Thomas Efferth

Thomas Efferth

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Thomas Efferth

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Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times.

J Ethnopharmacol 2019 Oct 4;243:112007. Epub 2019 Jun 4.

Natural Products Laboratory, IBL, Leiden University, PO Box 9505, 2300RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jep.2019.112007DOI Listing
October 2019

Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms.

J Ethnopharmacol 2019 Oct 29;242:112049. Epub 2019 Jun 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, 55128, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.112049DOI Listing
October 2019

Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells.

Eur J Pharmacol 2019 Oct 17;861:172618. Epub 2019 Aug 17.

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, China; College of Forestry, Beijing Forestry University, Beijing, 100083, China; Advanced Innovation Center for Tree Breeding By Molecular Design, Beijing Forestry University, Beijing, 100083, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.172618DOI Listing
October 2019

Cytotoxic flavonoids from two species.

Nat Prod Res 2019 Sep 16;33(18):2609-2617. Epub 2018 Apr 16.

b Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry , Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1080/14786419.2018.1462179DOI Listing
September 2019

Shikonin derivatives for cancer prevention and therapy.

Cancer Lett 2019 Sep 24;459:248-267. Epub 2019 May 24.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.04.033DOI Listing
September 2019

Editorial: Chemoprevention of cancer by natural products.

Authors:
Thomas Efferth

Cancer Lett 2019 Sep 27;459:13-14. Epub 2019 May 27.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.05.022DOI Listing
September 2019

MicroRNA targeting by quercetin in cancer treatment and chemoprotection.

Pharmacol Res 2019 Sep 8;147:104346. Epub 2019 Jul 8.

Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104346DOI Listing
September 2019

Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs.

Phytomedicine 2019 Sep 3;64:153082. Epub 2019 Sep 3.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.phymed.2019.153082DOI Listing
September 2019

Development of artemisinin resistance in malaria therapy.

Pharmacol Res 2019 Aug 14;146:104275. Epub 2019 May 14.

Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104275DOI Listing
August 2019

Combining the wisdoms of traditional medicine with cutting-edge science and technology at the forefront of medical sciences.

Phytomedicine 2019 Aug 29;64:153078. Epub 2019 Aug 29.

Harvard Medical School, McLean Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153078DOI Listing
August 2019

The pharmacology of the genus Sophora (Fabaceae): An updated review.

Phytomedicine 2019 Aug 21;64:153070. Epub 2019 Aug 21.

Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, 11566, Cairo, Egypt; Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153070DOI Listing
August 2019

Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.

Phytomedicine 2019 Jul 10;60:152881. Epub 2019 Mar 10.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152881DOI Listing
July 2019

Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy.

Phytomedicine 2019 Jul 15;60:152832. Epub 2019 Jan 15.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152832DOI Listing
July 2019

Broad-spectrum Cross-resistance to Anticancer Drugs Mediated by Epidermal Growth Factor Receptor.

Anticancer Res 2019 Jul;39(7):3585-3593

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.21873/anticanres.13505DOI Listing
July 2019

Interactions between artemisinin derivatives and P-glycoprotein.

Phytomedicine 2019 Jul 27;60:152998. Epub 2019 Jun 27.

Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152998DOI Listing
July 2019

Professor Hildebert Wagner celebrates his 90th birthday.

Authors:
Thomas Efferth

Phytomedicine 2019 Jul 20;60:153034. Epub 2019 Jul 20.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153034DOI Listing
July 2019

Cytotoxicity of Crude Extract and Isolated Constituents of the Bark towards Multifactorial Drug-Resistant Cancer Cells.

Evid Based Complement Alternat Med 2019 8;2019:8450158. Epub 2019 Jul 8.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany.

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http://dx.doi.org/10.1155/2019/8450158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644236PMC
July 2019

Tratt. and L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.

Nat Prod Res 2019 Jun 12;33(12):1809-1812. Epub 2018 Feb 12.

c Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry , Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1080/14786419.2018.1437432DOI Listing
June 2019

Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression.

