Thomas H Mosley

Thomas H Mosley

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Thomas H Mosley

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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Authors:
Paul S de Vries Michael R Brown Amy R Bentley Yun J Sung Thomas W Winkler Ioanna Ntalla Karen Schwander Aldi T Kraja Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Xuan Deng Rajkumar Dorajoo Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Evangelos Evangelou Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Joseph H Lee Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Muhammad Riaz M Abdullah Said Robert A Scott Tamar Sofer Alena Stančáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Yajuan Wang Erin B Ware Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Christie Ballantyne Eric Boerwinkle Ulrich Broeckel Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Ulf de Faire Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Jingzhong Ding Anna F Dominiczak Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul Virginia Fisher Terrence Forrester Oscar H Franco Yechiel Friedlander Mohsen Ghanbari Franco Giulianini Hans J Grabe Megan L Grove C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson Barbara V Howard M Arfan Ikram David R Jacobs Craig Johnson Jost Bruno Jonas Candace M Kammerer Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Heikki A Koistinen Ivana Kolcic Charles Kooperberg Jose E Krieger Steve B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Rozenn N Lemaitre Yize Li Jingjing Liang Jianjun Liu Kiang Liu Marie Loh Tin Louie Reedik Mägi Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Thomas H Mosley Kenneth J Mukamal Mike A Nalls Matthias Nauck Christopher P Nelson Nona Sotoodehnia Jeff R O'Connell Nicholette D Palmer Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Leslie J Raffel Olli T Raitakari Alex P Reiner Treva K Rice Stephen S Rich Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Nicholas Tan Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Diana van Heemst Dragana Vuckovic Melanie Waldenberger Lihua Wang Yujie Wang Zhe Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Markku Laakso Karin Leander Terho Lehtimäki Patrik K E Magnusson Brenda Penninx Alexandre C Pereira Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Wei Zheng Paul Elliott Kari E North Claude Bouchard Michele K Evans Vilmundur Gudnason Ching-Ti Liu Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Sharon L R Kardia Xiaofeng Zhu Charles N Rotimi Dennis O Mook-Kanamori Myriam Fornage Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Jingmin Liu Jerome I Rotter W James Gauderman Michael A Province Patricia B Munroe Kenneth Rice Daniel I Chasman L Adrienne Cupples Dabeeru C Rao Alanna C Morrison

Am J Epidemiol 2019 Jun;188(6):1033-1054

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.

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https://academic.oup.com/aje/advance-article/doi/10.1093/aje
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http://dx.doi.org/10.1093/aje/kwz005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545280PMC
June 2019

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jun 3. Epub 2019 Jun 3.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
June 2019

Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture.

Neurobiol Learn Mem 2019 05 4;161:106-114. Epub 2019 Apr 4.

Department of Pathology, University Mississippi Medical Center, Jackson, MS 39216, United States; Program in Neuroscience, University Mississippi Medical Center, Jackson, MS 39216, United States; Department of Psychiatry and Human Behavior, University Mississippi Medical Center, Jackson, MS 39216, United States; Department of Pharmacology and Toxicology, University Mississippi Medical Center, Jackson, MS 39216, United States; Memory Impairment and Neurodegenerative Dementia Center, University Mississippi Medical Center, Jackson, MS 39216, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2019.03.012DOI Listing
May 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:
Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2019 May 1;10(1):2068. Epub 2019 May 1.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1038/s41467-019-10160-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494826PMC
May 2019

A prospective study of serum metabolites and risk of ischemic stroke.

Neurology 2019 Apr 13;92(16):e1890-e1898. Epub 2019 Mar 13.

From the Brown Foundation Institute of Molecular Medicine, McGovern Medical School (D.S., X.J., M.F.), and School of Public Health (B.Y., E.B., M.F.), The University of Texas Health Science Center at Houston; Institute for Stroke and Dementia Research (S.T., M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; Johns Hopkins University School of Medicine (R.F.G.), Baltimore, MD; The University of Mississippi Medical Center (T.H.M.), Jackson; German Center for Neurodegenerative Diseases (DZNE, Munich) (M.D.); and Munich Cluster for Systems Neurology (SyNergy) (S.T., M.D.), Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550501PMC
April 2019

