Publications by authors named "Thomas Hankemeier"

100Publications

Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis.

Anesth Analg 2020 Oct 26. Epub 2020 Oct 26.

From the Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1213/ANE.0000000000005228DOI Listing
October 2020

High-Throughput Fractionation Coupled to Mass Spectrometry for Improved Quantitation in Metabolomics.

Anal Chem 2020 11 15;92(21):14330-14338. Epub 2020 Oct 15.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden 2333 CC, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.0c01375DOI Listing
November 2020

Numerical Representations of Metabolic Systems.

Anal Chem 2020 10 9;92(20):13614-13621. Epub 2020 Oct 9.

Analytical Biosciences, LACDR, Leiden University, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.9b05613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581014PMC
October 2020

Metabolic response of blood vessels to TNFα.

Elife 2020 08 4;9. Epub 2020 Aug 4.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

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http://dx.doi.org/10.7554/eLife.54754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476757PMC
August 2020

Atypical Spirotetronate Polyketides Identified in the Underexplored Genus .

J Org Chem 2020 Aug 31;85(16):10648-10657. Epub 2020 Jul 31.

Department of Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

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http://dx.doi.org/10.1021/acs.joc.0c01210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497648PMC
August 2020

Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening.

Int J Mol Sci 2020 Jul 7;21(13). Epub 2020 Jul 7.

Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333ZA Leiden, The Netherlands.

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http://dx.doi.org/10.3390/ijms21134804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370283PMC
July 2020

Harmonization of quality metrics and power calculation in multi-omic studies.

Nat Commun 2020 06 18;11(1):3092. Epub 2020 Jun 18.

Microbiology and Cell Science Department, Institute for Food and Agricultural Research, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1038/s41467-020-16937-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303201PMC
June 2020

CE-MS metabolic profiling of volume-restricted plasma samples from an acute mouse model for epileptic seizures to discover potentially involved metabolomic features.

Talanta 2020 Sep 1;217:121107. Epub 2020 May 1.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2020.121107DOI Listing
September 2020

Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes.

Transl Res 2020 08 11;222:17-27. Epub 2020 May 11.

University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2020.04.010DOI Listing
August 2020

Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis.

J Mol Med (Berl) 2020 05 20;98(5):751-760. Epub 2020 Apr 20.

Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00109-020-01907-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220886PMC
May 2020

Profiling nucleotides in low numbers of mammalian cells by sheathless CE-MS in positive ion mode: Circumventing corona discharge.

Electrophoresis 2020 03 13;41(5-6):360-369. Epub 2020 Jan 13.

Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.201900417DOI Listing
March 2020

Ebola Hemorrhagic Shock Syndrome-on-a-Chip.

iScience 2020 Jan 12;23(1):100765. Epub 2019 Dec 12.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333 CC, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.100765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941864PMC
January 2020

Beyond the Randomized Clinical Trial: Innovative Data Science to Close the Pediatric Evidence Gap.

Clin Pharmacol Ther 2020 04 22;107(4):786-795. Epub 2020 Jan 22.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cpt.1744DOI Listing
April 2020

Electromembrane Extraction of Highly Polar Compounds: Analysis of Cardiovascular Biomarkers in Plasma.

Metabolites 2019 Dec 18;10(1). Epub 2019 Dec 18.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/metabo10010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022788PMC
December 2019

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro.

J Vis Exp 2019 11 6(153). Epub 2019 Nov 6.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center.

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http://dx.doi.org/10.3791/59678DOI Listing
November 2019

Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.

Cell Rep 2019 11;29(7):1767-1777.e8

School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Division of Microbiology, National University of Galway, Galway, Ireland; APC Microbiome Ireland, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856723PMC
November 2019

Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species.

Metabolites 2019 Oct 11;9(10). Epub 2019 Oct 11.

Leibniz Institute of Plant Biochemistry, Bioinformatics and Scientific Data, Weinberg 3, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/metabo9100222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835487PMC
October 2019

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.

CPT Pharmacometrics Syst Pharmacol 2019 12 15;8(12):904-912. Epub 2019 Oct 15.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930857PMC
December 2019

Integration of three-phase microelectroextraction sample preparation into capillary electrophoresis.

