Thomas Fleming

Thomas Fleming

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Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links.

Exp Clin Endocrinol Diabetes 2019 Sep 13;127(8):497-504. Epub 2017 Apr 13.

Department Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-106443
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http://dx.doi.org/10.1055/s-0043-106443DOI Listing
September 2019

Cardiovascular Safety Trials of Antidiabetic Therapies to Treat Type 2 Diabetes: Perhaps Asking the Wrong Question?

Am J Hypertens 2019 Sep;32(10):927-929

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1093/ajh/hpz093DOI Listing
September 2019

Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis.

Sci Rep 2019 Sep 10;9(1):13074. Epub 2019 Sep 10.

Clinical Research Unit, Centre of Internal Medicine, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1038/s41598-019-49600-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736974PMC
September 2019

Regenerative Effect of Growth Hormone (GH) in the Retina after Kainic Acid Excitotoxic Damage.

Int J Mol Sci 2019 Sep 10;20(18). Epub 2019 Sep 10.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, Qro., 76230, Mexico.

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http://dx.doi.org/10.3390/ijms20184433DOI Listing
September 2019

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure.

Circulation 2019 Aug 14;140(7):580-594. Epub 2019 Jun 14.

Institute of Experimental Cardiology (M.K., M.D., J.G., U.O., L.H.L., J.B.), Heidelberg University, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031942DOI Listing
August 2019

Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial.

Arthritis Rheumatol 2019 Aug 30. Epub 2019 Aug 30.

Department of Biostatistics, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.1002/art.41095DOI Listing
August 2019

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.

Neurobiol Dis 2019 07 23;127:76-86. Epub 2019 Feb 23.

Department of Physiology and Center for Analgesia Research Excellence, College of Medicine, University of Kentucky Medical Center, Lexington, KY, United States of America; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.02.019DOI Listing
July 2019

The combination of loss of glyoxalase1 and obesity results in hyperglycemia.

JCI Insight 2019 Jun 20;4(12). Epub 2019 Jun 20.

Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1172/jci.insight.126154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629122PMC
June 2019

Methylglyoxal causes pain and hyperalgesia in human through C-fiber activation.

Pain 2019 Jun 18. Epub 2019 Jun 18.

Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1097/j.pain.0000000000001644DOI Listing
June 2019

Pleiotropic Effect of Lipoprotein-Apheresis on the Soluble Form of Activated Leukocyte Cell Adhesion Molecule (sALCAM) in Familial Hypercholesterolaemia.

Exp Clin Endocrinol Diabetes 2019 May 11;127(5):276-280. Epub 2018 Jun 11.

Internal Medicine 1 and Clinical Chemistry, UniversitätsKlinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany.

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http://dx.doi.org/10.1055/a-0630-0232DOI Listing
May 2019

CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.

Cell Mol Life Sci 2019 May 9. Epub 2019 May 9.

European Center for Angioscience (ECAS), Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00018-019-03127-zDOI Listing
May 2019

Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.

Exp Clin Endocrinol Diabetes 2019 Apr 8;127(4):203-214. Epub 2018 Feb 8.

Department of Medicine I and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0043-122382DOI Listing
April 2019

Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions.

Vasa 2019 Mar 13;48(2):186-192. Epub 2018 Nov 13.

1 Department of Vascular and Endovascular Surgery Heidelberg, University Hospital Heidelberg, Germany.

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https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000762
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http://dx.doi.org/10.1024/0301-1526/a000762DOI Listing
March 2019

Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model.

FASEB J 2019 Mar 28;33(3):4141-4153. Epub 2018 Nov 28.

Fifth Medical Department, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1096/fj.201801146RRDOI Listing
March 2019

Methylglyoxal evokes acute Ca transients in distinct cell types and increases agonist-evoked Ca entry in endothelial cells via CRAC channels.

Cell Calcium 2019 Mar 9;78:66-75. Epub 2019 Jan 9.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2019.01.002DOI Listing
March 2019

Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.

Biochim Biophys Acta Mol Basis Dis 2019 01 18;1865(1):73-85. Epub 2018 Oct 18.

URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy; Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183039
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http://dx.doi.org/10.1016/j.bbadis.2018.10.014DOI Listing
January 2019

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes.

Respiration 2018 6;96(1):29-40. Epub 2018 Jun 6.

Department of Endocrinology, Diabetology, and Clinical Chemistry, Internal Medicine I, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000488909DOI Listing
December 2018

Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria.

Diabetes Res Clin Pract 2018 Dec 31;146:191-201. Epub 2018 Oct 31.

University Hospital of Heidelberg, Department of Internal Medicine 1 and Clinical Chemistry, Heidelberg, Germany; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany; Joint Heidelberg-ICD Translational Diabetes Program, Helmoltz-Zentrum, Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183075
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http://dx.doi.org/10.1016/j.diabres.2018.10.020DOI Listing
December 2018

Pathways to Diagnosis for Teenagers and Young Adults with Cancer in European Nations: A Pilot Study.

J Adolesc Young Adult Oncol 2018 10 23;7(5):604-611. Epub 2018 Jul 23.

9 Teenage and Young Adult Cancer Services, Institute of Oncology , Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom .

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http://dx.doi.org/10.1089/jayao.2018.0045DOI Listing
October 2018

Growth hormone promotes synaptogenesis and protects neuroretinal dendrites against kainic acid (KA) induced damage.

Gen Comp Endocrinol 2018 09 15;265:111-120. Epub 2018 Feb 15.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, Qro 76230, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.ygcen.2018.02.011DOI Listing
September 2018

Protective Actions of Anserine Under Diabetic Conditions.

Int J Mol Sci 2018 Sep 13;19(9). Epub 2018 Sep 13.

Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

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http://www.mdpi.com/1422-0067/19/9/2751
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http://dx.doi.org/10.3390/ijms19092751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164239PMC
September 2018

Data Monitoring Committees: Current issues.

Clin Trials 2018 08 9;15(4):321-328. Epub 2018 Apr 9.

3 University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1177/1740774518764855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053319PMC
August 2018

Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.

Redox Biol 2018 06 1;16:113-122. Epub 2018 Mar 1.

Department of Cardiovascular Physiology, Heidelberg University, Heidelberg D-69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952877PMC
June 2018

Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.

Acta Diabetol 2018 Jun 15;55(6):585-592. Epub 2018 Mar 15.

Dietmar-Hopp Metabolic Center, Center for Child and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00592-018-1130-2
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http://dx.doi.org/10.1007/s00592-018-1130-2DOI Listing
June 2018

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Redox Biol 2018 05 22;15:12-21. Epub 2017 Nov 22.

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723277PMC
May 2018

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.

Cell Metab 2018 04 15;27(4):926-934.e8. Epub 2018 Mar 15.

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.02.003DOI Listing
April 2018

Purification and Characterization of the Soluble form of the Receptor for Advanced Glycation End-Products (sRAGE): A Novel Fast, Economical and Convenient Method.

Exp Clin Endocrinol Diabetes 2018 03 19;126(3):141-147. Epub 2017 Sep 19.

Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg.

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http://dx.doi.org/10.1055/s-0043-110478DOI Listing
March 2018

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in .

J Biol Chem 2018 03 2;293(13):4845-4859. Epub 2018 Feb 2.

