Thomas B L Kirkwood

Thomas B L Kirkwood

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Thomas B L Kirkwood

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Mitochondria in the signaling pathways that control longevity and health span.

Ageing Res Rev 2019 Sep 12;54:100940. Epub 2019 Aug 12.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, SUND, University of Copenhagen, 2200, Copenhagen N, Denmark; Laboratory of Molecular Gerontology, National Institute on Aging, 251 Bayview Blvd, Baltimore, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.100940DOI Listing
September 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Nat Commun 2019 Aug 14;10(1):3669. Epub 2019 Aug 14.

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.

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http://dx.doi.org/10.1038/s41467-019-11558-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694136PMC
August 2019

Do reef corals age?

Biol Rev Camb Philos Soc 2018 05 28;93(2):1192-1202. Epub 2017 Dec 28.

Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, U.K.

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http://dx.doi.org/10.1111/brv.12391DOI Listing
May 2018

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

EBioMedicine 2018 May 25;31:166-173. Epub 2018 Apr 25.

LLHW Centre for Ageing and Vitality, Newcastle University Institute for Ageing, The Medical School, Newcastle upon Tyne NE2 4HH, UK; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013780PMC
May 2018

Is There a Link Between Cognitive Reserve and Cognitive Function in the Oldest-Old?

J Gerontol A Biol Sci Med Sci 2018 03;73(4):499-505

Newcastle University Institute for Ageing and Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/gerona/glx140DOI Listing
March 2018

Longitudinal changes in global and domain specific cognitive function in the very-old: findings from the Newcastle 85+ Study.

Int J Geriatr Psychiatry 2018 02 22;33(2):298-306. Epub 2017 Jun 22.

Institute of Health and Society, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/gps.4743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811803PMC
February 2018

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions.

Genes (Basel) 2018 Feb 27;9(3). Epub 2018 Feb 27.

Institute of Cell and Molecular Biosciences and Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.3390/genes9030126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867847PMC
February 2018

Initial level and rate of change in grip strength predict all-cause mortality in very old adults.

Age Ageing 2017 11;46(6):970-976

AGE Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/ageing/afx087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860048PMC
November 2017

Pervasive gene expression responses to a fluctuating diet in Drosophila melanogaster: The importance of measuring multiple traits to decouple potential mediators of life span and reproduction.

Evolution 2017 Nov 25;71(11):2572-2583. Epub 2017 Sep 25.

Plant Sciences Group, Laboratory of Genetics, Wageningen University, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands.

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http://dx.doi.org/10.1111/evo.13327DOI Listing
November 2017

Explaining sex differences in lifespan in terms of optimal energy allocation in the baboon.

Evolution 2017 Oct 14;71(10):2280-2297. Epub 2017 Sep 14.

Institute for Cellular and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne NE4 5PL, United Kingdom.

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http://doi.wiley.com/10.1111/evo.13316
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http://dx.doi.org/10.1111/evo.13316DOI Listing
October 2017

Why and how are we living longer?

Exp Physiol 2017 09 2;102(9):1067-1074. Epub 2017 Aug 2.

University of Copenhagen Center for Healthy Aging, Department of Cellular and Molecular Medicine, Copenhagen, Denmark.

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http://doi.wiley.com/10.1113/EP086205
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http://dx.doi.org/10.1113/EP086205DOI Listing
September 2017

Is there evidence for a limit to human lifespan?

Nature 2017 06;546(7660):E11-E12

Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nature22788DOI Listing
June 2017

Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study.

J Cachexia Sarcopenia Muscle 2017 Apr 16;8(2):229-237. Epub 2016 Nov 16.

Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, Hampshire, UK.

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http://dx.doi.org/10.1002/jcsm.12157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377385PMC
April 2017

Growing more positive with age: The relationship between reproduction and survival in aging flies.

Exp Gerontol 2017 04 22;90:34-42. Epub 2017 Jan 22.

Plant Sciences Group, Laboratory of Genetics, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.

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http://dx.doi.org/10.1016/j.exger.2017.01.016DOI Listing
April 2017

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.

Nutrients 2017 Apr 13;9(4). Epub 2017 Apr 13.

Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.3390/nu9040379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409718PMC
April 2017

Can aging be programmed? A critical literature review.

Aging Cell 2016 Dec 17;15(6):986-998. Epub 2016 Aug 17.

Institute of Cell and Molecular Biosciences, and Institute for Ageing, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1111/acel.12510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398523PMC
December 2016

Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study.

