Thomas Gudermann

Thomas Gudermann

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Thomas Gudermann

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Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

Toxicol Lett 2019 Nov 17;316:119-126. Epub 2019 Sep 17.

Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2019.09.014DOI Listing
November 2019

Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.

Toxicol Lett 2019 Oct 9;314:172-180. Epub 2019 Aug 9.

Walther-Straub-Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany; Bundeswehr Medical Service Academy, 80937, Munich, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2019.07.023DOI Listing
October 2019

Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.

Arch Toxicol 2019 Sep 12. Epub 2019 Sep 12.

Bundeswehr Institute of Pharmacology and Toxicology, 80937, Munich, Germany.

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http://dx.doi.org/10.1007/s00204-019-02571-xDOI Listing
September 2019

Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.

Toxicol In Vitro 2019 Aug 16;58:245-255. Epub 2019 Mar 16.

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183081
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http://dx.doi.org/10.1016/j.tiv.2019.03.020DOI Listing
August 2019

Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6.

Mol Pharmacol 2019 Jul;96(1):90-98

Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL) (S.F., U.S., S.E., T.G., M.M.S., A.D.) and Institute for Cardiovascular Prevention (IPEK) (U.S.), Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Munich Heart Alliance, Munich, Germany (T.G., M.M.S.); and Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany (T.G., A.D.)

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http://dx.doi.org/10.1124/mol.119.115949DOI Listing
July 2019

Taste Receptors: New Players in Sperm Biology.

Int J Mol Sci 2019 Feb 22;20(4). Epub 2019 Feb 22.

Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/ijms20040967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413048PMC
February 2019

Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.

Chem Biol Interact 2019 Jan 2;298:80-85. Epub 2018 Nov 2.

Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilian-University Munich, Goethestraße 33, 80336, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183074
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http://dx.doi.org/10.1016/j.cbi.2018.10.030DOI Listing
January 2019

A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.

Chem Biol Interact 2019 Jan 28;298:121-128. Epub 2018 Nov 28.

Bundeswehr Institute of Pharmacology and Toxicology, 80937, Munich, Germany; Walther Straub Institute of Pharmacology and Toxicology, University of Munich, 80336, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.11.025DOI Listing
January 2019

TRPM7 reflected in Cryo-EMirror.

Cell Calcium 2018 12 15;76:129-131. Epub 2018 Nov 15.

Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany; German Center for Lung Research, Munich, Germany; German Centre for Cardiovascular Research, Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2018.11.004DOI Listing
December 2018

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Cell Signal 2018 11 25;51:13-22. Epub 2018 Jul 25.

Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2018.07.006DOI Listing
November 2018

Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling.

J Biol Chem 2018 11 14;293(44):17278-17290. Epub 2018 Sep 14.

From the Walther Straub Institute of Pharmacology and Toxicology, Medical Faculty, LMU Munich, Goethestrasse 33, 80336 Munich and.

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http://dx.doi.org/10.1074/jbc.RA118.004429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222112PMC
November 2018

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels.

Cells 2018 Nov 20;7(11). Epub 2018 Nov 20.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.3390/cells7110218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262340PMC
November 2018

Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.

Toxicol Lett 2018 Sep 13;293:2-8. Epub 2017 Sep 13.

Bundeswehr Institute of Pharmacology and Toxicology, 80937 Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2017.09.004DOI Listing
September 2018

Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.

Toxicol Lett 2018 Sep 14;293:133-139. Epub 2017 Sep 14.

Bundeswehr Institute of Pharmacology and Toxicology, 80937 Munich, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2017.09.008DOI Listing
September 2018

Sulfur mustard-induced epigenetic modifications over time - a pilot study.

Toxicol Lett 2018 Sep 16;293:45-50. Epub 2017 Nov 16.

Bundeswehr Institute of Pharmacology and Toxicology, 80937, Munich, Germany; Bundeswehr Medical Academy, Dept. Medical CBRN Defense, 80937, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03784274173146
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http://dx.doi.org/10.1016/j.toxlet.2017.11.010DOI Listing
September 2018

Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels.

Exp Physiol 2018 09 6;103(9):1185-1191. Epub 2018 Jul 6.

Excellence Cluster Cardiopulmonary System, German Center for Lung Research (DZL), Justus Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1113/EP087117DOI Listing
September 2018

TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia.

Pflugers Arch 2018 08 12;470(8):1231-1241. Epub 2018 May 12.

