Thijn R Brummelkamp

Thijn R Brummelkamp

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Thijn R Brummelkamp

Thijn R Brummelkamp

Publications by authors named "Thijn R Brummelkamp"

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SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

PLoS One 2019 12;14(2):e0212053. Epub 2019 Feb 12.

Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212053PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372190PMC
November 2019

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

Nat Struct Mol Biol 2019 Jul 1;26(7):567-570. Epub 2019 Jul 1.

Division of Biochemistry, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41594-019-0254-6DOI Listing
July 2019

The Tubulin Detyrosination Cycle: Function and Enzymes.

Trends Cell Biol 2019 01 10;29(1):80-92. Epub 2018 Sep 10.

Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Cancer Genomics Center, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.08.003DOI Listing
January 2019

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

Nat Commun 2019 01 9;10(1):100. Epub 2019 Jan 9.

Department of Medical Oncology, University Medical Center Groningen, Cancer Research Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-07927-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327059PMC
January 2019

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

Cancer Res 2018 12 13;78(23):6621-6631. Epub 2018 Sep 13.

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0545DOI Listing
December 2018

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

Curr Biol 2018 09 16;28(17):2685-2696.e4. Epub 2018 Aug 16.

Oncode Institute, Division of Cell Biology, the Netherlands Cancer Institute, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.06.026DOI Listing
September 2018

Viral escape from endosomes and host detection at a glance.

J Cell Sci 2018 08 3;131(15). Epub 2018 Aug 3.

Department of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

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http://dx.doi.org/10.1242/jcs.216259DOI Listing
August 2018

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

Cell Host Microbe 2018 05 19;23(5):636-643.e5. Epub 2018 Apr 19.

Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; CGC.nl, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.03.019DOI Listing
May 2018

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Cell Rep 2018 02;22(6):1424-1438

Oncode Institute, Divisions of Cell Biology and Biochemistry, the Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.034DOI Listing
February 2018

Vasohibins encode tubulin detyrosinating activity.

Science 2017 12 16;358(6369):1453-1456. Epub 2017 Nov 16.

Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

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http://dx.doi.org/10.1126/science.aao5676DOI Listing
December 2017

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Cell Host Microbe 2017 Nov;22(5):688-696.e5

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821226PMC
November 2017

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

Cell Host Microbe 2017 Oct;22(4):460-470.e5

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952603PMC
October 2017

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

J Virol 2016 02 18;90(3):1414-23. Epub 2015 Nov 18.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.02055-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719632PMC
February 2016

Enterovirus D68 receptor requirements unveiled by haploid genetics.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1399-404. Epub 2016 Jan 19.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1524498113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747778PMC
February 2016

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Chem Biol 2015 Dec 10;22(12):1643-52. Epub 2015 Dec 10.

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.10.014DOI Listing
December 2015

Gene essentiality and synthetic lethality in haploid human cells.

Science 2015 Nov 15;350(6264):1092-6. Epub 2015 Oct 15.

Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066CX, Amsterdam, Netherlands.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aac7557
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http://dx.doi.org/10.1126/science.aac7557DOI Listing
November 2015

Emerging intracellular receptors for hemorrhagic fever viruses.

Trends Microbiol 2015 Jul 21;23(7):392-400. Epub 2015 May 21.

Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, CX, 1066 The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0966842X150010
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http://dx.doi.org/10.1016/j.tim.2015.04.006DOI Listing
July 2015

GENE REGULATION. A HUSH for transgene expression.

Science 2015 Jun;348(6242):1433-4

Department of Cell Biology, Erasmus University Medical Center, 3015 GE Rotterdam, Netherlands

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http://dx.doi.org/10.1126/science.aac6529DOI Listing
June 2015

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

J Biol Chem 2014 Aug 16;289(35):24005-18. Epub 2014 Jul 16.

From the Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142,

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http://dx.doi.org/10.1074/jbc.M114.589275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148833PMC
August 2014

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

Cancer Res 2014 Jul;74(14):3810-20

Authors' Affiliations: Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands; and

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1960DOI Listing
July 2014

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

Science 2014 Jun;344(6188):1164-8

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan. Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1126/science.1252809DOI Listing
June 2014

Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

Science 2014 Jun;344(6191):1506-10

Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

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http://dx.doi.org/10.1126/science.1252480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239993PMC
June 2014

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Proc Natl Acad Sci U S A 2014 Apr 15;111(17):6431-6. Epub 2014 Apr 15.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.1323790111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035940PMC
April 2014

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Nat Cell Biol 2013 Dec 3;15(12):1473-85. Epub 2013 Nov 3.