Phytomedicine 2019 Jun 14;59:152890. Epub 2019 Mar 14.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193006
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http://dx.doi.org/10.1016/j.phymed.2019.152890DOI Listing
June 2019

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells.

Phytomedicine 2019 Jun 26;59:152771. Epub 2018 Nov 26.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183058
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http://dx.doi.org/10.1016/j.phymed.2018.11.031DOI Listing
June 2019

Vitamin K thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells.

Invest New Drugs 2019 Jun 29. Epub 2019 Jun 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, 55128, Mainz, Germany.

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http://dx.doi.org/10.1007/s10637-019-00810-7DOI Listing
June 2019

Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells.

J Ethnopharmacol 2019 May 29;235:28-37. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.01.031DOI Listing
May 2019

Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer.

Phytomedicine 2019 May 30;58:152853. Epub 2019 Jan 30.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Stawdenger Weg 5, 55128 Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193002
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http://dx.doi.org/10.1016/j.phymed.2019.152853DOI Listing
May 2019

2'O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo.

Chem Biol Interact 2019 May 6;304:20-27. Epub 2019 Mar 6.

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, China; College of Forestry, Beijing Forestry University, Beijing, 100083, China. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.02.029DOI Listing
May 2019

Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.

Phytomedicine 2019 May 6;58:152743. Epub 2018 Nov 6.

Phytomed AB, Vaxtorp, Halland, Sweden; EuroPharma USA Inc., 955 Challenger Dr., Green Bay, WI 54311, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.11.004DOI Listing
May 2019

Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes.

Aging (Albany NY) 2019 May;11(9):2797-2811

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.18632/aging.101952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535074PMC
May 2019

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells.

Phytomedicine 2019 May 2;62:152945. Epub 2019 May 2.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193011
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http://dx.doi.org/10.1016/j.phymed.2019.152945DOI Listing
May 2019

Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines.

Front Pharmacol 2019 21;10:542. Epub 2019 May 21.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2019.00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536578PMC
May 2019

Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study.

Phytomedicine 2019 May 30;62:152970. Epub 2019 May 30.

Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.

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http://dx.doi.org/10.1016/j.phymed.2019.152970DOI Listing
May 2019

Application of integrative cloud point extraction and concentration for the analysis of polyphenols and alkaloids in mulberry leaves.

J Pharm Biomed Anal 2019 Apr 10;167:132-139. Epub 2019 Feb 10.

Northeast Forestry University, Hexing Road 26, 150040, Harbin, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183253
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http://dx.doi.org/10.1016/j.jpba.2019.02.002DOI Listing
April 2019

Cardenolides: Insights from chemical structure and pharmacological utility.

Pharmacol Res 2019 03 21;141:123-175. Epub 2018 Dec 21.

Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, 55128 Mainz, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183118
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http://dx.doi.org/10.1016/j.phrs.2018.12.015DOI Listing
March 2019

Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells.

Phytomedicine 2019 Mar 9;56:246-260. Epub 2018 Nov 9.

EuroPharma USA Inc., 955 Challenger Dr., Green Bay, WI 54311; Phytomed AB, Vaxtorp, Halland, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.11.011DOI Listing
March 2019

Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes.

Phytomedicine 2019 Mar 28;55:269-281. Epub 2018 Jun 28.

Department of Pharmaceutical Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.phymed.2018.06.046DOI Listing
March 2019

Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells.

Phytomedicine 2019 Mar 19;55:80-91. Epub 2018 Oct 19.

EuroPharma USA Inc., 955 Challenger Dr., Green Bay, Wisconsin 54311 United States; Phytomed AB, Vaxtorp, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183054
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http://dx.doi.org/10.1016/j.phymed.2018.10.022DOI Listing
March 2019

Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds.

Invest New Drugs 2019 Mar 15. Epub 2019 Mar 15.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 55128, Mainz, Germany.

