Publications by authors named "Thomas Benzing"

100Publications

The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH).

Eur Geriatr Med 2020 Nov 18. Epub 2020 Nov 18.

Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s41999-020-00427-7DOI Listing
November 2020

The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study.

Aging Clin Exp Res 2020 Nov 1. Epub 2020 Nov 1.

Aging Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40520-020-01732-8DOI Listing
November 2020

The carboxy-terminus of the human ARPKD protein fibrocystin can control STAT3 signalling by regulating SRC-activation.

J Cell Mol Med 2020 Oct 28. Epub 2020 Oct 28.

Department of Pediatrics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.16014DOI Listing
October 2020

[COVID-19: The Perspective Of Nephrology].

Dtsch Med Wochenschr 2020 Jul 30;145(15):1068-1073. Epub 2020 Jul 30.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1164-4231DOI Listing
July 2020

A molecular mechanism explaining albuminuria in kidney disease.

Nat Metab 2020 May 11;2(5):461-474. Epub 2020 May 11.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42255-020-0204-yDOI Listing
May 2020

MOLECULAR DESIGN OF THE KIDNEY FILTRATION BARRIER.

Authors:
Thomas Benzing

Trans Am Clin Climatol Assoc 2020 ;131:125-139

COLOGNE, GERMANY.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358502PMC
January 2020

Affinity-Enhanced Multimeric VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia.

Hypertension 2020 Oct 6;76(4):1176-1184. Epub 2020 Jul 6.

From the Department II of Internal Medicine (M. Matin, B.S., P.T.B., T.B., H.H.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14974DOI Listing
October 2020

Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial.

Sci Rep 2020 03 23;10(1):5202. Epub 2020 Mar 23.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-61895-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089976PMC
March 2020

The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury.

J Am Soc Nephrol 2020 04 28;31(4):716-730. Epub 2020 Feb 28.

Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2019050534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191926PMC
April 2020

Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.

J Am Soc Nephrol 2020 03 11;31(3):544-559. Epub 2020 Feb 11.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2019030312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062218PMC
March 2020

Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling.

J Am Soc Nephrol 2020 03 10;31(3):532-542. Epub 2020 Jan 10.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2019020109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062224PMC
March 2020

Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans.

iScience 2019 Dec 27;22:466-476. Epub 2019 Nov 27.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne 50937, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne 50931, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926210PMC
December 2019

Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.

BMC Nephrol 2019 08 22;20(1):326. Epub 2019 Aug 22.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704495PMC
August 2019

The Multidimensional Prognostic Index in general practice: One-year follow-up study.

Int J Clin Pract 2019 Aug 13:e13403. Epub 2019 Aug 13.

Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.13403DOI Listing
August 2019

A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection.

BMC Nephrol 2019 08 5;20(1):296. Epub 2019 Aug 5.

Department II of Internal Medicine and Center for Molecular Medicine Cologne University of Cologne, Faculty of Medicine and University Hospital of Cologne, Uniklinik Köln, Kerpener Str. 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1472-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683457PMC
August 2019

Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Nat Rev Nephrol 2019 Jun;15(6):386

Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0156-1DOI Listing
June 2019

A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany.

Nephrol Dial Transplant 2019 12;34(12):1983-1986

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
Publisher Site
http://dx.doi.org/10.1093/ndt/gfz046DOI Listing
December 2019

Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling.

Cell Physiol Biochem 2019 ;52(5):1139-1150

Department II of Internal Medicine and Center for Rare Diseases Cologne, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
https://www.cellphysiolbiochem.com/Articles/000077/
Publisher Site
http://dx.doi.org/10.33594/000000077DOI Listing
May 2019

The prognostic significance of geriatric syndromes and resources.

Aging Clin Exp Res 2020 Jan 25;32(1):115-124. Epub 2019 Mar 25.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40520-019-01168-9
Publisher Site
http://dx.doi.org/10.1007/s40520-019-01168-9DOI Listing
January 2020

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura.

BMJ Open Gastroenterol 2019 8;6(1):e000252. Epub 2019 Feb 8.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgast-2018-000252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398868PMC
February 2019

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

J Am Soc Nephrol 2019 04 13;30(4):564-576. Epub 2019 Mar 13.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2018090914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442340PMC
April 2019

Glomerular podocytes in kidney health and disease.

Lancet 2019 03;393(10174):856-858

Department of Nephrology, Rambam Health Care Campus, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)33000-9DOI Listing
March 2019

Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Nat Rev Nephrol 2019 05;15(5):275-289

Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0119-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472952PMC
May 2019

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis.

