Thomas De Raedt

Thomas De Raedt

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Thomas De Raedt

Thomas De Raedt

Publications by authors named "Thomas De Raedt"

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Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium.

Authors:
Heba Ijaz Mateusz Koptyra Krutika S Gaonkar Jo Lynne Rokita Valerie P Baubet Lamiya Tauhid Yuankun Zhu Miguel Brown Gonzalo Lopez Bo Zhang Sharon J Diskin Zalman Vaksman Jennifer L Mason Elizabeth Appert Jena Lilly Rishi Lulla Thomas De Raedt Allison P Heath Alex Felmeister Pichai Raman Javad Nazarian Maria Rita Santi Phillip B Storm Adam Resnick Angela J Waanders Kristina A Cole

Neuro Oncol 2020 Jan;22(1):163-165

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia (CHOP) Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/neuonc/noz192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954395PMC
January 2020

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in -, and -Mutant Melanomas.

Authors:
Ophélia Maertens Ryan Kuzmickas Haley E Manchester Chloe E Emerson Alessandra G Gavin Caroline J Guild Terence C Wong Thomas De Raedt Christian Bowman-Colin Elodie Hatchi Levi A Garraway Keith T Flaherty Shailja Pathania Stephen J Elledge Karen Cichowski

Cancer Discov 2019 04 1;9(4):526-545. Epub 2019 Feb 1.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0879DOI Listing
April 2019

2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

Authors:
Michael J Fisher Allan J Belzberg Peter de Blank Thomas De Raedt Florent Elefteriou Rosalie E Ferner Marco Giovannini Gordon J Harris Michel Kalamarides Matthias A Karajannis AeRang Kim Conxi Lázaro Lu Q Le Wei Li Robert Listernick Staci Martin Helen Morrison Eric Pasmant Nancy Ratner Elisabeth Schorry Nicole J Ullrich David Viskochil Brian Weiss Brigitte C Widemann Yuan Zhu Annette Bakker Eduard Serra

Am J Med Genet A 2018 05;176(5):1258-1269

Hereditary Cancer Group, The Institute for Health Science Research Germans Trias i Pujol (IGTP)-PMPPC, Barcelona, Spain.

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http://dx.doi.org/10.1002/ajmg.a.38675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918269PMC
May 2018

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies.

Authors:
Ophélia Maertens Mila E McCurrach Benjamin S Braun Thomas De Raedt Inbal Epstein Tannie Q Huang Jennifer O Lauchle Hyerim Lee Jianqiang Wu Timothy P Cripe D Wade Clapp Nancy Ratner Kevin Shannon Karen Cichowski

Cancer Res 2017 11 9;77(21):5706-5711. Epub 2017 Oct 9.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668167PMC
November 2017

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.

Authors:
Sarah Naomi Olsen Ania Wronski Zafira Castaño Benjamin Dake Clare Malone Thomas De Raedt Miriam Enos Yoko S DeRose Wenhui Zhou Stephanie Guerra Massimo Loda Alana Welm Ann H Partridge Sandra S McAllister Charlotte Kuperwasser Karen Cichowski

Cancer Discov 2017 02 14;7(2):202-217. Epub 2016 Dec 14.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461361PMC
February 2017

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Authors:
Haikuo Zhang Jun Qi Jaime M Reyes Lewyn Li Prakash K Rao Fugen Li Charles Y Lin Jennifer A Perry Matthew A Lawlor Alexander Federation Thomas De Raedt Yvonne Y Li Yan Liu Melissa A Duarte Yanxi Zhang Grit S Herter-Sprie Eiki Kikuchi Julian Carretero Charles M Perou Jacob B Reibel Joshiawa Paulk Roderick T Bronson Hideo Watanabe Christine Fillmore Brainson Carla F Kim Peter S Hammerman Myles Brown Karen Cichowski Henry Long James E Bradner Kwok-Kin Wong

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.

Authors:
Thomas De Raedt Eline Beert Eric Pasmant Armelle Luscan Hilde Brems Nicolas Ortonne Kristian Helin Jason L Hornick Victor Mautner Hildegard Kehrer-Sawatzki Wade Clapp James Bradner Michel Vidaud Meena Upadhyaya Eric Legius Karen Cichowski

Nature 2014 Oct 13;514(7521):247-51. Epub 2014 Aug 13.

1] Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [2] Harvard Medical School, Boston, Massachusetts 02115, USA [3] Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature13561
Publisher Site
http://dx.doi.org/10.1038/nature13561DOI Listing
October 2014

The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.

Authors:
Armelle Luscan Ghjuvan'ghjacumu Shackleford Julien Masliah-Planchon Ingrid Laurendeau Nicolas Ortonne Jennifer Varin François Lallemand Karen Leroy Valérie Dumaine Mikael Hivelin Didier Borderie Thomas De Raedt Laurence Valeyrie-Allanore Frédérique Larousserie Benoît Terris Laurent Lantieri Michel Vidaud Dominique Vidaud Pierre Wolkenstein Béatrice Parfait Ivan Bièche Charbel Massaad Eric Pasmant

Clin Cancer Res 2014 Jan 11;20(2):358-71. Epub 2013 Nov 11.

Authors' Affiliations: UMR_S745 INSERM, Université Paris Descartes Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques; Department of Plastic and Reconstructive Surgery, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), PRES Sorbonne Paris Cité; Service d'Anatomie et Cytologie Pathologiques, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Université Paris Descartes; Service de Biochimie et de Génétique Moléculaire, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP); UMR8194 CNRS, PRES Sorbonne Paris Cité, Paris Descartes; Department of Orthopedic Surgery, Cochin Hospital; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Laboratory of Biochemistry; Tumour bank, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University; INSERM, U1016, Institut Cochin, and CNRS, UMR8104, Paris; Département de pathologie Assistance Publique-Hôpitaux de Paris (AP-HP) and Université Paris Est Créteil (UPEC); Platform of Biological Ressources; Department of Plastic and Reconstructive Surgery, Assistance Publique-Hôpitaux de Paris (AP-HP) and Université Paris Est Créteil (UPEC), Hôpital Henri-Mondor; Department of Dermatology, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP) and EA 4393 LIC, UPEC, Créteil, France; Laboratoire d'Oncogénétique, Institut Curie, Hôpital René Huguenin; FNCLCC, Saint-Cloud; and Genetics Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0780DOI Listing
January 2014

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.

Authors:
Sara Koenig McLaughlin Sarah Naomi Olsen Benjamin Dake Thomas De Raedt Elgene Lim Roderick Terry Bronson Rameen Beroukhim Kornelia Polyak Myles Brown Charlotte Kuperwasser Karen Cichowski

Cancer Cell 2013 Sep;24(3):365-78

Genetics Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822334PMC
September 2013

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.

Authors:
Eline Beert Hilde Brems Bruno Daniëls Ivo De Wever Frank Van Calenbergh Joseph Schoenaers Maria Debiec-Rychter Olivier Gevaert Thomas De Raedt Annick Van Den Bruel Thomy de Ravel Karen Cichowski Lan Kluwe Victor Mautner Raf Sciot Eric Legius

Genes Chromosomes Cancer 2011 Dec 24;50(12):1021-32. Epub 2011 Aug 24.

Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.20921DOI Listing
December 2011

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

Authors:
Thomas De Raedt Zandra Walton Jessica L Yecies Danan Li Yimei Chen Clare F Malone Ophélia Maertens Seung Min Jeong Roderick T Bronson Valerie Lebleu Raghu Kalluri Emmanuel Normant Marcia C Haigis Brendan D Manning Kwok-Kin Wong Kay F Macleod Karen Cichowski

Cancer Cell 2011 Sep;20(3):400-13

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233475PMC
September 2011

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.

Authors:
Junxia Min Alexander Zaslavsky Giuseppe Fedele Sara K McLaughlin Elizabeth E Reczek Thomas De Raedt Isil Guney David E Strochlic Laura E Macconaill Rameen Beroukhim Roderick T Bronson Sandra Ryeom William C Hahn Massimo Loda Karen Cichowski

Nat Med 2010 Mar 14;16(3):286-94. Epub 2010 Feb 14.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903662PMC
March 2010

Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.

