Thomas Graf

Thomas Graf

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Thomas Graf

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Whsc1 links pluripotency exit with mesendoderm specification.

Nat Cell Biol 2019 Jul 24;21(7):824-834. Epub 2019 Jun 24.

Center for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41556-019-0342-1DOI Listing
July 2019

Transcription Factor Stoichiometry Drives Cell Fate: Single-Cell Proteomics to the Rescue.

Authors:
Thomas Graf

Cell Stem Cell 2019 May;24(5):673-674

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.002DOI Listing
May 2019

Transcription factors and 3D genome conformation in cell-fate decisions.

Nature 2019 May 15;569(7756):345-354. Epub 2019 May 15.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://www.nature.com/articles/s41586-019-1182-7
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http://dx.doi.org/10.1038/s41586-019-1182-7DOI Listing
May 2019

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.

J Allergy Clin Immunol 2018 12 2;142(6):1793-1807. Epub 2018 Mar 2.

Department of Pulmonary Medicine, Erasmus MC Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.12.1006DOI Listing
December 2018

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.

Cell Stem Cell 2018 11 13;23(5):727-741.e9. Epub 2018 Sep 13.

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183040
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http://dx.doi.org/10.1016/j.stem.2018.08.016DOI Listing
November 2018

Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.

Methods Mol Biol 2018 ;1714:57-66

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7519-8_4DOI Listing
July 2018

OneD: increasing reproducibility of Hi-C samples with abnormal karyotypes.

Nucleic Acids Res 2018 05;46(8):e49

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain.

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http://dx.doi.org/10.1093/nar/gky064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934634PMC
May 2018

Hoxb5, a Trojan horse to generate T cells.

Nat Immunol 2018 03;19(3):210-212

Center for Genomic Regulation, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41590-018-0053-yDOI Listing
March 2018

Moving pharma contracting into the era of accountability.

Authors:
Thomas R Graf

Am J Manag Care 2017 12;23(14 Spec No.):SP580-SP581

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December 2017

Parallel sequencing lives, or what makes large sequencing projects successful.

Gigascience 2017 11;6(11):1-6

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1093/gigascience/gix100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714127PMC
November 2017

Covering the Stem Cell Explosion at the 2017 ISSCR Conference in Boston.

Authors:
Thomas Graf

Stem Cell Reports 2017 10;9(4):1017-1023

Centre for Genomic Regulation, Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.022DOI Listing
October 2017

Logical modeling of lymphoid and myeloid cell specification and transdifferentiation.

Proc Natl Acad Sci U S A 2017 06;114(23):5792-5799

Computational Systems Biology Team, Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, Ecole Normale Supérieure, Paris Sciences et Lettres Research University, 75005 Paris, France;

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http://dx.doi.org/10.1073/pnas.1610622114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468615PMC
June 2017

Thin-disk laser operation of Ti:sapphire.

Opt Lett 2017 Apr;42(8):1624-1627

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http://dx.doi.org/10.1364/OL.42.001624DOI Listing
April 2017

A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.

Mol Cell Biol 2017 02 1;37(4). Epub 2017 Feb 1.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00372-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288571PMC
February 2017

Very Rapid and Efficient Generation of Induced Pluripotent Stem Cells from Mouse Pre-B Cells.

Methods Mol Biol 2016 ;1357:45-56

Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), C/Dr Aiguader 88, PRBB Building, Barcelona, 08003, Spain.

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http://dx.doi.org/10.1007/7651_2014_133DOI Listing
October 2016

How does C/EBPα speed up cell reprogramming?

Cell Cycle 2016 09 7;15(18):2381-2. Epub 2016 Jun 7.

a Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology , Barcelona , Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026819PMC
http://dx.doi.org/10.1080/15384101.2016.1194138DOI Listing
September 2016

Medicaid Managed Care in an Integrated Health Care Delivery System: Lessons from Geisinger's Early Experience.

Popul Health Manag 2016 08 13;19(4):257-63. Epub 2015 Nov 13.