Biomed Res Int 2016 13;2016:8745670. Epub 2016 Jan 13.

Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; Institute for Cell and Molecular Bioscience, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1155/2016/8745670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738702PMC
November 2016

Macronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study.

Br J Nutr 2016 06 18;115(12):2170-80. Epub 2016 Apr 18.

2Newcastle University Institute for Ageing,Newcastle University,Newcastle upon Tyne NE2 4AX,UK.

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http://dx.doi.org/10.1017/S0007114516001379DOI Listing
June 2016

Respiratory health and disease in a U.K. population-based cohort of 85 year olds: The Newcastle 85+ Study.

Thorax 2016 Mar 5;71(3):255-66. Epub 2016 Jan 5.

Department of Respiratory Medicine, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK Institute for Ageing, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789822PMC
March 2016

Evolutionary significance of ageing in the wild.

Exp Gerontol 2015 Nov 17;71:89-94. Epub 2015 Aug 17.

Institute of Cell and Molecular Biosciences, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom; Institute for Ageing, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2015.08.006DOI Listing
November 2015

Serum osmolarity and haematocrit do not modify the association between the impedance index (Ht(2)/Z) and total body water in the very old: the Newcastle 85+ study.

Arch Gerontol Geriatr 2015 Jan-Feb;60(1):227-32. Epub 2014 Sep 17.

Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, Newcastle on Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.archger.2014.09.004DOI Listing
August 2015

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

Ann Epidemiol 2015 Aug 18;25(8):569-574.e3. Epub 2015 Mar 18.

The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1016/j.annepidem.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466018PMC
August 2015

The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study.

Arch Gerontol Geriatr 2015 May-Jun;60(3):405-11. Epub 2015 Feb 25.

Institute of Health and Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674943150003
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http://dx.doi.org/10.1016/j.archger.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407633PMC
July 2015

Grip strength and mortality: a biomarker of ageing?

Lancet 2015 Jul 13;386(9990):226-7. Epub 2015 May 13.

Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736146234
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http://dx.doi.org/10.1016/S0140-6736(14)62349-7DOI Listing
July 2015

Age-related frailty and its association with biological markers of ageing.

BMC Med 2015 Jul 13;13:161. Epub 2015 Jul 13.

Institute for Cell and Molecular Biosciences and Newcastle University Institute for Ageing, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1186/s12916-015-0400-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499935PMC
July 2015

Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study.

PLoS One 2014 10;9(10):e108370. Epub 2014 Oct 10.

Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193743PMC
June 2015

Evolution of asymmetric damage segregation : a modelling approach.

Subcell Biochem 2012 ;57:315-30

Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL, UK,

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http://dx.doi.org/10.1007/978-94-007-2561-4_14DOI Listing
May 2015

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling.

PLoS Comput Biol 2015 May 28;11(5):e1004246. Epub 2015 May 28.

Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1004246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447392PMC
May 2015

Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'.

Philos Trans R Soc Lond B Biol Sci 2015 Apr;370(1666)

Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK

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http://dx.doi.org/10.1098/rstb.2014.0379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360127PMC
April 2015

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

PLoS Genet 2014 Sep 18;10(9):e1004620. Epub 2014 Sep 18.

Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169240PMC
September 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.

PLoS Comput Biol 2014 Aug 28;10(8):e1003728. Epub 2014 Aug 28.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom; Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1003728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159174PMC
August 2014

The road to rack and ruin: selecting deleterious mitochondrial DNA variants.

Philos Trans R Soc Lond B Biol Sci 2014 Jul;369(1646):20130451

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1098/rstb.2013.0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032523PMC
July 2014

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.

Mech Ageing Dev 2014 Jul 7;139:22-30. Epub 2014 Jun 7.

Centre for Brain Ageing and Vitality, Institute for Ageing and Health, The Medical School, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908PMC
July 2014

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging.

Proc Natl Acad Sci U S A 2014 Feb 3;111(8):2972-7. Epub 2014 Feb 3.

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1314970111
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http://dx.doi.org/10.1073/pnas.1314970111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939916PMC
February 2014

Mitochondrial mutations and ageing: can mitochondrial deletion mutants accumulate via a size based replication advantage?

J Theor Biol 2014 Jan 17;340:111-8. Epub 2013 Sep 17.

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2013.09.009DOI Listing
January 2014

Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study.

