Thomas Carell

Thomas Carell

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Synthesis of an acpU phosphoramidite and incorporation of the hypermodified base into RNA.

Chem Commun (Camb) 2019 Oct;55(81):12216-12218

Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1039/c9cc06314eDOI Listing
October 2019

proto-Urea-RNA (Wöhler RNA) containing unusually stable urea nucleosides.

Angew Chem Int Ed Engl 2019 Oct 1. Epub 2019 Oct 1.

Ludwig-Maximilians-Universitat Munchen, Department of Chemistry and Biochemistry, Butenandtstraße 5-13, 81377, München, GERMANY.

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http://dx.doi.org/10.1002/anie.201911746DOI Listing
October 2019

A Click-chemistry based enrichable cross-linker for structural and protein interaction analysis by mass spectrometry.

Chembiochem 2019 Oct 8. Epub 2019 Oct 8.

Ludwig-Maximilians-Universitat Munchen, Department of Chemistry and Biochemistry, Butenandtstraße 5-13, 81377, München, GERMANY.

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http://dx.doi.org/10.1002/cbic.201900611DOI Listing
October 2019

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides.

Science 2019 10;366(6461):76-82

Center for Integrated Protein Science, Department of Chemistry, LMU München, Butenandtstrasse 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1126/science.aax2747DOI Listing
October 2019

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5-Aza-2'-deoxycytidine.

Angew Chem Int Ed Engl 2019 Sep 25;58(37):12984-12987. Epub 2019 Jul 25.

Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, Munich, Germany.

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http://dx.doi.org/10.1002/anie.201904794DOI Listing
September 2019

Nucleotide excision repair of abasic DNA lesions.

Nucleic Acids Res 2019 Sep;47(16):8537-8547

Unit "Responses to DNA Lesions", Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany.

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http://dx.doi.org/10.1093/nar/gkz558DOI Listing
September 2019

Triplet Induced Lesion Formation at CpT and TpC Sites in DNA.

Chemistry 2019 Sep 20. Epub 2019 Sep 20.

Ludwig-Maximilians-Universität München, Oettingenstr. 67, München, GERMANY.

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http://dx.doi.org/10.1002/chem.201903573DOI Listing
September 2019

A Click-Chemistry Linked 2'3'-cGAMP Analogue.

Chemistry 2019 Feb 17;25(8):2089-2095. Epub 2019 Jan 17.

Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1002/chem.201805409DOI Listing
February 2019

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions.

Chem Commun (Camb) 2019 Feb;55(13):1939-1942

Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1039/c8cc09435gDOI Listing
February 2019

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides.

Nat Protoc 2019 01;14(1):283-312

Center for Integrated Protein Science Munich (CiPSM), Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://www.nature.com/articles/s41596-018-0094-6
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http://dx.doi.org/10.1038/s41596-018-0094-6DOI Listing
January 2019

Publisher Correction: Non-canonical nucleosides and chemistry of the emergence of life.

Nat Commun 2019 01 15;10(1):325. Epub 2019 Jan 15.

Department of Chemistry at the Ludwig-Maximilians Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41467-019-08340-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333768PMC
January 2019

Non-canonical nucleosides and chemistry of the emergence of life.

Nat Commun 2018 12 12;9(1):5174. Epub 2018 Dec 12.

Department of Chemistry at the Ludwig-Maximilians Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41467-018-07222-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289997PMC
December 2018

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Nucleic Acids Res 2018 09;46(17):9044-9056

Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Faculty of Chemistry, University Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

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http://dx.doi.org/10.1093/nar/gky715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158614PMC
September 2018

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Chem Commun (Camb) 2018 Aug 16;54(62):8591-8593. Epub 2018 Jul 16.

Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1039/c8cc03980aDOI Listing
August 2018

Rethinking the tools of the RNA world.

Elife 2018 06 15;7. Epub 2018 Jun 15.

Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.7554/eLife.38297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003769PMC
June 2018

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations.

Angew Chem Int Ed Engl 2018 05 17;57(20):5943-5946. Epub 2018 Apr 17.

Center for Integrated Protein Science (CiPSM) at the Department, of Chemistry, LMU München, Butenandtstrasse 5-13, 81377, München, Germany.

