Thomas G Graeber

Thomas G Graeber

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Thomas G Graeber

Publications by authors named "Thomas G Graeber"

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Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule.

Cell Rep 2019 Dec;29(11):3488-3505.e9

UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, UCLA, Los Angeles, CA 90095, USA; UCLA Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.019DOI Listing
December 2019

A linear mixed model approach to gene expression-tumor aneuploidy association studies.

Sci Rep 2019 Aug 16;9(1):11944. Epub 2019 Aug 16.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41598-019-48302-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697733PMC
August 2019

Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.

Cancer Cell 2019 Jul;36(1):17-34.e7

Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA 90095, USA; California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703903PMC
July 2019

Interleukin 32 expression in human melanoma.

J Transl Med 2019 04 5;17(1):113. Epub 2019 Apr 5.

Department of Surgery, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12967-019-1862-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449995PMC
April 2019

A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.

Cell Rep 2018 09;24(12):3353-3366.e5

Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382070PMC
September 2018

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer.

J Vis Exp 2018 08 2(138). Epub 2018 Aug 2.

Graduate Program in Cellular and Molecular Pharmacology, School of Graduate Studies, Rutgers University, The State University of New Jersey; Graduate Program in Quantitative Biomedicine, School of Graduate Studies, Rutgers University, The State University of New Jersey; Department of Medicine, Division of Medical Oncology, Rutgers Robert Wood Johnson Medical School; Pharmacology, Rutgers Robert Wood Johnson Medical School; Cancer Metabolism and Growth Program, Rutgers Cancer Institute of New Jersey;

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http://dx.doi.org/10.3791/57996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126612PMC
August 2018

Making Mistakes Empowers Cancer Cells.

Trends Cancer 2018 07 29;4(7):461-463. Epub 2018 May 29.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.05.001DOI Listing
July 2018

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers.

Cancer Metab 2018 28;6. Epub 2018 Jun 28.

1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022704PMC
June 2018

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.

Cancer Cell 2018 05 12;33(5):890-904.e5. Epub 2018 Apr 12.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Building 114, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA 90095, USA; UCLA Metabolomics Center, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953834PMC
May 2018

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.

Cancer Cell 2018 05;33(5):905-921.e5

Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451645PMC
May 2018

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.

Cell 2018 04 15;173(2):470-484.e18. Epub 2018 Mar 15.

Department of Systems Biology, Beckman Research Institute, and City of Hope Comprehensive Cancer Center, Monrovia, CA 91016, USA; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284818PMC
April 2018

Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications.

BMC Cancer 2017 Jul 1;17(1):457. Epub 2017 Jul 1.

Department of Surgery, University of California Los Angeles, 10833 Le Conte Ave, California, Los Angeles, 90095, USA.

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http://dx.doi.org/10.1186/s12885-017-3447-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493892PMC
July 2017

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.

Cell Rep 2017 05;19(6):1189-1201

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173052
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http://dx.doi.org/10.1016/j.celrep.2017.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420824PMC
May 2017

Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells.

Cancer Immunol Res 2016 10 2;4(10):845-857. Epub 2016 Sep 2.

Division of Hematology/Oncology, Department of Medicine, University of California (UCLA), Los Angeles, California. Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California. Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, California. Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050168PMC
http://dx.doi.org/10.1158/2326-6066.CIR-16-0060DOI Listing
October 2016

Reality of Single Circulating Tumor Cell Sequencing for Molecular Diagnostics in Pancreatic Cancer.

J Mol Diagn 2016 09 1;18(5):688-696. Epub 2016 Jul 1.

Department of Surgery, University of California Los Angeles, Los Angeles, California; Department of Surgery, Greater Los Angeles Veterans Affairs Administration, Los Angeles, California; Center for Pancreatic Disease, University of California Los Angeles, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397706PMC
September 2016

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

N Engl J Med 2016 Sep 13;375(9):819-29. Epub 2016 Jul 13.

From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.).

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http://dx.doi.org/10.1056/NEJMoa1604958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007206PMC
September 2016

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells.

Cell Metab 2016 09 28;24(3):485-493. Epub 2016 Jul 28.

Molecular Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, Department of Pediatrics, and Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023506PMC
September 2016

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma.