1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Massachusetts Institute of Technology (MIT), Department of Biology, Cambridge, Massachusetts 02142, USA [3] Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4].

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http://dx.doi.org/10.1038/ncb2865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965854PMC
December 2013

Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.

Proc Natl Acad Sci U S A 2012 Jun 6;109(25):10059-64. Epub 2012 Jun 6.

Department of Biology, Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1120244109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382535PMC
June 2012

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT).

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16422-7. Epub 2011 Sep 19.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1109772108
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http://dx.doi.org/10.1073/pnas.1109772108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182710PMC
September 2011

Haploid genetic screens in human cells identify host factors used by pathogens.

Science 2009 Nov;326(5957):1231-5

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.1178955DOI Listing
November 2009

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

Mol Cancer Res 2008 Sep 22;6(9):1452-60. Epub 2008 Aug 22.

Division of Molecular Carcinogenesis, Center for Cancer Genomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0066DOI Listing
September 2008

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223.

Nature 2008 Feb 17;451(7182):1125-9. Epub 2008 Feb 17.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature06607DOI Listing
February 2008

YAP1 increases organ size and expands undifferentiated progenitor cells.

Curr Biol 2007 Dec 1;17(23):2054-60. Epub 2007 Nov 1.

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1016/j.cub.2007.10.039DOI Listing
December 2007

shRNA libraries and their use in cancer genetics.

Nat Methods 2006 Sep;3(9):701-6

Division of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nmeth921DOI Listing
September 2006

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

Nat Chem Biol 2006 Apr 13;2(4):202-6. Epub 2006 Feb 13.

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nchembio774DOI Listing
April 2006

Functional annotation of deubiquitinating enzymes using RNA interference.

Methods Enzymol 2005 ;398:554-67

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/S0076-6879(05)98045-2DOI Listing
December 2005

A genomic and functional inventory of deubiquitinating enzymes.

Cell 2005 Dec;123(5):773-86

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2005.11.007DOI Listing
December 2005

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Mol Cell 2005 Feb;17(3):331-9

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://ac.els-cdn.com/S1097276505010415/1-s2.0-S109727650501
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http://dspace.library.uu.nl/bitstream/handle/1874/17796/bern
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http://linkinghub.elsevier.com/retrieve/pii/S109727650501041
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http://dx.doi.org/10.1016/j.molcel.2005.01.008DOI Listing
February 2005

E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.

Oncogene 2004 Jul;23(30):5138-50

Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow, G12 8QQ, UK.

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http://dx.doi.org/10.1038/sj.onc.1207649DOI Listing
July 2004

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.

J Virol 2004 Mar;78(5):2601-5

Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC369246PMC
http://dx.doi.org/10.1128/jvi.78.5.2601-2605.2004DOI Listing
March 2004

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

Nature 2004 Mar;428(6981):431-7

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature02371DOI Listing
March 2004

New tools for functional mammalian cancer genetics.

Nat Rev Cancer 2003 10;3(10):781-9

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrc1191DOI Listing
October 2003

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

Nature 2003 Aug;424(6950):797-801

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature01811DOI Listing
August 2003

Stable suppression of tumorigenicity by virus-mediated RNA interference.

Cancer Cell 2002 Sep;2(3):243-7

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1535-6108(02)00122-8DOI Listing
September 2002

A system for stable expression of short interfering RNAs in mammalian cells.

Science 2002 Apr 21;296(5567):550-3. Epub 2002 Mar 21.

Division of Molecular Carcinogenesis, Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

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http://dx.doi.org/10.1126/science.1068999DOI Listing
April 2002

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

Genes Dev 2002 Mar;16(6):681-6

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gad.929302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155362PMC
March 2002

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

J Biol Chem 2002 Feb 17;277(8):6567-72. Epub 2001 Dec 17.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110492200
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http://dx.doi.org/10.1074/jbc.M110492200DOI Listing
February 2002