From the Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M117.805879
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http://dx.doi.org/10.1074/jbc.M117.805879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880143PMC
March 2018

Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Exp Clin Endocrinol Diabetes 2018 Jan 25;126(1):7-13. Epub 2017 Apr 25.

Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0043-106442DOI Listing
January 2018

Sensitive mass spectrometric assay for determination of 15-deoxy-Δ-prostaglandin J and its application in human plasma samples of patients with diabetes.

Anal Bioanal Chem 2018 Jan 16;410(2):521-528. Epub 2017 Nov 16.

Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00216-017-0748-1
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http://dx.doi.org/10.1007/s00216-017-0748-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750338PMC
January 2018

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry.

J Vis Exp 2017 12 6(130). Epub 2017 Dec 6.

Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg; German Center for Diabetes Research (DZD);

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http://dx.doi.org/10.3791/56538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755528PMC
December 2017

Chemosensory Responses of Plant Parasitic Nematodes to Selected Phytochemicals Reveal Long-Term Habituation Traits.

J Nematol 2017 Dec;49(4):462-471

Microbes & Pathogen Biology, Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 7BL, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770295PMC
December 2017

Characterization of aggregate load and pattern in living yeast cells by flow cytometry.

Biotechniques 2016 1;61(3):137-48. Epub 2016 Sep 1.

Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.2144/000114452DOI Listing
October 2017

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Redox Biol 2017 10 12;13:674-686. Epub 2017 Aug 12.

Department for Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173051
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http://dx.doi.org/10.1016/j.redox.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565788PMC
October 2017

Diabetes-Associated Biobanking: More Topical Than Ever?

Exp Clin Endocrinol Diabetes 2017 Oct 19;125(9):603-609. Epub 2017 Sep 19.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0042-123039DOI Listing
October 2017

Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus.

Langenbecks Arch Surg 2017 Sep 9;402(6):901-910. Epub 2017 Jul 9.

From the Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00423-017-1601-xDOI Listing
September 2017

Institutional Responsibility and the Flawed Genomic Biomarkers at Duke University: A Missed Opportunity for Transparency and Accountability.

Sci Eng Ethics 2017 08 23;23(4):1199-1205. Epub 2016 Nov 23.

School of Medicine, University of North Carolina-Chapel Hill, 101 Manning Dr, Chapel Hill, NC, 27514, USA.

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http://dx.doi.org/10.1007/s11948-016-9844-4DOI Listing
August 2017

Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification.

J Biol Chem 2017 08;292(31):12784-12785

From the German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany,

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http://dx.doi.org/10.1074/jbc.L117.798579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546020PMC
August 2017

A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.

Cell Rep 2017 08;20(6):1422-1434

Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich and Technical University Munich, 85764 Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.023DOI Listing
August 2017

ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.

J Diabetes Complications 2017 Jun 21;31(6):1058-1065. Epub 2017 Jan 21.

Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jdiacomp.2017.01.002DOI Listing
June 2017

Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study.

Authors:
Nicholas Kassebaum Hmwe Hmwe Kyu Leo Zoeckler Helen Elizabeth Olsen Katie Thomas Christine Pinho Zulfiqar A Bhutta Lalit Dandona Alize Ferrari Tsegaye Tewelde Ghiwot Simon I Hay Yohannes Kinfu Xiaofeng Liang Alan Lopez Deborah Carvalho Malta Ali H Mokdad Mohsen Naghavi George C Patton Joshua Salomon Benn Sartorius Roman Topor-Madry Stein Emil Vollset Andrea Werdecker Harvey A Whiteford Kalkidan Hasen Abate Kaja Abbas Solomon Abrha Damtew Muktar Beshir Ahmed Nadia Akseer Rajaa Al-Raddadi Mulubirhan Assefa Alemayohu Khalid Altirkawi Amanuel Alemu Abajobir Azmeraw T Amare Carl A T Antonio Johan Arnlov Al Artaman Hamid Asayesh Euripide Frinel G Arthur Avokpaho Ashish Awasthi Beatriz Paulina Ayala Quintanilla Umar Bacha Balem Demtsu Betsu Aleksandra Barac Till Winfried Bärnighausen Estifanos Baye Neeraj Bedi Isabela M Bensenor Adugnaw Berhane Eduardo Bernabe Oscar Alberto Bernal Addisu Shunu Beyene Sibhatu Biadgilign Boris Bikbov Cheryl Anne Boyce Alexandra Brazinova Gessessew Bugssa Hailu Austin Carter Carlos A Castañeda-Orjuela Ferrán Catalá-López Fiona J Charlson Abdulaal A Chitheer Jee-Young Jasmine Choi Liliana G Ciobanu John Crump Rakhi Dandona Robert P Dellavalle Amare Deribew Gabrielle deVeber Daniel Dicker Eric L Ding Manisha Dubey Amanuel Yesuf Endries Holly E Erskine Emerito Jose Aquino Faraon Andre Faro Farshad Farzadfar Joao C Fernandes Daniel Obadare Fijabi Christina Fitzmaurice Thomas D Fleming Luisa Sorio Flor Kyle J Foreman Richard C Franklin Maya S Fraser Joseph J Frostad Nancy Fullman Gebremedhin Berhe Gebregergs Alemseged Aregay Gebru Johanna M Geleijnse Katherine B Gibney Mahari Gidey Yihdego Ibrahim Abdelmageem Mohamed Ginawi Melkamu Dedefo Gishu Tessema Assefa Gizachew Elizabeth Glaser Audra L Gold Ellen Goldberg Philimon Gona Atsushi Goto Harish Chander Gugnani Guohong Jiang Rajeev Gupta Fisaha Haile Tesfay Graeme J Hankey Rasmus Havmoeller Martha Hijar Masako Horino H Dean Hosgood Guoqing Hu Kathryn H Jacobsen Mihajlo B Jakovljevic Sudha P Jayaraman Vivekanand Jha Tariku Jibat Catherine O Johnson Jost Jonas Amir Kasaeian Norito Kawakami Peter N Keiyoro Ibrahim Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar A Ahmad Kiadaliri Christian Kieling Daniel Kim Niranjan Kissoon Luke D Knibbs Ai Koyanagi Kristopher J Krohn Barthelemy Kuate Defo Burcu Kucuk Bicer Rachel Kulikoff G Anil Kumar Dharmesh Kumar Lal Hilton Y Lam Heidi J Larson Anders Larsson Dennis Odai Laryea Janni Leung Stephen S Lim Loon-Tzian Lo Warren D Lo Katharine J Looker Paulo A Lotufo Hassan Magdy Abd El Razek Reza Malekzadeh Desalegn Markos Shifti Mohsen Mazidi Peter A Meaney Kidanu Gebremariam Meles Peter Memiah Walter Mendoza Mubarek Abera Mengistie Gebremichael Welday Mengistu George A Mensah Ted R Miller Charles Mock Alireza Mohammadi Shafiu Mohammed Lorenzo Monasta Ulrich Mueller Chie Nagata Aliya Naheed Grant Nguyen Quyen Le Nguyen Elaine Nsoesie In-Hwan Oh Anselm Okoro Jacob Olusegun Olusanya Bolajoko O Olusanya Alberto Ortiz Deepak Paudel David M Pereira Norberto Perico Max Petzold Michael Robert Phillips Guilherme V Polanczyk Farshad Pourmalek Mostafa Qorbani Anwar Rafay Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Usha Ram Zane Rankin Giuseppe Remuzzi Andre M N Renzaho Hirbo Shore Roba David Rojas-Rueda Luca Ronfani Rajesh Sagar Juan Ramon Sanabria Muktar Sano Kedir Mohammed Itamar S Santos Maheswar Satpathy Monika Sawhney Ben Schöttker David C Schwebel James G Scott Sadaf G Sepanlou Amira Shaheen Masood Ali Shaikh June She Rahman Shiri Ivy Shiue Inga Dora Sigfusdottir Jasvinder Singh Naris Silpakit Alison Smith Chandrashekhar Sreeramareddy Jeffrey D Stanaway Dan J Stein Caitlyn Steiner Muawiyyah Babale Sufiyan Soumya Swaminathan Rafael Tabarés-Seisdedos Karen M Tabb Fentaw Tadese Mohammad Tavakkoli Bineyam Taye Stephanie Teeple Teketo Kassaw Tegegne Girma Temam Shifa Abdullah Sulieman Terkawi Bernadette Thomas Alan J Thomson Ruoyan Tobe-Gai Marcello Tonelli Bach Xuan Tran Christopher Troeger Kingsley N Ukwaja Olalekan Uthman Tommi Vasankari Narayanaswamy Venketasubramanian Vasiliy Victorovich Vlassov Elisabete Weiderpass Robert Weintraub Solomon Weldemariam Gebrehiwot Ronny Westerman Hywel C Williams Charles D A Wolfe Rachel Woodbrook Yuichiro Yano Naohiro Yonemoto Seok-Jun Yoon Mustafa Z Younis Chuanhua Yu Maysaa El Sayed Zaki Elias Asfaw Zegeye Liesl Joanna Zuhlke Christopher J L Murray Theo Vos

