Thomas E Wales

Thomas E Wales

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Thomas E Wales

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The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation.

J Biol Chem 2020 Mar 9. Epub 2020 Mar 9.

Department of Biological Chemistry, University of Michigan Medical School, United States.

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http://dx.doi.org/10.1074/jbc.RA120.012803DOI Listing
March 2020

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX.

Cell Rep 2020 Mar;30(10):3229-3239.e6

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.057DOI Listing
March 2020

Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A.

J Mol Biol 2020 Feb 6. Epub 2020 Feb 6.

Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA, 02118, United States; Amyloidosis Treatment and Research Center, Boston University School of Medicine, Boston, MA, 02118, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2020.01.029DOI Listing
February 2020

Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data.

Methods Mol Biol 2020 ;2051:407-435

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9744-2_18DOI Listing
January 2020

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

Nat Biotechnol 2019 10 19;37(10):1186-1197. Epub 2019 Aug 19.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0222-zDOI Listing
October 2019

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.

Proc Natl Acad Sci U S A 2019 10 7;116(43):21539-21544. Epub 2019 Oct 7.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011;

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http://dx.doi.org/10.1073/pnas.1907566116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815127PMC
October 2019

Structural basis of the atypical activation mechanism of KRAS.

J Biol Chem 2019 09 24;294(38):13964-13972. Epub 2019 Jul 24.

Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390

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http://dx.doi.org/10.1074/jbc.RA119.009131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755796PMC
September 2019

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.

Science 2019 08 27;365(6452). Epub 2019 Jun 27.

Department of Cell Biology, Harvard Medical School, and Howard Hughes Medical Institute, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aax1033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980381PMC
August 2019

Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding.

Expert Rev Proteomics 2019 Jul 24;16(7):613-625. Epub 2019 Jun 24.

b Department of Chemistry and Chemical Biology , Northeastern University , Boston , MA , USA.

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http://dx.doi.org/10.1080/14789450.2019.1633920DOI Listing
July 2019

Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.

Biochemistry 2019 03 4;58(10):1440-1449. Epub 2019 Mar 4.

Sorbonne Universités , UPMC Univ. Paris 06, CNRS, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, UMR8226, Institut de Biologie Physico-Chimique , 13 rue Pierre et Marie Curie , 75005 Paris , France.

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http://dx.doi.org/10.1021/acs.biochem.8b01308DOI Listing
March 2019

Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes.

Methods Mol Biol 2018 ;1764:153-171

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7759-8_10DOI Listing
February 2019

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.

Nat Struct Mol Biol 2018 07 2;25(7):616-622. Epub 2018 Jul 2.

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41594-018-0085-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044470PMC
July 2018

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

J Mol Biol 2018 02 16;430(3):310-321. Epub 2017 Dec 16.

Department of Chemistry and Chemical Biology, Maildrop 412TF, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801098PMC
February 2018

Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry.

J Chromatogr A 2017 Nov 3;1523:275-282. Epub 2017 Jun 3.

Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.05.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675777PMC
November 2017

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

Structure 2017 10 31;25(10):1481-1494.e4. Epub 2017 Aug 31.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629114PMC
October 2017

Allosteric sensitization of proapoptotic BAX.

Nat Chem Biol 2017 Sep 10;13(9):961-967. Epub 2017 Jul 10.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675120PMC
September 2017

Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2015 29;8:127-48. Epub 2015 May 29.

Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-anchem-062011-143113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989240PMC
December 2016

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

J Am Soc Mass Spectrom 2016 06 31;27(6):1048-61. Epub 2016 Mar 31.

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s13361-016-1365-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865444PMC
June 2016

Allosteric inhibition of antiapoptotic MCL-1.

Nat Struct Mol Biol 2016 06 9;23(6):600-7. Epub 2016 May 9.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900187PMC
June 2016

Dynamics of the Tec-family tyrosine kinase SH3 domains.

Protein Sci 2016 Apr 18;25(4):852-64. Epub 2016 Mar 18.

Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts, 02115.

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http://dx.doi.org/10.1002/pro.2887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941224PMC
April 2016

Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.

J Am Soc Mass Spectrom 2016 Apr 26;27(4):662-8. Epub 2016 Jan 26.

Department of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1007/s13361-015-1330-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829384PMC
April 2016

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

PLoS Comput Biol 2016 Mar 24;12(3):e1004826. Epub 2016 Mar 24.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807093PMC
March 2016

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

J Mol Biol 2016 Jan 10;428(2 Pt B):449-62. Epub 2015 Nov 10.

Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744490PMC
January 2016

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

PLoS One 2014 21;9(8):e105629. Epub 2014 Aug 21.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105629PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140816PMC
November 2015

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.

Biochemistry 2015 Oct 6;54(41):6382-91. Epub 2015 Oct 6.

Department of Chemistry & Chemical Biology, Northeastern University , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615603PMC
October 2015

Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Anal Chem 2015 Jul 2;87(14):7030-5. Epub 2015 Jul 2.

†Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, Massachusetts 02115-5000, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b01725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509969PMC
July 2015

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Mol Cell 2015 Mar 12;57(5):873-886. Epub 2015 Feb 12.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384643PMC
March 2015

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

J Mol Biol 2014 Oct 2;426(21):3656-69. Epub 2014 Sep 2.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188691PMC
October 2014

Considerations in the analysis of hydrogen exchange mass spectrometry data.

Methods Mol Biol 2013 ;1007:263-88

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-392-3_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713502PMC
December 2013

Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.

Anal Chem 2013 Dec 14;85(23):11185-8. Epub 2013 Nov 14.

Aileron Therapeutics, Inc., 281 Albany Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ac403173pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883098PMC
December 2013

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

J Mol Biol 2013 Sep 6;425(17):3192-204. Epub 2013 Jun 6.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751422PMC
September 2013

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Sci Signal 2013 Aug 27;6(290):ra76. Epub 2013 Aug 27.

Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.1126/scisignal.2004298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089953PMC
August 2013

Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.

Biochemistry 2013 Jul 8;52(29):5016-26. Epub 2013 Jul 8.

Center for Drug Discovery and Departments of Pharmaceutical Sciences and Chemistry and Chemical Biology, Northeastern University , Boston, Massachusetts 02115-5000, United States.

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http://dx.doi.org/10.1021/bi400430kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855488PMC
July 2013

Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.

Protein Sci 2013 Jun 29;22(6):774-87. Epub 2013 Apr 29.

Center for Drug Discovery and Department of Chemistry, Northeastern University, Boston, Massachusetts 02115-5000, USA.

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http://dx.doi.org/10.1002/pro.2257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690717PMC
June 2013

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

J Biol Chem 2013 Mar 9;288(9):6116-29. Epub 2013 Jan 9.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA.

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http://dx.doi.org/10.1074/jbc.M112.431312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585049PMC
March 2013

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Int Rev Phys Chem 2013 Jan;32(1):96-127

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115 USA.

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http://dx.doi.org/10.1080/0144235X.2012.751175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652491PMC
January 2013

Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

ACS Chem Neurosci 2012 May 20;3(5):393-9. Epub 2012 Mar 20.

Center for Drug Discovery and Department of Chemistry and Chemical Biology and Barnett Institute of Chemical and Biological Analysis, Northeastern University , Boston, Massachusetts 02115-5000, United States.

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http://dx.doi.org/10.1021/cn3000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400385PMC
May 2012

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

BMC Chem Biol 2012 Mar 15;12. Epub 2012 Mar 15.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1186/1472-6769-12-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328272PMC
March 2012

Conformational locking upon cooperative assembly of notch transcription complexes.

Structure 2012 Feb;20(2):340-9

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.str.2011.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285698PMC
February 2012

Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

J Mol Biol 2010 Apr 4;398(1):40-53. Epub 2010 Mar 4.

Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853235PMC
April 2010

High-speed and high-resolution UPLC separation at zero degrees Celsius.

Anal Chem 2008 Sep 2;80(17):6815-20. Epub 2008 Aug 2.

The Barnett Institute, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ac8008862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562353PMC
September 2008

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

J Mol Biol 2007 Nov 11;374(1):121-9. Epub 2007 Sep 11.

Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117379PMC
November 2007

Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis.

J Am Soc Mass Spectrom 2006 Nov 27;17(11):1498-1509. Epub 2006 Jul 27.

Department of Chemistry and Biochemistry and San Diego Supercomputer Center, University of California-San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/j.jasms.2006.05.014DOI Listing
November 2006

Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.

Biochemistry 2006 Jun;45(25):7733-9

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA.

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http://dx.doi.org/10.1021/bi060438xDOI Listing
June 2006

Partial unfolding of diverse SH3 domains on a wide timescale.

J Mol Biol 2006 Apr 6;357(5):1592-604. Epub 2006 Feb 6.

Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.01.075DOI Listing
April 2006

Hydrogen exchange mass spectrometry for the analysis of protein dynamics.

Mass Spectrom Rev 2006 Jan-Feb;25(1):158-70

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.

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http://dx.doi.org/10.1002/mas.20064DOI Listing
February 2006

Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold.

Proc Natl Acad Sci U S A 2006 Feb 10;103(8):2600-4. Epub 2006 Feb 10.

Department of Chemistry, Duke University, Durham, NC 27708, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0508121103
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http://dx.doi.org/10.1073/pnas.0508121103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413781PMC
February 2006

Facile chemical synthesis and equilibrium unfolding properties of CopG.

Protein Sci 2004 Jul 28;13(7):1918-26. Epub 2004 May 28.

Department of Chemistry, Box 90346, Duke University, Durham, NC 27708-0346, USA.

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http://dx.doi.org/10.1110/ps.04671804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279938PMC
July 2004