Kidney Int 2019 04 13;95(4):846-858. Epub 2019 Feb 13.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.10.034DOI Listing
April 2019

[Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]

Dtsch Med Wochenschr 2019 02 13;144(4):276-281. Epub 2019 Feb 13.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0759-7180DOI Listing
February 2019

Management of autosomal-dominant polycystic kidney disease-state-of-the-art.

Clin Kidney J 2018 Dec 17;11(Suppl 1):i2-i13. Epub 2018 Dec 17.

Department II of Internal Medicine, Center for Molecular Medicine Cologne, University of Cologne, Germany.

View Article

Download full-text PDF

Source
https://academic.oup.com/ckj/article/11/suppl_1/i2/5232640
Publisher Site
http://dx.doi.org/10.1093/ckj/sfy103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295602PMC
December 2018

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Kidney Int 2019 02 3;95(2):333-349. Epub 2018 Dec 3.

Department II of Internal Medicine, University of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.08.037DOI Listing
February 2019

New associations of the Multidimensional Prognostic Index.

Z Gerontol Geriatr 2019 Aug 7;52(5):460-467. Epub 2018 Nov 7.

Ageing Clinical Research, Dpt. II for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00391-018-01471-6
Publisher Site
http://dx.doi.org/10.1007/s00391-018-01471-6DOI Listing
August 2019

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents.

Genes Brain Behav 2018 11 14;17(8):e12516. Epub 2018 Sep 14.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gbb.12516DOI Listing
November 2018

Urine-derived cells: a promising diagnostic tool in Fabry disease patients.

Sci Rep 2018 07 23;8(1):11042. Epub 2018 Jul 23.

Department II of Internal Medicine Medicine and Center for Rare Diseases Cologne, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-29240-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056427PMC
July 2018

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Cell Rep 2018 05;23(8):2495-2508

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of Medicine IV, Medical Center and Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, 79104 Freiburg, Germany; Center for Systems Biology (ZBSA), Albert Ludwigs University, 79104 Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.04.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986710PMC
May 2018

Protein half-life determines expression of proteostatic networks in podocyte differentiation.

FASEB J 2018 09 25;32(9):4696-4713. Epub 2018 Apr 25.

Department II of Internal Medicine, University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201701307RDOI Listing
September 2018

Cystic Kidney Diseases From the Adult Nephrologist's Point of View.

Front Pediatr 2018 22;6:65. Epub 2018 Mar 22.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2018.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875104PMC
March 2018

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Kidney Int 2018 06 9;93(6):1308-1319. Epub 2018 Mar 9.

Department II of Internal Medicine, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2017.12.012DOI Listing
June 2018

Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T.

MAGMA 2018 Jun 23;31(3):367-374. Epub 2017 Oct 23.

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10334-017-0658-4DOI Listing
June 2018

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

EMBO Rep 2017 09 14;18(9):1521-1535. Epub 2017 Jul 14.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201643846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579364PMC
September 2017

Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer.

BMC Med Genet 2017 05 12;18(1):53. Epub 2017 May 12.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12881-017-0416-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429543PMC
May 2017

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations.

Pediatr Nephrol 2017 Jul 31;32(7):1269-1273. Epub 2017 Mar 31.

Department of Pediatrics, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-017-3648-xDOI Listing
July 2017

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.

Kidney Int 2017 06 7;91(6):1510-1517. Epub 2017 Feb 7.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2016.12.011DOI Listing
June 2017

Burden of multimorbidity and outcome in ambulatory geriatric hemodialysis patients : Report from the QiN registry in Germany.

Z Gerontol Geriatr 2018 Jan 10;51(1):60-66. Epub 2016 Nov 10.

Department II of Internal Medicine - QiN group, University Hospital of Cologne, Gleueler Straße 176-178, 50935, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00391-016-1149-3DOI Listing
January 2018

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.

Am J Physiol Cell Physiol 2016 09 29;311(3):C404-17. Epub 2016 Jun 29.

Department II of Internal Medicine, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00121.2016DOI Listing
September 2016

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Am J Physiol Renal Physiol 2016 07 27;311(1):F112-9. Epub 2016 Apr 27.

Department II of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00171.2016DOI Listing
July 2016

Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.

N Engl J Med 2016 May 27;374(19):1853-63. Epub 2016 Apr 27.