Authors:
Lauren T McGillicuddy Jody A Fromm Pablo E Hollstein Sara Kubek Rameen Beroukhim Thomas De Raedt Bryan W Johnson Sybil M G Williams Phioanh Nghiemphu Linda M Liau Tim F Cloughesy Paul S Mischel Annabel Parret Jeanette Seiler Gerd Moldenhauer Klaus Scheffzek Anat O Stemmer-Rachamimov Charles L Sawyers Cameron Brennan Ludwine Messiaen Ingo K Mellinghoff Karen Cichowski

Cancer Cell 2009 Jul;16(1):44-54

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897249PMC
July 2009

Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions.

Authors:
Katharina Steinmann Lan Kluwe David N Cooper Hilde Brems Thomas De Raedt Eric Legius Viktor-Felix Mautner Hildegard Kehrer-Sawatzki

Eur J Hum Genet 2008 May 23;16(5):572-80. Epub 2008 Jan 23.

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/sj.ejhg.5202002DOI Listing
May 2008

Therapy-related acute myeloid leukemia in a child with Noonan syndrome and clonal duplication of the germline PTPN11 mutation.

Authors:
Christophe F Chantrain Priscilla Jijon Thomas De Raedt Christiane Vermylen Hélène A Poirel Eric Legius Bénédicte Brichard

Pediatr Blood Cancer 2007 Jan;48(1):101-4

Department of Pediatric Hematology-Oncology, St-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.

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http://doi.wiley.com/10.1002/pbc.20527
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http://dx.doi.org/10.1002/pbc.20527DOI Listing
January 2007

Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA.

Authors:
Thomas de Raedt Jan Cools Maria Debiec-Rychter Hilde Brems Nicole Mentens Raf Sciot Jacques Himpens Ivo de Wever Patrick Schöffski Peter Marynen Eric Legius

Gastroenterology 2006 Dec;131(6):1907-12

Department of Human Genetics, Catholic University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2006.07.002DOI Listing
December 2006

Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.

Authors:
Thomas De Raedt Matthew Stephens Ine Heyns Hilde Brems Daisy Thijs Ludwine Messiaen Karen Stephens Conxi Lazaro Katharina Wimmer Hildegard Kehrer-Sawatzki Dominique Vidaud Lan Kluwe Peter Marynen Eric Legius

Nat Genet 2006 Dec 19;38(12):1419-23. Epub 2006 Nov 19.

Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/ng1920DOI Listing
December 2006

Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients.

Authors:
Thomas De Raedt Ophélia Maertens Magdalena Chmara Hilde Brems Ine Heyns Raf Sciot Elisa Majounie Meena Upadhyaya Sofie De Schepper Frank Speleman Ludwine Messiaen Joris Robert Vermeesch Eric Legius

Genes Chromosomes Cancer 2006 Oct;45(10):893-904

Center for Human Genetics, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.20353DOI Listing
October 2006

Comprehensive NF1 screening on cultured Schwann cells from neurofibromas.

Authors:
Ophélia Maertens Hilde Brems Jo Vandesompele Thomas De Raedt Ine Heyns Thorsten Rosenbaum Sofie De Schepper Anne De Paepe Geert Mortier Sandra Janssens Frank Speleman Eric Legius Ludwine Messiaen

Hum Mutat 2006 Oct;27(10):1030-40

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1002/humu.20389DOI Listing
October 2006

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients.

Authors:
Ophélia Maertens Hans Prenen Maria Debiec-Rychter Agnieszka Wozniak Raf Sciot Patrick Pauwels Ivo De Wever Joris R Vermeesch Thomas de Raedt Anne De Paepe Frank Speleman Allan van Oosterom Ludwine Messiaen Eric Legius

Hum Mol Genet 2006 Mar 6;15(6):1015-23. Epub 2006 Feb 6.

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1093/hmg/ddl016DOI Listing
March 2006

Genomic organization and evolution of the NF1 microdeletion region.

Authors:
Thomas De Raedt Hilde Brems Catalina Lopez-Correa Joris Robert Vermeesch Peter Marynen Eric Legius

Genomics 2004 Aug;84(2):346-60

Center of Human Genetics, KULeuven, Herestraat 49, 3000 Louvain, Belgium.

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http://dx.doi.org/10.1016/j.ygeno.2004.03.006DOI Listing
August 2004