Publications by authors named "Thomas F Westbrook"

44Publications

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

Cell Chem Biol 2020 Oct 20. Epub 2020 Oct 20.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.10.001DOI Listing
October 2020

Energy-stress-mediated AMPK activation inhibits ferroptosis.

Nat Cell Biol 2020 02 6;22(2):225-234. Epub 2020 Feb 6.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41556-020-0461-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008777PMC
February 2020

Reduction of Global H3K27me Enhances HER2/ErbB2 Targeted Therapy.

Cell Rep 2019 10;29(2):249-257.e8

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.105DOI Listing
October 2019

Correction: A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 03;38(13):2436

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0587-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608334PMC
March 2019

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 02 7;38(7):913-934. Epub 2018 Sep 7.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514858PMC
February 2019

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Cell 2018 04 22;173(2):499-514.e23. Epub 2018 Mar 22.

Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643283PMC
April 2018

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

Neuron 2016 Oct 6;92(2):407-418. Epub 2016 Oct 6.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745060PMC
October 2016

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.

Cell Rep 2015 Jun 21;11(9):1486-500. Epub 2015 May 21.

Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464939PMC
June 2015

The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.

Cancer Cell 2015 Feb 15;27(2):193-210. Epub 2015 Jan 15.

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326554PMC
February 2015

The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.

Cell Rep 2014 Nov 6;9(4):1318-32. Epub 2014 Nov 6.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://www.cell.com/cms/attachment/2020816778/2040986338/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400865
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http://dx.doi.org/10.1016/j.celrep.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427000PMC
November 2014

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.

Nat Commun 2014 Jun 9;5:4088. Epub 2014 Jun 9.

1] Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA [2] Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA [3] Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA [4] Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA [5] Department of Dermatology, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA [6] Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms5088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052366PMC
June 2014

Plk2 regulates mitotic spindle orientation and mammary gland development.

Development 2014 Apr 5;141(7):1562-71. Epub 2014 Mar 5.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/dev.108258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957376PMC
April 2014

A role for PVRL4-driven cell-cell interactions in tumorigenesis.

Elife 2013 Apr 30;2:e00358. Epub 2013 Apr 30.

Department of Genetics , Harvard Medical School , Boston , United States ; Division of Genetics , Howard Hughes Medical Institute, Brigham and Women's Hospital , Boston , United States.

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http://dx.doi.org/10.7554/eLife.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641523PMC
April 2013

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Cell 2009 May;137(5):835-48

Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2009.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768667PMC
May 2009

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

Nature 2008 Mar;452(7185):370-4

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature06780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688689PMC
March 2008

Cancer proliferation gene discovery through functional genomics.

Science 2008 Feb;319(5863):620-4

Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1149200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981870PMC
February 2008

A genetic screen for candidate tumor suppressors identifies REST.

Cell 2005 Jun;121(6):837-48

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.03.033DOI Listing
June 2005

E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).

Mol Cell Biol 2002 Oct;22(20):7041-52

Department of Microbiology and Immunology. Department of Biochemistry and Biophysics. The Cancer Center, University of Rochester, Rochester, New York 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139800PMC
http://dx.doi.org/10.1128/mcb.22.20.7041-7052.2002DOI Listing
October 2002

Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest.

J Virol 2002 Jan;76(2):619-32

Department of Microbiology and Immunology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136809PMC
http://dx.doi.org/10.1128/jvi.76.2.619-632.2002DOI Listing
January 2002