Walther Straub Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU Munich, Nußbaumstr. 26, 80336, Munich, Germany.

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http://link.springer.com/10.1007/s00424-018-2148-6
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http://dx.doi.org/10.1007/s00424-018-2148-6DOI Listing
August 2018

Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 () In Vitro.

Cells 2018 Aug 31;7(9). Epub 2018 Aug 31.

Bundeswehr Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität Munich, 80937 Munich, Germany.

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http://dx.doi.org/10.3390/cells7090126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162519PMC
August 2018

Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species.

Adv Exp Med Biol 2017 ;967:195-225

Excellence Cluster Cardio-pulmonary System, University of Giessen Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Aulweg 130, 35392, Giessen, Germany.

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http://dx.doi.org/10.1007/978-3-319-63245-2_12DOI Listing
April 2018

Role of kinase-coupled TRP channels in mineral homeostasis.

Pharmacol Ther 2018 04 9;184:159-176. Epub 2017 Nov 9.

Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany; German Center for Lung Research, Munich, Germany; German Centre for Cardiovascular Research, Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.11.003DOI Listing
April 2018

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Arterioscler Thromb Vasc Biol 2018 02 16;38(2):344-352. Epub 2017 Nov 16.

From the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.310391
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http://dx.doi.org/10.1161/ATVBAHA.117.310391DOI Listing
February 2018

PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels.

Cell Chem Biol 2018 02 21;25(2):215-223.e3. Epub 2017 Dec 21.

Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.008DOI Listing
February 2018

Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.

Arch Toxicol 2018 Jan 20;92(1):337-346. Epub 2017 Sep 20.

Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany.

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http://dx.doi.org/10.1007/s00204-017-2064-0DOI Listing
January 2018

Assessment of TRPM7 functions by drug-like small molecules.

Cell Calcium 2017 11 14;67:166-173. Epub 2017 Mar 14.

Walther-Straub Institute of Pharmacology and Toxicology, LMU, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.03.004DOI Listing
November 2017

Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases.

Cell Calcium 2017 11 26;67:123-137. Epub 2017 Apr 26.

Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU Munich, Germany.

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http://dx.doi.org/10.1016/j.ceca.2017.04.005DOI Listing
November 2017

Cell calcium special issue: Preface.

Cell Calcium 2017 11 2;67:21. Epub 2017 Aug 2.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie & PZMS, Medizinische Fakultaet, Universitaet des Saarlandes, 66421 Homburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.08.001DOI Listing
November 2017

Erratum to: Dynamic monitoring of G-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors.

Pflugers Arch 2017 09;469(9):1231-1232

Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Goethestr. 33, 80336, Munich, Germany.

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http://link.springer.com/10.1007/s00424-017-1985-z
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http://dx.doi.org/10.1007/s00424-017-1985-zDOI Listing
September 2017

Dynamic monitoring of G-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors.

Pflugers Arch 2017 06 6;469(5-6):725-737. Epub 2017 Apr 6.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Goethestr. 33, 80336, Munich, Germany.

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http://link.springer.com/10.1007/s00424-017-1975-1
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http://dx.doi.org/10.1007/s00424-017-1975-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438440PMC
June 2017

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature.

Front Immunol 2017 16;8:707. Epub 2017 Jun 16.

Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Justus Liebig University of Giessen, Giessen, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472666PMC
June 2017

N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.

Arch Toxicol 2017 May 13;91(5):2179-2189. Epub 2016 Oct 13.

Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, Goethestraße 33, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00204-016-1873-xDOI Listing
May 2017

Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.

Biochim Biophys Acta Mol Basis Dis 2017 02 6;1863(2):560-568. Epub 2016 Dec 6.

Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), University of Munich, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439163033
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http://dx.doi.org/10.1016/j.bbadis.2016.12.002DOI Listing
February 2017

S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA.

Chem Biol Interact 2017 Jan 3;262:12-18. Epub 2016 Dec 3.

Bundeswehr Institute of Pharmacology and Toxicology, 80937 Munich, Germany; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.12.002DOI Listing
January 2017

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol.

Proc Natl Acad Sci U S A 2017 01 19;114(1):E37-E46. Epub 2016 Dec 19.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1612263114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224389PMC
January 2017

Mechanosensitive G Protein-Coupled Receptors Mediate Myogenic Vasoconstriction.

Microcirculation 2016 11;23(8):621-625

Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/micc.12293DOI Listing
November 2016

Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression.