Age Ageing 2014 Jan 11;43(1):57-63. Epub 2013 Oct 11.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1093/ageing/aft153DOI Listing
January 2014

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

Neurobiol Aging 2013 Dec 30;34(12):2889.e1-4. Epub 2013 Apr 30.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906612PMC
December 2013

Untangling functional declines in the locomotion of aging worms.

Cell Metab 2013 Sep;18(3):303-4

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.08.013DOI Listing
September 2013

Life-history evolution and the polyphenic regulation of somatic maintenance and survival.

Q Rev Biol 2013 Sep;88(3):185-218

Institut für Populationsgenetik, Vetmeduni Vienna, A-1210 Vienna, Austria.

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September 2013

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals.

Aging Cell 2013 Aug 7;12(4):728-31. Epub 2013 Jun 7.

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1111/acel.12098DOI Listing
August 2013

The predictive adaptive response: modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments.

Am Nat 2013 Feb 14;181(2):E28-42. Epub 2013 Jan 14.

Evolutionary Biology Group, Leiden University, P.O. Box 9516, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1086/668818DOI Listing
February 2013

Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study.

Heart 2012 Oct 2;98(19):1418-23. Epub 2012 Aug 2.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1136/heartjnl-2012-302457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437786PMC
October 2012

A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation.

BMC Syst Biol 2012 Oct 10;6:130. Epub 2012 Oct 10.

Campus for Ageing and Vitality, Newcastle University, Henry Wellcome Biogerontology Building, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1186/1752-0509-6-130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574035PMC
October 2012

The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support.

Bioessays 2012 Aug 29;34(8):692-700. Epub 2012 May 29.

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1002/bies.201200014DOI Listing
August 2012

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach.

Mol Neurodegener 2012 Jul 2;7:32. Epub 2012 Jul 2.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1186/1750-1326-7-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583291PMC
July 2012

The place of genetics in ageing research.

Nat Rev Genet 2012 07 10;13(8):589-94. Epub 2012 Jul 10.

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer Building, #701, Bronx, New York City, New York 10461, USA.

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http://dx.doi.org/10.1038/nrg3290DOI Listing
July 2012

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

Mech Ageing Dev 2012 Jun 1;133(6):456-66. Epub 2012 Jun 1.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1016/j.mad.2012.05.005DOI Listing
June 2012

Differences in the accumulation of mitochondrial defects with age in mice and humans.

Mech Ageing Dev 2011 Nov-Dec;132(11-12):588-91. Epub 2011 Oct 12.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.mad.2011.10.004DOI Listing
April 2012

Commentary: ageing--what's all the noise about? Developments after Gärtner.

Int J Epidemiol 2012 Apr 20;41(2):351-2. Epub 2012 Jan 20.

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http://dx.doi.org/10.1093/ije/dyr220DOI Listing
April 2012

Speed-bumps ahead for the genetics of later-life diseases.

Trends Genet 2011 Oct 6;27(10):387-8. Epub 2011 Aug 6.

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http://dx.doi.org/10.1016/j.tig.2011.07.001DOI Listing
October 2011

On the programmed/non-programmed nature of ageing within the life history.

Curr Biol 2011 Sep;21(18):R701-7

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.cub.2011.07.020DOI Listing
September 2011

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.

Age Ageing 2011 Jul 27;40(4):494-500. Epub 2011 May 27.

Department of Public Health and Primary Care, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/ageing/afr048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114621PMC
July 2011

Systems biology of ageing and longevity.

Philos Trans R Soc Lond B Biol Sci 2011 Jan;366(1561):64-70

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
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http://dx.doi.org/10.1098/rstb.2010.0275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001307PMC
January 2011

Global aging and the brain.

Nutr Rev 2010 Dec;68 Suppl 2:S65-9

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

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https://academic.oup.com/nutritionreviews/article-lookup/doi
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http://dx.doi.org/10.1111/j.1753-4887.2010.00343.xDOI Listing
December 2010

The connections between general and reproductive senescence and the evolutionary basis of menopause.

Ann N Y Acad Sci 2010 Aug;1204:21-9

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05520.xDOI Listing
August 2010

Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

PLoS One 2010 Apr 2;5(4):e10022. Epub 2010 Apr 2.

Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848859PMC
April 2010

Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells.

Mech Ageing Dev 2009 Apr;130(4):216-21

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.mad.2008.12.007DOI Listing
April 2009

A mathematical model of aging-related and cortisol induced hippocampal dysfunction.

