Thomas F Schulz

Thomas F Schulz

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Thomas F Schulz

Thomas F Schulz

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Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8.

J Med Chem 2019 Apr 12;62(8):3924-3939. Epub 2019 Apr 12.

Department of Drug Design and Optimization (DDOP) , Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI) , Campus E8.1 , 66123 Saarbrücken , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01827DOI Listing
April 2019

Kaposi sarcoma herpesvirus pathogenesis.

Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)

Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany

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http://dx.doi.org/10.1098/rstb.2016.0275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597742PMC
October 2017

Editorial overview: Viruses and cancer: How tumor viruses affect the cellular genome.

Curr Opin Virol 2017 10;26:vi-vii

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2017.10.005DOI Listing
October 2017

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.

J Virol 2017 07 26;91(14). Epub 2017 Jun 26.

Institute of Virology, Hannover Medical School, Hannover, Germany, and German Centre for Infection Research, Hannover-Braunschweig Site, Germany

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http://dx.doi.org/10.1128/JVI.01083-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487577PMC
July 2017

Rhadinoviral interferon regulatory factor homologues.

Biol Chem 2017 07;398(8):857-870

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http://dx.doi.org/10.1515/hsz-2017-0111DOI Listing
July 2017

Proliferation status defines functional properties of endothelial cells.

Cell Mol Life Sci 2017 04 16;74(7):1319-1333. Epub 2016 Nov 16.

Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany.

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http://dx.doi.org/10.1007/s00018-016-2417-5DOI Listing
April 2017

Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain.

Neurobiol Dis 2017 Mar 22;99:121-132. Epub 2016 Dec 22.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.12.020DOI Listing
March 2017

KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.

Curr Opin Virol 2016 10 9;20:11-19. Epub 2016 Aug 9.

Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2016.07.008DOI Listing
October 2016

Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.

Nat Commun 2016 06 22;7:11995. Epub 2016 Jun 22.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1038/ncomms11995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917963PMC
June 2016

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.

Am J Hum Genet 2015 Nov 8;97(5):738-43. Epub 2015 Oct 8.

School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.ajhg.2015.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667104PMC
November 2015

Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.

Curr Opin Virol 2015 Oct 29;14:116-28. Epub 2015 Sep 29.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2015.08.016DOI Listing
October 2015

Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells.

PLoS Pathog 2015 Aug 21;11(8):e1005105. Epub 2015 Aug 21.

Institute of Virology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), Braunschweig, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1005105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546648PMC
August 2015

K1 and K15 of Kaposi's Sarcoma-Associated Herpesvirus Are Partial Functional Homologues of Latent Membrane Protein 2A of Epstein-Barr Virus.

J Virol 2015 Jul 6;89(14):7248-61. Epub 2015 May 6.

Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Centre for Infection Research (DZIF) Partner Site, Munich, Germany

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http://dx.doi.org/10.1128/JVI.00839-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473585PMC
July 2015

Generation of high-titre virus stocks using BrK.219, a B-cell line infected stably with recombinant Kaposi's sarcoma-associated herpesvirus.

J Virol Methods 2015 Jun 28;217:79-86. Epub 2015 Feb 28.

Institute of Virology, Hannover Medical School, Carl-Neuberg-Str.1, Hannover D-30625, Germany; German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2015.02.022DOI Listing
June 2015

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA.

Proc Natl Acad Sci U S A 2015 May 6;112(21):6694-9. Epub 2015 May 6.

Department of Structural Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; Institute of Virology, Hannover Medical School, 30625 Hannover, Germany; and

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http://dx.doi.org/10.1073/pnas.1421804112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450395PMC
May 2015

The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma.

J Pathol 2015 Jan;235(2):368-80

Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany.

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http://dx.doi.org/10.1002/path.4441DOI Listing
January 2015

A human adenovirus species B subtype 21a associated with severe pneumonia.

J Infect 2014 Nov 27;69(5):490-9. Epub 2014 Jun 27.

Institut für Virologie, Medizinische Hochschule, Hannover, Germany; Netzwerk Atemwegsinfektionen des Robert-Koch-Institutes, Adenovirus Konsiliarlabor, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2014.06.015DOI Listing
November 2014

Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA.

Acta Crystallogr F Struct Biol Commun 2014 Nov 25;70(Pt 11):1570-4. Epub 2014 Oct 25.

Department of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1107/S2053230X14019906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231869PMC
November 2014

High-level human herpesvirus-8 viremia and multicentric Castleman's disease following initiation of highly active antiretroviral therapy.

AIDS 2014 Jul;28(11):1698-700

aRoyal Free London NHS Foundation Trust, Pond Street bNorth Middlesex University Hospital NHS Trust, Sterling Way, London cNorfolk and Norwich University Hospitals, Norwich, UK dInstitute for Virology and National Reference Centre for EBV and HHV6-8, Medizinische Hochschule, Hannover, Germany.

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http://dx.doi.org/10.1097/QAD.0000000000000287DOI Listing
July 2014

Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation.

Semin Cancer Biol 2014 Jun 28;26:69-77. Epub 2014 Jan 28.

Institute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2014.01.008DOI Listing
June 2014

Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

PLoS Pathog 2013 16;9(5):e1003336. Epub 2013 May 16.

Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.plos.org/10.1371/journal.ppat.1003336
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http://dx.doi.org/10.1371/journal.ppat.1003336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656114PMC
December 2013

Next-generation sequencing fails to identify human virus sequences in cutaneous squamous cell carcinoma.

Int J Cancer 2012 Oct 27;131(7):E1173-9. Epub 2012 Apr 27.

Institute of Virology, Hannover Medical School, Hannover, Germany.

