Publications by authors named "Thomas C Smyrk"

100Publications

A Broad-Based Submucosal Polyp.

Gastroenterology 2020 Dec 18. Epub 2020 Dec 18.

Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, USA.

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December 2020

Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination.

Pancreatology 2020 Sep 14;20(6):1115-1122. Epub 2020 Jul 14.

Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA; Department of Medical Oncology, Department of Oncology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA. Electronic address:

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September 2020

Pancreatic ductal adenocarcinoma is associated with a unique endocrinopathy distinct from type 2 diabetes mellitus.

Pancreatology 2020 Jul 22;20(5):929-935. Epub 2020 May 22.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address:

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July 2020

Mesenchymal Hamartoma in Children: A Diagnostic Challenge.

Case Rep Pediatr 2019 16;2019:4132842. Epub 2019 Sep 16.

Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.

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September 2019

Biliary Amyloidoma as a Cause for Pancreatitis.

Clin Gastroenterol Hepatol 2019 10;17(11):A25-A26

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

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October 2019

Solid Pseudopapillary Neoplasms of the Pancreas: A Large American Cohort.

Pancreas 2019 04;48(4):e21-e22

Division of Medical Oncology Mayo Clinic Rochester, MN Department of Oncology Clinica Santa Maria Santiago, Chile Department of Internal Medicine Mayo Clinic Rochester, MN Division of Medical Oncology Mayo Clinic Rochester, MN Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, MN Division of Medical Oncology Mayo Clinic Rochester, MN

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April 2019

A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis.

Am J Gastroenterol 2018 Sep 2;113(9):1398-1399. Epub 2018 Jul 2.

Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA. Division of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55905, USA. Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN 55905, USA. Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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September 2018

Highly Discriminant Methylated DNA Markers for the Non-endoscopic Detection of Barrett's Esophagus.

Am J Gastroenterol 2018 08 12;113(8):1156-1166. Epub 2018 Jun 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA. Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA. Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

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August 2018

Fasting Blood Glucose Levels Provide Estimate of Duration and Progression of Pancreatic Cancer Before Diagnosis.

Gastroenterology 2018 08 30;155(2):490-500.e2. Epub 2018 Apr 30.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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August 2018

Histologic and immunohistochemical differences between hereditary and sporadic diffuse gastric carcinoma.

Hum Pathol 2018 04 4;74:64-72. Epub 2018 Jan 4.

Division of Anatomic Pathology, Mayo Clinic, Rochester, 55905, MN. Electronic address:

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April 2018

Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms.

Pancreatology 2018 Jan 14;18(1):46-53. Epub 2017 Nov 14.

Department of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

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January 2018

Is Standard Histology Sufficient to Detect Cytomegalovirus Reactivation in Inflammatory Bowel Disease?

Am J Clin Pathol 2017 11;148(5):459-460

Division of Laboratory Medicine and Pathology Mayo ClinicRochester, MN.

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November 2017

Practical Approach to the Flattened Duodenal Biopsy.

Authors:
Thomas C Smyrk

Surg Pathol Clin 2017 Dec 23;10(4):823-839. Epub 2017 Sep 23.

Department of Pathology, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address:

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December 2017

Isolated Acute Terminal Ileitis Without Preexisting Inflammatory Bowel Disease Rarely Progresses to Crohn's Disease.

Dig Dis Sci 2017 12 24;62(12):3557-3562. Epub 2017 Oct 24.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

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December 2017

Recurrent Jejunal Intussusception Caused by Heterotopic Pancreas Mass.

Clin Gastroenterol Hepatol 2017 12 13;15(12):e175-e176. Epub 2017 Jul 13.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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December 2017

Occurrence of IgG4 in Esophageal Lichen Planus.

Clin Gastroenterol Hepatol 2017 12 10;15(12):1975-1977. Epub 2017 Jun 10.

Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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December 2017

Long-standing Crohn's disease and its implication on anal squamous cell cancer management.

Int J Colorectal Dis 2017 May 14;32(5):661-666. Epub 2017 Mar 14.

Division of Colon and Rectal Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

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May 2017

A Malignant Mimic.

Gastroenterology 2017 Apr 1;152(5):953-955. Epub 2017 Mar 1.

Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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April 2017

Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis.

World J Gastroenterol 2017 Feb;23(5):859-868

Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.

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February 2017

Malignant transformation of biliary adenofibroma: a rare biliary cystic tumor.

J Gastrointest Oncol 2016 Dec;7(6):E107-E112

Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.

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December 2016

Emerging secondary syphilis presenting as syphilitic hepatitis.

Hepatology 2017 06 24;65(6):2113-2115. Epub 2017 Apr 24.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

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June 2017

Diagnostic Performance of MR Elastography and Vibration-controlled Transient Elastography in the Detection of Hepatic Fibrosis in Patients with Severe to Morbid Obesity.

Radiology 2017 05 18;283(2):418-428. Epub 2016 Nov 18.

From the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).

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May 2017

Increased Rates of Clostridium difficile Infection and Poor Outcomes in Patients with IBD with Cytomegalovirus.

Inflamm Bowel Dis 2016 11;22(11):2688-2693

*Division of Gastroenterology and Hepatology, University of Ottawa, Ottawa, Ontario, Canada; †Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; ‡Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; and §Department of Anatomical Pathology, Mayo Clinic, Rochester, Minnesota.