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http://dx.doi.org/10.1002/anie.201801919DOI Listing
May 2018

Non-canonical Bases in the Genome: The Regulatory Information Layer in DNA.

Angew Chem Int Ed Engl 2018 04 8;57(16):4296-4312. Epub 2018 Mar 8.

Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1002/anie.201708228DOI Listing
April 2018

A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry.

Angew Chem Int Ed Engl 2018 03 15;57(11):2958-2962. Epub 2018 Feb 15.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1002/anie.201708867DOI Listing
March 2018

5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo.

Nat Chem Biol 2018 Jan 27;14(1):72-78. Epub 2017 Nov 27.

Center for Integrated Protein Science Munich CiPSM at the Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1038/nchembio.2531DOI Listing
January 2018

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.

Nat Commun 2018 01 11;9(1):163. Epub 2018 Jan 11.

Center for Integrated Protein Science Munich CiPSM at the Department of Chemistry, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.

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http://www.nature.com/articles/s41467-017-02639-1
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http://dx.doi.org/10.1038/s41467-017-02639-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765019PMC
January 2018

Synthesis of RNA Containing 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine.

Chemistry 2017 Nov 20;23(63):15894-15898. Epub 2017 Oct 20.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1002/chem.201704216DOI Listing
November 2017

Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.

Nucleic Acids Res 2017 Nov;45(19):11033-11042

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany.

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http://dx.doi.org/10.1093/nar/gkx718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737506PMC
November 2017

N-methyladenosine (mA) recruits and repels proteins to regulate mRNA homeostasis.

Nat Struct Mol Biol 2017 Oct 4;24(10):870-878. Epub 2017 Sep 4.

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1038/nsmb.3462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725193PMC
October 2017

Quantitative LC-MS Provides No Evidence for m dA or m dC in the Genome of Mouse Embryonic Stem Cells and Tissues.

Angew Chem Int Ed Engl 2017 09 30;56(37):11268-11271. Epub 2017 Mar 30.

Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, LMU München, Butenandtstr. 5-13, 81377, München, Germany.

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http://dx.doi.org/10.1002/anie.201700424DOI Listing
September 2017

The chemistries and consequences of DNA and RNA methylation and demethylation.

RNA Biol 2017 09 25;14(9):1099-1107. Epub 2017 Apr 25.

a Department of Chemistry , Ludwig-Maximilians-Universität München , Butenandtstrasse, Munich , Germany.

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http://dx.doi.org/10.1080/15476286.2017.1318241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699545PMC
September 2017

Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ.

Chembiochem 2017 09 24;18(17):1716-1720. Epub 2017 Jul 24.

Center for Integrated Protein Science (CiPSM), Department of Chemistry, LMU München, Butenandtstrasse 5-13, 81377, München, Germany.

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http://doi.wiley.com/10.1002/cbic.201700209
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http://dx.doi.org/10.1002/cbic.201700209DOI Listing
September 2017

5-Formyl- and 5-Carboxydeoxycytidines Do Not Cause Accumulation of Harmful Repair Intermediates in Stem Cells.

J Am Chem Soc 2017 08 21;139(30):10359-10364. Epub 2017 Jul 21.

Center for Integrated Protein Science at the Department of Chemistry, LMU Munich , Butenandtstrasse 5-13, Munich 81377, Germany.

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http://dx.doi.org/10.1021/jacs.7b04131DOI Listing
August 2017

Structural Insights into the Recognition of N -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14.

Chembiochem 2017 07 30;18(14):1379-1382. Epub 2017 May 30.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, München, Germany.

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http://dx.doi.org/10.1002/cbic.201700169DOI Listing
July 2017

Direct observation of a deoxyadenosyl radical in an active enzyme environment.

FEBS Lett 2016 Dec 16;590(24):4489-4494. Epub 2016 Dec 16.

Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Germany.

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http://dx.doi.org/10.1002/1873-3468.12498DOI Listing
December 2016

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex.

Chemistry 2016 Oct 8;22(43):15350-15359. Epub 2016 Sep 8.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1002/chem.201602784DOI Listing
October 2016

Synthesis of (R)-Configured 2'-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides.

