Publications by authors named "Thomas Fleming"

230Publications

Quantification of All-Trans Retinoic Acid by Liquid Chromatography-Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes.

Metabolites 2021 Jan 19;11(1). Epub 2021 Jan 19.

Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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January 2021

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

Nat Commun 2021 01 18;12(1):426. Epub 2021 Jan 18.

Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany.

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January 2021

Michaelis-Menten Kinetics Measurements of Aldo-Keto Reductases for Various Substrates in Murine Tissue.

STAR Protoc 2020 Dec 7;1(3):100206. Epub 2020 Dec 7.

Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg 69120, Germany.

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December 2020

Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them.

N Engl J Med 2020 Dec 2. Epub 2020 Dec 2.

The affiliations of the members of the WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation are the Office of Vaccines Research and Review, Food and Drug Administration, Silver Spring (P.R.K.), the School of Medicine, University of Maryland (M.M.L.), and Johns Hopkins University (S.P.), Baltimore, and the National Institute of Allergy and Infectious Diseases, Bethesda (M.N.) - all in Maryland; the Department of Biostatistics (T.R.F.), Fred Hutchinson Cancer Research Center (T.R.F., E.H.), University of Washington, Seattle; the Department of Biostatistics, University of Florida, Gainesville (I.M.L.); the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (R.P., V.B.); the Indian Council of Medical Research, New Delhi (B.B.); the Faculty of Medicine of the Universidad Nacional Autónoma de México, Mexico City (A.C.); the Coalition for Epidemic Preparedness Innovations, Hamburg, Germany (J.C.); the University of Pennsylvania, Philadelphia (S.S.E., S.P.); the University of the West Indies, Kingston, Jamaica (J.P.F.); the World Health Organization, Geneva (A.M.H.-R., M.J.R., S.S.); the Department of Health Security, Finnish Institute for Health and Welfare, Helsinki (H.M.N.);and the Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg (H.R.), and the Centre for the AIDS Programme of Research in South Africa, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban (J.S.) - both in South Africa.

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December 2020

Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish.

iScience 2020 Dec 3;23(12):101763. Epub 2020 Nov 3.

Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.

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December 2020

Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.

Mol Metab 2021 Jan 6;43:101114. Epub 2020 Nov 6.

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

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January 2021

Maintaining confidentiality of emerging results in COVID-19 vaccine trials is essential.

Lancet 2020 11 27;396(10263):1611-1613. Epub 2020 Oct 27.

Health Emergencies Programme, World Health Organization, CH-1211 Geneva 27, Switzerland. Electronic address:

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November 2020

The Glyoxalase System-New Insights into an Ancient Metabolism.

Antioxidants (Basel) 2020 Oct 1;9(10). Epub 2020 Oct 1.

Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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October 2020

Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans.

Redox Biol 2020 Oct 16;37:101723. Epub 2020 Sep 16.

Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

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October 2020

Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.

Cell Rep 2020 Sep;32(12):108160

Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg 69120, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany.

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September 2020

COVID-19 vaccine trials should seek worthwhile efficacy.

Lancet 2020 09 27;396(10253):741-743. Epub 2020 Aug 27.

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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September 2020

Male-predominant galanin mediates androgen-dependent aggressive chases in medaka.

Elife 2020 08 12;9. Epub 2020 Aug 12.

Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

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August 2020

Trial designs for evaluating combination HIV prevention approaches.

HIV Res Clin Pract 2020 Apr - Jun;21(2-3):72-82. Epub 2020 Jul 23.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

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July 2020

Achieving effective informed oversight by DMCs in COVID clinical trials.

J Clin Epidemiol 2020 10 10;126:167-171. Epub 2020 Jul 10.

University of Washington, Seattle, USA.

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October 2020

Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.

J Diabetes Complications 2020 Sep 2;34(9):107648. Epub 2020 Jun 2.

Department of internal medicine I and clinical chemistry, University Hospital Heidelberg, Heidelberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

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September 2020