Thomas A Rando

Thomas A Rando

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Thomas A Rando

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Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.

Cell Rep 2019 May;27(7):2029-2035.e5

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.074DOI Listing
May 2019

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling.

Cell Stem Cell 2019 Feb;24(2):213-225

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413865PMC
February 2019

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells.

Cell Stem Cell 2018 10 20;23(4):544-556.e4. Epub 2018 Sep 20.

Paul F. Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173623PMC
October 2018

Biomechanics show stem cell necessity for effective treatment of volumetric muscle loss using bioengineered constructs.

NPJ Regen Med 2018 10;3:18. Epub 2018 Oct 10.

1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 USA.

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http://www.nature.com/articles/s41536-018-0057-0
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http://dx.doi.org/10.1038/s41536-018-0057-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180087PMC
October 2018

The regenerative rehabilitation collection: a forum for an emerging field.

NPJ Regen Med 2018 19;3:20. Epub 2018 Oct 19.

4Rehabilitation R&D REAP, VA Palo Alto Health Care System, Palo Alto, CA 94304 USA.

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http://dx.doi.org/10.1038/s41536-018-0058-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195606PMC
October 2018

Monitoring disease activity noninvasively in the model of Duchenne muscular dystrophy.

Proc Natl Acad Sci U S A 2018 07 9;115(30):7741-7746. Epub 2018 Jul 9.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1802425115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064991PMC
July 2018

A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.

Dev Cell 2018 07;46(2):135-143

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183050
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http://dx.doi.org/10.1016/j.devcel.2018.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075730PMC
July 2018

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.

Cell Stem Cell 2018 03;22(3):306-309

Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931336PMC
March 2018

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Cell Stem Cell 2017 Dec;21(6):806-818.e5

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA; Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena 07745, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823264PMC
December 2017

Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo.

Cell Rep 2017 Nov;21(7):1994-2004

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711481PMC
November 2017

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.

Proc Natl Acad Sci U S A 2017 10 9;114(43):E8996-E9005. Epub 2017 Oct 9.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1708725114
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http://dx.doi.org/10.1073/pnas.1708725114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664522PMC
October 2017

Macrophage-released ADAMTS1 promotes muscle stem cell activation.

Nat Commun 2017 09 22;8(1):669. Epub 2017 Sep 22.

Department of Pediatrics, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41467-017-00522-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610267PMC
September 2017

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.

Aging Cell 2017 06 30;16(3):518-528. Epub 2017 Mar 30.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Kaufmann Medical Building, Suite 201, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1111/acel.12578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418187PMC
June 2017

Interaction between epigenetic and metabolism in aging stem cells.

Curr Opin Cell Biol 2017 04 24;45:1-7. Epub 2017 Jan 24.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Glenn Center for the Biology of Aging, Stanford University, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.

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http://dx.doi.org/10.1016/j.ceb.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482778PMC
April 2017

Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c.

Proc Natl Acad Sci U S A 2017 04 28;114(15):E3071-E3080. Epub 2017 Mar 28.

The Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1613592114
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http://dx.doi.org/10.1073/pnas.1613592114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393251PMC
April 2017

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G.

Cell Rep 2017 04;19(3):479-486

Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Regenerative Rehabilitation, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468096PMC
April 2017

Fleeting factors, turning back time.

Authors:
Thomas A Rando

Nat Biotechnol 2017 03;35(3):218-220

Glenn Center for the Biology of Aging at Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.3817DOI Listing
March 2017

The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.

NPJ Regen Med 2017 3;2. Epub 2017 Mar 3.

Kathryn W. Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Salisbury Cove, ME 04672 USA.

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http://dx.doi.org/10.1038/s41536-017-0008-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677970PMC
March 2017

Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis.

Nature 2016 12 28;540(7632):276-279. Epub 2016 Nov 28.

Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California, USA.

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http://www.nature.com/doifinder/10.1038/nature20160
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http://dx.doi.org/10.1038/nature20160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384334PMC
December 2016

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.

Annu Rev Biomed Eng 2015 ;17:217-42

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305.

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http://dx.doi.org/10.1146/annurev-bioeng-071114-040640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858326PMC
September 2016

An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy.