Sci Rep 2016 09 9;6:32776. Epub 2016 Sep 9.

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität., München, 80336 München, Germany.

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http://dx.doi.org/10.1038/srep32776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017209PMC
September 2016

Glucose Enhances Basal or Melanocortin-Induced cAMP-Response Element Activity in Hypothalamic Cells.

Mol Endocrinol 2016 Jul 4;30(7):748-62. Epub 2016 May 4.

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, 80336 Munich, Germany.

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http://dx.doi.org/10.1210/me.2016-1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426577PMC
July 2016

Endogenous 5-HT2C Receptors Phosphorylate the cAMP Response Element Binding Protein via Protein Kinase C-Promoted Activation of Extracellular-Regulated Kinases-1/2 in Hypothalamic mHypoA-2/10 Cells.

J Pharmacol Exp Ther 2016 07 26;358(1):39-49. Epub 2016 Apr 26.

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, München, Germany

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http://dx.doi.org/10.1124/jpet.116.232397DOI Listing
July 2016

The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.

J Cell Physiol 2016 May 16;231(5):1114-29. Epub 2015 Nov 16.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universit, ä, t M, ü, nchen, München, Germany.

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http://dx.doi.org/10.1002/jcp.25209DOI Listing
May 2016

Mibefradil represents a new class of benzimidazole TRPM7 channel agonists.

Pflugers Arch 2016 Apr 16;468(4):623-34. Epub 2015 Dec 16.

Walther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Goethestrasse 33, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00424-015-1772-7DOI Listing
April 2016

Unravelling a new mechanism linking actin polymerization and gene transcription.

Nucleus 2016 Apr 22;7(2):121-5. Epub 2016 Apr 22.

a Walther Straub Institute of Pharmacology and Toxicology , Ludwig-Maximilians-University , Munich , Germany.

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http://dx.doi.org/10.1080/19491034.2016.1171433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916864PMC
April 2016

NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

Pflugers Arch 2016 Jan 1;468(1):23-41. Epub 2015 Oct 1.

Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardiopulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Aulweg 130, 35392, Giessen, Germany.

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http://dx.doi.org/10.1007/s00424-015-1731-3DOI Listing
January 2016

Oxygen physiology: sensors and ion channels.

Pflugers Arch 2016 Jan 21;468(1):1-2. Epub 2015 Nov 21.

Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1007/s00424-015-1762-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700094PMC
January 2016

Isolation of Nicotinic Acid (Vitamin B3) and N-Propylamine after Myosmine Peroxidation.

J Agric Food Chem 2016 Jan 23;64(1):178-84. Epub 2015 Dec 23.

Walther-Straub-Institute of Pharmacology and Toxicology, University of Munich , Nussbaumstrasse 26, D-80336 Munich, Germany.

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http://dx.doi.org/10.1021/acs.jafc.5b04913DOI Listing
January 2016

Cholinergic urethral brush cells are widespread throughout placental mammals.

Int Immunopharmacol 2015 Nov 1;29(1):51-6. Epub 2015 Jun 1.

Institute for Anatomy and Cell Biology, Justus-Liebig-University, 35385 Giessen, Germany; German Center for Lung Research (DZL), Germany.

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http://dx.doi.org/10.1016/j.intimp.2015.05.038DOI Listing
November 2015

Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.

Int Immunopharmacol 2015 Nov 20;29(1):143-7. Epub 2015 Jun 20.

Institute for Anatomy and Cell Biology, Justus-Liebig-University Giessen, German Center for Lung Research, Giessen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15675769150029
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http://dx.doi.org/10.1016/j.intimp.2015.06.005DOI Listing
November 2015

A novel cholinergic epithelial cell with chemosensory traits in the murine conjunctiva.

Int Immunopharmacol 2015 Nov 26;29(1):45-50. Epub 2015 Jun 26.

Institute for Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2015.06.027DOI Listing
November 2015

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.

Sci Signal 2015 Nov 10;8(402):ra112. Epub 2015 Nov 10.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich 80336, Germany.

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http://dx.doi.org/10.1126/scisignal.aad2959DOI Listing
November 2015

Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agents.

Arch Toxicol 2015 Sep 14;89(9):1631-43. Epub 2014 Nov 14.

Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilian-University Munich, Goethestraße 33, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00204-014-1414-4DOI Listing
September 2015

Receptors, G proteins, and integration of calcium signalling.