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Authors:
Yun Ju Sung Lisa de Las Fuentes Thomas W Winkler Daniel I Chasman Amy R Bentley Aldi T Kraja Ioanna Ntalla Helen R Warren Xiuqing Guo Karen Schwander Alisa K Manning Michael R Brown Hugues Aschard Mary F Feitosa Nora Franceschini Yingchang Lu Ching-Yu Cheng Xueling Sim Dina Vojinovic Jonathan Marten Solomon K Musani Tuomas O Kilpeläinen Melissa A Richard Stella Aslibekyan Traci M Bartz Rajkumar Dorajoo Changwei Li Yongmei Liu Tuomo Rankinen Albert Vernon Smith Salman M Tajuddin Bamidele O Tayo Wei Zhao Yanhua Zhou Nana Matoba Tamar Sofer Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Franco Giulianini Anuj Goel Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Candace M Kammerer Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Wen-Jane Lee Keng-Hung Lin Jian'an Luan Leo-Pekka Lyytikäinen Colin A McKenzie Christopher P Nelson Raymond Noordam Robert A Scott Wayne H H Sheu Alena Stančáková Fumihiko Takeuchi Peter J van der Most Tibor V Varga Robert J Waken Heming Wang Yajuan Wang Erin B Ware Stefan Weiss Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Tamuno Alfred Najaf Amin Dan E Arking Tin Aung R Graham Barr Lawrence F Bielak Eric Boerwinkle Erwin P Bottinger Peter S Braund Jennifer A Brody Ulrich Broeckel Brian Cade Archie Campbell Mickaël Canouil Aravinda Chakravarti Massimiliano Cocca Francis S Collins John M Connell Renée de Mutsert H Janaka de Silva Marcus Dörr Qing Duan Charles B Eaton Georg Ehret Evangelos Evangelou Jessica D Faul Nita G Forouhi Oscar H Franco Yechiel Friedlander He Gao Bruna Gigante C Charles Gu Preeti Gupta Saskia P Hagenaars Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Albert Hofman Barbara V Howard Steven C Hunt Marguerite R Irvin Yucheng Jia Tomohiro Katsuya Joel Kaufman Nicola D Kerrison Chiea Chuen Khor Woon-Puay Koh Heikki A Koistinen Charles B Kooperberg Jose E Krieger Michiaki Kubo Zoltan Kutalik Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Joseph H Lee Benjamin Lehne Daniel Levy Cora E Lewis Yize Li Sing Hui Lim Ching-Ti Liu Jianjun Liu Jingmin Liu Yeheng Liu Marie Loh Kurt K Lohman Tin Louie Reedik Mägi Koichi Matsuda Thomas Meitinger Andres Metspalu Lili Milani Yukihide Momozawa Thomas H Mosley Mike A Nalls Ubaydah Nasri Jeff R O'Connell Adesola Ogunniyi Walter R Palmas Nicholette D Palmer James S Pankow Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek David Porteous Olli T Raitakari Frida Renström Treva K Rice Paul M Ridker Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Charumathi Sabanayagam Babatunde L Salako Kevin Sandow Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Mario Sims Colleen M Sitlani Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Melanie Waldenberger Lihua Wang Ya Xing Wang Wen Bin Wei Gregory Wilson Mary K Wojczynski Yong-Bing Xiang Jie Yao Jian-Min Yuan Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Yii-Der Ida Chen David R Weir Ulf de Faire Ian J Deary Tõnu Esko Martin Farrall Terrence Forrester Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo Lessa Horta Yi-Jen Hung Jost Bruno Jonas Norihiro Kato Jaspal S Kooner Markku Laakso Terho Lehtimäki Kae-Woei Liang Patrik K E Magnusson Albertine J Oldehinkel Alexandre C Pereira Thomas Perls Rainer Rauramaa Susan Redline Rainer Rettig Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Nicholas J Wareham Hugh Watkins Ananda R Wickremasinghe Tangchun Wu Yoichiro Kamatani Cathy C Laurie Claude Bouchard Richard S Cooper Michele K Evans Vilmundur Gudnason James Hixson Sharon L R Kardia Stephen B Kritchevsky Bruce M Psaty Rob M van Dam Donna K Arnett Dennis O Mook-Kanamori Myriam Fornage Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Ruth J F Loos Alex P Reiner Charles N Rotimi Laura J Bierut Xiaofeng Zhu L Adrienne Cupples Michael A Province Jerome I Rotter Paul W Franks Kenneth Rice Paul Elliott Mark J Caulfield W James Gauderman Patricia B Munroe Dabeeru C Rao Alanna C Morrison

Hum Mol Genet 2019 Apr 10. Epub 2019 Apr 10.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz070DOI Listing
April 2019

Neural correlates of domain-specific cognitive decline: The ARIC-NCS Study.

Neurology 2019 Mar 6;92(10):e1051-e1063. Epub 2019 Feb 6.

From the Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Radiology (M.L.S., J.L.G., C.G.S. C.R.J.), Information Technology (M.L.S., J.L.G.), and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Epidemiology (A.W., A.G., R.F.G., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Johns Hopkins University Center on Aging and Health (A.G.), Baltimore, MD; and Department of Geriatrics (T.H.M.), University of Mississippi Medical Center, Jackson.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000007042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442014PMC
March 2019

Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study.

Neurology 2019 Mar 13;92(11):e1256-e1267. Epub 2019 Feb 13.

From the Departments of Neurology (K.A.W., R.F.G.) and Epidemiology (R.F.G., A.W., A.L.G., E.S.), Johns Hopkins University, Baltimore, MD; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Medicine (T.H.M., B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.