Cell Discov 2016 6;2:16028. Epub 2016 Sep 6.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA; Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012007PMC
September 2016

CRAF R391W is a melanoma driver oncogene.

Sci Rep 2016 06 8;6:27454. Epub 2016 Jun 8.

Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/srep27454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897636PMC
June 2016

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.

Cell Metab 2016 05;23(5):921-9

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062745PMC
http://dx.doi.org/10.1016/j.cmet.2016.04.007DOI Listing
May 2016

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.

Mol Cancer Res 2016 Apr 1;14(4):344-53. Epub 2016 Feb 1.

Departments of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834240PMC
April 2016

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.

Nat Commun 2016 Apr 29;7:11457. Epub 2016 Apr 29.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 650 Charles East Young Drive South, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms11457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855534PMC
April 2016

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.

PLoS One 2015 26;10(3):e0121833. Epub 2015 Mar 26.

Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121833PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374917PMC
February 2016

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.

Cell Rep 2016 Feb 11;14(7):1590-1601. Epub 2016 Feb 11.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816454PMC
February 2016

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.

Nat Commun 2015 Nov 12;6:8873. Epub 2015 Nov 12.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 90095 California, USA.

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http://dx.doi.org/10.1038/ncomms9873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660206PMC
November 2015

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

FASEB J 2015 Sep 21;29(9):3750-61. Epub 2015 May 21.

*Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA; and Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California Nanosystems Institute and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA

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http://www.fasebj.org/doi/10.1096/fj.15-271510
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http://dx.doi.org/10.1096/fj.15-271510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550377PMC
September 2015

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

Cell Metab 2015 Sep 16;22(3):508-15. Epub 2015 Jul 16.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663076PMC
September 2015

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Cancer Cell 2015 Jul;28(1):97-113

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531387PMC
July 2015

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

BMC Cancer 2015 May 5;15:356. Epub 2015 May 5.

Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s12885-015-1377-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432503PMC
May 2015

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.

Sci Transl Med 2015 Mar;7(279):279ra41

Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA. Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa4691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765379PMC
March 2015

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):E420-9. Epub 2015 Jan 20.

Howard Hughes Medical Institute and Department of Biological Chemistry,

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http://dx.doi.org/10.1073/pnas.1424576112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321275PMC
February 2015

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.

Mol Cancer 2015 Feb 3;14:27. Epub 2015 Feb 3.

Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s12943-015-0293-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320814PMC
February 2015

Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

J Invest Dermatol 2015 Jan 11;135(1):151-159. Epub 2014 Aug 11.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268388PMC
January 2015

Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors.

Mol Cancer Res 2014 Dec 4;12(12):1740-54. Epub 2014 Aug 4.

Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California. Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-14
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http://dx.doi.org/10.1158/1541-7786.MCR-14-0159DOI Listing
December 2014

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism.

ISME J 2014 Nov 29;8(11):2193-206. Epub 2014 Apr 29.

1] Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/ismej.2014.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992076PMC
November 2014

Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.

PLoS One 2014 6;9(1):e84488. Epub 2014 Jan 6.

Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084488PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882224PMC
September 2014

Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma.

Clin Cancer Res 2014 Jul 8;20(13):3446-57. Epub 2014 May 8.

Authors' Affiliations: Division of Hematology-Oncology, Department of Medicine; Division of Surgical-Oncology, Department of Surgery; Department of Molecular and Medical Pharmacology; and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079734PMC
July 2014

CTLA4 blockade broadens the peripheral T-cell receptor repertoire.

Clin Cancer Res 2014 May 28;20(9):2424-32. Epub 2014 Feb 28.

Authors' Affiliations: Division of Hematology-Oncology, Department of Medicine, Departments of Molecular and Medical Pharmacology, Medicine Statistics core, and Pathology and Laboratory Medicine, Division of Surgical-Oncology, Department of Surgery, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California; Fred Hutchinson Cancer Research Center; Adaptive Biotechnologies, Seattle, Washington; and Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008652PMC
May 2014

Complexity of metastasis-associated SDF-1 ligand signaling in breast cancer stem cells.

Proc Natl Acad Sci U S A 2014 May 14;111(21):7503-4. Epub 2014 May 14.