J Mol Med (Berl) 2015 Sep;93(9):937-40

Max Delbrück Center for Molecular Medicine (MDC), Berlin-Buch, Germany.

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http://dx.doi.org/10.1007/s00109-015-1330-yDOI Listing
September 2015

AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.

Hypertension 2015 Jul 1;66(1):108-16. Epub 2015 Jun 1.

From the Walter-Brendel Centre of Experimental Medicine and Biomedical Center (H.S., K.M.S., S.B., C.-P.K., M.W., J.Q., T.F., U.P.) and Walther Straub Institute, Pharmacology (S.E., M.M.y.S., T.G.), Ludwig-Maximilians Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (H.S., K.M.S., S.B., U.P.); DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (H.S., K.M.S., S.B., T.F., M.M.y.S., T.G., U.P.); Division of Cell Signalling and Immunology, University of Dundee, Scotland, United Kingdom (D.G.H.); Institute of Vegetative Physiology, University of Cologne, Köln, Germany (L.T.L., G.P.); and Pharmacology, Toxicology and Clinical Pharmacy, Department of Pharmacy, Universität Tübingen, Tübingen, Germany (P.R.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05514DOI Listing
July 2015

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.

Mol Endocrinol 2015 Mar 13;29(3):445-59. Epub 2015 Jan 13.

Walther-Straub-Institut für Pharmakologie und Toxikologie (A.B., V.B., H.J.S., S.M., E.G., T.G.), Ludwig-Maximilians-Universität München, München, Germany 80336; and The Institute of Molecular, Cell and Systems Biology (S.J.Y.), College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow GC12 8QQ, United Kingdom.

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http://dx.doi.org/10.1210/me.2014-1300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414754PMC
March 2015

Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report.

Arterioscler Thromb Vasc Biol 2015 Jan 13;35(1):121-6. Epub 2014 Nov 13.

From the Walther Straub Institute of Pharmacology and Toxicology (U.S., S.B., T.G., M.MyS.), Ludwig Maximilians University of Munich, Munich, Germany; and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (T.G., M.MyS.), Munich, Germany.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304844
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http://dx.doi.org/10.1161/ATVBAHA.114.304844DOI Listing
January 2015

Natural and Synthetic Modulators of the TRPM7 Channel.

Cells 2014 Nov 27;3(4):1089-101. Epub 2014 Nov 27.

Walther Straub Institute of Pharmacology and Toxicology, University of Munich, Goethestrasse 33, 80336 Munich, Germany..

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http://dx.doi.org/10.3390/cells3041089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276914PMC
November 2014

RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

J Mol Cell Biol 2014 Oct 19;6(5):434-7. Epub 2014 Sep 19.

Walther Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany

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http://dx.doi.org/10.1093/jmcb/mju037DOI Listing
October 2014

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

Cells 2014 Sep 29;3(4):939-62. Epub 2014 Sep 29.

Walther-Straub-Institute for Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), School of Medicine, LM-University of Munich, Nussbaumstr. 26, 80336 Munich, Germany.

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http://dx.doi.org/10.3390/cells3040939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276908PMC
September 2014

Wnt5a/β-catenin signaling drives calcium-induced differentiation of human primary keratinocytes.

J Invest Dermatol 2014 Aug 21;134(8):2183-2191. Epub 2014 Mar 21.

Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.149DOI Listing
August 2014

Novel role of mechanosensitive AT1B receptors in myogenic vasoconstriction.

Pflugers Arch 2014 Jul 8;466(7):1343-53. Epub 2013 Oct 8.

Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Goethestr. 33, 80336, Munich, Germany.

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http://link.springer.com/10.1007/s00424-013-1372-3
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http://dx.doi.org/10.1007/s00424-013-1372-3DOI Listing
July 2014

TRPC6: physiological function and pathophysiological relevance.

Handb Exp Pharmacol 2014 ;222:157-88

Walther-Straub-Institute for Pharmacology and Toxicology, School of Medicine, LM-University of Munich, 80336, Munich, Germany,

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http://dx.doi.org/10.1007/978-3-642-54215-2_7DOI Listing
July 2014

TRPM6.

Handb Exp Pharmacol 2014 ;222:503-20

Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestrasse 33, Munich, 80336, Germany,

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http://dx.doi.org/10.1007/978-3-642-54215-2_20DOI Listing
July 2014

Pharmacology and signaling of MAS-related G protein-coupled receptors.

