Thomas E Lloyd

Thomas E Lloyd

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Thomas E Lloyd

Thomas E Lloyd

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How can an understanding of the C9orf72 gene translate into amyotrophic lateral sclerosis therapies?

Expert Rev Neurother 2019 Oct 3;19(10):895-897. Epub 2019 Jul 3.

Department of Neurology, School of Medicine, Johns Hopkins University , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/14737175.2019.1635884DOI Listing
October 2019

Identification of distinctive interferon gene signatures in different types of myositis.

Neurology 2019 Sep 21;93(12):e1193-e1204. Epub 2019 Aug 21.

From the National Institute of Arthritis and Musculoskeletal and Skin Diseases (I.P.-F, M.C.-D, A.D., K.P., P.P., F.W.M., A.L.M.), NIH, Bethesda; Johns Hopkins University School of Medicine (I.P.-F., M.C.-D., J.P., J.A., L.C.-S., T.E.L., A.M.C., A.L.M.), Baltimore, MD; Clinic Hospital and the University of Barcelona (J.C.M., J.M.G.-J.); Vall d'Hebron Hospital and Autonomous University of Barcelona (A.S.-O.); and Faculty of Health Sciences (I.P.-F.), Universitat Oberta de Catalunya, Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000008128DOI Listing
September 2019

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice.

J Vis Exp 2019 Sep 16(151). Epub 2019 Sep 16.

Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine; Department of Neurology, Johns Hopkins University School of Medicine; Department of Neuroscience, Johns Hopkins University School of Medicine;

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http://dx.doi.org/10.3791/59966DOI Listing
September 2019

Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.

J Nutr Biochem 2019 Feb 14;64:170-181. Epub 2018 Nov 14.

Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA 10029; Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA 10468. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363841PMC
February 2019

FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons.

Brain Res 2018 08 3;1693(Pt A):55-66. Epub 2018 Apr 3.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347466PMC
August 2018

Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism.

Brain Res 2018 08 9;1693(Pt A):109-120. Epub 2018 May 9.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.04.043DOI Listing
August 2018

Fifteen-year longitudinal follow-up of a patient with severe early-onset Charcot-Marie-Tooth disease type 2A.

Muscle Nerve 2018 05 26;57(5):E126-E128. Epub 2018 Jan 26.

Department of Neurology, Johns Hopkins University School of Medicine, John G. Rangos Building, 855 North Wolfe Street, Suite 227 Baltimore, Maryland, 21205, USA.

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http://dx.doi.org/10.1002/mus.26047DOI Listing
May 2018

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Cell 2018 05 5;173(4):958-971.e17. Epub 2018 Apr 5.

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Cellular and Molecular Medicine Program, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183030
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http://dx.doi.org/10.1016/j.cell.2018.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083872PMC
May 2018

New Developments in the Genetics of Inclusion Body Myositis.

Curr Rheumatol Rep 2018 04 2;20(5):26. Epub 2018 Apr 2.

Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11926-018-0738-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374100PMC
April 2018

Internal grant review to increase grant funding for junior investigators.

Ann Neurol 2017 10 4;82(4):497-502. Epub 2017 Oct 4.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1002/ana.25040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761667PMC
October 2017

Overlapping features of polymyositis and inclusion body myositis in HIV-infected patients.

Neurology 2017 Apr 10;88(15):1454-1460. Epub 2017 Mar 10.

From the Johns Hopkins University School of Medicine (T.E.L., E.H.M., L.C.-S., N.S., A.L.M.), Baltimore; and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (I.P.-F., K.P., A.L.M.), National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000003821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386438PMC
April 2017

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Neuron 2017 Apr;94(1):93-107.e6

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595097PMC
April 2017

Tdp-43 cryptic exons are highly variable between cell types.

Mol Neurodegener 2017 02 2;12(1):13. Epub 2017 Feb 2.

Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s13024-016-0144-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289002PMC
February 2017

Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease.

J Magn Reson Imaging 2016 12 29;44(6):1513-1521. Epub 2016 Apr 29.

Neurology, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/jmri.25293DOI Listing
December 2016

A Case of Morvan Syndrome Mimicking Amyotrophic Lateral Sclerosis With Frontotemporal Dementia.

J Clin Neuromuscul Dis 2016 Jun;17(4):207-11

*Department of Neurology, Johns Hopkins Hospital, Baltimore, MD; and ‡Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1097/CND.0000000000000118DOI Listing
June 2016

Nucleocytoplasmic transport in C9orf72-mediated ALS/FTD.

Nucleus 2016 Apr 26;7(2):132-7. Epub 2016 Apr 26.

a Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/19491034.2016.1172152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916865PMC
April 2016

FIG4 regulates lysosome membrane homeostasis independent of phosphatase function.

Hum Mol Genet 2016 Feb 11;25(4):681-92. Epub 2015 Dec 11.

Department of Neurology, and The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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http://dx.doi.org/10.1093/hmg/ddv505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743688PMC
February 2016

Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.

Arthritis Care Res (Hoboken) 2016 Jan;68(1):66-71

National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, and Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/acr.22600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887848PMC
January 2016

Drosophila models of neurologic disease.