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November 2016

Montelukast Does not Maintain Symptom Remission After Topical Steroid Therapy for Eosinophilic Esophagitis.

Clin Gastroenterol Hepatol 2017 02 17;15(2):214-221.e2. Epub 2016 Sep 17.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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February 2017

Optimization of a Scoring System to Predict Microscopic Colitis in a Cohort of Patients With Chronic Diarrhea.

J Clin Gastroenterol 2017 Mar;51(3):228-234

*Department of Internal Medicine †Mayo Clinic College of Medicine Divisions of ‡Anatomic Pathology §Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

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March 2017

A Biomarker Panel to Detect Synchronous Neoplasm in Non-neoplastic Surveillance Biopsies from Patients with Ulcerative Colitis.

Inflamm Bowel Dis 2016 07;22(7):1568-74

Divisions of *Experimental Pathology and Medicine, †Gastroenterology and Hepatology, ‡Biostatistics, and §Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.

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July 2016

DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance.

Inflamm Bowel Dis 2016 07;22(7):1559-67

*Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; †Department of Internal Medicine, Rhode Island Memorial Hospital, Pawtucket, Rhode Island; ‡Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota; and §Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.

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July 2016

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy: Conclusions From a Review of Literature.

Pancreas 2016 09;45(8):1104-10

From the *Department of Medicine, Saint Peter's University Hospital-Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ; and †Division of Gastroenterology and Hepatology, Department of Medicine; ‡Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology; §Department of Physiology and Biomedical Engineering; and ∥Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN.

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September 2016

Sessile Serrated Polyps are Precursors of Colon Carcinomas With Deficient DNA Mismatch Repair.

Clin Gastroenterol Hepatol 2016 07 17;14(7):1056-9. Epub 2016 Feb 17.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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July 2016

A common variant in MTHFR influences response to chemoradiotherapy and recurrence of rectal cancer.

Am J Cancer Res 2015 15;5(10):3231-40. Epub 2015 Sep 15.

Department of Genetics, Cell Biology & Development, University of Minnesota Minneapolis, MN, USA ; Department of Medicine, University of Minnesota Minneapolis, MN, USA.

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December 2015

Impact of Intratumoral Inflammation on Survival After Pancreatic Cancer Resection.

Pancreas 2016 Jan;45(1):123-6

From the *Division of Gastroenterology and Hepatology, †Department of Pathology, ‡Health Sciences Research, Mayo Clinic Rochester, MN.

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January 2016

Endoscopic overestimation of colorectal polyp size.

Gastrointest Endosc 2016 Jan 28;83(1):201-8. Epub 2015 Aug 28.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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January 2016

Detection of Cytomegalovirus in Patients with Inflammatory Bowel Disease: Where to Biopsy and How Many Biopsies?

Inflamm Bowel Dis 2015 Dec;21(12):2833-8

*Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; †Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; and ‡Department of Pathology, Mayo Clinic, Rochester, Minnesota.

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December 2015

Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort.

Am J Surg Pathol 2015 Oct;39(10):1340-6

*Division of Anatomic Pathology †Department of Health Sciences Research ‡Division of Experimental Pathology #Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN §Van Andel Research Institute, Grand Rapids, MI ∥University of Southern California, USC/Norris Comprehensive Cancer Center, Los Angeles, CA ¶Department of Epidemiology, The University of Iowa, Iowa City, IA.

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October 2015

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma.

Biomed Res Int 2015 27;2015:593572. Epub 2015 May 27.

Department of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA ; Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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March 2016

Comparison of Three Ki-67 Index Quantification Methods and Clinical Significance in Pancreatic Neuroendocrine Tumors.

Endocr Pathol 2015 Sep;26(3):255-62

Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

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September 2015

Magnetic Resonance Elastography: A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation.

Mayo Clin Proc 2015 Jul 6;90(7):882-94. Epub 2015 Jun 6.

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.

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July 2015

Metformin suppresses pancreatic tumor growth with inhibition of NFκB/STAT3 inflammatory signaling.

Pancreas 2015 May;44(4):636-47

From the *Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN; †Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick; ‡Department of Epidemiology, School of Public Health, Rutgers, The State University of New Jersey, Piscataway, NJ; and §Department of Biochemistry and Molecular Biology, ∥Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, and ¶Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

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May 2015

Serum IgG4 elevation in pancreatic cancer: diagnostic and prognostic significance and association with autoimmune pancreatitis.

Pancreas 2015 May;44(4):557-60

From the Divisions of *Internal Medicine, †Gastroenterology and Hepatology, and ‡Laboratory Medicine, Mayo Clinic, Rochester, MN.

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May 2015

A novel role for KLF14 in T regulatory cell differentiation.

Cell Mol Gastroenterol Hepatol 2015 Mar;1(2):188-202.e4

Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine (CIM), Mayo Clinic Rochester.

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March 2015

Rituximab for IgG4-related disease: a prospective, open-label trial.

Ann Rheum Dis 2015 Jun 9;74(6):1171-7. Epub 2015 Feb 9.

Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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June 2015

Gastric amyloidosis: clinicopathological correlations in 79 cases from a single institution.

Hum Pathol 2015 Apr 7;46(4):491-8. Epub 2015 Jan 7.

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905.

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April 2015

Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.

Gastroenterology 2015 May 28;148(5):978-90. Epub 2015 Jan 28.

Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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May 2015