BMC Neurosci 2009 Mar 25;10:26. Epub 2009 Mar 25.

Henry Wellcome Building, Biogerontology Building, Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, England, NE4 6BE, UK.

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http://dx.doi.org/10.1186/1471-2202-10-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680862PMC
March 2009

Gerontology: Healthy old age.

Nature 2008 Oct;455(7214):739-40

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http://dx.doi.org/10.1038/455739aDOI Listing
October 2008

A systematic look at an old problem.

Nature 2008 Feb;451(7179):644-7

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/451644aDOI Listing
February 2008

Medical challenges of improving the quality of a longer life.

JAMA 2008 Feb;299(6):688-90

Department of Geriatrics and Rehabilitation, University of Geneva, Hopital des 3 Chêne Ch Pont Bochet, Thônex-Geneva, Switzerland.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.29
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http://dx.doi.org/10.1001/jama.299.6.688DOI Listing
February 2008

Testing evolutionary theories of menopause.

Proc Biol Sci 2007 Dec;274(1628):2943-9

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1098/rspb.2007.1028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291159PMC
December 2007

Mitochondria and ageing: winning and losing in the numbers game.

Bioessays 2007 Sep;29(9):908-17

Centre for Integrated Systems Biology of Ageing and Nutrition, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/bies.20634DOI Listing
September 2007

Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions.

Biogerontology 2006 Aug 5;7(4):287-95. Epub 2006 Jul 5.

School of Clinical Medical Sciences-Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle Upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1007/s10522-006-9027-9DOI Listing
August 2006

Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans.

Biogerontology 2006 Jun;7(3):165-8

Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences-Gerontology, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK.

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http://link.springer.com/10.1007/s10522-006-9006-1
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http://dx.doi.org/10.1007/s10522-006-9006-1DOI Listing
June 2006

Tools for the SBML Community.

Bioinformatics 2006 Mar 12;22(5):628-9. Epub 2006 Jan 12.

School of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK.

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http://dx.doi.org/10.1093/bioinformatics/btk042DOI Listing
March 2006

Food restriction, evolution and ageing.

Mech Ageing Dev 2005 Sep;126(9):1011-6

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2005.03.021DOI Listing
September 2005

Time of our lives. What controls the length of life?

EMBO Rep 2005 Jul;6 Spec No:S4-8

Institute for Ageing and Health, The University of Newcastle, Newcastle upon Tyne, UK.

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http://embor.embopress.org/cgi/doi/10.1038/sj.embor.7400419
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http://dx.doi.org/10.1038/sj.embor.7400419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369269PMC
July 2005

Asymmetry and the origins of ageing.

Mech Ageing Dev 2005 May;126(5):533-4

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http://dx.doi.org/10.1016/j.mad.2005.02.001DOI Listing
May 2005

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Mech Ageing Dev 2005 Mar;126(3):439-43

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2004.09.008DOI Listing
March 2005

Understanding the odd science of aging.

Cell 2005 Feb;120(4):437-47

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740500101
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http://dx.doi.org/10.1016/j.cell.2005.01.027DOI Listing
February 2005

Modelling the disposable soma theory of ageing.

Mech Ageing Dev 2005 Jan;126(1):99-103

School of Clinical Medical Sciences-Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2004.09.026DOI Listing
January 2005

Modelling the actions of chaperones and their role in ageing.

Mech Ageing Dev 2005 Jan;126(1):119-31

Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences-Gerontology, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2004.09.031DOI Listing
January 2005

Intrinsic ageing of gut epithelial stem cells.

Mech Ageing Dev 2004 Dec;125(12):911-5

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2004.09.004DOI Listing
December 2004

A mathematical model of ageing in yeast.

J Theor Biol 2004 Jul;229(2):189-96

Henry Wellcome Laboratory for Biogerontology Research, SCMS-Gerontology, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.jtbi.2004.03.015DOI Listing
July 2004

Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees.

Exp Gerontol 2004 May;39(5):767-73

Department of Animal Science, Centre for Integrative Genetics, Agricultural University of Norway, P.O. Box 5025, 1432 Aas, Norway.

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http://dx.doi.org/10.1016/j.exger.2004.02.010DOI Listing
May 2004

Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo.

Nucleic Acids Res 2003 Nov;31(21):6198-205

School of Clinical Medical Sciences-Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275480PMC
http://dx.doi.org/10.1093/nar/gkg840DOI Listing
November 2003