JAMA Pediatr 2017 06;171(6):573-592

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamapediatrics.2017.0250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540012PMC
June 2017

Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.

Clin Ther 2017 Jun 27;39(6):1132-1144.e2. Epub 2017 May 27.

Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.clinthera.2017.05.340DOI Listing
June 2017

Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.

Diabetes Metab Res Rev 2017 05 15;33(4). Epub 2016 May 15.

The GDS Group consists of M. Roden (speaker), H. Al-Hasani, A.E. Buyken, J. Eckel, G. Geerling C. Herder, A. Icks, J. Kotzka, O. Kuß, E. Lammert, J. Lundbom, D. Markgraf, K. Müssig, W. Rathmann, J. Szendrödi, D. Ziegler, and their co-workers who are responsible for the design and conduct of the GDS.

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http://dx.doi.org/10.1002/dmrr.2811DOI Listing
May 2017

STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.

J Neuroimmunol 2017 05 11;306:76-82. Epub 2017 Mar 11.

Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2017.03.008DOI Listing
May 2017

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Int J Mol Sci 2017 May 5;18(5). Epub 2017 May 5.

Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms18050984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454897PMC
May 2017

Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma.

BMC Cancer 2017 05 26;17(1):382. Epub 2017 May 26.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12885-017-3367-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446730PMC
May 2017

A scavenger peptide prevents methylglyoxal induced pain in mice.

Biochim Biophys Acta Mol Basis Dis 2017 03 6;1863(3):654-662. Epub 2016 Dec 6.

Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz-Zentrum, München-Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2016.12.001DOI Listing
March 2017

Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

J Diabetes Complications 2017 Feb 1;31(2):304-310. Epub 2016 Oct 1.

Department of Medicine 1 and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; 5(th) Medical Department, University Medical Center, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.jdiacomp.2016.09.014DOI Listing
February 2017

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification.

J Biol Chem 2017 Jan 30;292(2):685-690. Epub 2016 Nov 30.

From the German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany,

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http://dx.doi.org/10.1074/jbc.M116.743823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241742PMC
January 2017

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

Nat Commun 2016 11 9;7:13267. Epub 2016 Nov 9.

Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes Program, Internal Medicine I, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/ncomms13267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105165PMC
November 2016

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice.

J Diabetes Res 2016 15;2016:2981639. Epub 2015 Dec 15.

Department of Vascular and Endovascular Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1155/2016/2981639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693023PMC
October 2016

Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level.

J Vasc Surg 2016 10 29;64(4):990-4. Epub 2016 Jul 29.

Department of Vascular and Endovascular Surgery, University of Heidelberg, Heidelberg, Germany; Vaskuläre Biomaterialbank Heidelberg (Vascular Biobank Heidelberg), University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jvs.2016.04.025DOI Listing
October 2016

The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule.

BMC Endocr Disord 2016 Oct 13;16(1):56. Epub 2016 Oct 13.

Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12902-016-0138-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064930PMC
October 2016

Antiretroviral Therapy for the Prevention of HIV-1 Transmission.

N Engl J Med 2016 09 18;375(9):830-9. Epub 2016 Jul 18.

From the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill (M.S.C., M.C.H., I.F.H., J.E.); the Divisions of Vaccine and Infectious Disease (Y.Q.C., X.C.Z.) and Public Health Science (Y.Q.C.) and the Statistical Center for HIV/AIDS Research and Prevention (L.C.), Fred Hutchinson Cancer Research Center, and the Department of Biostatistics, University of Washington (T.R.F.) - both in Seattle; FHI 360, Washington, DC (M.M.), and Durham, NC (T.G.); Y.R. Gaitonde Center for AIDS Research and Education, Chennai (N.K.), and National AIDS Research Institute, Pune (S.V.G.) - both in India; University of Zimbabwe, Harare (J.G.H.); College of Medicine-Johns Hopkins Project, Blantyre, Malawi (J.K.); Instituto de Pesquisa Clinica Evandro Chagas (B.G.) and Hospital Geral de Nova Iguacu and Laboratorio de AIDS e Imunologia Molecular-IOC/Fiocruz (J.H.S.P.), Rio de Janeiro, and Servico de Infectologia, Hospital Nossa Senhora da Conceicao/GHC, Porto Alegre (B.R.S.) - both in Brazil; Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand (S.C.); Fenway Institute (K.H.M.) and Harvard School of Public Health (M.E.) - both in Boston; the Departments of Pathology (S.H.E., E.P.-M., S.E.H.) and Medicine (A.D.R.), Johns Hopkins University School of Medicine, the Department of Epidemiology, Bloomberg School of Public Health (T.E.T.), and Johns Hopkins Bloomberg School of Public Health (D.D.C.), Baltimore, and the Division of AIDS (V.E., D.B.) and Laboratory of Immunoregulation (A.D.R.), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda - both in Maryland; Botswana Harvard AIDS Institute, Gaborone (J.M.); Centers for Disease Control and Prevention (CDC) Division of HIV/AIDS Prevention/KEMRI-CDC Research and Public Health Collaboration HIV Research Branch, Kisumu, Kenya (L.A.M.); Perinatal HIV Research Unit (R.P.) and Clinical HIV Research Unit, Department of Medicine, Faculty of Health Scien

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http://dx.doi.org/10.1056/NEJMoa1600693DOI Listing
September 2016

Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type.

J Neurosci 2016 09;36(36):9313-25

Institute of Experimental and Clinical Pharmacology and Toxicology, German Research Centre for Cardiovascular Research, 23562 Lübeck, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.0473-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601875PMC
September 2016

Internalization and synaptogenic effect of GH in retinal ganglion cells (RGCs).

Gen Comp Endocrinol 2016 08 30;234:151-60. Epub 2016 Mar 30.