Nat Biotechnol 2016 07 30;34(7):752-9. Epub 2016 May 30.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.3576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942359PMC
July 2016

UTX in muscle regeneration--the right dose and the right time.

J Clin Invest 2016 Apr 21;126(4):1233-5. Epub 2016 Mar 21.

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http://dx.doi.org/10.1172/JCI86798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811162PMC
April 2016

Stem cells and healthy aging.

Science 2015 Dec;350(6265):1199-204

Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA, and Center for Regenerative Rehabilitation, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/science.aab3388DOI Listing
December 2015

Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells.

Stem Cell Reports 2015 Oct 3;5(4):621-32. Epub 2015 Sep 3.

Paul F. Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624935PMC
October 2015

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting.

Nat Protoc 2015 Oct 24;10(10):1612-24. Epub 2015 Sep 24.

The Glenn Center for the Biology of Aging and the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nprot.2015.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793971PMC
October 2015

Mimicking the niche: cytokines expand muscle stem cells.

Cell Res 2015 Jul 26;25(7):761-2. Epub 2015 Jun 26.

1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA [2] Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA [3] Center for Tissue Regeneration, Repair, and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1038/cr.2015.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493285PMC
July 2015

The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction.

Mol Med 2015 Feb 19;20:579-89. Epub 2015 Feb 19.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.2119/molmed.2014.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365068PMC
February 2015

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.

EMBO J 2014 Dec 14;33(23):2782-97. Epub 2014 Oct 14.

Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA Neurology Service and Rehabilitation Research and Developmental Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA

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http://dx.doi.org/10.15252/embj.201488278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282556PMC
December 2014

A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.

Sci Transl Med 2014 Dec;6(267):267ra176

Paul F. Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Neurology Service, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350665PMC
December 2014

The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.

PLoS One 2013 30;8(10):e77787. Epub 2013 Oct 30.

The G.W. Hooper Foundation, Departments of Bioengineering and Therapeutic Sciences, Pharmaceutical Chemistry, and Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America ; Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077787PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813726PMC
September 2014

Translational strategies and challenges in regenerative medicine.

Nat Med 2014 Aug;20(8):814-21

1] California Institute for Regenerative Medicine (CIRM), San Francisco, California, USA. [2].

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http://www.nature.com/articles/nm.3627
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http://dx.doi.org/10.1038/nm.3627DOI Listing
August 2014

H3K4me3 breadth is linked to cell identity and transcriptional consistency.

Cell 2014 Jul;158(3):673-88

Department of Genetics, Stanford University, Stanford CA 94305, USA; Paul F. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford CA 94305, USA; Cancer Biology Program, Stanford University, Stanford CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137894PMC
July 2014

The mortal strand hypothesis: non-random chromosome inheritance and the biased segregation of damaged DNA.

Semin Cell Dev Biol 2013 Aug-Sep;24(8-9):653-60. Epub 2013 May 21.

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.semcdb.2013.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786026PMC
June 2014

Stem cells as vehicles for youthful regeneration of aged tissues.

J Gerontol A Biol Sci Med Sci 2014 Jun;69 Suppl 1:S39-42

Rehabilitation R&D Program, REAP, VA Palo Alto Health Care System, Palo Alto, California. Department of Neurology and Neurological Sciences, Stanford University, California.

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http://dx.doi.org/10.1093/gerona/glu043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022127PMC
June 2014

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).

Nature 2014 Jun 25;510(7505):393-6. Epub 2014 May 25.

1] Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA [2] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA [3] Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1038/nature13255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065227PMC
June 2014

Alive and well? Exploring disease by studying lifespan.

Curr Opin Genet Dev 2014 Jun 6;26:33-40. Epub 2014 Jul 6.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253307PMC
June 2014

FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal.

Stem Cell Reports 2014 Apr 20;2(4):414-26. Epub 2014 Mar 20.

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA ; Neurology Service and Rehabilitation Research and Developmental Center of Excellence, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.stemcr.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986584PMC
April 2014

Regenerative medicine: Of fish and men.

Authors:
Thomas A Rando

Nat Chem Biol 2014 Feb;10(2):91-2

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nchembio.1449DOI Listing
February 2014

Numb-deficient satellite cells have regeneration and proliferation defects.

