Thomas D Hurley

Thomas D Hurley

UNVERIFIED PROFILE

Are you Thomas D Hurley?   Register this Author

Register author
Thomas D Hurley

Thomas D Hurley

Publications by authors named "Thomas D Hurley"

Are you Thomas D Hurley?   Register this Author

60Publications

498Reads

26Profile Views

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Cell Rep 2019 Mar;26(11):3061-3075.e6

Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Division of Hematology-Oncology, Department of Internal Medicine, Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.02.032DOI Listing
March 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24519456183030
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505PMC
December 2018

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.

Cell Stem Cell 2017 03 29;20(3):303-314.e5. Epub 2016 Dec 29.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337165PMC
March 2017

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

J Med Chem 2017 03 6;60(6):2439-2455. Epub 2017 Mar 6.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine , Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765548PMC
March 2017

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.

Biochemistry 2017 Jan 20;56(1):179-188. Epub 2016 Dec 20.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine , Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.6b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516924PMC
January 2017

Incorporation of phosphate into glycogen by glycogen synthase.

Arch Biochem Biophys 2016 05 29;597:21-9. Epub 2016 Mar 29.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2016.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843132PMC
May 2016

Genes encoding enzymes involved in ethanol metabolism.

Alcohol Res 2012 ;34(3):339-44

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756590PMC
April 2016

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.

Chem Biol Interact 2015 Jun 4;234:29-37. Epub 2014 Nov 4.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2014.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414680PMC
June 2015

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Chem Biol Interact 2015 Jun 12;234:18-28. Epub 2014 Dec 12.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2014.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414715PMC
June 2015

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.

Chem Biol Interact 2015 Jun 29;234:38-44. Epub 2015 Jan 29.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2014.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414788PMC
June 2015

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.

J Med Chem 2015 Feb 10;58(4):1964-75. Epub 2015 Feb 10.

Department of Biochemistry and Molecular Biology Indiana University School of Medicine 635 Barnhill Drive, Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm501900sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344389PMC
February 2015

Hominids adapted to metabolize ethanol long before human-directed fermentation.

Proc Natl Acad Sci U S A 2015 Jan 1;112(2):458-63. Epub 2014 Dec 1.

Foundation for Applied Molecular Evolution, Gainesville, FL 32604; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1404167111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299227PMC
January 2015

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2.

J Chem Inf Model 2014 Jul 30;54(7):2105-16. Epub 2014 Jun 30.

Department of Biochemistry and Molecular Biology, ‡Melvin and Bren Simon Cancer Center, §Center for Computational Biology and Bioinformatics, and ⊥Stark Neurosciences Institute, Indiana University School of Medicine , 535 Barnhill Drive, Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci5002026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114474PMC
July 2014

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.

J Med Chem 2014 Feb 31;57(3):714-22. Epub 2014 Jan 31.

Department of Biochemistry & Molecular Biology, Indiana University School of Medicine , MS4053, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/jm401377v
Publisher Site
http://dx.doi.org/10.1021/jm401377vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954746PMC
February 2014

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.

J Med Chem 2014 Jan 10;57(2):449-61. Epub 2014 Jan 10.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine , Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm401508pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988914PMC
January 2014

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):20976-81. Epub 2013 Dec 9.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1310106111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876246PMC
December 2013

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.

J Biol Chem 2013 Oct 31;288(42):30181-91. Epub 2013 Aug 31.

From the Krannert Institute of Cardiology and the Departments of Medicine and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.501585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798486PMC
October 2013

Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations.

J Chem Inf Model 2013 Oct 8;53(10):2659-70. Epub 2013 Oct 8.

Indiana University Department of Biochemistry and Molecular Biology, ‡Center for Computational Biology and Bioinformatics, §Department of Chemistry and Chemical Biology (IUPUI), ∥Stark Neurosciences Research Institute, Indiana University School of Medicine , 535 Barnhill Drive, Indianapolis, Indiana 46202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci400312vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058328PMC
October 2013

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.

Protein Expr Purif 2013 Aug 24;90(2):78-83. Epub 2013 May 24.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5126, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2013.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720772PMC
August 2013

Catalytic contribution of threonine 244 in human ALDH2.

Chem Biol Interact 2013 Feb 4;202(1-3):32-40. Epub 2013 Jan 4.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2012.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602351PMC
February 2013

Glycogen and its metabolism: some new developments and old themes.

Biochem J 2012 Feb;441(3):763-87

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.biochemj.org/content/ppbiochemj/441/3/763.full.pd
Web Search
http://biochemj.org/lookup/doi/10.1042/BJ20111416
Publisher Site
http://dx.doi.org/10.1042/BJ20111416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945249PMC
February 2012

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

J Biol Chem 2011 Dec 21;286(50):43486-94. Epub 2011 Oct 21.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.293597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234859PMC
December 2011

A new crystal form of mouse thiamin pyrophosphokinase.

Int J Biochem Mol Biol 2011 ;2(2):111-8

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088427PMC
November 2011

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.

J Biol Chem 2011 Sep 11;286(39):33999-4006. Epub 2011 Aug 11.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.264531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190777PMC
September 2011

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes.