Department of Physiology, University of Alberta, Edmonton T6G 2H7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygcen.2016.03.025DOI Listing
August 2016

Exogenous RNA interference exposes contrasting roles for sugar exudation in host-finding by plant pathogens.

Int J Parasitol 2016 07 29;46(8):473-7. Epub 2016 Mar 29.

School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2016.02.005DOI Listing
July 2016

Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

Reprod Toxicol 2016 07 22;62:62-70. Epub 2016 Apr 22.

Department of Medical Cell Biology, Medical Faculty of Uppsala University, Biomedical Centre, P.O. Box 751, SE-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.reprotox.2016.04.015DOI Listing
July 2016

Nitrosative stress but not glycemic parameters correlate with improved neuropathy in nonseverely obese diabetic patients after Roux-Y gastric bypass.

Surg Obes Relat Dis 2015 Jul-Aug;11(4):847-54. Epub 2014 Dec 16.

Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.soard.2014.12.007DOI Listing
May 2016

RAGE-mediated inflammation in patients with septic shock.

J Surg Res 2016 05 20;202(2):315-27. Epub 2016 Jan 20.

Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.01.019DOI Listing
May 2016

Shiga Toxin 2a-Induced Endothelial Injury in Hemolytic Uremic Syndrome: A Metabolomic Analysis.

J Infect Dis 2016 Mar 17;213(6):1031-40. Epub 2015 Nov 17.

Department of Pediatrics I, University Children's Hospital Heidelberg.

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http://dx.doi.org/10.1093/infdis/jiv540DOI Listing
March 2016

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study.

Authors:
Hmwe H Kyu Christine Pinho Joseph A Wagner Jonathan C Brown Amelia Bertozzi-Villa Fiona J Charlson Luc Edgar Coffeng Lalit Dandona Holly E Erskine Alize J Ferrari Christina Fitzmaurice Thomas D Fleming Mohammad H Forouzanfar Nicholas Graetz Caterina Guinovart Juanita Haagsma Hideki Higashi Nicholas J Kassebaum Heidi J Larson Stephen S Lim Ali H Mokdad Maziar Moradi-Lakeh Shaun V Odell Gregory A Roth Peter T Serina Jeffrey D Stanaway Awoke Misganaw Harvey A Whiteford Timothy M Wolock Sarah Wulf Hanson Foad Abd-Allah Semaw Ferede Abera Laith J Abu-Raddad Fadia S AlBuhairan Azmeraw T Amare Carl Abelardo T Antonio Al Artaman Suzanne L Barker-Collo Lope H Barrero Corina Benjet Isabela M Bensenor Zulfiqar A Bhutta Boris Bikbov Alexandra Brazinova Ismael Campos-Nonato Carlos A Castañeda-Orjuela Ferrán Catalá-López Rajiv Chowdhury Cyrus Cooper John A Crump Rakhi Dandona Louisa Degenhardt Robert P Dellavalle Samath D Dharmaratne Emerito Jose A Faraon Valery L Feigin Thomas Fürst Johanna M Geleijnse Bradford D Gessner Katherine B Gibney Atsushi Goto David Gunnell Graeme J Hankey Roderick J Hay John C Hornberger H Dean Hosgood Guoqing Hu Kathryn H Jacobsen Sudha P Jayaraman Panniyammakal Jeemon Jost B Jonas André Karch Daniel Kim Sungroul Kim Yoshihiro Kokubo Barthelemy Kuate Defo Burcu Kucuk Bicer G Anil Kumar Anders Larsson Janet L Leasher Ricky Leung Yongmei Li Steven E Lipshultz Alan D Lopez Paulo A Lotufo Raimundas Lunevicius Ronan A Lyons Marek Majdan Reza Malekzadeh Taufiq Mashal Amanda J Mason-Jones Yohannes Adama Melaku Ziad A Memish Walter Mendoza Ted R Miller Charles N Mock Joseph Murray Sandra Nolte In-Hwan Oh Bolajoko Olubukunola Olusanya Katrina F Ortblad Eun-Kee Park Angel J Paternina Caicedo Scott B Patten George C Patton David M Pereira Norberto Perico Frédéric B Piel Suzanne Polinder Svetlana Popova Farshad Pourmalek D Alex Quistberg Giuseppe Remuzzi Alina Rodriguez David Rojas-Rueda Dietrich Rothenbacher David H Rothstein Juan Sanabria Itamar S Santos David C Schwebel Sadaf G Sepanlou Amira Shaheen Rahman Shiri Ivy Shiue Vegard Skirbekk Karen Sliwa Chandrashekhar T Sreeramareddy Dan J Stein Timothy J Steiner Lars Jacob Stovner Bryan L Sykes Karen M Tabb Abdullah Sulieman Terkawi Alan J Thomson Andrew L Thorne-Lyman Jeffrey Allen Towbin Kingsley Nnanna Ukwaja Tommi Vasankari Narayanaswamy Venketasubramanian Vasiliy Victorovich Vlassov Stein Emil Vollset Elisabete Weiderpass Robert G Weintraub Andrea Werdecker James D Wilkinson Solomon Meseret Woldeyohannes Charles D A Wolfe Yuichiro Yano Paul Yip Naohiro Yonemoto Seok-Jun Yoon Mustafa Z Younis Chuanhua Yu Maysaa El Sayed Zaki Mohsen Naghavi Christopher J L Murray Theo Vos

JAMA Pediatr 2016 Mar;170(3):267-87

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamapediatrics.2015.4276DOI Listing
March 2016

Evaluating interventions for Ebola: The need for randomized trials.

Clin Trials 2016 Feb 14;13(1):6-9. Epub 2016 Jan 14.

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1740774515616944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767552PMC
February 2016