Department of Molecular and Medical Pharmacology,Crump Institute for Molecular Imaging,University of California at Los Angeles Metabolomics and Proteomics Center,Jonsson Comprehensive Cancer Center, andCalifornia NanoSystems Institute, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1405991111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040584PMC
May 2014

Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.

Cell Metab 2014 Apr;19(4):694-701

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294542PMC
April 2014

COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors.

Mol Oncol 2014 Mar 1;8(2):250-60. Epub 2013 Dec 1.

Department of Medicine (Division of Hematology-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Surgery (Division of Surgical-Oncology), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943738PMC
March 2014

Doxycycline alters metabolism and proliferation of human cell lines.

PLoS One 2013 31;8(5):e64561. Epub 2013 May 31.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669316PMC
February 2014

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.

Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4762-9. Epub 2013 Nov 18.

Department of Microbiology, Immunology, and Molecular Genetics, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, Division of Hematology and Oncology, Department of Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Institute for Molecular Medicine, California NanoSystems Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

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http://dx.doi.org/10.1073/pnas.1319948110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856845PMC
December 2013

Phosphoproteomic analysis of aortic endothelial cells activated by oxidized phospholipids.

Methods Mol Biol 2013 ;1000:53-69

Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-62703-405-0_5DOI Listing
September 2013

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

J Clin Invest 2013 Mar 1;123(3):1371-81. Epub 2013 Feb 1.

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI66236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582139PMC
March 2013

BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy.

Cancer Res 2012 Aug 12;72(16):3928-37. Epub 2012 Jun 12.

Department of Surgery, Division of Surgical Oncology, Crump Institute for Molecular Imaging, UCLA Biomedical Physics Interdepartmental Graduate Program, Los Angeles, University of California Los Angeles, Los Angeles, California 90095-1782, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422880PMC
August 2012

Determining PTEN functional status by network component deduced transcription factor activities.

PLoS One 2012 8;7(2):e31053. Epub 2012 Feb 8.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031053PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275574PMC
July 2012

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Nat Med 2012 Mar 25;18(4):555-63. Epub 2012 Mar 25.

Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nm.2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348859PMC
March 2012

MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.

Nat Med 2012 Jan 29;18(2):267-73. Epub 2012 Jan 29.

Orthopaedic Hospital Research Center, University of California-Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nm.2584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274599PMC
January 2012

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.

Proc Natl Acad Sci U S A 2012 Jan 17;109(5):1643-8. Epub 2012 Jan 17.

Department of Microbiology, Immunology, and Molecular Genetics, Crump Institute for Molecular Imaging, Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.1120985109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277127PMC
January 2012

Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.

Cancer Cell 2011 Jun 27;19(6):792-804. Epub 2011 May 27.

Department of Molecular and Medical Pharmacology and Institute for Molecular Medicine, School of Medicine, University of California, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157296PMC
June 2011

Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.

Sci Signal 2011 Mar 29;4(166):ra18. Epub 2011 Mar 29.

Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.

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http://dx.doi.org/10.1126/scisignal.2001314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057100PMC
March 2011

Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples.

Cancer Res 2010 Nov 13;70(21):8299-308. Epub 2010 Sep 13.

Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989903PMC
November 2010

Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures.

Nucleic Acids Res 2010 Sep 21;38(17):e169. Epub 2010 Jul 21.

Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, Institute for Molecular Medicine, Jonsson Comprehensive Cancer Center and California NanoSystems Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/nar/gkq636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943622PMC
September 2010

Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis.

J Proteome Res 2010 Jun;9(6):2812-24

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1770, USA.

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http://dx.doi.org/10.1021/pr901194xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922471PMC
June 2010

Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids.

Arterioscler Thromb Vasc Biol 2007 Feb 16;27(2):332-8. Epub 2006 Nov 16.

Departments of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1161/01.ATV.0000252842.57585.dfDOI Listing
February 2007

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.

Nat Med 2005 Jun 8;11(6):653-60. Epub 2005 May 8.

Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/nm1246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409736PMC
June 2005

Cross-species comparisons of cancer signaling.

Nat Genet 2005 Jan;37(1):7-8

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http://www.nature.com/articles/ng0105-7
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http://dx.doi.org/10.1038/ng0105-7DOI Listing
January 2005

Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

Cancer Cell 2003 Sep;4(3):223-38

Department of Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/s1535-6108(03)00197-1DOI Listing
September 2003