Org Lett 2016 09 19;18(17):4368-71. Epub 2016 Aug 19.

Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstraße 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b02110DOI Listing
September 2016

5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites.

Angew Chem Int Ed Engl 2016 09 25;55(39):11797-800. Epub 2016 Aug 25.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, München, Germany.

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http://dx.doi.org/10.1002/anie.201605994DOI Listing
September 2016

A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway.

Science 2016 May;352(6287):833-6

Ludwig-Maximilians-Universität München, Department für Chemie, D-81377 Munich, Germany.

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http://dx.doi.org/10.1126/science.aad2808DOI Listing
May 2016

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release.

Nanoscale 2016 Apr;8(15):8101-10

Department of Chemistry, Nanosystems Initiative Munich (NIM), Center for Nano Science (CeNS), and Center for Integrated Protein Science Munich (CIPSM), University of Munich (LMU), Butenandtstr. 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1039/c5nr08163gDOI Listing
April 2016

Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines.

Org Lett 2016 Mar 17;18(5):1068-71. Epub 2016 Feb 17.

Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b00190DOI Listing
March 2016

Bioorthogonal Chemistry—Introduction and Overview [corrected].

Top Curr Chem (Cham) 2016 Feb 1;374(1). Epub 2016 Feb 1.

Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610, Prague 6, Czech Republic.

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http://dx.doi.org/10.1007/s41061-016-0010-xDOI Listing
February 2016

Erratum to: Bioorthogonal Chemistry-Introduction and Overview.

Top Curr Chem (Cham) 2016 02 25;374(2):12. Epub 2016 Feb 25.

Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610, Prague 6, Czech Republic.

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http://dx.doi.org/10.1007/s41061-016-0014-6DOI Listing
February 2016

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair.

J Am Chem Soc 2016 Jan 21;138(1):186-90. Epub 2015 Dec 21.

BioMolecular Optics and Center for Integrated Protein Science, Ludwigs-Maximilians-Universität München , Oettingenstrasse 67, 80538 München, Germany.

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http://dx.doi.org/10.1021/jacs.5b09753DOI Listing
January 2016

Molecular mechanisms of xeroderma pigmentosum (XP) proteins.

Q Rev Biophys 2016 Jan 10;49:e5. Epub 2016 Feb 10.

Center for Integrated Protein Science at the Department of Chemistry,Ludwig-Maximilians Universität München,Butenandtstr. 5-13,81377 Munich,Germany.

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http://dx.doi.org/10.1017/S0033583515000268DOI Listing
January 2016

A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.

Target Oncol 2015 Dec 6;10(4):523-33. Epub 2015 Jan 6.

Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s11523-014-0354-5DOI Listing
December 2015

DNA Repair.

Authors:
Thomas Carell

Angew Chem Int Ed Engl 2015 Dec 19;54(51):15330-3. Epub 2015 Nov 19.

Center for Integrated Protein Science, CiPSM, Department für Chemie, Ludwig-Maximilians Universität München, Butenandtstrasse 5-13, 81377 München (Germany) http://www.carellgroup.de.

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http://dx.doi.org/10.1002/anie.201509770DOI Listing
December 2015

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.

Angew Chem Int Ed Engl 2015 Oct 3;54(42):12511-4. Epub 2015 Jul 3.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201502722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643189PMC
October 2015

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8272-7. Epub 2015 Jun 22.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, 81377 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1508509112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500287PMC
July 2015

Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases.

J Phys Chem B 2015 Jul 2;119(28):8685-92. Epub 2015 Jul 2.

†BioMolecular Optics and Center for Integrated Protein Science, Ludwig-Maximilians- Universität München Oettingenstrasse 67, 80538 München, Germany.

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http://dx.doi.org/10.1021/acs.jpcb.5b04694DOI Listing
July 2015

Effect of Opalescence® bleaching gels on the elution of dental composite components.

Dent Mater 2015 Jun 18;31(6):745-57. Epub 2015 Apr 18.

Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-University of Munich, Goethestr. 70, 80336 Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Nussbaumstr. 26, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dental.2015.03.016DOI Listing
June 2015

Release and protein binding of components from resin based composites in native saliva and other extraction media.