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http://dx.doi.org/10.1212/WNL.0000000000007094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511107PMC
March 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study.

Alzheimers Dement 2019 Feb 12;15(2):273-281. Epub 2018 Oct 12.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368879PMC
February 2019

Neuroimaging findings in midlife and risk of late-life dementia over 20 years of follow-up.

Neurology 2019 Feb 18;92(9):e917-e923. Epub 2019 Jan 18.

From the Department of Preventive Medicine (N.A.W.) and Department of Medicine (B.G.W., T.H.M.), Division of Geriatrics, University of Mississippi Medical Center, Jackson; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Radiology (D.K.S.), University of Washington Medical Center, Seattle; and Division of Public Health Sciences (L.H.C.), Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1212/WNL.0000000000006989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404467PMC
February 2019

Longitudinal analysis of epigenome-wide DNA methylation reveals novel smoking-related loci in African Americans.

Epigenetics 2019 Feb 14;14(2):171-184. Epub 2019 Mar 14.

a Department of Epidemiology , School of Public Health, University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/15592294.2019.1581589DOI Listing
February 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Authors:
Tuomas O Kilpeläinen Amy R Bentley Raymond Noordam Yun Ju Sung Karen Schwander Thomas W Winkler Hermina Jakupović Daniel I Chasman Alisa Manning Ioanna Ntalla Hugues Aschard Michael R Brown Lisa de Las Fuentes Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary F Feitosa Minjung Kho Solomon K Musani Melissa Richard Heming Wang Zhe Wang Traci M Bartz Lawrence F Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando P Hartwig Andrea R V R Horimoto Changwei Li Kurt K Lohman Jonathan Marten Xueling Sim Albert V Smith Salman M Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah E Harris Meian He Fang-Chi Hsu Anne U Jackson Jing Hua Zhao Aldi T Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja M Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather M Stringham Fumihiko Takeuchi Peter J van der Most Tibor V Varga Niek Verweij Erin B Ware Wanqing Wen Xiaoyin Li Lisa R Yanek Najaf Amin Donna K Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H Janaka de Silva Paul S de Vries Ayşe Demirkan Jingzhong Ding Charles B Eaton Jessica D Faul Yechiel Friedlander Kelley P Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven C Hunt M Arfan Ikram Jost B Jonas Woon-Puay Koh Pirjo Komulainen Jose E Krieger Stephen B Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl D Langefeld Claudia Langenberg Lenore J Launer Karin Leander Rozenn N Lemaitre Cora E Lewis Jingjing Liang Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen L Mohlke Thomas H Mosley Alison D Murray Mike A Nalls Ei-Ei Khaing Nang Christopher P Nelson Sotoodehnia Nona Jill M Norris Chiamaka Vivian Nwuba Jeff O'Connell Nicholette D Palmer George J Papanicolau Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek David J Porteous Alaitz Poveda Olli T Raitakari Stephen S Rich Neil Risch Jennifer G Robinson Lynda M Rose Igor Rudan Pamela J Schreiner Robert A Scott Stephen S Sidney Mario Sims Jennifer A Smith Harold Snieder Tamar Sofer John M Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent D Taylor Michael Y Tsai Jaakko Tuomilehto André G Uitterlinden M Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden Ulf de Faire Ian J Deary Paul Elliott Tõnu Esko Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo A Lakka Terho Lehtimäki Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Nilesh J Samani Xiao-Ou Shu Pim van der Harst Jana V Van Vliet-Ostaptchouk Peter Vollenweider Lynne E Wagenknecht Ya X Wang Nicholas J Wareham David R Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele K Evans Paul W Franks Vilmundur Gudnason Caroline Hayward Bernardo L Horta Tanika N Kelly Yongmei Liu Kari E North Alexandre C Pereira Paul M Ridker E Shyong Tai Rob M van Dam Ervin R Fox Sharon L R Kardia Ching-Ti Liu Dennis O Mook-Kanamori Michael A Province Susan Redline Cornelia M van Duijn Jerome I Rotter Charles B Kooperberg W James Gauderman Bruce M Psaty Kenneth Rice Patricia B Munroe Myriam Fornage L Adrienne Cupples Charles N Rotimi Alanna C Morrison Dabeeru C Rao Ruth J F Loos

Nat Commun 2019 01 22;10(1):376. Epub 2019 Jan 22.

Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, 10029, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-08008-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342931PMC
January 2019

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.

J Alzheimers Dis 2019 ;68(2):517-521

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-180785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443418PMC
January 2019

Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults.

J Am Geriatr Soc 2018 Oct 24;66(10):1919-1926. Epub 2018 Sep 24.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://doi.wiley.com/10.1111/jgs.15470
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http://dx.doi.org/10.1111/jgs.15470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181772PMC
October 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-06234-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214PMC
September 2018

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Stroke 2018 Aug;49(8):1812-1819

From the Institute of Molecular Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (M.F., X.J.).