J Chromatogr A 2020 Jan 26;1610:460570. Epub 2019 Sep 26.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2300 RA Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.chroma.2019.460570DOI Listing
January 2020

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum.

Sci Rep 2019 08 26;9(1):12370. Epub 2019 Aug 26.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-48876-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710273PMC
August 2019

LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

J Chromatogr A 2019 Dec 31;1608:460413. Epub 2019 Jul 31.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.460413DOI Listing
December 2019

Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

J Pharmacol Exp Ther 2019 10 1;371(1):15-24. Epub 2019 Aug 1.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (R.C.v.W., E.H.J.K., V.K., T.K., A.C.H., T.H., P.H.v.d.G.) and Animal Sciences and Health, Institute of Biology Leiden (A.O., H.P.S.), Leiden University, Leiden, The Netherlands; and Certara QSP, Canterbury, United Kingdom (P.H.v.d.G.)

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http://dx.doi.org/10.1124/jpet.119.260299DOI Listing
October 2019

CE-MS for anionic metabolic profiling: An overview of methodological developments.

Electrophoresis 2019 09 4;40(18-19):2349-2359. Epub 2019 Jun 4.

Biomedical Microscale Analytics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/elps.201900115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771621PMC
September 2019

Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics.

Electrophoresis 2019 09 2;40(18-19):2309-2320. Epub 2019 May 2.

Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1002/elps.201900126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767474PMC
September 2019

Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biomass-Limited Samples.

Methods Mol Biol 2019 ;1972:165-172

Biomedical Microscale Analytics, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-9213-3_11DOI Listing
August 2019

The influence of neuronal electrical activity on the mammalian central clock metabolome.

Metabolomics 2018 09 17;14(10):122. Epub 2018 Sep 17.

Department of Cellular and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1423-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153692PMC
September 2018

Global testing of shifts in metabolic phenotype.

Metabolomics 2018 10 4;14(10):139. Epub 2018 Oct 4.

Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1435-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208751PMC
October 2018

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Sci Rep 2019 02 15;9(1):2149. Epub 2019 Feb 15.

Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-019-38530-w
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http://dx.doi.org/10.1038/s41598-019-38530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609PMC
February 2019

Automated microfluidic cell culture of stem cell derived dopaminergic neurons.

Sci Rep 2019 02 11;9(1):1796. Epub 2019 Feb 11.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1038/s41598-018-34828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370836PMC
February 2019

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

J Ind Microbiol Biotechnol 2019 Mar 7;46(3-4):483-492. Epub 2019 Feb 7.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10295-019-02140-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403205PMC
March 2019

Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain.

CPT Pharmacometrics Syst Pharmacol 2019 02 24;8(2):107-117. Epub 2019 Jan 24.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389346PMC
February 2019

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

AAPS J 2018 12 18;21(1):11. Epub 2018 Dec 18.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Room number 0.2.11, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-018-0278-6DOI Listing
December 2018

Utility of sheathless capillary electrophoresis-mass spectrometry for metabolic profiling of limited sample amounts.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 6;1105:10-14. Epub 2018 Dec 6.

Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.12.004DOI Listing
January 2019

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Alzheimers Dement 2019 02 15;15(2):232-244. Epub 2018 Oct 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454538PMC
February 2019

Plasma lipid profiling of tissue-specific insulin resistance in human obesity.

Int J Obes (Lond) 2019 05 21;43(5):989-998. Epub 2018 Sep 21.

Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://www.nature.com/articles/s41366-018-0189-8
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http://dx.doi.org/10.1038/s41366-018-0189-8DOI Listing
May 2019

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Obesity (Silver Spring) 2018 08 1;26(8):1332-1337. Epub 2018 Aug 1.

Department of Medicine, Division of Endocrinology Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/oby.22245DOI Listing
August 2018

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

J Bacteriol 2018 10 24;200(20). Epub 2018 Sep 24.

Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands

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http://jb.asm.org/lookup/doi/10.1128/JB.00290-18
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http://dx.doi.org/10.1128/JB.00290-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153666PMC
October 2018

Fusing metabolomics data sets with heterogeneous measurement errors.