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http://doi.wiley.com/10.1002/ijc.27581
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http://dx.doi.org/10.1002/ijc.27581DOI Listing
October 2012

A role for the internal repeat of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen in the persistence of an episomal viral genome.

J Virol 2012 Feb 16;86(3):1883-7. Epub 2011 Nov 16.

Institute of Virology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1128/JVI.06029-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264353PMC
February 2012

WHAT do viruses BET on?

Front Biosci (Landmark Ed) 2010 Jan 1;15:537-49. Epub 2010 Jan 1.

Hannover Medical School, Institute of Virology, Hannover, Germany.

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http://dx.doi.org/10.2741/3632DOI Listing
January 2010

The contribution of systems biology and reverse genetics to the understanding of Kaposi's sarcoma-associated herpesvirus pathogenesis in endothelial cells.

Thromb Haemost 2009 Dec;102(6):1117-34

Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1160/TH09-07-0472DOI Listing
December 2009

Cancer and viral infections in immunocompromised individuals.

Authors:
Thomas F Schulz

Int J Cancer 2009 Oct;125(8):1755-63

Institute of Virology, Hannover Medical School, Hannover 60325, Germany.

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http://dx.doi.org/10.1002/ijc.24741DOI Listing
October 2009

Community-acquired respiratory viral infections in lung transplant recipients: a single season cohort study.

Transplantation 2009 May;87(10):1530-7

Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/TP.0b013e3181a4857dDOI Listing
May 2009

A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activation.

J Virol 2009 Mar 7;83(6):2563-74. Epub 2009 Jan 7.

Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen-Nuremberg, Schwabachanlage 10, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1128/JVI.01512-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648262PMC
March 2009

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

PLoS Pathog 2009 Mar 6;5(3):e1000324. Epub 2009 Mar 6.

Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.ppat.1000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648312PMC
March 2009

HIV-associated lymphomas and gamma-herpesviruses.

Blood 2009 Feb 27;113(6):1213-24. Epub 2008 Oct 27.

Department of Pathology, National Cancer Institute of Milan, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2008-09-180315DOI Listing
February 2009

Is the Epstein-Barr virus EBNA-1 protein an oncogen?

Proc Natl Acad Sci U S A 2009 Feb 11;106(7):2091-2. Epub 2009 Feb 11.

Institute of Virology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1073/pnas.0812575106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650111PMC
February 2009

Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.

J Gen Virol 2007 Jun;88(Pt 6):1698-707

Department of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1099/vir.0.82807-0DOI Listing
June 2007

HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus.

Mol Cancer 2007 Apr 13;6:28. Epub 2007 Apr 13.

Department of Microbiology, Tumor and Cell Biology (MTC) and Center for Integrative Recognition in the Immune System, Karolinska Institute, Stockholm, Sweden.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-6-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857702PMC
April 2007

Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study.

Int J Cancer 2007 Mar;120(5):1129-35

Centre d'Estudis Epidemiològics sobre l'HIV/SIDA de Catalunya, Departament de Salut, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

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http://dx.doi.org/10.1002/ijc.22281DOI Listing
March 2007

Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population.

J Infect Dis 2007 Mar 5;195(6):809-16. Epub 2007 Feb 5.

Institute of Virology, Hannover Medical School, Hannover, 30625, Germany.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/5118
Publisher Site
http://dx.doi.org/10.1086/511827DOI Listing
March 2007

Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.

J Virol 2007 Jan 18;81(1):42-58. Epub 2006 Oct 18.

Institut für Virologie, Medizinische Hochschule Hannover, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1128/JVI.00648-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797256PMC
January 2007

Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

J Gen Virol 2006 May;87(Pt 5):1047-74

Institut für Virologie, Medizinische Hochschule Hannover, Germany.

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http://dx.doi.org/10.1099/vir.0.81598-0DOI Listing
May 2006

The pleiotropic effects of Kaposi's sarcoma herpesvirus.

Authors:
Thomas F Schulz

J Pathol 2006 Jan;208(2):187-98

Department of Virology, Hannover Medical School, Germany.

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http://dx.doi.org/10.1002/path.1904DOI Listing
January 2006

Absence of Kaposi's sarcoma-associated herpesvirus in patients with pulmonary arterial hypertension.

Am J Respir Crit Care Med 2005 Dec 28;172(12):1581-5. Epub 2005 Sep 28.

Institute of Virology, Hannover Medical School, Carl Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1164/rccm.200504-546OCDOI Listing
December 2005

EBV latent membrane protein-1 protects B cells from apoptosis by inhibition of BAX.

Blood 2005 Apr 21;105(8):3263-9. Epub 2004 Dec 21.

University of Erlangen-Nürnberg, Department of Surgery, Division of Molecular and Experimental Surgery, Schwabachanlage 10, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1182/blood-2004-07-2752DOI Listing
April 2005

Mother-to-child transmission of human herpesvirus-8 in South Africa.

J Infect Dis 2004 Sep 11;190(6):1068-75. Epub 2004 Aug 11.

Liverpool School of Tropical Medicine, Liverpool, and Cancer Research UK Epidemiology Unit, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/423326DOI Listing
September 2004

Human herpesvirus 8: biology and role in the pathogenesis of Kaposi's sarcoma and other AIDS-related malignancies.

Curr HIV/AIDS Rep 2004 Apr;1(1):5-11

Department of Virology, Hannover Medical School, Carl-Neuberg-Strasse1, D-30625 Hannover, Germany.

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April 2004

Transmission and disease association of Kaposi's sarcoma-associated herpesvirus: recent developments.

Curr Opin Infect Dis 2004 Feb;17(1):53-7

Department of Virology, Hannover Medical School, Hannover, Germany.

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February 2004