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http://dx.doi.org/10.1161/STROKEAHA.118.020689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202149PMC
August 2018

Left ventricular ejection time is an independent predictor of incident heart failure in a community-based cohort.

Eur J Heart Fail 2018 07 4;20(7):1106-1114. Epub 2017 Sep 4.

Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/ejhf.928DOI Listing
July 2018

A comparison of manual tracing and FreeSurfer for estimating hippocampal volume over the adult lifespan.

Hum Brain Mapp 2018 06 21;39(6):2500-2513. Epub 2018 Feb 21.

Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1002/hbm.24017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951757PMC
June 2018

Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results.

Alzheimers Dement 2018 05 18;14(5):579-589. Epub 2017 Dec 18.

Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA; Memory Impairment and Neurodegenerative Dementia (MIND) Center, The University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938099PMC
May 2018

DNA methylation in the APOE genomic region is associated with cognitive function in African Americans.

BMC Med Genomics 2018 05 8;11(1):43. Epub 2018 May 8.

Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, 4602 SPH Tower, Ann Arbor, MI, 48109-2029, USA.

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https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12920-018-0363-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941603PMC
May 2018

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2018 05 11;14(5):e1007345. Epub 2018 May 11.

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http://dx.doi.org/10.1371/journal.pgen.1007345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947884PMC
May 2018

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:
Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2018 05 29;9(1):2098. Epub 2018 May 29.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1038/s41467-018-04362-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974083PMC
May 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study.

Neurology 2018 Apr 16;90(14):e1248-e1256. Epub 2018 Mar 16.

From the Departments of Internal Medicine (T.M.H., S.C.) and Radiology (A.M.), and Division of Public Health Sciences (L.E.W.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology (G.H., P.P.), University of North Carolina at Chapel Hill; Departments of Radiology (D.W., Y.Z.) and Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (D.K.), Mayo Clinic, Rochester, MN; and Department of Medicine (T.H.M.), University of Mississippi Medical Center, Jackson.

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http://dx.doi.org/10.1212/WNL.0000000000005259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890613PMC
April 2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Authors:
Yun J Sung Thomas W Winkler Lisa de Las Fuentes Amy R Bentley Michael R Brown Aldi T Kraja Karen Schwander Ioanna Ntalla Xiuqing Guo Nora Franceschini Yingchang Lu Ching-Yu Cheng Xueling Sim Dina Vojinovic Jonathan Marten Solomon K Musani Changwei Li Mary F Feitosa Tuomas O Kilpeläinen Melissa A Richard Raymond Noordam Stella Aslibekyan Hugues Aschard Traci M Bartz Rajkumar Dorajoo Yongmei Liu Alisa K Manning Tuomo Rankinen Albert Vernon Smith Salman M Tajuddin Bamidele O Tayo Helen R Warren Wei Zhao Yanhua Zhou Nana Matoba Tamar Sofer Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Franco Giulianini Anuj Goel Sarah E Harris Fernando Pires Hartwig Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Mika Kähönen Anuradhani Kasturiratne Brigitte Kühnel Karin Leander Wen-Jane Lee Keng-Hung Lin Jian 'an Luan Colin A McKenzie He Meian Christopher P Nelson Rainer Rauramaa Nicole Schupf Robert A Scott Wayne H H Sheu Alena Stančáková Fumihiko Takeuchi Peter J van der Most Tibor V Varga Heming Wang Yajuan Wang Erin B Ware Stefan Weiss Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Tamuno Alfred Najaf Amin Dan Arking Tin Aung R Graham Barr Lawrence F Bielak Eric Boerwinkle Erwin P Bottinger Peter S Braund Jennifer A Brody Ulrich Broeckel Claudia P Cabrera Brian Cade Yu Caizheng Archie Campbell Mickaël Canouil Aravinda Chakravarti Ganesh Chauhan Kaare Christensen Massimiliano Cocca Francis S Collins John M Connell Renée de Mutsert H Janaka de Silva Stephanie Debette Marcus Dörr Qing Duan Charles B Eaton Georg Ehret Evangelos Evangelou Jessica D Faul Virginia A Fisher Nita G Forouhi Oscar H Franco Yechiel Friedlander He Gao Bruna Gigante Misa Graff C Charles Gu Dongfeng Gu Preeti Gupta Saskia P Hagenaars Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Makoto Hirata Albert Hofman Barbara V Howard Steven Hunt Marguerite R Irvin Yucheng Jia Roby Joehanes Anne E Justice Tomohiro Katsuya Joel Kaufman Nicola D Kerrison Chiea Chuen Khor Woon-Puay Koh Heikki A Koistinen Pirjo Komulainen Charles Kooperberg Jose E Krieger Michiaki Kubo Johanna Kuusisto Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Sing Hui Lim Shiow Lin Ching-Ti Liu Jianjun Liu Jingmin Liu Kiang Liu Yeheng Liu Marie Loh Kurt K Lohman Jirong Long Tin Louie Reedik Mägi Anubha Mahajan Thomas Meitinger Andres Metspalu Lili Milani Yukihide Momozawa Andrew P Morris Thomas H Mosley Peter Munson Alison D Murray Mike A Nalls Ubaydah Nasri Jill M Norris Kari North Adesola Ogunniyi Sandosh Padmanabhan Walter R Palmas Nicholette D Palmer James S Pankow Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Olli T Raitakari Frida Renström Treva K Rice Paul M Ridker Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Charumathi Sabanayagam Babatunde L Salako Kevin Sandow Carsten O Schmidt Pamela J Schreiner William R Scott Sudha Seshadri Peter Sever Colleen M Sitlani Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Melanie Waldenberger Lihua Wang Ya X Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Jian-Min Yuan Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Yii-Der Ida Chen Ulf de Faire Ian J Deary Tõnu Esko Martin Farrall Terrence Forrester Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo Lessa Horta Yi-Jen Hung Jost B Jonas Norihiro Kato Jaspal S Kooner Markku Laakso Terho Lehtimäki Kae-Woei Liang Patrik K E Magnusson Anne B Newman Albertine J Oldehinkel Alexandre C Pereira Susan Redline Rainer Rettig Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Wei Zheng Yoichiro Kamatani Cathy C Laurie Claude Bouchard Richard S Cooper Michele K Evans Vilmundur Gudnason Sharon L R Kardia Stephen B Kritchevsky Daniel Levy Jeff R O'Connell Bruce M Psaty Rob M van Dam Mario Sims Donna K Arnett Dennis O Mook-Kanamori Tanika N Kelly Ervin R Fox Caroline Hayward Myriam Fornage Charles N Rotimi Michael A Province Cornelia M van Duijn E Shyong Tai Tien Yin Wong Ruth J F Loos Alex P Reiner Jerome I Rotter Xiaofeng Zhu Laura J Bierut W James Gauderman Mark J Caulfield Paul Elliott Kenneth Rice Patricia B Munroe Alanna C Morrison L Adrienne Cupples Dabeeru C Rao Daniel I Chasman