1 Geisinger Health System , Danville, Pennsylvania.

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http://dx.doi.org/10.1089/pop.2015.0079DOI Listing
August 2016

Impact of climate change on freshwater resources in a heterogeneous coastal aquifer of Bremerhaven, Germany: A three-dimensional modeling study.

J Contam Hydrol 2015 Jun-Jul;177-178:107-21. Epub 2015 Apr 8.

Geosciences Center, University of Göttingen, Goldschmidtstr 3, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.jconhyd.2015.03.014DOI Listing
July 2016

The Effect of Porous Medium Storage on Unstable Density-Driven Solute Transport.

Ground Water 2015 Sep-Oct;53(5):806-9. Epub 2014 Nov 13.

DHI-WASY GmbH, Berlin, Germany.

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http://dx.doi.org/10.1111/gwat.12285DOI Listing
May 2016

Beta-lactam versus beta- lactam/macrolide therapy in pediatric outpatient pneumonia.

Pediatr Pulmonol 2016 May 14;51(5):541-8. Epub 2015 Sep 14.

Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/ppul.23312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309318PMC
May 2016

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming.

Cell Stem Cell 2016 05 10;18(5):597-610. Epub 2016 Mar 10.

Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG) and Pompeu Fabra University, Dr Aiguader 88, 08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858530PMC
May 2016

C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.

Nat Cell Biol 2016 Apr 14;18(4):371-81. Epub 2016 Mar 14.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.

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http://dx.doi.org/10.1038/ncb3326DOI Listing
April 2016

Human Monocytes Engage an Alternative Inflammasome Pathway.

Immunity 2016 Apr 29;44(4):833-46. Epub 2016 Mar 29.

Institute of Molecular Medicine, University Hospital Bonn, 53127 Bonn, Germany; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.012DOI Listing
April 2016

Value of primary care diabetes management: long-term cost impacts.

Am J Manag Care 2016 Mar 1;22(3):e88-94. Epub 2016 Mar 1.

Geisinger Center for Health Research, 100 N Academy Ave, MC 44-00, Danville, PA 17822. E-mail:

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March 2016

Geisinger's Retail Innovation Journey.

Front Health Serv Manage 2015 ;31(3):16-31

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December 2015

Systematic investigation of non-Boussinesq effects in variable-density groundwater flow simulations.

J Contam Hydrol 2015 Dec 23;183:82-98. Epub 2015 Oct 23.

Institute of Fluid Mechanics and Environmental Physics in Civil Engineering, Appelstraß e 9A, 30167 Hannover, Germany.

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http://dx.doi.org/10.1016/j.jconhyd.2015.10.004DOI Listing
December 2015

Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells.

Sci Data 2014 27;1:140008. Epub 2014 May 27.

Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG) , Dr Aiguader 88, 08003, Barcelona , Spain ; Universitat Pompeu Fabra (UPF) , Dr Aiguader 88, 08003, Barcelona, Spain ; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys 23 , 08010, Barcelona, Spain.

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http://dx.doi.org/10.1038/sdata.2014.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322579PMC
November 2015

Leveraging data to systematically improve care: coronary artery disease management at Geisinger.

J Ambul Care Manage 2014 Jul-Sep;37(3):199-205

Geisinger Health System, Danville, Pennsylvania.

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http://dx.doi.org/10.1097/JAC.0000000000000038DOI Listing
October 2015

Comparative Effectiveness of Beta-lactam Versus Macrolide Monotherapy in Children with Pneumonia Diagnosed in the Outpatient Setting.

Pediatr Infect Dis J 2015 Aug;34(8):839-42

From the *Division of Hospital Medicine, †Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; ‡General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts; §Population Health, Geisinger Health System, Danville, Pennsylvania; ¶Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and ‖Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/INF.0000000000000740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573783PMC
August 2015

The Economic Burden of Obesity by Glycemic Stage in the United States.