Chem Biol Interact 2011 May 22;191(1-3):153-8. Epub 2011 Feb 22.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2011.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103606PMC
May 2011

Phosphate incorporation during glycogen synthesis and Lafora disease.

Cell Metab 2011 Mar;13(3):274-82

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2011.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124772PMC
March 2011

Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition.

Chem Res Toxicol 2010 Nov 18;23(11):1843-50. Epub 2010 Oct 18.

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx100317q
Publisher Site
http://dx.doi.org/10.1021/tx100317qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989800PMC
November 2010

Structural basis for glucose-6-phosphate activation of glycogen synthase.

Proc Natl Acad Sci U S A 2010 Oct 27;107(41):17563-8. Epub 2010 Sep 27.

Department of Biochemistry and Molelcular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1006340107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955087PMC
October 2010

High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.

Protein Sci 2010 Aug;19(8):1469-79

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923500PMC
August 2010

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Nat Struct Mol Biol 2010 Feb 10;17(2):159-64. Epub 2010 Jan 10.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857674PMC
February 2010

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.

J Biol Chem 2010 Jan 18;285(3):1950-6. Epub 2009 Nov 18.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.042986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804353PMC
January 2010

Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals.

Bioorg Med Chem Lett 2009 Jan 1;19(1):237-41. Epub 2008 Nov 1.

The Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.10.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798806PMC
January 2009

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.

J Med Chem 2008 Oct 12;51(19):6110-20. Epub 2008 Sep 12.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm8005788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737180PMC
October 2008

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Science 2008 Sep;321(5895):1493-5

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1158554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741612PMC
September 2008

Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.

Biochemistry 2007 Dec 20;46(49):14075-86. Epub 2007 Nov 20.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi701023z
Publisher Site
http://dx.doi.org/10.1021/bi701023zDOI Listing
December 2007

Structural basis for regulation of protein phosphatase 1 by inhibitor-2.

J Biol Chem 2007 Sep 18;282(39):28874-83. Epub 2007 Jul 18.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M703472200DOI Listing
September 2007

Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

J Biol Chem 2007 Apr 27;282(17):12940-50. Epub 2007 Feb 27.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M607959200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885376PMC
April 2007

Direct detection of glycogenin reaction products during glycogen initiation.

Biochem Biophys Res Commun 2006 Sep 28;348(2):374-8. Epub 2006 Jul 28.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202-5122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2006.07.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635985PMC
September 2006

Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis.

Biochemistry 2006 Aug;45(31):9445-53

Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907-1153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi060718cDOI Listing
August 2006

Pyrithiamine as a substrate for thiamine pyrophosphokinase.

J Biol Chem 2006 Mar 19;281(10):6601-7. Epub 2005 Dec 19.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M510951200DOI Listing
March 2006

Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

Chem Res Toxicol 2006 Jan;19(1):102-10

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx0501839
Publisher Site
http://dx.doi.org/10.1021/tx0501839DOI Listing
January 2006

Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.

J Biol Chem 2005 Aug 27;280(34):30550-6. Epub 2005 Jun 27.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M502345200
Publisher Site
http://dx.doi.org/10.1074/jbc.M502345200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262676PMC
August 2005

Requirements for catalysis in mammalian glycogenin.

J Biol Chem 2005 Jun 22;280(25):23892-9. Epub 2005 Apr 22.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M502344200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266300PMC
June 2005

Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases.

Biochemistry 2005 Jun;44(22):8022-9

Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907-1153, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi050038u
Publisher Site
http://dx.doi.org/10.1021/bi050038uDOI Listing
June 2005

Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors.

Biochemistry 2004 Oct;43(39):12555-62

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Room MS 4017, Indianapolis, Indiana 46202-5122, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi0489107
Publisher Site
http://dx.doi.org/10.1021/bi0489107DOI Listing
October 2004

Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1.

J Pharmacol Exp Ther 2004 Aug 13;310(2):469-76. Epub 2004 Apr 13.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1345 W 16th Street, L3-304, Indianapolis, IN 46202-2111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.104.067116DOI Listing
August 2004

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase.

Biochemistry 2003 Jun;42(23):7100-9

Program in Medical Biophysics and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi034182wDOI Listing
June 2003

Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).

Chem Biol Interact 2003 Feb;143-144:195-200

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive Room 4023A, Indianapolis, IN 46202-5122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0009-2797(02)00203-xDOI Listing
February 2003

Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation.

Biochemistry 2002 Dec;41(51):15189-94

Center for Structural Biology, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi026705qDOI Listing
December 2002

Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes.

Biochemistry 2002 Sep;41(35):10778-86

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0257639DOI Listing
September 2002

Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase.

Biochemistry 2002 Jun;41(22):7156-68

Department of Biochemistry, Purdue University, 1153 Biochemisty Building, West Layfayette, Indiana 47907-1153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi012197tDOI Listing
June 2002

Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.

J Mol Biol 2002 May;319(2):463-77

Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive Indianapolis, IN 46202-5122, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002228360200305
Publisher Site
http://dx.doi.org/10.1016/S0022-2836(02)00305-4DOI Listing
May 2002

Lessons from a bacterial cocaine esterase.

Nat Struct Biol 2002 Jan;9(1):4-5

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nsb0102-4
Publisher Site
http://dx.doi.org/10.1038/nsb0102-4DOI Listing
January 2002