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http://dx.doi.org/10.1007/s10637-019-00752-0DOI Listing
March 2019

Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells.

Nat Prod Res 2019 Mar 21:1-8. Epub 2019 Mar 21.

b Department of Pharmaceutical Biology , Institute of Pharmacy and Biochemistry, Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1080/14786419.2019.1587424DOI Listing
March 2019

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening.

J Adv Res 2019 Mar 31;16:145-156. Epub 2018 Oct 31.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz 55128, Germany.

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http://dx.doi.org/10.1016/j.jare.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412170PMC
March 2019

Anti-poliovirus activity of Nerium oleander aqueous extract.

Nat Prod Res 2019 Mar 25:1-4. Epub 2019 Mar 25.

c Frankincense Biodiversity Unit, Research Center , Dhofar University , Salalah , Oman.

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http://dx.doi.org/10.1080/14786419.2019.1582046DOI Listing
March 2019

Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome.

Oncotarget 2019 Mar 8;10(20):1918-1931. Epub 2019 Mar 8.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://www.oncotarget.com/fulltext/26727
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http://dx.doi.org/10.18632/oncotarget.26727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443015PMC
March 2019

Biopiracy of medicinal plants: Finding fair solutions for the use of natural resources.

Authors:
Thomas Efferth

Phytomedicine 2019 02 3;53:294-295. Epub 2018 Jul 3.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183023
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http://dx.doi.org/10.1016/j.phymed.2018.06.047DOI Listing
February 2019

Selective inhibition of P-gp transporter by goniothalamin derivatives sensitizes resistant cancer cells to chemotherapy.

J Nat Med 2019 Jan 31;73(1):226-235. Epub 2018 Jul 31.

Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, CHEMPARK, Kaiser-Wilhelm-Allee,Geb. E39, 51368, Leverkusen, Germany.

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http://dx.doi.org/10.1007/s11418-018-1230-xDOI Listing
January 2019

Collateral sensitivity of natural products in drug-resistant cancer cells.

Biotechnol Adv 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193000
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http://dx.doi.org/10.1016/j.biotechadv.2019.01.009DOI Listing
January 2019

Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.

Phytomedicine 2018 Dec 20;51:112-119. Epub 2018 Jun 20.

Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.06.030DOI Listing
December 2018

Cell Harvesting Methods Affect Cellular Integrity of Adherent Cells During Apoptosis Detection.

Anticancer Res 2018 Dec;38(12):6669-6672

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.21873/anticanres.13034DOI Listing
December 2018

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.

Phytomedicine 2018 Nov 20;50:257-284. Epub 2018 Sep 20.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.09.204DOI Listing
November 2018

Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.

Phytomedicine 2018 Nov 20;50:285-299. Epub 2018 Sep 20.

EuroPharma USA Inc., 955 Challenger Dr., Green Bay, WI 54311, USA; Phytomed AB,Bofinkvagen 1, 31275 Vaxtorp, Halland, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.09.202DOI Listing
November 2018

Identification of fatal outcome in a childhood nasopharyngeal carcinoma patient by protein expression profiling.

Int J Oncol 2018 Oct 19;53(4):1721-1731. Epub 2018 Jul 19.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, D-55128 Mainz, Germany.

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http://dx.doi.org/10.3892/ijo.2018.4491DOI Listing
October 2018

Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.

Fitoterapia 2018 Oct 13;130:54-60. Epub 2018 Aug 13.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2018.08.002DOI Listing
October 2018

Prospecting for cytotoxic and antiprotozoal 4-aryl-4H-chromenes and 10-aryldihydropyrano[2,3-f]chromenes.

Arch Pharm (Weinheim) 2018 Oct 23;351(10):e1800100. Epub 2018 Aug 23.

Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

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http://dx.doi.org/10.1002/ardp.201800100DOI Listing
October 2018

Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells.

Oncol Lett 2018 Oct 23;16(4):4640-4648. Epub 2018 Jul 23.

