Publications by authors named "Thomas Dick"

100Publications

Response to: The post-inspiratory complex (PiCo), what is the evidence?

J Physiol 2021 Jan 1;599(1):361-362. Epub 2020 Dec 1.

The Florey Institute of Neuroscience & Mental Health, University of Melbourne, 30 Royal Parade, Parkville, Victoria, Australia.

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January 2021

Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties.

Front Microbiol 2020 27;11:575586. Epub 2020 Oct 27.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States.

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October 2020

Single Cell Analysis of Drug Susceptibility of During Macrophage Infection.

Antibiotics (Basel) 2020 Oct 17;9(10). Epub 2020 Oct 17.

Department of Microbiology and Immunology, Yong Loo Lin School of Medcine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore.

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October 2020

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2020 11 17;64(12). Epub 2020 Nov 17.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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November 2020

Traube-Hering waves are formed by interaction of respiratory sinus arrhythmia and pulse pressure modulation in healthy men.

J Appl Physiol (1985) 2020 Nov 17;129(5):1193-1202. Epub 2020 Sep 17.

Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia.

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November 2020

Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition.

ACS Infect Dis 2020 07 29;6(7):1882-1893. Epub 2020 May 29.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117545 Singapore.

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July 2020

Brainstem inflammation modulates the ventilatory pattern and its variability after acute lung injury in rodents.

J Physiol 2020 07 21;598(13):2791-2811. Epub 2020 May 21.

Division of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, Cleveland, Ohio, United States.

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July 2020

Pyrazinamide triggers degradation of its target aspartate decarboxylase.

Nat Commun 2020 04 3;11(1):1661. Epub 2020 Apr 3.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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April 2020

Extreme Drug Tolerance of "Persisters".

Front Microbiol 2020 4;11:359. Epub 2020 Mar 4.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States.

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March 2020

Rifabutin: A Repurposing Candidate for Lung Disease.

Authors:
Thomas Dick

Front Microbiol 2020 27;11:371. Epub 2020 Feb 27.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States.

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February 2020

Volumetric mapping of the functional neuroanatomy of the respiratory network in the perfused brainstem preparation of rats.

J Physiol 2020 06 16;598(11):2061-2079. Epub 2020 Apr 16.

The Florey Institute of Neuroscience & Mental Health, University of Melbourne, Melbourne, Australia.

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June 2020

Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.

Brain Behav Immun 2020 07 22;87:610-633. Epub 2020 Feb 22.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes VA Medical Center, Cleveland, OH 44106, United States. Electronic address:

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July 2020

Antituberculosis Activity of the Antimalaria Cytochrome Oxidase Inhibitor SCR0911.

ACS Infect Dis 2020 04 5;6(4):725-737. Epub 2020 Mar 5.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Republic of Singapore.

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April 2020

Reply to Vargas and Farhat: mutants in human tuberculosis.

Proc Natl Acad Sci U S A 2020 02 19;117(8):3913-3914. Epub 2020 Feb 19.

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ 07103;

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February 2020

Rifabutin Suppresses Inducible Clarithromycin Resistance in by Blocking Induction of and .

Antibiotics (Basel) 2020 Feb 10;9(2). Epub 2020 Feb 10.

Department of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, 340 Kingsland Street, Nutley, NJ 07110, USA.

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February 2020

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus.

Antimicrob Agents Chemother 2020 03 24;64(4). Epub 2020 Mar 24.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

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March 2020

Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline.

Antibiotics (Basel) 2019 Dec 11;8(4). Epub 2019 Dec 11.

Center for Drug Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.

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December 2019

Rifabutin Is Active against Mycobacterium abscessus in Mice.

Antimicrob Agents Chemother 2020 01 27;64(2). Epub 2020 Jan 27.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

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January 2020

Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase.

Biochem Biophys Res Commun 2020 02 21;522(2):374-380. Epub 2019 Nov 21.

Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore. Electronic address:

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February 2020

Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design.

Prog Biophys Mol Biol 2020 05 16;152:64-73. Epub 2019 Nov 16.

Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore. Electronic address:

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May 2020

Targeted protein degradation in antibacterial drug discovery?

Prog Biophys Mol Biol 2020 05 16;152:10-14. Epub 2019 Nov 16.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA; Department of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USA. Electronic address:

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May 2020

TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity.

Antimicrob Agents Chemother 2020 01 27;64(2). Epub 2020 Jan 27.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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January 2020

Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide.

Trends Pharmacol Sci 2019 12 6;40(12):930-940. Epub 2019 Nov 6.

Center for Discovery and Innovation, Hackensack Meridian Health, 340 Kingsland Street Building 102, Nutley, NJ 07110, USA; Department of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, 340 Kingsland Street, Nutley, NJ 07110, USA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Republic of Singapore.

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December 2019

Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation.

Front Physiol 2019 23;10:887. Epub 2019 Jul 23.

Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

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July 2019

TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of F-ATP Synthase.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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October 2019

Editorial: NTM-The New Uber-Bugs.