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Authors:
Mohammad H Forouzanfar Lily Alexander H Ross Anderson Victoria F Bachman Stan Biryukov Michael Brauer Richard Burnett Daniel Casey Matthew M Coates Aaron Cohen Kristen Delwiche Kara Estep Joseph J Frostad K C Astha Hmwe H Kyu Maziar Moradi-Lakeh Marie Ng Erica Leigh Slepak Bernadette A Thomas Joseph Wagner Gunn Marit Aasvang Cristiana Abbafati Ayse Abbasoglu Ozgoren Foad Abd-Allah Semaw F Abera Victor Aboyans Biju Abraham Jerry Puthenpurakal Abraham Ibrahim Abubakar Niveen M E Abu-Rmeileh Tania C Aburto Tom Achoki Ademola Adelekan Koranteng Adofo Arsène K Adou José C Adsuar Ashkan Afshin Emilie E Agardh Mazin J Al Khabouri Faris H Al Lami Sayed Saidul Alam Deena Alasfoor Mohammed I Albittar Miguel A Alegretti Alicia V Aleman Zewdie A Alemu Rafael Alfonso-Cristancho Samia Alhabib Raghib Ali Mohammed K Ali François Alla Peter Allebeck Peter J Allen Ubai Alsharif Elena Alvarez Nelson Alvis-Guzman Adansi A Amankwaa Azmeraw T Amare Emmanuel A Ameh Omid Ameli Heresh Amini Walid Ammar Benjamin O Anderson Carl Abelardo T Antonio Palwasha Anwari Solveig Argeseanu Cunningham Johan Arnlöv Valentina S Arsic Arsenijevic Al Artaman Rana J Asghar Reza Assadi Lydia S Atkins Charles Atkinson Marco A Avila Baffour Awuah Alaa Badawi Maria C Bahit Talal Bakfalouni Kalpana Balakrishnan Shivanthi Balalla Ravi Kumar Balu Amitava Banerjee Ryan M Barber Suzanne L Barker-Collo Simon Barquera Lars Barregard Lope H Barrero Tonatiuh Barrientos-Gutierrez Ana C Basto-Abreu Arindam Basu Sanjay Basu Mohammed O Basulaiman Carolina Batis Ruvalcaba Justin Beardsley Neeraj Bedi Tolesa Bekele Michelle L Bell Corina Benjet Derrick A Bennett Habib Benzian Eduardo Bernabé Tariku J Beyene Neeraj Bhala Ashish Bhalla Zulfiqar A Bhutta Boris Bikbov Aref A Bin Abdulhak Jed D Blore Fiona M Blyth Megan A Bohensky Berrak Bora Başara Guilherme Borges Natan M Bornstein Dipan Bose Soufiane Boufous Rupert R Bourne Michael Brainin Alexandra Brazinova Nicholas J Breitborde Hermann Brenner Adam D M Briggs David M Broday Peter M Brooks Nigel G Bruce Traolach S Brugha Bert Brunekreef Rachelle Buchbinder Linh N Bui Gene Bukhman Andrew G Bulloch Michael Burch Peter G J Burney Ismael R Campos-Nonato Julio C Campuzano Alejandra J Cantoral Jack Caravanos Rosario Cárdenas Elisabeth Cardis David O Carpenter Valeria Caso Carlos A Castañeda-Orjuela Ruben E Castro Ferrán Catalá-López Fiorella Cavalleri Alanur Çavlin Vineet K Chadha Jung-Chen Chang Fiona J Charlson Honglei Chen Wanqing Chen Zhengming Chen Peggy P Chiang Odgerel Chimed-Ochir Rajiv Chowdhury Costas A Christophi Ting-Wu Chuang Sumeet S Chugh Massimo Cirillo Thomas K D Claßen Valentina Colistro Mercedes Colomar Samantha M Colquhoun Alejandra G Contreras Cyrus Cooper Kimberly Cooperrider Leslie T Cooper Josef Coresh Karen J Courville Michael H Criqui Lucia Cuevas-Nasu James Damsere-Derry Hadi Danawi Lalit Dandona Rakhi Dandona Paul I Dargan Adrian Davis Dragos V Davitoiu Anand Dayama E Filipa de Castro Vanessa De la Cruz-Góngora Diego De Leo Graça de Lima Louisa Degenhardt Borja del Pozo-Cruz Robert P Dellavalle Kebede Deribe Sarah Derrett Don C Des Jarlais Muluken Dessalegn Gabrielle A deVeber Karen M Devries Samath D Dharmaratne Mukesh K Dherani Daniel Dicker Eric L Ding Klara Dokova E Ray Dorsey Tim R Driscoll Leilei Duan Adnan M Durrani Beth E Ebel Richard G Ellenbogen Yousef M Elshrek Matthias Endres Sergey P Ermakov Holly E Erskine Babak Eshrati Alireza Esteghamati Saman Fahimi Emerito Jose A Faraon Farshad Farzadfar Derek F J Fay Valery L Feigin Andrea B Feigl Seyed-Mohammad Fereshtehnejad Alize J Ferrari Cleusa P Ferri Abraham D Flaxman Thomas D Fleming Nataliya Foigt Kyle J Foreman Urbano Fra Paleo Richard C Franklin Belinda Gabbe Lynne Gaffikin Emmanuela Gakidou Amiran Gamkrelidze Fortuné G Gankpé Ron T Gansevoort Francisco A García-Guerra Evariste Gasana Johanna M Geleijnse Bradford D Gessner Pete Gething Katherine B Gibney Richard F Gillum Ibrahim A M Ginawi Maurice Giroud Giorgia Giussani Shifalika Goenka Ketevan Goginashvili Hector Gomez Dantes Philimon Gona Teresita Gonzalez de Cosio Dinorah González-Castell Carolyn C Gotay Atsushi Goto Hebe N Gouda Richard L Guerrant Harish C Gugnani Francis Guillemin David Gunnell Rahul Gupta Rajeev Gupta Reyna A Gutiérrez Nima Hafezi-Nejad Holly Hagan Maria Hagstromer Yara A Halasa Randah R Hamadeh Mouhanad Hammami Graeme J Hankey Yuantao Hao Hilda L Harb Tilahun Nigatu Haregu Josep Maria Haro Rasmus Havmoeller Simon I Hay Mohammad T Hedayati Ileana B Heredia-Pi Lucia Hernandez Kyle R Heuton Pouria Heydarpour Martha Hijar Hans W Hoek Howard J Hoffman John C Hornberger H Dean Hosgood Damian G Hoy Mohamed Hsairi Guoqing Hu Howard Hu Cheng Huang John J Huang Bryan J Hubbell Laetitia Huiart Abdullatif Husseini Marissa L Iannarone Kim M Iburg Bulat T Idrisov Nayu Ikeda Kaire Innos Manami Inoue Farhad Islami Samaya Ismayilova Kathryn H Jacobsen Henrica A Jansen Deborah L Jarvis Simerjot K Jassal Alejandra Jauregui Sudha Jayaraman Panniyammakal Jeemon Paul N Jensen Vivekanand Jha Fan Jiang Guohong Jiang Ying Jiang Jost B Jonas Knud Juel Haidong Kan Sidibe S Kany Roseline Nadim E Karam André Karch Corine K Karema Ganesan Karthikeyan Anil Kaul Norito Kawakami Dhruv S Kazi Andrew H Kemp Andre P Kengne Andre Keren Yousef S Khader Shams Eldin Ali Hassan Khalifa Ejaz A Khan Young-Ho Khang Shahab Khatibzadeh Irma Khonelidze Christian Kieling Daniel Kim Sungroul Kim Yunjin Kim Ruth W Kimokoti Yohannes Kinfu Jonas M Kinge Brett M Kissela Miia Kivipelto Luke D Knibbs Ann Kristin Knudsen Yoshihiro Kokubo M Rifat Kose Soewarta Kosen Alexander Kraemer Michael Kravchenko Sanjay Krishnaswami Hans Kromhout Tiffany Ku Barthelemy Kuate Defo Burcu Kucuk Bicer Ernst J Kuipers Chanda Kulkarni Veena S Kulkarni G Anil Kumar Gene F Kwan Taavi Lai Arjun Lakshmana Balaji Ratilal Lalloo Tea Lallukka