Thomas B Clarke

Thomas B Clarke

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Thomas B Clarke

Thomas B Clarke

Publications by authors named "Thomas B Clarke"

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21Publications

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Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling.

Nat Microbiol 2020 Feb 6;5(2):304-313. Epub 2020 Jan 6.

MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Diseases, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41564-019-0640-1DOI Listing
February 2020

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

Gastroenterology 2018 11 17;155(5):1495-1507.e15. Epub 2018 Jul 17.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom; School of Biosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183477
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http://dx.doi.org/10.1053/j.gastro.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347096PMC
November 2018

The microbiota protects against respiratory infection via GM-CSF signaling.

Nat Commun 2017 11 15;8(1):1512. Epub 2017 Nov 15.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK.

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http://www.nature.com/articles/s41467-017-01803-x
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http://dx.doi.org/10.1038/s41467-017-01803-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688119PMC
November 2017

Mathematical Modeling of Colonization, Invasive Infection and Treatment.

Front Physiol 2017 2;8:115. Epub 2017 Mar 2.

Department of Bioengineering, Imperial College London London, UK.

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http://dx.doi.org/10.3389/fphys.2017.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332394PMC
March 2017

The regulation of host defences to infection by the microbiota.

Immunology 2017 Jan 9;150(1):1-6. Epub 2016 Aug 9.

MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/imm.12634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221693PMC
January 2017

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids.

Nat Microbiol 2016 Oct 24;2:16194. Epub 2016 Oct 24.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1038/nmicrobiol.2016.194DOI Listing
October 2016

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.

Blood 2016 05 17;127(20):2460-71. Epub 2016 Mar 17.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and Department of Microbiology, New York University School of Medicine, New York, NY.

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http://dx.doi.org/10.1182/blood-2015-10-675173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874226PMC
May 2016

Microbial programming of systemic innate immunity and resistance to infection.

Authors:
Thomas B Clarke

PLoS Pathog 2014 Dec 4;10(12):e1004506. Epub 2014 Dec 4.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1004506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256436PMC
December 2014

Early innate immunity to bacterial infection in the lung is regulated systemically by the commensal microbiota via nod-like receptor ligands.

Authors:
Thomas B Clarke

Infect Immun 2014 Nov 18;82(11):4596-606. Epub 2014 Aug 18.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.02212-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249320PMC
November 2014

Intracellular sensors of extracellular bacteria.

Immunol Rev 2011 Sep;243(1):9-25

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01039.xDOI Listing
September 2011

Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium.

Cell Host Microbe 2011 May;9(5):404-14

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.chom.2011.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536975PMC
May 2011

Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae.

J Mol Biol 2010 Feb 1;396(3):634-45. Epub 2009 Dec 1.

Yokohama City University, Suehiro 1-7-29, Tsurumi, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1016/j.jmb.2009.11.055DOI Listing
February 2010

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity.

Nat Med 2010 Feb 17;16(2):228-31. Epub 2010 Jan 17.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.2087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497535PMC
February 2010

Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice.

J Clin Invest 2009 Jul 8;119(7):1899-909. Epub 2009 Jun 8.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1172/JCI36731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701860PMC
July 2009

Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4.

Biochemistry 2009 Mar;48(12):2675-83

Department of Biological Sciences, University of Warwick, Coventry, UK.

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http://dx.doi.org/10.1021/bi801993xDOI Listing
March 2009

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing.

PLoS Pathog 2007 Aug;3(8):e118

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0030118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950946PMC
August 2007