Front Microbiol 2019 12;10:1299. Epub 2019 Jun 12.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States.

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June 2019

Repositioning rifamycins for Mycobacterium abscessus lung disease.

Expert Opin Drug Discov 2019 09 14;14(9):867-878. Epub 2019 Jun 14.

a Center for Discovery and Innovation, Hackensack Meridian Health , Nutley , NJ , USA.

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September 2019

Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus.

Antimicrob Agents Chemother 2019 08 25;63(8). Epub 2019 Jul 25.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

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August 2019

Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.

Respir Physiol Neurobiol 2019 07 27;265:161-171. Epub 2019 Mar 27.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA.

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July 2019

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in .

mBio 2019 03 26;10(2). Epub 2019 Mar 26.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA

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March 2019

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption.

Front Microbiol 2018 4;9:2960. Epub 2018 Dec 4.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States.

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December 2018

Rapid and robust restoration of breathing long after spinal cord injury.

Nat Commun 2018 11 27;9(1):4843. Epub 2018 Nov 27.

Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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November 2018

Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε.

J Struct Biol 2018 12 17;204(3):420-434. Epub 2018 Oct 17.

Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Republic of Singapore. Electronic address:

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December 2018

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst.

Front Microbiol 2018 15;9:1898. Epub 2018 Aug 15.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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August 2018

TB drug susceptibility is more than MIC.

Nat Microbiol 2018 09;3(9):971-972

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.

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September 2018

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs.

Front Microbiol 2018 19;9:1627. Epub 2018 Jul 19.

Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.

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July 2018

Periodicity: A Characteristic of Heart Rate Variability Modified by the Type of Mechanical Ventilation After Acute Lung Injury.

Front Physiol 2018 19;9:772. Epub 2018 Jun 19.

Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, United States.

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June 2018

Teicoplanin - Tigecycline Combination Shows Synergy Against .

Front Microbiol 2018 11;9:932. Epub 2018 May 11.

The Public Health Research Institute, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, NJ, United States.

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May 2018

NTM drug discovery: status, gaps and the way forward.

Drug Discov Today 2018 08 7;23(8):1502-1519. Epub 2018 Apr 7.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, 225 Warren Street, Newark, NJ 07103, USA. Electronic address:

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August 2018

Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.

Brain Behav Immun 2018 05 28;70:398-422. Epub 2018 Mar 28.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes VA Medical Center, Cleveland, OH 44106, United States. Electronic address:

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May 2018

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2018 05 26;62(5). Epub 2018 Apr 26.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA

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May 2018

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.

Eur J Med Chem 2018 Jan 7;144:262-276. Epub 2017 Dec 7.

Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, 117543, Singapore. Electronic address:

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January 2018

Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.

Antimicrob Agents Chemother 2018 03 23;62(3). Epub 2018 Feb 23.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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March 2018

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents.

ACS Med Chem Lett 2017 Nov 9;8(11):1165-1170. Epub 2017 Oct 9.

Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543.

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November 2017

Phasic inhibition as a mechanism for generation of rapid respiratory rhythms.

Proc Natl Acad Sci U S A 2017 11 13;114(48):12815-12820. Epub 2017 Nov 13.

Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106;

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November 2017

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

ACS Infect Dis 2017 11 18;3(11):807-819. Epub 2017 Oct 18.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore , 5 Science Drive 2, Singapore 117545.

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November 2017

Vancomycin and Clarithromycin Show Synergy against .

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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December 2017

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates.

Front Microbiol 2017 15;8:1539. Epub 2017 Aug 15.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore.

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August 2017

Draft Genome Sequence of 11.

Genome Announc 2017 Aug 10;5(32). Epub 2017 Aug 10.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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August 2017

Bifurcation of the respiratory response to lung inflation in anesthetized dogs.

Respir Physiol Neurobiol 2017 10 8;244:26-31. Epub 2017 Jul 8.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA; Department of Medicine and MetroHealth Research Institute, Case Western Reserve University and MetroHealth Medical Center, OH, USA. Electronic address:

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October 2017

Draft Genome Sequence of Bamboo.

Genome Announc 2017 May 18;5(20). Epub 2017 May 18.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore

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May 2017

Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.

Front Microbiol 2017 27;8:746. Epub 2017 Apr 27.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore.

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April 2017

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation.

J Biol Chem 2017 07 11;292(27):11262-11279. Epub 2017 May 11.

From the Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Republic of Singapore,

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July 2017

Rifabutin Is Active against Mycobacterium abscessus Complex.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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June 2017

Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease.

mSphere 2017 Mar-Apr;2(2). Epub 2017 Mar 15.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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March 2017

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties.

J Med Chem 2017 04 28;60(7):2745-2763. Epub 2017 Mar 28.

Department of Pharmacy and ‡Department of Microbiology and Immunology, National University of Singapore , Singapore 117543, Singapore.

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April 2017

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.

Antimicrob Agents Chemother 2017 05 24;61(5). Epub 2017 Apr 24.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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May 2017

Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.