Dent Mater 2015 May 24;31(5):496-504. Epub 2015 Feb 24.

Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-University of Munich, Goethestr. 70, 80336 Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Nussbaumstr. 26, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.dental.2015.01.016DOI Listing
May 2015

Orchestrating the biosynthesis of an unnatural pyrrolysine amino Acid for its direct incorporation into proteins inside living cells.

Chemistry 2015 May 2;21(21):7701-4. Epub 2015 Apr 2.

Center for Integrative Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, Butenandtstrasse 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/chem.201500971DOI Listing
May 2015

TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

Cell Rep 2015 Apr 2;11(2):283-94. Epub 2015 Apr 2.

Center for Integrated Protein Science Munich CiPS(M) at the Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.020DOI Listing
April 2015

Cell-penetrating and neurotargeting dendritic siRNA nanostructures.

Angew Chem Int Ed Engl 2015 Feb 17;54(6):1946-9. Epub 2014 Dec 17.

Center for Integrative Protein Science, Department of Chemistry, Ludwig-Maximilians University München, Butenandtstrasse 5-13, 81377 Munich (Germany) http://www.carellgroup.de.

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http://doi.wiley.com/10.1002/anie.201409803
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http://dx.doi.org/10.1002/anie.201409803DOI Listing
February 2015

"Post-it" type connected DNA created with a reversible covalent cross-link.

Angew Chem Int Ed Engl 2015 Jan 28;54(3):796-800. Epub 2014 Nov 28.

Department of Chemistry and Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München (Germany) http://www.carellgroup.de.

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http://dx.doi.org/10.1002/anie.201407854DOI Listing
January 2015

DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides.

Chem Sci 2015 Jan 11;6(1):632-638. Epub 2014 Aug 11.

Department of Chemistry , Ludwig-Maximilians-University Munich , Butenandtstraße 5-13 , 81377 , Munich , Germany . Email:

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http://dx.doi.org/10.1039/c4sc01567cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588782PMC
January 2015

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase.

Chem Commun (Camb) 2014 Nov;50(91):14201-4

Department of Biomolecular Mechanisms, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1039/c4cc05158kDOI Listing
November 2014

Watson-Crick base pairing controls excited-state decay in natural DNA.

Angew Chem Int Ed Engl 2014 Oct 4;53(42):11366-9. Epub 2014 Sep 4.

BioMolecular Optics and Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, Oettingenstrasse 67, 80538 Munich (Germany); Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201406286DOI Listing
October 2014

Ribose-protonated DNA base excision repair: a combined theoretical and experimental study.

Angew Chem Int Ed Engl 2014 Sep 25;53(38):10044-8. Epub 2014 Jul 25.

Chair of Theoretical Chemistry, Department of Chemistry, University of Munich (LMU), Butenandtstrasse 7, 81377 Munich (Germany); Center for Integrated Protein Science (CIPSM) at the Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201403334DOI Listing
September 2014

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.

Blood 2014 Aug 1;124(7):1110-8. Epub 2014 Jul 1.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1182/blood-2013-08-518514DOI Listing
August 2014

Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain.

Chembiochem 2014 Mar 13;15(5):743-8. Epub 2014 Feb 13.

Institute of Biochemistry, Faculty of Chemistry, University Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany).

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http://dx.doi.org/10.1002/cbic.201300740DOI Listing
March 2014

Charge separation and charge delocalization identified in long-living states of photoexcited DNA.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):4369-74. Epub 2014 Mar 10.

BioMolecular Optics and Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, 80538 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1323700111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970531PMC
March 2014

Strand-specific recognition of DNA damages by XPD provides insights into nucleotide excision repair substrate versatility.

J Biol Chem 2014 Feb 14;289(6):3613-24. Epub 2013 Dec 14.

From the Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany and.

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http://dx.doi.org/10.1074/jbc.M113.523001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916561PMC
February 2014

Fingerprinting DNA oxidation processes: IR characterization of the 5-methyl-2'-deoxycytidine radical cation.

Chemphyschem 2014 Feb 2;15(3):420-3. Epub 2014 Jan 2.