From INSERM, Centre de Recherche des Cordeliers, Unité 1138, Centre National de la Recherche Scientifique, ERL8228 Université Pierre et Marie Curie and Université Paris-Descartes, Paris (K.L., E.S., S.D.); Institute of Human Genetics (B.B.B., A.W., B.R., J.A., G.Y.), Department of Pathology (H.G.), Cologne Center for Genomics and Center for Molecular Medicine (H.T., J.A., P.N.), Department II of Internal Medicine and Center for Molecular Medicine Cologne (M.P.B., T.B., M.M.R.), and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases and Systems Biology of Aging Cologne (T.B., M.M.R.) - all at the University of Cologne, Cologne, the Department of Cellular and Integrative Physiology, University Medical Center Hamburg, Hamburg (H.V.), University Children's Hospital, Philipps University Marburg (H.W.S.), and Kuratorium für Heimdialyse, Pediatric Kidney Center (G.K.), Marburg, the Institute of Human Genetics, University Health Services Göttingen, Göttingen (G.Y.), and the Department of General Pediatrics, University Hospital Münster, Münster (K.P.S., M. Konrad) - all in Germany; the Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center (S.-S.Y., S.-H.L.), and Institute of BioMedical Sciences, Academia Sinica (S.-S.Y.) - both in Taipei, Taiwan; the Department of Biomedical Molecular Biology, Inflammation Research Center, VIB/Ghent University, Ghent (D.P., M.J.M.B.), Unité de Recherche en Physiologie Moléculaire, University of Namur, Namur (C.D., O.B.), and the Division of Nephrology, University Children's Hospital Leuven (E.L.) - all in Belgium; the Divisions of Neonatology (K.B.) and Nephrology (M. Kömhoff), Beatrix Children's Hospital, and the Departments of Obstetrics and Gynecology (L.K.D., S.A.S.), Pathology and Medical Biology (A.T.), and Genetics (T.J.K.) - all at University Medical Center Groningen, Groningen, the Netherlands; and University Children's Hospital Graz

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1507629DOI Listing
May 2016

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.

BMC Mol Biol 2016 Apr 18;17:11. Epub 2016 Apr 18.

Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12867-016-0064-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835897PMC
April 2016

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

J Biol Chem 2016 May 5;291(22):11596-607. Epub 2016 Apr 5.

From the Department II of Internal Medicine and Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, and Systems Biology of Ageing Cologne, University of Cologne, 50937 Cologne, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.712539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882430PMC
May 2016

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Cell 2016 Mar;165(1):125-138

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD) Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2016.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157157PMC
March 2016

Hypertension: Testing for pre-eclampsia: paving the way to early diagnosis.

Authors:
Thomas Benzing

Nat Rev Nephrol 2016 Apr 29;12(4):200-2. Epub 2016 Feb 29.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Kerpener Street 62, 50937 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2016.21DOI Listing
April 2016

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

Hum Mol Genet 2016 Apr 19;25(7):1328-44. Epub 2016 Jan 19.

Department II of Internal Medicine, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddw016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787903PMC
April 2016

Endothelial cilia protect against atherosclerosis.

EMBO Rep 2016 Feb 14;17(2):125-6. Epub 2016 Jan 14.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD) University of Cologne, Cologne, Germany Systems Biology of Ageing Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201541890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290808PMC
February 2016

Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia.

J Am Soc Nephrol 2016 Mar 24;27(3):903-13. Epub 2015 Sep 24.

Renal Division and Department of Medicine and Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Response in Aging Associated Diseases, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2015020157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769204PMC
March 2016

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

Am J Physiol Renal Physiol 2015 Oct 12;309(7):F617-26. Epub 2015 Aug 12.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00059.2015DOI Listing
October 2015

[Renal diagnostics in arterial hypertension].

MMW Fortschr Med 2015 Jul;157(13):65-7

Klinik II für Innere Medizin Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Kerpenerstr. 62, D-50937, Köln, Deutschland,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s15006-015-3357-yDOI Listing
July 2015

Pleiotropic signaling evoked by tumor necrosis factor in podocytes.

Am J Physiol Renal Physiol 2015 Jul 27;309(2):F98-108. Epub 2015 May 27.

Department of Biology and Biochemistry, University of Houston, Houston, Texas; Division of Nephrology, Baylor College of Medicine, Houston, Texas

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00146.2015DOI Listing
July 2015

Proteomic analysis of the kidney filtration barrier--Problems and perspectives.

Proteomics Clin Appl 2015 Dec 11;9(11-12):1053-68. Epub 2015 Aug 11.

Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prca.201400201DOI Listing
December 2015

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.