Am J Physiol Regul Integr Comp Physiol 2017 02 14;312(2):R172-R188. Epub 2016 Dec 14.

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio;

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February 2017

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2017 02 24;61(2). Epub 2017 Jan 24.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore

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February 2017

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis.

BMC Genomics 2016 10 26;17(1):837. Epub 2016 Oct 26.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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October 2016

Effects of ion channel noise on neural circuits: an application to the respiratory pattern generator to investigate breathing variability.

J Neurophysiol 2017 01 19;117(1):230-242. Epub 2016 Oct 19.

Department of Electrical Engineering and Computer Science, School of Engineering, Case Western Reserve University, Cleveland, Ohio

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January 2017

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.

ACS Infect Dis 2016 09 8;2(9):616-626. Epub 2016 Aug 8.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Republic of Singapore.

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September 2016

C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea.

Respir Physiol Neurobiol 2017 01 15;235:88-94. Epub 2016 Oct 15.

Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH, United States; School of Medicine, Case Western Reserve University, Cleveland, OH, United States. Electronic address:

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January 2017

Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria.

Front Microbiol 2016 7;7:1392. Epub 2016 Sep 7.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore; BSL3 Core Facility, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore.

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September 2016

Rel Is Required for Morphogenesis of Resting Cells in Mycobacterium smegmatis.

Front Microbiol 2016 31;7:1390. Epub 2016 Aug 31.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore Singapore, Singapore.

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September 2016

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.

Antimicrob Agents Chemother 2016 11 21;60(11):6977-6979. Epub 2016 Oct 21.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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November 2016

Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties.

Eur J Med Chem 2016 Nov 30;123:684-703. Epub 2016 Jul 30.

Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, 169856, Singapore; Duke-NUS Medical School, SRP Neuroscience and Behavioural Disorders, 169857, Singapore. Electronic address:

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November 2016

Mild Nutrient Starvation Triggers the Development of a Small-Cell Survival Morphotype in Mycobacteria.

Front Microbiol 2016 16;7:947. Epub 2016 Jun 16.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore Singapore, Singapore.

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July 2016

Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development.

Future Microbiol 2016 05 9;11:643-50. Epub 2016 May 9.

Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545.

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May 2016

Boromycin Kills Mycobacterial Persisters without Detectable Resistance.

Front Microbiol 2016 22;7:199. Epub 2016 Feb 22.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore Singapore, Singapore.

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March 2016

Alternative approaches to well-being and engagement in Vanuatu.

Authors:
Thomas Dick

Australas Psychiatry 2015 Dec;23(6 Suppl):52-4

PhD Candidate, Southern Cross University, Gold Coast, QLD, Australia

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December 2015

Eagle Effect in Nonreplicating Persister Mycobacteria.

Antimicrob Agents Chemother 2015 Dec 8;59(12):7786-9. Epub 2015 Sep 8.

Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore

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December 2015

Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea.

J Neurophysiol 2015 Oct 22;114(4):2162-86. Epub 2015 Jul 22.

Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida;

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October 2015

Metabolic flexibility and morphological plasticity in mycobacteria.

Future Microbiol 2015 ;10(4):449-52

Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Singapore 117545, Republic of Singapore.

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January 2016

The new tuberculosis drug Perchlozone® shows cross-resistance with thiacetazone.

Int J Antimicrob Agents 2015 Apr 3;45(4):430-3. Epub 2015 Feb 3.

Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Block MD4A, Singapore 117545, Republic of Singapore. Electronic address:

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April 2015

Antibacterial drug discovery: doing it right.

Chem Biol 2015 Jan;22(1):5-6

Antibacterial Drug Discovery Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117545, Republic of Singapore. Electronic address:

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January 2015

Respiratory modulation of sympathetic activity is attenuated in adult rats conditioned with chronic hypobaric hypoxia.

Respir Physiol Neurobiol 2015 Jan 22;206:53-60. Epub 2014 Nov 22.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States; Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, United States.

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January 2015

Increased cardio-respiratory coupling evoked by slow deep breathing can persist in normal humans.

Respir Physiol Neurobiol 2014 Dec 28;204:99-111. Epub 2014 Sep 28.

Department of Physiology, Michigan State University, East Lansing, MI, United States.

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December 2014

Reactive dirty fragments: implications for tuberculosis drug discovery.

Curr Opin Microbiol 2014 Oct 30;21:7-12. Epub 2014 Jul 30.

Antibacterial Drug Discovery Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Block MD4A, Singapore 117597, Republic of Singapore. Electronic address:

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October 2014

Cardiorespiratory coupling: common rhythms in cardiac, sympathetic, and respiratory activities.

Prog Brain Res 2014 ;209:191-205

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.

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April 2015

Learning to breathe: habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.

Respir Physiol Neurobiol 2014 May 22;195:44-9. Epub 2014 Feb 22.

Department of Medicine, Case Western Reserve University, Cleveland, USA.

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May 2014