Am J Hum Genet 2018 03 15;102(3):375-400. Epub 2018 Feb 15.

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985266PMC
March 2018

Association of midlife lipids with 20-year cognitive change: A cohort study.

Alzheimers Dement 2018 02 12;14(2):167-177. Epub 2017 Sep 12.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.07.757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803364PMC
February 2018

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study.

Clin Epigenetics 2017 14;9:21. Epub 2017 Feb 14.

Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler Street, 77030 Houston, TX USA.

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http://dx.doi.org/10.1186/s13148-016-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310061PMC
December 2017

Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study.

Alzheimers Dement 2017 Dec 16;13(12):1345-1354. Epub 2017 Jun 16.

Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723547PMC
December 2017

Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness.

J Cardiovasc Med (Hagerstown) 2017 Dec;18(12):954-961

aDivision of CardiologybDepartment of Medicine, Center for Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MississippicDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MinnesotadDepartment of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical CentereResearch Service, G.V. (Sonny) Montgomery Veterans Affairs Medical CenterfDivision of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

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http://dx.doi.org/10.2459/JCM.0000000000000549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100745PMC
December 2017

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

Am J Hum Genet 2017 Dec 30;101(6):888-902. Epub 2017 Nov 30.

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812919PMC
December 2017

Neuroimaging Correlates of Cerebral Microbleeds: The ARIC Study (Atherosclerosis Risk in Communities).

Stroke 2017 11 10;48(11):2964-2972. Epub 2017 Oct 10.

From the Departments of Neurology (J.G.R., D.S.K.) and Radiology (K.K., C.R.J., P.V.), Mayo Clinic, Rochester, MN; Department of Data Science, Gertrude Ford MIND Center (J.S., M.E.G.) and Department of Medicine (T.H.M., B.G.W.), University of Mississippi Medical Center, Jackson; Department of Neurology (M.S.A., R.F.G.), Johns Hopkins University, Baltimore, MD; and Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