Exp Neurol 2015 Dec;274(Pt A):1-3

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.expneurol.2015.10.004DOI Listing
December 2015

Myositis-specific autoantibodies are specific for myositis compared to genetic muscle disease.

Neurol Neuroimmunol Neuroinflamm 2015 Dec 19;2(6):e172. Epub 2015 Nov 19.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (A.L.M.), NIH, Bethesda; the Departments of Neurology (A.L.M., L.C.-S., T.E.L., K.R.W.), Medicine (L.C.-R., L.C.-S.), and Neuroscience (T.E.L., K.R.W.), Johns Hopkins University School of Medicine, Baltimore; and The Hugo W. Moser Research Institute (K.R.W.), Kennedy Krieger, Baltimore, MD.

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http://dx.doi.org/10.1212/NXI.0000000000000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676353PMC
December 2015

Spectrum of Muscle Histopathologic Findings in Forty-Two Scleroderma Patients With Weakness.

Arthritis Care Res (Hoboken) 2015 Oct;67(10):1416-25

Johns Hopkins University School of Medicine and National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1002/acr.22620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580502PMC
October 2015

Laing distal myopathy pathologically resembling inclusion body myositis.

Ann Clin Transl Neurol 2014 Dec 6;1(12):1053-8. Epub 2014 Nov 6.

Department of Neurology, Johns Hopkins University School of Medicine Baltimore, Maryland ; Department of Neuroscience, Johns Hopkins University School of Medicine Baltimore, Maryland.

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http://dx.doi.org/10.1002/acn3.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284131PMC
December 2014

A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.

Neuron 2014 Nov 30;84(4):764-77. Epub 2014 Oct 30.

Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, 6431 Fannin Street, Houston, TX 77030, USA; Graduate Program in Developmental Biology, Baylor College of Medicine, 1250 Moursund Street, Suite N1125.14, Mailstop NR-1125, Houston, TX 77030, USA; Graduate Programs in Cell and Regulatory Biology (CRB) and Neuroscience, Graduate School of Biomedical Sciences, University of Texas School of Medicine, Houston, TX 77030. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254599PMC
November 2014

The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.

Hum Mol Genet 2014 Jul 25;23(14):3810-22. Epub 2014 Feb 25.

Department of Neurology, and The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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http://dx.doi.org/10.1093/hmg/ddu094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065154PMC
July 2014

Evaluation and construction of diagnostic criteria for inclusion body myositis.

Neurology 2014 Jul 27;83(5):426-33. Epub 2014 Jun 27.

From the Departments of Neurology (T.E.L., A.L.M.), Neuroscience (T.E.L.), and Medicine (A.L.M.), Johns Hopkins University School of Medicine and Johns Hopkins Bayview Myositis Center, Baltimore, MD; Department of Neurology (A.A.A., S.A.G.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (M.D.W.), University of Washington, Seattle; Department of Neurology (M.N.), Australian Neuromuscular Research Institute, University of Western Australia; and Children's Hospital Informatics Program (S.A.G.), Boston Children's Hospital and Harvard-MIT Division of Health Sciences and Technology, Boston, MA.

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http://www.neurology.org/content/83/5/426.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000064
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132572PMC
July 2014

WIDE AWAKE mediates the circadian timing of sleep onset.

Neuron 2014 Apr 13;82(1):151-66. Epub 2014 Mar 13.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982794PMC
April 2014

Peripheral neuropathy: clinical and electrophysiological considerations.

Neuroimaging Clin N Am 2014 Feb 25;24(1):49-65. Epub 2013 May 25.

Department of Neurology, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.nic.2013.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329247PMC
February 2014

Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila.

Development 2013 Feb;140(3):627-38

Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1242/dev.085100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561792PMC
February 2013

Axonal transport disruption in peripheral nerve disease: From Jack's discoveries as a resident to recent contributions.

Authors:
Thomas E Lloyd

J Peripher Nerv Syst 2012 Dec;17 Suppl 3:46-51

Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/j.1529-8027.2012.00431.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365469PMC
December 2012

Sciatic nerve tumor and tumor-like lesions - uncommon pathologies.

Skeletal Radiol 2012 Jul 13;41(7):763-74. Epub 2012 Mar 13.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00256-012-1384-7DOI Listing
July 2012

Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture.

Cell 2012 Mar;148(5):1029-38

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674120015
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http://dx.doi.org/10.1016/j.cell.2011.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294265PMC
March 2012

Novel therapeutic approaches for inclusion body myositis.

Authors:
Thomas E Lloyd

Curr Opin Rheumatol 2010 Nov;22(6):658-64

Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe St./Meyer 5-119, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1097/BOR.0b013e32833f0f4aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365473PMC
November 2010

Flightless flies: Drosophila models of neuromuscular disease.

Ann N Y Acad Sci 2010 Jan;1184:e1-20

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062507PMC
http://dx.doi.org/10.1111/j.1749-6632.2010.05432.xDOI Listing
January 2010

When cell biology meets development: endocytic regulation of signaling pathways.

Genes Dev 2002 Jun;16(11):1314-36

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.989602
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http://dx.doi.org/10.1101/gad.989602DOI Listing
June 2002

Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.

Cell 2002 Jan;108(2):261-9

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00611-6DOI Listing
January 2002