Hilton Lam Qing Lan Van C Lansingh Heidi J Larson Anders Larsson Dennis O Laryea Pablo M Lavados Alicia E Lawrynowicz Janet L Leasher Jong-Tae Lee James Leigh Ricky Leung Miriam Levi Yichong Li Yongmei Li Juan Liang Xiaofeng Liang Stephen S Lim M Patrice Lindsay Steven E Lipshultz Shiwei Liu Yang Liu Belinda K Lloyd Giancarlo Logroscino Stephanie J London Nancy Lopez Joannie Lortet-Tieulent Paulo A Lotufo Rafael Lozano Raimundas Lunevicius Jixiang Ma Stefan Ma Vasco M P Machado Michael F MacIntyre Carlos Magis-Rodriguez Abbas A Mahdi Marek Majdan Reza Malekzadeh Srikanth Mangalam Christopher C Mapoma Marape Marape Wagner Marcenes David J Margolis Christopher Margono Guy B Marks Randall V Martin Melvin B Marzan Mohammad T Mashal Felix Masiye Amanda J Mason-Jones Kunihiro Matsushita Richard Matzopoulos Bongani M Mayosi Tasara T Mazorodze Abigail C McKay Martin McKee Abigail McLain Peter A Meaney Catalina Medina Man Mohan Mehndiratta Fabiola Mejia-Rodriguez Wubegzier Mekonnen Yohannes A Melaku Michele Meltzer Ziad A Memish Walter Mendoza George A Mensah Atte Meretoja Francis Apolinary Mhimbira Renata Micha Ted R Miller Edward J Mills Awoke Misganaw Santosh Mishra Norlinah Mohamed Ibrahim Karzan A Mohammad Ali H Mokdad Glen L Mola Lorenzo Monasta Julio C Montañez Hernandez Marcella Montico Ami R Moore Lidia Morawska Rintaro Mori Joanna Moschandreas Wilkister N Moturi Dariush Mozaffarian Ulrich O Mueller Mitsuru Mukaigawara Erin C Mullany Kinnari S Murthy Mohsen Naghavi Ziad Nahas Aliya Naheed Kovin S Naidoo Luigi Naldi Devina Nand Vinay Nangia K M Venkat Narayan Denis Nash Bruce Neal Chakib Nejjari Sudan P Neupane Charles R Newton Frida N Ngalesoni Jean de Dieu Ngirabega Grant Nguyen Nhung T Nguyen Mark J Nieuwenhuijsen Muhammad I Nisar José R Nogueira Joan M Nolla Sandra Nolte Ole F Norheim Rosana E Norman Bo Norrving Luke Nyakarahuka In-Hwan Oh Takayoshi Ohkubo Bolajoko O Olusanya Saad B Omer John Nelson Opio Ricardo Orozco Rodolfo S Pagcatipunan Amanda W Pain Jeyaraj D Pandian Carlo Irwin A Panelo Christina Papachristou Eun-Kee Park Charles D Parry Angel J Paternina Caicedo Scott B Patten Vinod K Paul Boris I Pavlin Neil Pearce Lilia S Pedraza Andrea Pedroza Ljiljana Pejin Stokic Ayfer Pekericli David M Pereira Rogelio Perez-Padilla Fernando Perez-Ruiz Norberto Perico Samuel A L Perry Aslam Pervaiz Konrad Pesudovs Carrie B Peterson Max Petzold Michael R Phillips Hwee Pin Phua Dietrich Plass Dan Poenaru Guilherme V Polanczyk Suzanne Polinder Constance D Pond C Arden Pope Daniel Pope Svetlana Popova Farshad Pourmalek John Powles Dorairaj Prabhakaran Noela M Prasad Dima M Qato Amado D Quezada D Alex A Quistberg Lionel Racapé Anwar Rafay Kazem Rahimi Vafa Rahimi-Movaghar Sajjad Ur Rahman Murugesan Raju Ivo Rakovac Saleem M Rana Mayuree Rao Homie Razavi K Srinath Reddy Amany H Refaat Jürgen Rehm Giuseppe Remuzzi Antonio L Ribeiro Patricia M Riccio Lee Richardson Anne Riederer Margaret Robinson Anna Roca Alina Rodriguez David Rojas-Rueda Isabelle Romieu Luca Ronfani Robin Room Nobhojit Roy George M Ruhago Lesley Rushton Nsanzimana Sabin Ralph L Sacco Sukanta Saha Ramesh Sahathevan Mohammad Ali Sahraian Joshua A Salomon Deborah Salvo Uchechukwu K Sampson Juan R Sanabria Luz Maria Sanchez Tania G Sánchez-Pimienta Lidia Sanchez-Riera Logan Sandar Itamar S Santos Amir Sapkota Maheswar Satpathy James E Saunders Monika Sawhney Mete I Saylan Peter Scarborough Jürgen C Schmidt Ione J C Schneider Ben Schöttker David C Schwebel James G Scott Soraya Seedat Sadaf G Sepanlou Berrin Serdar Edson E Servan-Mori Gavin Shaddick Saeid Shahraz Teresa Shamah Levy Siyi Shangguan Jun She Sara Sheikhbahaei Kenji Shibuya Hwashin H Shin Yukito Shinohara Rahman Shiri Kawkab Shishani Ivy Shiue Inga D Sigfusdottir Donald H Silberberg Edgar P Simard Shireen Sindi Abhishek Singh Gitanjali M Singh Jasvinder A Singh Vegard Skirbekk Karen Sliwa Michael Soljak Samir Soneji Kjetil Søreide Sergey Soshnikov Luciano A Sposato Chandrashekhar T Sreeramareddy Nicolas J C Stapelberg Vasiliki Stathopoulou Nadine Steckling Dan J Stein Murray B Stein Natalie Stephens Heidi Stöckl Kurt Straif Konstantinos Stroumpoulis Lela Sturua Bruno F Sunguya Soumya Swaminathan Mamta Swaroop Bryan L Sykes Karen M Tabb Ken Takahashi Roberto T Talongwa Nikhil Tandon David Tanne Marcel Tanner Mohammad Tavakkoli Braden J Te Ao Carolina M Teixeira Martha M Téllez Rojo Abdullah S Terkawi José Luis Texcalac-Sangrador Sarah V Thackway Blake Thomson Andrew L Thorne-Lyman Amanda G Thrift George D Thurston Taavi Tillmann Myriam Tobollik Marcello Tonelli Fotis Topouzis Jeffrey A Towbin Hideaki Toyoshima Jefferson Traebert Bach X Tran Leonardo Trasande Matias Trillini Ulises Trujillo Zacharie Tsala Dimbuene Miltiadis Tsilimbaris Emin Murat Tuzcu Uche S Uchendu Kingsley N Ukwaja Selen B Uzun Steven van de Vijver Rita Van Dingenen Coen H van Gool Jim van Os Yuri Y Varakin Tommi J Vasankari Ana Maria N Vasconcelos Monica S Vavilala Lennert J Veerman Gustavo Velasquez-Melendez N Venketasubramanian Lakshmi Vijayakumar Salvador Villalpando Francesco S Violante Vasiliy Victorovich Vlassov Stein Emil Vollset Gregory R Wagner Stephen G Waller Mitchell T Wallin Xia Wan Haidong Wang JianLi Wang Linhong Wang Wenzhi Wang Yanping Wang Tati S Warouw Charlotte H Watts Scott Weichenthal Elisabete Weiderpass Robert G Weintraub Andrea Werdecker K Ryan Wessells Ronny Westerman Harvey A Whiteford James D Wilkinson Hywel C Williams Thomas N Williams Solomon M Woldeyohannes Charles D A Wolfe John Q Wong Anthony D Woolf Jonathan L Wright Brittany Wurtz Gelin Xu Lijing L Yan Gonghuan Yang Yuichiro Yano Pengpeng Ye Muluken Yenesew Gökalp K Yentür Paul Yip Naohiro Yonemoto Seok-Jun Yoon Mustafa Z Younis Zourkaleini Younoussi Chuanhua Yu Maysaa E Zaki Yong Zhao Yingfeng Zheng Maigeng Zhou Jun Zhu Shankuan Zhu Xiaonong Zou Joseph R Zunt Alan D Lopez Theo Vos Christopher J Murray