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http://dx.doi.org/10.1161/STROKEAHA.117.018336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685663PMC
November 2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Authors:
Nese Direk Stephanie Williams Jennifer A Smith Stephan Ripke Tracy Air Azmeraw T Amare Najaf Amin Bernhard T Baune David A Bennett Douglas H R Blackwood Dorret Boomsma Gerome Breen Henriette N Buttenschøn Enda M Byrne Anders D Børglum Enrique Castelao Sven Cichon Toni-Kim Clarke Marilyn C Cornelis Udo Dannlowski Philip L De Jager Ayse Demirkan Enrico Domenici Cornelia M van Duijn Erin C Dunn Johan G Eriksson Tonu Esko Jessica D Faul Luigi Ferrucci Myriam Fornage Eco de Geus Michael Gill Scott D Gordon Hans Jörgen Grabe Gerard van Grootheest Steven P Hamilton Catharina A Hartman Andrew C Heath Karin Hek Albert Hofman Georg Homuth Carsten Horn Jouke Jan Hottenga Sharon L R Kardia Stefan Kloiber Karestan Koenen Zoltán Kutalik Karl-Heinz Ladwig Jari Lahti Douglas F Levinson Cathryn M Lewis Glyn Lewis Qingqin S Li David J Llewellyn Susanne Lucae Kathryn L Lunetta Donald J MacIntyre Pamela Madden Nicholas G Martin Andrew M McIntosh Andres Metspalu Yuri Milaneschi Grant W Montgomery Ole Mors Thomas H Mosley Joanne M Murabito Bertram Müller-Myhsok Markus M Nöthen Dale R Nyholt Michael C O'Donovan Brenda W Penninx Michele L Pergadia Roy Perlis James B Potash Martin Preisig Shaun M Purcell Jorge A Quiroz Katri Räikkönen John P Rice Marcella Rietschel Margarita Rivera Thomas G Schulze Jianxin Shi Stanley Shyn Grant C Sinnamon Johannes H Smit Jordan W Smoller Harold Snieder Toshiko Tanaka Katherine E Tansey Alexander Teumer Rudolf Uher Daniel Umbricht Sandra Van der Auwera Erin B Ware David R Weir Myrna M Weissman Gonneke Willemsen Jingyun Yang Wei Zhao Henning Tiemeier Patrick F Sullivan

Biol Psychiatry 2017 09 8;82(5):322-329. Epub 2016 Dec 8.

Department of Psychiatry, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Psychiatric Genomics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.biopsych.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462867PMC
September 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults.

J Gerontol A Biol Sci Med Sci 2017 Aug;72(8):1080-1086

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1093/gerona/glx081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861899PMC
August 2017

Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline.

Diabetes Care 2017 07 12;40(7):879-886. Epub 2017 May 12.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-220
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http://dx.doi.org/10.2337/dc16-2203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481977PMC
July 2017

Adiposity, Change in Adiposity, and Cognitive Decline in Mid- and Late Life.

J Am Geriatr Soc 2017 Jun 1;65(6):1282-1288. Epub 2017 Mar 1.

Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1111/jgs.14786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478448PMC
June 2017

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2017 May 12;13(5):e1006728. Epub 2017 May 12.

Epidemiology, Gilling School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446189PMC
May 2017

Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study.

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 26;174(3):269-282. Epub 2016 Oct 26.

Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1002/ajmg.b.32509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935000PMC
April 2017

Intracranial atherosclerosis and dementia: The Atherosclerosis Risk in Communities (ARIC) Study.

Neurology 2017 Apr 22;88(16):1556-1563. Epub 2017 Mar 22.

From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; Welch Center for Prevention, Epidemiology, and Clinical Research (Y.Z., R.F.G., A.M.R., E.G.), Johns Hopkins Bloomberg School of Public Health; The Russell H. Morgan Department of Radiology and Radiological Sciences (Y.Q., L.L., B.A.W.) and Department of Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (M.F.K.S.), University of Minnesota School of Medicine, Minneapolis; Department of Medicine, Division of Geriatrics (T.H.M.), The University of Mississippi School of Medicine, Jackson; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Neurology (D.S.K.), The Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000003837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395073PMC
April 2017

Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study.

J Card Fail 2017 Jan 15;23(1):47-55. Epub 2016 Nov 15.

Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, Mississippi. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219935PMC
January 2017

Heart Failure Stages Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study.

Circulation 2017 Jan 23;135(3):224-240. Epub 2016 Nov 23.

From Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.M.S., B.C., S.D.S.); Gillings School of Global Public Health (L.L., A.K.N., G.H.) and School of Medicine (P.C., C.S.), University of North Carolina, Chapel Hill; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M., J.C.); Wake Forest School of Medicine, Winston-Salem, NC (D.K.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (S.K., A.R.F.); Divisions of Geriatrics and Neurology, University of Mississippi Medical Center, Jackson (T.H.M.); and Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Washington, DC (J.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241178PMC
January 2017

A SAS macro for the joint modeling of longitudinal outcomes and multiple competing risk dropouts.

Comput Methods Programs Biomed 2017 Jan 18;138:23-30. Epub 2016 Oct 18.

Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, New Guyton Research Building G562, 2500 North State Street, Jackson, MS 39216, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmpb.2016.10.003DOI Listing
January 2017

Contemporary Assessment of Left Ventricular Diastolic Function in Older Adults: The Atherosclerosis Risk in Communities Study.

Circulation 2017 01 7;135(5):426-439. Epub 2016 Dec 7.

From Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.M.S., B.C., T.B.-S., S.C., S.D.S.); Wake Forest University School of Medicine, Winston-Salem, NC (D.K.); Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark (T.B.-S., J.S.J.); Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M.); Cardiovascular Division, (S.K.) and Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Divisions of Geriatrics and Neurology, University of Mississippi Medical Center, Jackson (T.H.M.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.D.W.); and University of North Carolina Gillings School of Global Public Health, Chapel Hill (G.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285443PMC
January 2017

Novel genetic loci associated with hippocampal volume.