Pharmacoeconomics 2015 Jul;33(7):735-48

Retrospective Observational Studies, Evidera, 430 Bedford Street, Suite 300, Lexington, MA, 02420, USA,

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http://dx.doi.org/10.1007/s40273-014-0248-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486397PMC
July 2015

Heat and solute tracers: how do they compare in heterogeneous aquifers?

Ground Water 2015 Apr 9;53 Suppl 1:10-20. Epub 2013 Dec 9.

National Centre for Groundwater Research and Training and School of the Environment, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.

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http://dx.doi.org/10.1111/gwat.12146DOI Listing
April 2015

Reduced acute inpatient care was largest savings component of Geisinger Health System's patient-centered medical home.

Health Aff (Millwood) 2015 Apr;34(4):636-44

Glenn D. Steele is president and CEO of Geisinger Health System.

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http://dx.doi.org/10.1377/hlthaff.2014.0855DOI Listing
April 2015

Adjunct Systemic Corticosteroid Therapy in Children With Community-Acquired Pneumonia in the Outpatient Setting.

J Pediatric Infect Dis Soc 2015 Mar 27;4(1):21-7. Epub 2014 Mar 27.

Division of Hospital Medicine Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center Department of Pediatrics, the University of Cincinnati College of Medicine, Ohio.

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http://jpids.oxfordjournals.org/content/early/2014/03/26/jpi
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http://jpids.oxfordjournals.org/cgi/doi/10.1093/jpids/piu017
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http://dx.doi.org/10.1093/jpids/piu017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965878PMC
March 2015

Generation of dense plume fingers in saturated-unsaturated homogeneous porous media.

J Contam Hydrol 2015 Feb 9;173:69-82. Epub 2014 Dec 9.

Institute of Fluid Mechanics and Environmental Physics in Civil Engineering, Leibniz Universität Hannover, Appelstr. 9A, 30167 Hannover, Germany.

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http://dx.doi.org/10.1016/j.jconhyd.2014.11.008DOI Listing
February 2015

A new path to leukemia with WIT.

Mol Cell 2015 Feb;57(4):573-574

Center for Genomic Regulation, C/Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain; Pompeu Fabra University, Plaça de la Mercè, 10, 08002 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.005DOI Listing
February 2015

Variation in the risk of progression between glycemic stages across different levels of body mass index: evidence from a United States electronic health records system.

Curr Med Res Opin 2015 Jan 16;31(1):115-24. Epub 2014 Oct 16.

Retrospective Observational Studies , Evidera, Bethesda, MD , USA.

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http://dx.doi.org/10.1185/03007995.2014.971356DOI Listing
January 2015

Hi-TEC reprogramming for organ regeneration.

Nat Cell Biol 2014 Sep;16(9):824-5

1] Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Spain [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncb3032DOI Listing
September 2014

Chronic care model strategies in the United States and Germany deliver patient-centered, high-quality diabetes care.

Health Aff (Millwood) 2014 Sep;33(9):1540-8

Thomas R. Graf is chief medical officer for population health and longitudinal care service lines, Geisinger Health System.

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http://dx.doi.org/10.1377/hlthaff.2014.0428DOI Listing
September 2014

Primary care diabetes bundle management: 3-year outcomes for microvascular and macrovascular events.

Am J Manag Care 2014 Jun 1;20(6):e175-82. Epub 2014 Jun 1.

100 N. Academy Ave, Danville, PA 17822-3836. E-mail:

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June 2014

C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages.

Mol Cell Biol 2014 Mar 13;34(6):1145-57. Epub 2014 Jan 13.

Chromatin and Disease Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1128/MCB.01487-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958044PMC
March 2014

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Nature 2014 Feb 15;506(7487):235-9. Epub 2013 Dec 15.

1] Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain [3] Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010 Barcelona, Spain.

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http://www.tesisenred.net/bitstream/handle/10803/283484/tbds
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http://sys.91sqs.com/mobilenews/pdfs/C%20EBP%CE%B1%E8%83%BD%
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http://www.nature.com/doifinder/10.1038/nature12885
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http://dx.doi.org/10.1038/nature12885DOI Listing
February 2014

Determination of the complex acoustic scattering matrix of a right-angled duct.