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.

Mol Cancer 2015 Dec 3;14:204. Epub 2015 Dec 3.

Department of Otolaryngology, Head and Neck Surgery, Section Experimental and Translational Head and Neck Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669670PMC
December 2015

Carnosine metabolism in diabetes is altered by reactive metabolites.

Amino Acids 2015 Nov 17;47(11):2367-76. Epub 2015 Jun 17.

Centre for Paediatric and Adolescence Medicine, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00726-015-2024-zDOI Listing
November 2015

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

Authors:
Christopher J L Murray Ryan M Barber Kyle J Foreman Ayse Abbasoglu Ozgoren Foad Abd-Allah Semaw F Abera Victor Aboyans Jerry P Abraham Ibrahim Abubakar Laith J Abu-Raddad Niveen M Abu-Rmeileh Tom Achoki Ilana N Ackerman Zanfina Ademi Arsène K Adou José C Adsuar Ashkan Afshin Emilie E Agardh Sayed Saidul Alam Deena Alasfoor Mohammed I Albittar Miguel A Alegretti Zewdie A Alemu Rafael Alfonso-Cristancho Samia Alhabib Raghib Ali François Alla Peter Allebeck Mohammad A Almazroa Ubai Alsharif Elena Alvarez Nelson Alvis-Guzman Azmeraw T Amare Emmanuel A Ameh Heresh Amini Walid Ammar H Ross Anderson Benjamin O Anderson Carl Abelardo T Antonio Palwasha Anwari Johan Arnlöv Valentina S Arsic Arsenijevic Al Artaman Rana J Asghar Reza Assadi Lydia S Atkins Marco A Avila Baffour Awuah Victoria F Bachman Alaa Badawi Maria C Bahit Kalpana Balakrishnan Amitava Banerjee Suzanne L Barker-Collo Simon Barquera Lars Barregard Lope H Barrero Arindam Basu Sanjay Basu Mohammed O Basulaiman Justin Beardsley Neeraj Bedi Ettore Beghi Tolesa Bekele Michelle L Bell Corina Benjet Derrick A Bennett Isabela M Bensenor Habib Benzian Eduardo Bernabé Amelia Bertozzi-Villa Tariku J Beyene Neeraj Bhala Ashish Bhalla Zulfiqar A Bhutta Kelly Bienhoff Boris Bikbov Stan Biryukov Jed D Blore Christopher D Blosser Fiona M Blyth Megan A Bohensky Ian W Bolliger Berrak Bora Başara Natan M Bornstein Dipan Bose Soufiane Boufous Rupert R A Bourne Lindsay N Boyers Michael Brainin Carol E Brayne Alexandra Brazinova Nicholas J K Breitborde Hermann Brenner Adam D Briggs Peter M Brooks Jonathan C Brown Traolach S Brugha Rachelle Buchbinder Geoffrey C Buckle Christine M Budke Anne Bulchis Andrew G Bulloch Ismael R Campos-Nonato Hélène Carabin Jonathan R Carapetis Rosario Cárdenas David O Carpenter Valeria Caso Carlos A Castañeda-Orjuela Ruben E Castro Ferrán Catalá-López Fiorella Cavalleri Alanur Çavlin Vineet K Chadha Jung-Chen Chang Fiona J Charlson Honglei Chen Wanqing Chen Peggy P Chiang Odgerel Chimed-Ochir Rajiv Chowdhury Hanne Christensen Costas A Christophi Massimo Cirillo Matthew M Coates Luc E Coffeng Megan S Coggeshall Valentina Colistro Samantha M Colquhoun Graham S Cooke Cyrus Cooper Leslie T Cooper Luis M Coppola Monica Cortinovis Michael H Criqui John A Crump Lucia Cuevas-Nasu Hadi Danawi Lalit Dandona Rakhi Dandona Emily Dansereau Paul I Dargan Gail Davey Adrian Davis Dragos V Davitoiu Anand Dayama Diego De Leo Louisa Degenhardt Borja Del Pozo-Cruz Robert P Dellavalle Kebede Deribe Sarah Derrett Don C Des Jarlais Muluken Dessalegn Samath D Dharmaratne Mukesh K Dherani Cesar Diaz-Torné Daniel Dicker Eric L Ding Klara Dokova E Ray Dorsey Tim R Driscoll Leilei Duan Herbert C Duber Beth E Ebel Karen M Edmond Yousef M Elshrek Matthias Endres Sergey P Ermakov Holly E Erskine Babak Eshrati Alireza Esteghamati Kara Estep Emerito Jose A Faraon Farshad Farzadfar Derek F Fay Valery L Feigin David T Felson Seyed-Mohammad Fereshtehnejad Jefferson G Fernandes Alize J Ferrari Christina Fitzmaurice Abraham D Flaxman Thomas D Fleming Nataliya Foigt Mohammad H Forouzanfar F Gerry R Fowkes Urbano Fra Paleo Richard C Franklin Thomas Fürst Belinda Gabbe Lynne Gaffikin Fortuné G Gankpé Johanna M Geleijnse Bradford D Gessner Peter Gething Katherine B Gibney Maurice Giroud Giorgia Giussani Hector Gomez Dantes Philimon Gona Diego González-Medina Richard A Gosselin Carolyn C Gotay Atsushi Goto Hebe N Gouda Nicholas Graetz Harish C Gugnani Rahul Gupta Rajeev Gupta Reyna A Gutiérrez Juanita Haagsma Nima Hafezi-Nejad Holly Hagan Yara A Halasa Randah R Hamadeh Hannah Hamavid Mouhanad Hammami Jamie Hancock Graeme J Hankey Gillian M Hansen Yuantao Hao Hilda L Harb Josep Maria Haro Rasmus Havmoeller Simon I Hay Roderick J Hay Ileana B Heredia-Pi Kyle R Heuton Pouria Heydarpour Hideki Higashi Martha Hijar Hans W Hoek Howard J Hoffman H Dean Hosgood Mazeda Hossain Peter J Hotez Damian G Hoy Mohamed Hsairi Guoqing Hu Cheng Huang John J Huang Abdullatif Husseini Chantal Huynh Marissa L Iannarone Kim M Iburg Kaire Innos Manami Inoue Farhad Islami Kathryn H Jacobsen Deborah L Jarvis Simerjot K Jassal Sun Ha Jee Panniyammakal Jeemon Paul N Jensen Vivekanand Jha Guohong Jiang Ying Jiang Jost B Jonas Knud Juel Haidong Kan André Karch Corine K Karema Chante Karimkhani Ganesan Karthikeyan Nicholas J Kassebaum Anil Kaul Norito Kawakami Konstantin Kazanjan Andrew H Kemp Andre P Kengne Andre Keren Yousef S Khader Shams Eldin A Khalifa Ejaz A Khan Gulfaraz Khan Young-Ho Khang Christian Kieling Daniel Kim Sungroul Kim Yunjin Kim Yohannes Kinfu Jonas M Kinge Miia Kivipelto Luke D Knibbs Ann Kristin Knudsen Yoshihiro Kokubo Soewarta Kosen Sanjay Krishnaswami Barthelemy Kuate Defo Burcu Kucuk Bicer