Authors:
Derrek P Hibar Hieab H H Adams Neda Jahanshad Ganesh Chauhan Jason L Stein Edith Hofer Miguel E Renteria Joshua C Bis Alejandro Arias-Vasquez M Kamran Ikram Sylvane Desrivières Meike W Vernooij Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Ashley H Beecham Alexa Beiser Manon Bernard Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Qiang Chen Christopher R K Ching Vincent Chouraki Gabriel Cuellar-Partida Fabrice Crivello Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Oliver Grimm Michael E Griswold Tulio Guadalupe Boris A Gutman Johanna Hass Unn K Haukvik David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Kjetil N Jørgensen Nazanin Karbalai Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre F Marquand Mar Matarin Karen A Mather Manuel Mattheisen David R McKay Yuri Milaneschi Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Paul Nyquist Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Lukas Pirpamer Benno Pütz Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Stefan Ropele Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Arvin Saremi Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Stella Trompet Dhananjay Vaidya Jeroen Van der Grond Sven J Van der Lee Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Katharina Wittfeld Girma Woldehawariat Christiane Wolf Thomas Wolfers Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Anton J M De Craen Eco J C De Geus Philip L De Jager Greig I De Zubicaray Ian J Deary Stéphanie Debette Charles DeCarli Norman Delanty Chantal Depondt Anita DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Christian Enzinger Susanne Erk Thomas Espeseth Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Myriam Fornage Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Asta K Håberg Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Matthew Huentelman Hilleke E Hulshoff Pol Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Francis J McMahon Katie L McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Helena Schmidt Peter R Schofield Sigurdur Sigursson Andrew Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Magda Tsolaki Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad van der Lugt Nic J A van der Wee Neeltje E M Van Haren Dennis van 't Ent Marie-Jose Van Tol Badri N Vardarajan Bruno Vellas Dick J Veltman Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright Ronald H Zielke Alan B Zonderman Nicholas G Martin Cornelia M Van Duijn Margaret J Wright W T Longstreth Gunter Schumann Hans J Grabe Barbara Franke Lenore J Launer Sarah E Medland Sudha Seshadri Paul M Thompson M Arfan Ikram

Nat Commun 2017 01 18;8:13624. Epub 2017 Jan 18.

Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632PMC
January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:
Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112PMC
December 2016

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

Authors:
Pradeep Natarajan Joshua C Bis Lawrence F Bielak Amanda J Cox Marcus Dörr Mary F Feitosa Nora Franceschini Xiuqing Guo Shih-Jen Hwang Aaron Isaacs Min A Jhun Maryam Kavousi Ruifang Li-Gao Leo-Pekka Lyytikäinen Riccardo E Marioni Ulf Schminke Nathan O Stitziel Hayato Tada Jessica van Setten Albert V Smith Dina Vojinovic Lisa R Yanek Jie Yao Laura M Yerges-Armstrong Najaf Amin Usman Baber Ingrid B Borecki J Jeffrey Carr Yii-Der Ida Chen L Adrienne Cupples Pim A de Jong Harry de Koning Bob D de Vos Ayse Demirkan Valentin Fuster Oscar H Franco Mark O Goodarzi Tamara B Harris Susan R Heckbert Gerardo Heiss Udo Hoffmann Albert Hofman Ivana Išgum J Wouter Jukema Mika Kähönen Sharon L R Kardia Brian G Kral Lenore J Launer Joe Massaro Roxana Mehran Braxton D Mitchell Thomas H Mosley Renée de Mutsert Anne B Newman Khanh-Dung Nguyen Kari E North Jeffrey R O'Connell Matthijs Oudkerk James S Pankow Gina M Peloso Wendy Post Michael A Province Laura M Raffield Olli T Raitakari Dermot F Reilly Fernando Rivadeneira Frits Rosendaal Samantha Sartori Kent D Taylor Alexander Teumer Stella Trompet Stephen T Turner Andre G Uitterlinden Dhananjay Vaidya Aad van der Lugt Uwe Völker Joanna M Wardlaw Christina L Wassel Stefan Weiss Mary K Wojczynski Diane M Becker Lewis C Becker Eric Boerwinkle Donald W Bowden Ian J Deary Abbas Dehghan Stephan B Felix Vilmundur Gudnason Terho Lehtimäki Rasika Mathias Dennis O Mook-Kanamori Bruce M Psaty Daniel J Rader Jerome I Rotter James G Wilson Cornelia M van Duijn Henry Völzke Sekar Kathiresan Patricia A Peyser Christopher J O'Donnell

Circ Cardiovasc Genet 2016 Dec 21;9(6):511-520. Epub 2016 Nov 21.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418659PMC
December 2016

Associations Between Serum Inflammatory Markers and Hippocampal Volume in a Community Sample.