BioMolecular Optics and Center for Integrated Protein Science, Ludwig-Maximilians-Universität, Oettingenstr. 67, 80538 München (Germany), Fax: (+49) 89-2180-9202; Center for Integrated Protein Science, Department für Chemie, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 München (Germany).

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http://dx.doi.org/10.1002/cphc.201300954DOI Listing
February 2014

Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine.

Angew Chem Int Ed Engl 2014 Jan 26;53(1):315-8. Epub 2013 Nov 26.

Center for Integrated Protein Science, Department für Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München (Germany) http://www.carellgroup.de.

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http://dx.doi.org/10.1002/anie.201308469DOI Listing
January 2014

Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions.

Photochem Photobiol 2014 01 2;90(1):1-14. Epub 2013 Dec 2.

Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.

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http://dx.doi.org/10.1111/php.12197DOI Listing
January 2014

Structural insights into incorporation of norbornene amino acids for click modification of proteins.

Chembiochem 2013 Nov 11;14(16):2114-8. Epub 2013 Sep 11.

Department of Chemistry, TU Munich, Lichtenbergstrasse 4, 85748 Garching (Germany).

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http://dx.doi.org/10.1002/cbic.201300435DOI Listing
November 2013

Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine.

J Am Chem Soc 2013 Oct 17;135(39):14593-9. Epub 2013 Sep 17.

Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, ‡Chair for Theoretical Chemistry at the Department of Chemistry, §Center for Drug Research at the Department of Pharmacy, Ludwig-Maximilians-Universität München , Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1021/ja403229yDOI Listing
October 2013

Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts.

Dent Mater 2013 Sep 31;29(9):971-9. Epub 2013 Jul 31.

Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-University of Munich, Goethestr. 70, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.dental.2013.07.007DOI Listing
September 2013

Norbornenes in inverse electron-demand Diels-Alder reactions.

Chemistry 2013 Sep 11;19(40):13309-12. Epub 2013 Sep 11.

Department of Chemistry, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich (Germany), Fax: (+49) 89 2180 77756.

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http://dx.doi.org/10.1002/chem.201301838DOI Listing
September 2013

Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions.

Nat Chem Biol 2013 Jul 19;9(7):455-61. Epub 2013 May 19.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1038/nchembio.1254DOI Listing
July 2013

Regioselective metalations of pyrimidines and pyrazines by using frustrated Lewis pairs of BF3·OEt2 and hindered magnesium- and zinc-amide bases.

Angew Chem Int Ed Engl 2013 Jun 23;52(26):6776-80. Epub 2013 May 23.

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.

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http://dx.doi.org/10.1002/anie.201301694DOI Listing
June 2013

Total synthesis of the hypermodified RNA bases wybutosine and hydroxywybutosine and their quantification together with other modified RNA bases in plant materials.

Chemistry 2013 Mar 18;19(13):4244-8. Epub 2013 Feb 18.

Center for Integrated Protein Science (CIPS) at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1002/chem.201204209DOI Listing
March 2013

Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system.

Chem Commun (Camb) 2013 Jan 28;49(4):379-81. Epub 2012 Nov 28.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität, Munich, Butenandtstrasse 5-13, D-81377, Munich, Germany.

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http://dx.doi.org/10.1039/c2cc37836aDOI Listing
January 2013

The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair.

Chem Commun (Camb) 2013 Jan;49(7):722-4

Center for Integrative Protein Science at the Department for Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1039/c2cc37735gDOI Listing
January 2013

Synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxycytidine-triphosphates and their incorporation into oligonucleotides by polymerase chain reaction.

Org Lett 2013 Jan 3;15(2):366-9. Epub 2013 Jan 3.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1021/ol3033219DOI Listing
January 2013

Catalysis and regulation.

Authors:
Thomas Carell

Curr Opin Struct Biol 2012 Dec 8;22(6):689-90. Epub 2012 Nov 8.

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http://dx.doi.org/10.1016/j.sbi.2012.10.006DOI Listing
December 2012

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme.

Nucleic Acids Res 2012 Oct 2;40(18):9308-18. Epub 2012 Jul 2.