Department of Neurosurgery, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, P.R. China.

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http://dx.doi.org/10.3892/ol.2018.9192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126342PMC
October 2018

Repurposing of Bromocriptine for Cancer Therapy.

Front Pharmacol 2018 8;9:1030. Epub 2018 Oct 8.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2018.01030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187981PMC
October 2018

Ancistrolikokine I and further 5,8'-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko and their cytotoxic activities against drug-sensitive and multidrug resistant human leukemia cells.

Fitoterapia 2018 Sep 22;129:114-125. Epub 2018 Jun 22.

Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2018.06.009DOI Listing
September 2018

Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway.

J Cell Mol Med 2018 09 11;22(9):4423-4436. Epub 2018 Jul 11.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1111/jcmm.13742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111873PMC
September 2018

The hydrolysis of 6-phosphogluconolactone in the second step of pentose phosphate pathway occurs via a two-water mechanism.

Biophys Chem 2018 09 12;240:98-106. Epub 2018 Jun 12.

Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Sector H-12, 44000 Islamabad, Pakistan; Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, 02118 Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bpc.2018.06.002DOI Listing
September 2018

Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells.

Phytomedicine 2018 Sep 18;48:112-119. Epub 2017 Dec 18.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113173019
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http://dx.doi.org/10.1016/j.phymed.2017.12.016DOI Listing
September 2018

Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant .

Molecules 2018 Sep 1;23(9). Epub 2018 Sep 1.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany.

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http://dx.doi.org/10.3390/molecules23092221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225227PMC
September 2018

Diabetes and Metabolism Disorders Medicinal Plants: A Glance at the Past and a Look to the Future 2018.

Evid Based Complement Alternat Med 2018 30;2018:5843298. Epub 2018 Sep 30.

Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1155/2018/5843298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188851PMC
September 2018

Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells.

J Ethnopharmacol 2018 Aug 27;222:21-33. Epub 2018 Apr 27.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2018.04.036DOI Listing
August 2018

Prevention of carcinogenesis and metastasis by Artemisinin-type drugs.

Cancer Lett 2018 08 8;429:11-18. Epub 2018 May 8.

Department of Experimental Surgery - Cancer Metastasis, Medical Faculty Mannheim, Center for Biomedicine and Medical Technology Mannheim (CBTM), Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht-Karls University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.05.008DOI Listing
August 2018

The activity of Artemisia spp. and their constituents against Trypanosomiasis.

Phytomedicine 2018 Aug 9;47:184-191. Epub 2018 Jun 9.

Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183018
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http://dx.doi.org/10.1016/j.phymed.2018.06.002DOI Listing
August 2018

Prevention from radiation damage by natural products.

Phytomedicine 2018 Aug 13;47:192-200. Epub 2017 Nov 13.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2017.11.005DOI Listing
August 2018

In vivo acute toxicity of detoxified Fuzi (lateral root of Aconitum carmichaeli) after a traditional detoxification process.

EXCLI J 2018 31;17:889-899. Epub 2018 Aug 31.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://www.excli.de/vol17/Huang_31082018_proof.pdf
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http://dx.doi.org/10.17179/excli2018-1607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295630PMC
August 2018

Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana.

Fitoterapia 2018 Jul 30;128:26-30. Epub 2018 Apr 30.

Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2018.04.019DOI Listing
July 2018

Total Synthesis and Biological Investigation of (-)-Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific.

Angew Chem Int Ed Engl 2018 07 10;57(27):8293-8296. Epub 2018 Jun 10.

Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, 04301, Leipzig, Germany.

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http://doi.wiley.com/10.1002/anie.201802015
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http://dx.doi.org/10.1002/anie.201802015DOI Listing
July 2018

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.

Bioorg Med Chem 2018 07 24;26(12):3610-3618. Epub 2018 May 24.

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.05.041DOI Listing
July 2018

Natural Products as a Source for New Leads in Cancer Research and Treatment.

