DOI Listing
December 2015

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

J Am Heart Assoc 2015 Oct 26;4(10):e002203. Epub 2015 Oct 26.

Duke University Medical Center, Durham, NC (A.G., R.K.D.) Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC (R.K.D.) Duke Institute for Brain Sciences, Duke University, Durham, NC (R.K.D.) Institute of Genome Science and Policy, Durham, NC (R.K.D.).

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http://dx.doi.org/10.1161/JAHA.115.002203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845113PMC
October 2015

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture.

Lab Chip 2015 Jun;15(11):2419-28

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg.

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http://xlink.rsc.org/?DOI=C5LC00180C
Publisher Site
http://dx.doi.org/10.1039/c5lc00180cDOI Listing
June 2015

Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.

Anal Chem 2015 Jun 27;87(12):5921-9. Epub 2015 May 27.

†Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.

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http://dx.doi.org/10.1021/ac504268yDOI Listing
June 2015