Department of Biomolecular Mechanisms, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/nar/gks603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467042PMC
October 2012

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

Angew Chem Int Ed Engl 2012 Oct 4;51(44):11162-5. Epub 2012 Oct 4.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201203769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533783PMC
October 2012

Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells.

J Am Chem Soc 2012 Aug 23;134(30):12330-3. Epub 2012 Jul 23.

Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität , Munich, Germany.

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http://dx.doi.org/10.1021/ja303251fDOI Listing
August 2012

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA.

Nucleic Acids Res 2012 Jul 15;40(13):6235-40. Epub 2012 Mar 15.

Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Ludwig-Maximilians University, Munich 81377, Germany.

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http://dx.doi.org/10.1093/nar/gks240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401430PMC
July 2012

Surface "click" reaction of DNA followed by directed metalization for the construction of contactable conducting nanostructures.

Angew Chem Int Ed Engl 2012 Jul 15;51(30):7586-8. Epub 2012 Jun 15.

Institut für Anorganische Chemie, RWTH Aachen University; JARA-Fundamentals of Future Information Technologies, Landoltweg 1, 52074 Aachen, Germany.

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http://doi.wiley.com/10.1002/anie.201202401
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http://dx.doi.org/10.1002/anie.201202401DOI Listing
July 2012

Structure and function of noncanonical nucleobases.

Angew Chem Int Ed Engl 2012 Jul 28;51(29):7110-31. Epub 2012 Jun 28.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany.

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http://doi.wiley.com/10.1002/anie.201201193
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http://dx.doi.org/10.1002/anie.201201193DOI Listing
July 2012

Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing.

Angew Chem Int Ed Engl 2012 Jun 29;51(26):6516-20. Epub 2012 May 29.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, Butenandtstrasse 5-13, 81377 München, Germany.

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http://dx.doi.org/10.1002/anie.201202583DOI Listing
June 2012

ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization.

J Chem Phys 2012 May;136(20):204307

Department of Chemistry, Ludwig-Maximilians University Munich, Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1063/1.4720090DOI Listing
May 2012

A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper-free click reaction.

Angew Chem Int Ed Engl 2012 Apr 21;51(18):4466-9. Epub 2012 Mar 21.

Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201109252DOI Listing
April 2012

Discovery and mutagenicity of a guanidinoformimine lesion as a new intermediate of the oxidative deoxyguanosine degradation pathway.

J Am Chem Soc 2012 Mar 29;134(10):4925-30. Epub 2012 Feb 29.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität, Munich, Butenandtstraße 5-13, D-81377 Munich, Germany.

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http://dx.doi.org/10.1021/ja211435dDOI Listing
March 2012

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity.

Nucleic Acids Res 2012 Jan 9;40(1):170-80. Epub 2011 Sep 9.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel,

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http://dx.doi.org/10.1093/nar/gkr596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245908PMC
January 2012

Mechanism of UV-induced formation of Dewar lesions in DNA.

Angew Chem Int Ed Engl 2012 Jan 23;51(2):408-11. Epub 2011 Nov 23.

Faculty of Physics, Center for Integrative Protein Science, Ludwig Maximilians University Munich, Oettingenstrasse 67, 80538 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201106231DOI Listing
January 2012

Improved synthesis and mutagenicity of oligonucleotides containing 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine.

Chemistry 2011 Dec 8;17(49):13782-8. Epub 2011 Nov 8.

Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-University, Butenandtstr. 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/chem.201102782DOI Listing
December 2011

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling.

EMBO Rep 2011 Oct 28;12(11):1127-34. Epub 2011 Oct 28.

Department of Biochemistry at the Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, Munich 81377, Germany.

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http://dx.doi.org/10.1038/embor.2011.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207106PMC
October 2011

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA.

PLoS Biol 2011 Oct 25;9(10):e1001183. Epub 2011 Oct 25.

Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.1001183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201922PMC
October 2011

Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair.

Nat Chem 2011 Aug 28;3(10):794-800. Epub 2011 Aug 28.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians University Munich, Butenandtstrasse 5-13, D-81377 Munich, Germany.

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http://www.nature.com/articles/nchem.1117
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http://dx.doi.org/10.1038/nchem.1117DOI Listing
August 2011