Ernst J Kuipers Chanda Kulkarni Veena S Kulkarni G Anil Kumar Hmwe H Kyu Taavi Lai Ratilal Lalloo Tea Lallukka Hilton Lam Qing Lan Van C Lansingh Anders Larsson Alicia E B Lawrynowicz Janet L Leasher James Leigh Ricky Leung Carly E Levitz Bin Li Yichong Li Yongmei Li Stephen S Lim Maggie Lind Steven E Lipshultz Shiwei Liu Yang Liu Belinda K Lloyd Katherine T Lofgren Giancarlo Logroscino Katharine J Looker Joannie Lortet-Tieulent Paulo A Lotufo Rafael Lozano Robyn M Lucas Raimundas Lunevicius Ronan A Lyons Stefan Ma Michael F Macintyre Mark T Mackay Marek Majdan Reza Malekzadeh Wagner Marcenes David J Margolis Christopher Margono Melvin B Marzan Joseph R Masci Mohammad T Mashal Richard Matzopoulos Bongani M Mayosi Tasara T Mazorodze Neil W Mcgill John J Mcgrath Martin Mckee Abigail Mclain Peter A Meaney Catalina Medina Man Mohan Mehndiratta Wubegzier Mekonnen Yohannes A Melaku Michele Meltzer Ziad A Memish George A Mensah Atte Meretoja Francis A Mhimbira Renata Micha Ted R Miller Edward J Mills Philip B Mitchell Charles N Mock Norlinah Mohamed Ibrahim Karzan A Mohammad Ali H Mokdad Glen L D Mola Lorenzo Monasta Julio C Montañez Hernandez Marcella Montico Thomas J Montine Meghan D Mooney Ami R Moore Maziar Moradi-Lakeh Andrew E Moran Rintaro Mori Joanna Moschandreas Wilkister N Moturi Madeline L Moyer Dariush Mozaffarian William T Msemburi Ulrich O Mueller Mitsuru Mukaigawara Erin C Mullany Michele E Murdoch Joseph Murray Kinnari S Murthy Mohsen Naghavi Aliya Naheed Kovin S Naidoo Luigi Naldi Devina Nand Vinay Nangia K M Venkat Narayan Chakib Nejjari Sudan P Neupane Charles R Newton Marie Ng Frida N Ngalesoni Grant Nguyen Muhammad I Nisar Sandra Nolte Ole F Norheim Rosana E Norman Bo Norrving Luke Nyakarahuka In-Hwan Oh Takayoshi Ohkubo Summer L Ohno Bolajoko O Olusanya John Nelson Opio Katrina Ortblad Alberto Ortiz Amanda W Pain Jeyaraj D Pandian Carlo Irwin A Panelo Christina Papachristou Eun-Kee Park Jae-Hyun Park Scott B Patten George C Patton Vinod K Paul Boris I Pavlin Neil Pearce David M Pereira Rogelio Perez-Padilla Fernando Perez-Ruiz Norberto Perico Aslam Pervaiz Konrad Pesudovs Carrie B Peterson Max Petzold Michael R Phillips Bryan K Phillips David E Phillips Frédéric B Piel Dietrich Plass Dan Poenaru Suzanne Polinder Daniel Pope Svetlana Popova Richie G Poulton Farshad Pourmalek Dorairaj Prabhakaran Noela M Prasad Rachel L Pullan Dima M Qato D Alex Quistberg Anwar Rafay Kazem Rahimi Sajjad U Rahman Murugesan Raju Saleem M Rana Homie Razavi K Srinath Reddy Amany Refaat Giuseppe Remuzzi Serge Resnikoff Antonio L Ribeiro Lee Richardson Jan Hendrik Richardus D Allen Roberts David Rojas-Rueda Luca Ronfani Gregory A Roth Dietrich Rothenbacher David H Rothstein Jane T Rowley Nobhojit Roy George M Ruhago Mohammad Y Saeedi Sukanta Saha Mohammad Ali Sahraian Uchechukwu K A Sampson Juan R Sanabria Logan Sandar Itamar S Santos Maheswar Satpathy Monika Sawhney Peter Scarborough Ione J Schneider Ben Schöttker Austin E Schumacher David C Schwebel James G Scott Soraya Seedat Sadaf G Sepanlou Peter T Serina Edson E Servan-Mori Katya A Shackelford Amira Shaheen Saeid Shahraz Teresa Shamah Levy Siyi Shangguan Jun She Sara Sheikhbahaei Peilin Shi Kenji Shibuya Yukito Shinohara Rahman Shiri Kawkab Shishani Ivy Shiue Mark G Shrime Inga D Sigfusdottir Donald H Silberberg Edgar P Simard Shireen Sindi Abhishek Singh Jasvinder A Singh Lavanya Singh Vegard Skirbekk Erica Leigh Slepak Karen Sliwa Samir Soneji Kjetil Søreide Sergey Soshnikov Luciano A Sposato Chandrashekhar T Sreeramareddy Jeffrey D Stanaway Vasiliki Stathopoulou Dan J Stein Murray B Stein Caitlyn Steiner Timothy J Steiner Antony Stevens Andrea Stewart Lars J Stovner Konstantinos Stroumpoulis Bruno F Sunguya Soumya Swaminathan Mamta Swaroop Bryan L Sykes Karen M Tabb Ken Takahashi Nikhil Tandon David Tanne Marcel Tanner Mohammad Tavakkoli Hugh R Taylor Braden J Te Ao Fabrizio Tediosi Awoke M Temesgen Tara Templin Margreet Ten Have Eric Y Tenkorang Abdullah S Terkawi Blake Thomson Andrew L Thorne-Lyman Amanda G Thrift George D Thurston Taavi Tillmann Marcello Tonelli Fotis Topouzis Hideaki Toyoshima Jefferson Traebert Bach X Tran Matias Trillini Thomas Truelsen Miltiadis Tsilimbaris Emin M Tuzcu Uche S Uchendu Kingsley N Ukwaja Eduardo A Undurraga Selen B Uzun Wim H Van Brakel Steven Van De Vijver Coen H van Gool Jim Van Os Tommi J Vasankari N Venketasubramanian Francesco S Violante Vasiliy V Vlassov Stein Emil Vollset Gregory R Wagner Joseph Wagner Stephen G Waller Xia Wan Haidong Wang Jianli Wang Linhong Wang Tati S Warouw Scott Weichenthal Elisabete Weiderpass Robert G Weintraub Wang Wenzhi Andrea Werdecker Ronny Westerman Harvey A Whiteford James D Wilkinson Thomas N Williams Charles D Wolfe Timothy M Wolock Anthony D Woolf Sarah Wulf Brittany Wurtz Gelin Xu Lijing L Yan Yuichiro Yano Pengpeng Ye Gökalp K Yentür Paul Yip Naohiro Yonemoto Seok-Jun Yoon Mustafa Z Younis Chuanhua Yu Maysaa E Zaki Yong Zhao Yingfeng Zheng David Zonies Xiaonong Zou Joshua A Salomon Alan D Lopez Theo Vos

A First Report of Anguina pacificae in Ireland.

J Nematol 2015 Jun;47(2):97-104

Parasitology, Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 7BL, United Kingdom. ; Agri-Food and Biosciences Institute, Belfast, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492294PMC
June 2015