Proc Natl Acad Sci U S A 2013 Nov 29;110(46):18549-54. Epub 2013 Oct 29.

School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501.

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http://dx.doi.org/10.1073/pnas.1311628110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831958PMC
November 2013

The ins and outs of aging and longevity.

Authors:
Thomas A Rando

Annu Rev Physiol 2013 ;75:617-9

Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

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http://dx.doi.org/10.1146/annurev-physiol-092712-103439DOI Listing
August 2013

Cardiac aging and rejuvenation--a sense of humors?

N Engl J Med 2013 Aug;369(6):575-6

Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1056/NEJMcibr1306063DOI Listing
August 2013

Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells.

Dev Biol 2013 Jul 29;379(2):195-207. Epub 2013 Apr 29.

Paul F. Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679295PMC
July 2013

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.

Cell Rep 2013 Jul 27;4(1):189-204. Epub 2013 Jun 27.

The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103025PMC
July 2013

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity.

Aging Cell 2013 Jun 10;12(3):525-30. Epub 2013 Apr 10.

Department of Bioengineering, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1111/acel.12065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072458PMC
June 2013

Molecular regulation of stem cell quiescence.

Nat Rev Mol Cell Biol 2013 Jun;14(6):329-40

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nrm3591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808888PMC
June 2013

A sexy spin on nonrandom chromosome segregation.

Cell Stem Cell 2013 Jun;12(6):641-3

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.stem.2013.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715869PMC
June 2013

Assessment of disease activity in muscular dystrophies by noninvasive imaging.

J Clin Invest 2013 May 24;123(5):2298-305. Epub 2013 Apr 24.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305-5235, USA.

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http://dx.doi.org/10.1172/JCI68458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638910PMC
May 2013

All's well that ends well: alternative polyadenylation and its implications for stem cell biology.

Curr Opin Cell Biol 2013 Apr 25;25(2):222-32. Epub 2013 Jan 25.

Paul F. Glenn Laboratories for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ceb.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615088PMC
April 2013

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

Cell 2013 Apr;153(2):376-88

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.

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http://dx.doi.org/10.1016/j.cell.2013.02.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663598PMC
April 2013

Sprouting a new take on stem cell aging.

EMBO J 2012 Nov 5;31(21):4103-5. Epub 2012 Oct 5.

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/emboj.2012.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492738PMC
November 2012

Recent advances in the pathogenesis and treatment of neuromuscular diseases.

Authors:
Thomas A Rando

Curr Opin Neurol 2012 Oct;25(5):586-7

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http://dx.doi.org/10.1097/WCO.0b013e328357f2a1DOI Listing
October 2012

The place of genetics in ageing research.

Nat Rev Genet 2012 07 10;13(8):589-94. Epub 2012 Jul 10.

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer Building, #701, Bronx, New York City, New York 10461, USA.

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http://dx.doi.org/10.1038/nrg3290DOI Listing
July 2012

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches.

Cell Cycle 2012 Jun 15;11(12):2260-7. Epub 2012 Jun 15.

Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.

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http://dx.doi.org/10.4161/cc.20437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383588PMC
June 2012

Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.

Cell Stem Cell 2012 May;10(5):504-14

Center of Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.stem.2012.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348769PMC
May 2012

Alternative polyadenylation mediates microRNA regulation of muscle stem cell function.

Cell Stem Cell 2012 Mar;10(3):327-36

The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.stem.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306803PMC
March 2012

Notch signaling is necessary to maintain quiescence in adult muscle stem cells.

Stem Cells 2012 Feb;30(2):232-42

Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1002/stem.773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384696PMC
February 2012

Maintenance of muscle stem-cell quiescence by microRNA-489.

Nature 2012 Feb 23;482(7386):524-8. Epub 2012 Feb 23.

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature10834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292200PMC
February 2012

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.

Cell 2012 Jan;148(1-2):46-57

The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2012.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336960PMC
January 2012

Emerging models and paradigms for stem cell ageing.

Nat Cell Biol 2011 May;13(5):506-12

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncb0511-506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257978PMC
May 2011

Manifestations and mechanisms of stem cell aging.