PLoS One 2018 26;13(4):e0195939. Epub 2018 Apr 26.

Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919515PMC
July 2018

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Anal Chim Acta 2018 Aug 3;1020:62-75. Epub 2018 Mar 3.

Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183029
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http://dx.doi.org/10.1016/j.aca.2018.02.055DOI Listing
August 2018

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Anal Bioanal Chem 2018 Apr 2;410(10):2551-2568. Epub 2018 Mar 2.

Department of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s00216-018-0912-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857282PMC
April 2018

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Sci Rep 2018 02 27;8(1):3688. Epub 2018 Feb 27.

LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Sylviusweg72, 2333BE, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-22074-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829193PMC
February 2018

Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

Oncotarget 2018 Jan 11;9(2):2028-2034. Epub 2017 Dec 11.

Leiden Academic Centre for Drug Research, Faculty of Mathematics and Natural Sciences, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.23175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788618PMC
January 2018

Blood-based metabolic signatures in Alzheimer's disease.

Alzheimers Dement (Amst) 2017 6;8:196-207. Epub 2017 Sep 6.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607205PMC
September 2017

Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission.

J Photochem Photobiol B 2017 Oct 7;175:291-296. Epub 2017 Sep 7.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.09.002DOI Listing
October 2017

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Diabetes 2017 11 28;66(11):2915-2926. Epub 2017 Aug 28.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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http://dx.doi.org/10.2337/db17-0199DOI Listing
November 2017

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Sci Rep 2017 08 8;7(1):7558. Epub 2017 Aug 8.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-07980-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548787PMC
August 2017

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Eur J Pharm Sci 2017 Nov 12;109S:S32-S38. Epub 2017 May 12.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.027DOI Listing
November 2017

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Eur J Pharm Sci 2017 Nov 11;109S:S15-S21. Epub 2017 May 11.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.018DOI Listing
November 2017

Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism.

Sci Rep 2017 04 27;7(1):1229. Epub 2017 Apr 27.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-01229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430737PMC
April 2017

Role of amino acids in rheumatoid arthritis studied by metabolomics.

Int J Rheum Dis 2019 Jan 22;22(1):38-46. Epub 2017 Mar 22.

Analytical BioSciences, LACDR, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/1756-185X.13062DOI Listing
January 2019

Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis.

J Photochem Photobiol B 2017 Mar 3;168:98-106. Epub 2017 Feb 3.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.12.036DOI Listing
March 2017

Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response.

J Photochem Photobiol B 2017 Mar 22;168:1-11. Epub 2017 Jan 22.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300, RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands; SU BioMedicine, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Changchun University of Chinese Medicine, No. 1035, Boshuo Rd, Jingyue Economic Development District, Changchun 130117, China.

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http://dx.doi.org/10.1016/j.jphotobiol.2017.01.018DOI Listing
March 2017

Feasibility of ultra-performance liquid chromatography-ion mobility-time-of-flight mass spectrometry in analyzing oxysterols.

J Chromatogr A 2017 Mar 18;1487:147-152. Epub 2017 Jan 18.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.01.039DOI Listing
March 2017

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Metabolomics 2017 19;13(1). Epub 2016 Dec 19.

Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-016-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165030PMC
December 2016

Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine.

J Photochem Photobiol B 2017 Jan 17;166:86-93. Epub 2016 Nov 17.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA, The Netherlands; Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands; SU BioMedicine, Utrechtseweg 48, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.jphotobiol.2016.11.013DOI Listing
January 2017

A novel method for serum lipoprotein profiling using high performance capillary isotachophoresis.

Anal Chim Acta 2016 Nov 5;944:57-69. Epub 2016 Oct 5.

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Faculty of Science, Universiteit Leiden, Einsteinweg 55, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.aca.2016.09.038DOI Listing
November 2016

Sheathless Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biological Samples.

J Vis Exp 2016 10 1(116). Epub 2016 Oct 1.

Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University;

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http://dx.doi.org/10.3791/54535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092098PMC
October 2016