Thomas Floss

Thomas Floss

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Thomas Floss

Thomas Floss

Publications by authors named "Thomas Floss"

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Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

Nucleic Acids Res 2017 04;45(6):3102-3115

Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1093/nar/gkw1258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389556PMC
April 2017

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.

Elife 2016 Jan 8;5:e09584. Epub 2016 Jan 8.

Vollum Institute, Howard Hughes Medical Institute, Oregon Health and Science University, Portland, United States.

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http://dx.doi.org/10.7554/eLife.09584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728133PMC
January 2016

HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.

PLoS One 2014 15;9(8):e105478. Epub 2014 Aug 15.

Institute of Virology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Virology and Epidemiology of Viral Diseases, University Clinic Tübingen, Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105478PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134290PMC
December 2015

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

PLoS One 2014 15;9(12):e114918. Epub 2014 Dec 15.

Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich, Germany; German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health, Neuherberg, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; German Center for Vertigo and Balance Disorders, Munich, Germany; German Network for Mitochondrial Disorders (mitoNET), Munich, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2147508:2/comp
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http://dx.plos.org/10.1371/journal.pone.0114918
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114918PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266617PMC
November 2015

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.

Nat Commun 2015 Mar 26;6:6669. Epub 2015 Mar 26.

1] Department of Biology, Institute of Immunology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland [2] Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland BT9 7AE, UK.

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http://dx.doi.org/10.1038/ncomms7669DOI Listing
March 2015

Mga is essential for the survival of pluripotent cells during peri-implantation development.

Development 2015 Jan;142(1):31-40

Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA

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http://dx.doi.org/10.1242/dev.111104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299147PMC
January 2015

HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.

Circ Res 2014 Jun 18;115(1):23-31. Epub 2014 Apr 18.

From the Molecular Medicine Unit, Institute of Child Health, University College London, London, United Kingdom (I.M.D., K.L.v.B., R.J.A., P.J.S.); Institute of Developmental Genetics (T.F., W.W.) and Technische Universität München-Weihenstephan, Institute of Developmental Genetics (T.F., W.W.), Helmholtz Zentrum München, Neuherberg/Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Munich, Munich, Germany (W.W.); Munich Cluster for Systems Neurology (SyNergy), Adolf Butenandt Institute, Ludwig-Maximilians-Universität München, Munich, Germany (W.W.); and Departments of Cardiovascular Medicine (D.S., S.B.) and Cardiovascular Medicine (I.M.D.), University of Oxford, Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.30330
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http://dx.doi.org/10.1161/CIRCRESAHA.115.303300DOI Listing
June 2014

Highly efficient targeted mutagenesis in mice using TALENs.

Genetics 2013 Nov 26;195(3):703-13. Epub 2013 Aug 26.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Munich, Germany.

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http://dx.doi.org/10.1534/genetics.113.156570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813858PMC
November 2013

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.

Nat Commun 2012 ;3:1119

Department of Biology, Institute of Immunology, National University of Ireland Maynooth, Maynooth, Ireland.

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http://dx.doi.org/10.1038/ncomms2127DOI Listing
February 2013

Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.

Blood 2011 Jul 25;118(3):554-64. Epub 2011 May 25.

Differentiation and Cancer Program, Center for Genomic Regulation and UPF, Barcelona, Spain.

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http://dx.doi.org/10.1182/blood-2010-12-322081DOI Listing
July 2011

Phenotypic annotation of the mouse X chromosome.

Genome Res 2010 Aug 14;20(8):1154-64. Epub 2010 Jun 14.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gr.105106.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909578PMC
August 2010

Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development.

Genesis 2009 Oct;47(10):697-707

Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1002/dvg.20553DOI Listing
October 2009

Enhanced gene trapping in mouse embryonic stem cells.

Nucleic Acids Res 2008 Nov 23;36(20):e133. Epub 2008 Sep 23.

Department of Molecular Hematology, University of Frankfurt Medical School, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1093/nar/gkn603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582619PMC
November 2008

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.

Genesis 2008 Sep;46(9):463-77

Helmholtz Center Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, Munich, Neuherberg, Germany.

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http://dx.doi.org/10.1002/dvg.20421DOI Listing
September 2008

Conditional gene trapping using the FLEx system.

Methods Mol Biol 2008 ;435:127-38

Institute of Developmental Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany.

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http://dx.doi.org/10.1007/978-1-59745-232-8_9DOI Listing
April 2008

Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

Cancer Res 2007 Oct;67(19):9047-54

Institute of Toxicology, GSF National Research Center for Environment and Health, Neuherberg, Germany.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-0312DOI Listing
October 2007

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

Nat Med 2007 Mar 18;13(3):324-31. Epub 2007 Feb 18.

Department of Cell and Developmental Biology, 1156 Basic Research Building II, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nm1552DOI Listing
March 2007

Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development.

Mol Cell Biol 2006 Dec 25;26(24):9291-301. Epub 2006 Sep 25.

Laboratory for Molecular Cancer Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Technologiepark, 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1128/MCB.01183-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698517PMC
December 2006

The Hsp90 cochaperone p23 is essential for perinatal survival.

Mol Cell Biol 2006 Dec 25;26(23):8976-83. Epub 2006 Sep 25.

Département de Biologie Cellulaire, Université de Genève, Sciences III, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1128/MCB.00734-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636834PMC
December 2006

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.

Nucleic Acids Res 2006 Feb 13;34(3):e25. Epub 2006 Feb 13.

Department of Molecular Hematology, University of Frankfurt Medical School, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1093/nar/gnj026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369290PMC
February 2006

Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.

Genesis 2005 Jun;42(2):91-103

GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany.

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http://doi.wiley.com/10.1002/gene.20128
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http://dx.doi.org/10.1002/gene.20128DOI Listing
June 2005

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.

PLoS Biol 2004 Nov 5;2(11):e327. Epub 2004 Oct 5.

Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pbio.0020327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521171PMC
November 2004

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.

Genomics 2004 Jun;83(6):1134-40

Department of Bacteriology and Immunology, Haartman Institute, and Molecular Medicine, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ygeno.2004.01.001DOI Listing
June 2004

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

Proc Natl Acad Sci U S A 2003 Aug 6;100(17):9918-22. Epub 2003 Aug 6.

Institute of Developmental Genetics, GSF-National Research Center for Environment and Health, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1073/pnas.1633296100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187885PMC
August 2003

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

J Am Soc Nephrol 2002 Jun;13(6):1586-94

Biomedicum, Molecular Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1097/01.asn.0000016142.29721.22DOI Listing
June 2002