BMC Nephrol 2015 Apr 14;16:55. Epub 2015 Apr 14.

Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Kerpener Str. 62, Cologne, 50937, Germany.

View Article

Download full-text PDF

Source
http://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-
Publisher Site
http://dx.doi.org/10.1186/s12882-015-0053-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445526PMC
April 2015

The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.

Nat Rev Nephrol 2015 Sep 14;11(9):515-34. Epub 2015 Apr 14.

Department of Developmental Therapeutics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2015.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902186PMC
September 2015

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.

Development 2015 Apr;142(7):1254-66

Division of Nephrology, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.119735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378252PMC
April 2015

New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014.

Kidney Int 2015 May 25;87(5):885-93. Epub 2015 Feb 25.

1] Renal Division, University Medical Center Freiburg, Freiburg, Germany [2] BIOSS, Albert-Ludwigs University Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ki.2015.5DOI Listing
May 2015

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms.

J Am Soc Nephrol 2015 Sep 30;26(9):2097-104. Epub 2015 Jan 30.

Division of Nephrology, Department of Medicine and Harvard Stem Cell Institute, Cambridge, Massachusetts

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2014090940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552122PMC
September 2015

The grand challenge of nephrology.

Front Med (Lausanne) 2014 18;1:28. Epub 2014 Sep 18.

Department of Medicine, Rush University , Chicago, IL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2014.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291843PMC
January 2015

Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control.

Authors:
Thomas Benzing

Nat Rev Nephrol 2015 Mar 16;11(3):129-31. Epub 2014 Dec 16.

Department II of Internal Medicine and Centre for Molecular Medicine Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2014.241DOI Listing
March 2015

Cyclin I and p35 determine the subcellular distribution of Cdk5.

Am J Physiol Cell Physiol 2015 Feb 10;308(4):C339-47. Epub 2014 Dec 10.

Department of Internal Medicine and Nephrology, Center for Molecular Medicine, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00168.2014DOI Listing
February 2015

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.

Proteomics 2015 Apr 19;15(7):1326-31. Epub 2015 Jan 19.

Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201400235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512310PMC
April 2015

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.

Nat Cell Biol 2014 Dec 24;16(12):1168-1179. Epub 2014 Nov 24.

Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250074PMC
December 2014

An approach to cystic kidney diseases: the clinician's view.

Nat Rev Nephrol 2014 Dec 30;10(12):687-99. Epub 2014 Sep 30.

Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Straße 62, 50397 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2014.173DOI Listing
December 2014

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.

J Biol Chem 2014 Sep 6;289(38):26344-56. Epub 2014 Aug 6.

From the Department II of Internal Medicine and Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), and Systems Biology of Ageing Cologne, University of Cologne, 50931 Cologne, Germany,

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M114.562165
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.562165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176241PMC
September 2014

Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function.

Ann Hematol 2014 Oct 29;93(10):1645-54. Epub 2014 May 29.

Geriatrics Department, University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00277-014-2110-4
Publisher Site
http://dx.doi.org/10.1007/s00277-014-2110-4DOI Listing
October 2014

Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment.

AIDS 2014 Jul;28(12):1783-9

aDepartment II of Internal Medicine bDepartment I of Internal Medicine, University Hospital of Cologne cInstitute of Medical Statistics, Informatics and Epidemiology, University of Cologne dGerman Centre for Infection Research (DZIF), Partner Site Bonn-Cologne eCenter for Molecular Medicine Cologne fCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) gSystems Biology of Ageing Cologne, University of Cologne, Cologne, Germany. *Dr Sophia Gravemann and Dr Paul T. Brinkkoetter contributed equally to the writing of the article.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000000324DOI Listing
July 2014

Label-free quantitative proteomic analysis of the YAP/TAZ interactome.

Am J Physiol Cell Physiol 2014 May 26;306(9):C805-18. Epub 2014 Feb 26.

Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00339.2013DOI Listing
May 2014

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again.

J Am Soc Nephrol 2014 Jun 20;25(6):1140-7. Epub 2014 Feb 20.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, and Systems Biology of Aging Cologne, University of Cologne, Cologne, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2013101037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033383PMC
June 2014

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.

J Am Soc Nephrol 2014 Jul 7;25(7):1509-22. Epub 2014 Feb 7.

Department of Internal Medicine II, Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Systems Biology of Ageing Cologne,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2013070760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073431PMC
July 2014

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane.

FASEB J 2014 Apr 13;28(4):1769-79. Epub 2014 Jan 13.

1Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. P.T.B.,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.13-240309DOI Listing
April 2014