Evid Based Complement Alternat Med 2018 15;2018:8243680. Epub 2018 Jul 15.

MARE-Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, Peniche, Portugal.

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http://dx.doi.org/10.1155/2018/8243680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076959PMC
July 2018

Molecular bases of the poor response of liver cancer to chemotherapy.

Clin Res Hepatol Gastroenterol 2018 06 12;42(3):182-192. Epub 2018 Mar 12.

Experimental Hepatology and Drug Targeting (HEVEFARM), University of Salamanca, IBSAL, Salamanca, Spain; Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain.

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http://dx.doi.org/10.1016/j.clinre.2017.12.006DOI Listing
June 2018

Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

ACS Med Chem Lett 2018 Jun 21;9(6):534-539. Epub 2017 Dec 21.

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00412
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http://dx.doi.org/10.1021/acsmedchemlett.7b00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004568PMC
June 2018

Antimicrobial and Antioxidant Activities of Natural Compounds.

Evid Based Complement Alternat Med 2018 6;2018:1945179. Epub 2018 Jun 6.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1155/2018/1945179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011080PMC
June 2018

Insights into apoptotic proteins in chemotherapy: quantification techniques and informing therapy choice.

Expert Rev Proteomics 2018 05 30;15(5):413-429. Epub 2018 Apr 30.

a Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy , Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1080/14789450.2018.1468755DOI Listing
May 2018

Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).

Front Pharmacol 2018 15;9:481. Epub 2018 May 15.

Medical and Clinical Affairs Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, Darmstadt, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962668PMC
May 2018

In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan.

Nat Prod Bioprospect 2018 Apr 16;8(2):97-105. Epub 2018 Feb 16.

Department of Pharmaceutical Biology, Johannes Gutenberg University, 55128, Mainz, Germany.

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http://dx.doi.org/10.1007/s13659-018-0155-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913048PMC
April 2018

Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds.

Molecules 2018 Apr 6;23(4). Epub 2018 Apr 6.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 55128 Mainz, Germany.

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http://dx.doi.org/10.3390/molecules23040841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017613PMC
April 2018

Aloe-emodin as drug candidate for cancer therapy.

Oncotarget 2018 Apr 3;9(25):17770-17796. Epub 2018 Apr 3.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 55128 Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.24880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915154PMC
April 2018

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by and Analyses.

Front Pharmacol 2018 16;9:355. Epub 2018 Apr 16.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911471PMC
April 2018

A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.

Phytomedicine 2018 Apr 19;43:78-85. Epub 2018 Mar 19.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.03.035DOI Listing
April 2018

Ancistrocyclinones A and B, unprecedented pentacyclic N,C-coupled naphthylisoquinoline alkaloids, from the Chinese liana Ancistrocladus tectorius.

Org Biomol Chem 2018 02;16(9):1581-1590

Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1039/c7ob03092dDOI Listing
February 2018

Molecular Determinants of Sensitivity or Resistance of Cancer Cells Toward Sanguinarine.

Front Pharmacol 2018 26;9:136. Epub 2018 Feb 26.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834429PMC
February 2018

Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology.

Front Pharmacol 2018 27;9:143. Epub 2018 Feb 27.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835320PMC
February 2018

Medicinal Plants from Near East for Cancer Therapy.

Front Pharmacol 2018 31;9:56. Epub 2018 Jan 31.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fphar.2018.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797783PMC
January 2018

Threats to human health by great ocean garbage patches.

Lancet Planet Health 2017 Nov 9;1(8):e301-e303. Epub 2017 Nov 9.

Institute for the History, Philosophy, and Ethics of Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1016/S2542-5196(17)30140-7DOI Listing
November 2017

Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against , Human Cytomegalovirus, and Leukemia Cells.

ACS Omega 2017 Jun 1;2(6):2422-2431. Epub 2017 Jun 1.

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Henkestraße 42, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1021/acsomega.7b00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044832PMC
June 2017