J Cell Biol 2011 Apr;193(2):257-66

Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1083/jcb.201010131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080271PMC
April 2011

Stem cell ageing and non-random chromosome segregation.

Philos Trans R Soc Lond B Biol Sci 2011 Jan;366(1561):85-93

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
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http://dx.doi.org/10.1098/rstb.2010.0279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001309PMC
January 2011

Taf1 regulates Pax3 protein by monoubiquitination in skeletal muscle progenitors.

Mol Cell 2010 Dec;40(5):749-61

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023311PMC
December 2010

Heterogeneity in the muscle satellite cell population.

Semin Cell Dev Biol 2010 Oct 19;21(8):845-54. Epub 2010 Sep 19.

Department of Neurology and Neurological Sciences, Stanford University, School of Medicine, Stanford, CA 94305-5235, USA.

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http://dx.doi.org/10.1016/j.semcdb.2010.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967620PMC
October 2010

Epigenetics and aging.

Authors:
Thomas A Rando

Exp Gerontol 2010 Apr 23;45(4):253-4. Epub 2009 Dec 23.

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http://dx.doi.org/10.1016/j.exger.2009.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838984PMC
April 2010

Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides.

Nucleic Acids Res 2009 Dec;37(22):7468-82

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1093/nar/gkp757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794159PMC
December 2009

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

Dev Biol 2009 Nov 21;335(1):93-105. Epub 2009 Aug 21.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259687PMC
November 2009

Biomarker system for studying muscle, stem cells, and cancer in vivo.

FASEB J 2009 Aug 30;23(8):2681-90. Epub 2009 Mar 30.

Greehey Children's Cancer Research Institute and Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.

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http://dx.doi.org/10.1096/fj.08-128116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717773PMC
August 2009

Turning back time: reversing tissue pathology to enhance stem cell engraftment.

Authors:
Thomas A Rando

Cell Stem Cell 2008 Sep;3(3):232-4

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, VA Palo Alto Health Care Systems, Stanford, CA 94305-5235, USA.

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http://dx.doi.org/10.1016/j.stem.2008.08.006DOI Listing
September 2008

Stem cell review series: aging of the skeletal muscle stem cell niche.

Aging Cell 2008 Aug 28;7(4):590-8. Epub 2008 Jun 28.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2008.00399.xDOI Listing
August 2008

Technology insight: therapy for Duchenne muscular dystrophy-an opportunity for personalized medicine?

Nat Clin Pract Neurol 2008 Mar 12;4(3):149-58. Epub 2008 Feb 12.

Neurology Service at the Veterans Affairs Palo Alto Health Care System, CA, USA.

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http://www.nature.com/articles/ncpneuro0737
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http://dx.doi.org/10.1038/ncpneuro0737DOI Listing
March 2008

Get personal with gene therapy for muscular dystrophy.

Authors:
Thomas A Rando

Lancet Neurol 2008 Mar;7(3):196-8

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http://dx.doi.org/10.1016/S1474-4422(08)70029-2DOI Listing
March 2008

Intrinsic changes and extrinsic influences of myogenic stem cell function during aging.

Stem Cell Rev 2007 ;3(3):226-37

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

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January 2008

[Proteasomal degradation of Pax3 in skeletal muscle progenitors: one ubiquitin does the trick!].

Med Sci (Paris) 2008 Jan;24(1):31-3

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1051/medsci/200824131DOI Listing
January 2008

A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

Cell Stem Cell 2008 Jan;2(1):50-9

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305-5235 USA.

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http://dx.doi.org/10.1016/j.stem.2007.10.006DOI Listing
January 2008

Ageing: from stem to stern.

Nature 2007 Sep;449(7160):288-91

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http://dx.doi.org/10.1038/449288aDOI Listing
September 2007

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.

Science 2007 Aug;317(5839):807-10

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.1144090DOI Listing
August 2007

Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.

Cell 2007 Jul;130(2):349-62

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2007.05.044DOI Listing
July 2007

Gene delivery to muscle.

Curr Protoc Hum Genet 2002 Feb;Chapter 13:Unit13.4

Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1002/0471142905.hg1304s31DOI Listing
February 2002