Pharmacol Rev 2014 Jul;66(3):570-97

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany

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http://dx.doi.org/10.1124/pr.113.008425DOI Listing
July 2014

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Mol Biol Cell 2014 Mar 22;25(6):948-64. Epub 2014 Jan 22.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians University, 81377 München, Germany Department of Pharmacy, Ludwig-Maximilians University, 81377 München, Germany Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University, 79104 Freiburg, Germany Institute for Anatomy, University of Duisburg-Essen, 45141 Essen, Germany.

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http://www.molbiolcell.org/doi/10.1091/mbc.e13-09-0523
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http://dx.doi.org/10.1091/mbc.E13-09-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952862PMC
March 2014

Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as "sweet spots" for targeted therapies.

Rev Physiol Biochem Pharmacol 2013 ;165:31-65

Rudolf Boehm-Institut für Pharmakologie und Toxikologie, Selbständige Abteilung für Klinische Pharmakologie, Universität Leipzig, Härtelstr. 16-18, Leipzig, 04107, Germany.

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http://dx.doi.org/10.1007/112_2012_10DOI Listing
February 2014

TSH induces metallothionein 1 in thyrocytes via Gq/11- and PKC-dependent signaling.

J Mol Endocrinol 2013 4;51(1):79-90. Epub 2013 Jun 4.

Medical Department III, University Hospital Aachen, D-52074 Aachen, Germany.

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http://dx.doi.org/10.1530/JME-12-0200DOI Listing
January 2014

Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells.

Chem Biol Interact 2013 Dec 30;206(3):462-71. Epub 2013 Aug 30.

Rudolf-Boehm Institute of Pharmacology and Toxicology, Clinical Pharmacology, University Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cbi.2013.08.012DOI Listing
December 2013

Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.

Am J Respir Crit Care Med 2013 Dec;188(12):1451-9

1 Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1164/rccm.201307-1252OCDOI Listing
December 2013

Optical control of TRPV1 channels.

Angew Chem Int Ed Engl 2013 Sep 19;52(37):9845-8. Epub 2013 Jul 19.

Department of Chemistry, Ludwig-Maximilians-University, Munich and Center of Integrated Protein Science, Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201302530DOI Listing
September 2013

Pro-senescence therapy for hepatocellular carcinoma.

Aging (Albany NY) 2013 Sep;5(9):639-40

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808695PMC
http://dx.doi.org/10.18632/aging.100601DOI Listing
September 2013

STIMulating stress fibers in endothelial cells.

Sci Signal 2013 Mar 19;6(267):pe8. Epub 2013 Mar 19.

Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Goethestrasse 33, D-80336 Munich, Germany.

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http://dx.doi.org/10.1126/scisignal.2004051DOI Listing
March 2013

Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells.

Biochem Pharmacol 2013 Feb 5;85(3):426-38. Epub 2012 Dec 5.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilian University, 80336 München, Germany.

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http://dx.doi.org/10.1016/j.bcp.2012.11.019DOI Listing
February 2013

Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.

J Biol Chem 2012 Nov 16;287(49):40956-71. Epub 2012 Oct 16.

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München 80336 München, Germany.

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http://dx.doi.org/10.1074/jbc.M112.408617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510799PMC
November 2012

TRPM7: a unique channel involved in magnesium homeostasis.

Int J Biochem Cell Biol 2012 Aug 24;44(8):1381-4. Epub 2012 May 24.

School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.biocel.2012.05.010DOI Listing
August 2012

Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.

J Pharmacol Exp Ther 2012 Jul 27;342(1):41-52. Epub 2012 Mar 27.

Walther-Straub-Institut of Pharmacology and Toxicology, Ludwig-Maximilians University of Munich, Goethestrasse 33, 80336 Munich, Germany.

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http://dx.doi.org/10.1124/jpet.112.192757DOI Listing
July 2012

Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells.

Mol Endocrinol 2012 Apr 23;26(4):643-54. Epub 2012 Feb 23.

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, Goethestrasse 33, 80336 München, Germany.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2011-1218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417139PMC
April 2012

G protein-mediated stretch reception.

Am J Physiol Heart Circ Physiol 2012 Mar 6;302(6):H1241-9. Epub 2012 Jan 6.

Walther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Germany.

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http://www.physiology.org/doi/10.1152/ajpheart.00818.2011
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March 2012