Authors:
Thomas Graf Jie Pan

J Acoust Soc Am 2013 Jul;134(1):292-9

School of Engineering and Architecture, Lucerne University, Technikumstrasse 21, CH-6048 Horw, Switzerland.

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http://dx.doi.org/10.1121/1.4807508DOI Listing
July 2013

True real-time cardiac MRI in free breathing without ECG synchronization using a novel sequence with radial k-space sampling and balanced SSFP contrast mode.

Int J Cardiovasc Imaging 2013 Jun 19;29(5):1059-67. Epub 2013 Jan 19.

Department of Diagnostic and Interventional Radiology, Clinic of the Goethe University, Haus 23 C UG, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10554-013-0183-0DOI Listing
June 2013

Improving patient experience by transforming primary care: evidence from Geisinger's patient-centered medical homes.

Popul Health Manag 2013 Jun 13;16(3):157-63. Epub 2013 Feb 13.

Geisinger Health System, Danville, PA, USA.

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http://dx.doi.org/10.1089/pop.2012.0048DOI Listing
June 2013

Modelling the effects of tides and storm surges on coastal aquifers using a coupled surface-subsurface approach.

J Contam Hydrol 2013 Jun 26;149:61-75. Epub 2013 Mar 26.

Institute of Fluid Mechanics in Civil Engineering, Leibniz Universität Hannover, Appelstr. 9A, 30167 Hannover, Germany.

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http://dx.doi.org/10.1016/j.jconhyd.2013.03.002DOI Listing
June 2013

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.

Blood 2013 May 5;121(22):4463-72. Epub 2013 Apr 5.

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation, Barcelona, Spain.

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http://dx.doi.org/10.1182/blood-2012-09-457929DOI Listing
May 2013

Amplification of cylindrically polarized laser beams in single crystal fiber amplifiers.

Opt Express 2013 May;21(9):11376-81

Institut für Strahlwerkzeuge, Universität Stuttgart, Pfaffenwaldring 43, D-70569 Stuttgart, Germany.

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http://dx.doi.org/10.1364/OE.21.011376DOI Listing
May 2013

C/EBPα induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity.

Cell Rep 2013 Apr 28;3(4):1153-63. Epub 2013 Mar 28.

Center for Genomic Regulation, Universidad Pompeu Fabra and Institució Catalana de Recerca i Estudis Avançats, Dr. Aiguader 88, 08003 Barcelona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130011
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http://dx.doi.org/10.1016/j.celrep.2013.03.003DOI Listing
April 2013

Power scaling of fundamental-mode thin-disk lasers using intracavity deformable mirrors.

Opt Lett 2012 Dec;37(24):5033-5

Institut für Strahlwerkzeuge, Universität Stuttgart Pfaffenwaldring 43, Stuttgart 70569, Germany.

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http://dx.doi.org/10.1364/OL.37.005033DOI Listing
December 2012

Passively mode-locked Yb3+:Sc2SiO5 thin-disk laser.

Opt Lett 2012 Nov;37(22):4750-2

Graduate School of Excellence, University of Stuttgart, Nobelstrasse 12, Stuttgart 70569, Germany.

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http://dx.doi.org/10.1364/ol.37.004750DOI Listing
November 2012

Comparison between ray-tracing and physical optics for the computation of light absorption in capillaries--the influence of diffraction and interference.

Opt Express 2012 Nov;20(24):26606-17

Department of Materials Science and Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing, China.

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http://dx.doi.org/10.1364/OE.20.026606DOI Listing
November 2012

Linearly polarized, narrow-linewidth, and tunable Yb:YAG thin-disk laser.

Opt Lett 2012 Oct;37(20):4188-90

Institut für Strahlwerkzeuge, Universität Stuttgart, Pfaffenwaldring 43, Stuttgart, Germany.

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http://dx.doi.org/10.1364/OL.37.004188DOI Listing
October 2012