J Am Geriatr Soc 2016 09 22;64(9):1823-9. Epub 2016 Aug 22.

Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1111/jgs.14283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026883PMC
September 2016

Life-course blood pressure in relation to brain volumes.

Alzheimers Dement 2016 08 29;12(8):890-9. Epub 2016 Apr 29.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980244PMC
August 2016

The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE.

Neurology 2016 Aug 1;87(5):473-80. Epub 2016 Jul 1.

From the Department of Neurology (R.F.G., A.L.C.S.), Department of Radiology, Section of High-Resolution Brain PET Imaging (Y.Z., X.C., A.R., D.F.W.), and Departments of Psychiatry (D.F.W.) and Neuroscience (D.F.W.), Johns Hopkins University School of Medicine; Departments of Epidemiology (R.F.G., A.L.C.S., A.R.S.) and Environmental Health Sciences (D.F.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Departments of Radiology (E.G.) and Medicine (T.H.M.), University of Mississippi Medical Center, Jackson; Hagerstown Imaging (N.G.), MD; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and Department of Radiology (A.M.) and Division of Public Health Sciences (L.E.W.), Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1212/WNL.0000000000002914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970663PMC
August 2016

Loss-of-function variants influence the human serum metabolome.

Sci Adv 2016 08 31;2(8):e1600800. Epub 2016 Aug 31.

Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/sciadv.1600800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007069PMC
August 2016

Social support and cognition in a community-based cohort: the Atherosclerosis Risk in Communities (ARIC) study.

Age Ageing 2016 07 21;45(4):475-80. Epub 2016 Apr 21.

Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/ageing/afw060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006245PMC
July 2016

Associations Between Inflammation and Physical Function in African Americans and European Americans with Prevalent Cardiovascular Risk Factors.

J Am Geriatr Soc 2016 07 16;64(7):1448-55. Epub 2016 Jun 16.

Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1111/jgs.14229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094054PMC
July 2016

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Authors:
Ching-Ti Liu Sridharan Raghavan Nisa Maruthur Edmond Kato Kabagambe Jaeyoung Hong Maggie C Y Ng Marie-France Hivert Yingchang Lu Ping An Amy R Bentley Anne M Drolet Kyle J Gaulton Xiuqing Guo Loren L Armstrong Marguerite R Irvin Man Li Leonard Lipovich Denis V Rybin Kent D Taylor Charles Agyemang Nicholette D Palmer Brian E Cade Wei-Min Chen Marco Dauriz Joseph A C Delaney Todd L Edwards Daniel S Evans Michele K Evans Leslie A Lange Aaron Leong Jingmin Liu Yongmei Liu Uma Nayak Sanjay R Patel Bianca C Porneala Laura J Rasmussen-Torvik Marieke B Snijder Sarah C Stallings Toshiko Tanaka Lisa R Yanek Wei Zhao Diane M Becker Lawrence F Bielak Mary L Biggs Erwin P Bottinger Donald W Bowden Guanjie Chen Adolfo Correa David J Couper Dana C Crawford Mary Cushman John D Eicher Myriam Fornage Nora Franceschini Yi-Ping Fu Mark O Goodarzi Omri Gottesman Kazuo Hara Tamara B Harris Richard A Jensen Andrew D Johnson Min A Jhun Andrew J Karter Margaux F Keller Abel N Kho Jorge R Kizer Ronald M Krauss Carl D Langefeld Xiaohui Li Jingling Liang Simin Liu William L Lowe Thomas H Mosley Kari E North Jennifer A Pacheco Patricia A Peyser Alan L Patrick Kenneth M Rice Elizabeth Selvin Mario Sims Jennifer A Smith Salman M Tajuddin Dhananjay Vaidya Mary P Wren Jie Yao Xiaofeng Zhu Julie T Ziegler Joseph M Zmuda Alan B Zonderman Aeilko H Zwinderman Adebowale Adeyemo Eric Boerwinkle Luigi Ferrucci M Geoffrey Hayes Sharon L R Kardia Iva Miljkovic James S Pankow Charles N Rotimi Michele M Sale Lynne E Wagenknecht Donna K Arnett Yii-Der Ida Chen Michael A Nalls Michael A Province W H Linda Kao David S Siscovick Bruce M Psaty James G Wilson Ruth J F Loos Josée Dupuis Stephen S Rich Jose C Florez Jerome I Rotter Andrew P Morris James B Meigs

Am J Hum Genet 2016 Jul 16;99(1):56-75. Epub 2016 Jun 16.

Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005440PMC
July 2016

Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS).

Alzheimers Dement (Amst) 2016 6;3:73-82. Epub 2016 May 6.

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1016/j.dadm.2016.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925799PMC
July 2016

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

J Am Heart Assoc 2016 07 14;5(7). Epub 2016 Jul 14.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1161/JAHA.115.002603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015357PMC
July 2016