Thierry Vernet

Thierry Vernet

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Thierry Vernet

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A multidrug ABC transporter with a taste for GTP.

Sci Rep 2018 02 2;8(1):2309. Epub 2018 Feb 2.

University of Lyon, CNRS, UMR5086 "Molecular Microbiology and Structural Biochemistry", IBCP, 7 Passage du Vercors, F-69367, Lyon, France.

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http://dx.doi.org/10.1038/s41598-018-20558-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797166PMC
February 2018

Deciphering Key Residues Involved in the Virulence-promoting Interactions between and Human Plasminogen.

J Biol Chem 2017 02 23;292(6):2217-2225. Epub 2016 Dec 23.

From the Institut de Biologie Structurale (IBS), Université Grenoble Alpes, Commissariat à l'Energie Atomique (CEA), CNRS, 38044 Grenoble, France

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http://dx.doi.org/10.1074/jbc.M116.764209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313095PMC
February 2017

Enterococcus hirae LcpA (Psr), a new peptidoglycan-binding protein localized at the division site.

BMC Microbiol 2016 Oct 12;16(1):239. Epub 2016 Oct 12.

Physiologie et génétique bactérienne, Centre d'Ingénierie des Protéines, Université de Liège, Institut de Chimie, Liège, B-4000, Belgium.

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http://dx.doi.org/10.1186/s12866-016-0844-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059904PMC
October 2016

Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system.

Amino Acids 2016 09 21;48(9):2205-14. Epub 2016 May 21.

Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, Av. Vital Brasil 1500, São Paulo, 05503-000, Brazil.

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http://dx.doi.org/10.1007/s00726-016-2255-7DOI Listing
September 2016

Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition.

PLoS One 2015 2;10(12):e0143374. Epub 2015 Dec 2.

Equipe labellisée Ligue 2015-UMR 7242, CNRS-Université de Strasbourg, CNRS, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143374PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667898PMC
June 2016

Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan.

PLoS One 2015 30;10(4):e0125377. Epub 2015 Apr 30.

Université Grenoble Alpes, Institut de Biologie Structurale (IBS), 71 Avenue des Martyrs, F-38044 Grenoble, France; CNRS UMR5075, IBS, F-38044 Grenoble, France; CEA, DSV, IBS, F-38044 Grenoble, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125377PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415926PMC
October 2015

Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies.

J Mol Recognit 2015 Oct 11;28(10):635-44. Epub 2015 May 11.

Biotechnologie et signalisation cellulaire, Université de Strasbourg, CNRS, ESBS, Boulevard Sébastien Brant BP10413, 67412, Illkirch, France.

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http://dx.doi.org/10.1002/jmr.2477DOI Listing
October 2015

Full-length structure of the major autolysin LytA.

Acta Crystallogr D Biol Crystallogr 2015 Jun 23;71(Pt 6):1373-81. Epub 2015 May 23.

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.

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http://dx.doi.org/10.1107/S1399004715007403DOI Listing
June 2015

Reconstitution of membrane protein complexes involved in pneumococcal septal cell wall assembly.

PLoS One 2013 23;8(9):e75522. Epub 2013 Sep 23.

Institut de Biologie Structurale, Université Grenoble Alpes, Grenoble, France ; Institut de Biologie Structurale, Direction des Sciences du Vivant, Commissariat à l'energie atomique et aux Energies Alternatives, Grenoble, France ; Institut de Biologie Structurale, Centre National de la Recherche Scientifique, Grenoble, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075522PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798694PMC
February 2015

Mechanism of β-lactam action in Streptococcus pneumoniae: the piperacillin paradox.

Antimicrob Agents Chemother 2015 Jan 10;59(1):609-21. Epub 2014 Nov 10.

Université Grenoble Alpes, IBS, Grenoble, France CNRS, IBS, Grenoble, France CEA, IBS, Grenoble, France

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http://dx.doi.org/10.1128/AAC.04283-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291406PMC
January 2015

New insights into histidine triad proteins: solution structure of a Streptococcus pneumoniae PhtD domain and zinc transfer to AdcAII.

PLoS One 2013 28;8(11):e81168. Epub 2013 Nov 28.

Institut de Biologie Structurale, Université Grenoble Alpes, Grenoble, France ; Institut de Biologie Structurale, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique et aux Energies Alternatives, Grenoble, France ; Institut de Biologie Structurale, Centre National de la Recherche Scientifique, Grenoble, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842936PMC
December 2014

The elongation of ovococci.

Microb Drug Resist 2014 Jun 28;20(3):215-21. Epub 2014 Apr 28.

CNRS, Institut de Biologie Structurale (IBS), UMR 5075, CEA, Direction des Sciences du Vivant (DSV), IBS, and Université Grenoble Alpes , Grenoble, France .

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http://dx.doi.org/10.1089/mdr.2014.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050454PMC
June 2014

In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae.

ACS Chem Biol 2013 Dec 30;8(12):2688-96. Epub 2013 Sep 30.

Université Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble F-38027, France.

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http://dx.doi.org/10.1021/cb400575tDOI Listing
December 2013

On-chip microbial culture for the specific detection of very low levels of bacteria.

Lab Chip 2013 Oct 2;13(20):4024-32. Epub 2013 Aug 2.

CREAB Group, SPrAM, UMR CEA / CNRS / UJF, Institut des Nanosciences et Cryogénie, 38054 Grenoble cedex 9, France.

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http://dx.doi.org/10.1039/c3lc50473eDOI Listing
October 2013

Structure-function analysis of the LytM domain of EnvC, an activator of cell wall remodelling at the Escherichia coli division site.

Mol Microbiol 2013 Aug 23;89(4):690-701. Epub 2013 Jul 23.

Department of Microbiology and Immunobiology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/mmi.12304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923381PMC
August 2013

PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones.

Biochemistry 2012 Oct 21;51(39):7755-65. Epub 2012 Sep 21.

Université Joseph Fourier-Grenoble 1, Institut de Biologie Structurale, Grenoble, France.

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http://dx.doi.org/10.1021/bi300762pDOI Listing
October 2012

Peptidoglycan assembly machines: the biochemical evidence.

Microb Drug Resist 2012 Jun 20;18(3):256-60. Epub 2012 Mar 20.

Commissariat à l'Energie Nucléaire, Institut de Biologie Structurale, Grenoble, France.

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http://dx.doi.org/10.1089/mdr.2011.0236DOI Listing
June 2012

The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length.

FEBS J 2012 Jun 8;279(11):2071-81. Epub 2012 May 8.

CEA, Institut de Biologie Structurale, Grenoble, France.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08592.xDOI Listing
June 2012

Structural basis for the substrate specificity of a novel β-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6.

J Biol Chem 2011 Dec 19;286(50):43004-12. Epub 2011 Oct 19.

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

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http://dx.doi.org/10.1074/jbc.M111.256578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234876PMC
December 2011

Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence.

Mol Microbiol 2011 Nov 24;82(4):904-16. Epub 2011 Oct 24.

CEA, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, 41 Rue Jules Horowitz, 38027 Grenoble cedex 1, France.

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http://dx.doi.org/10.1111/j.1365-2958.2011.07862.xDOI Listing
November 2011

Structural and enzymatic characterization of the streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH.

J Biol Chem 2011 Oct 23;286(41):35906-14. Epub 2011 Aug 23.

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.228585
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.228585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195627PMC
October 2011

Expression of a chloroplast ATP/ADP transporter in E. coli membranes: behind the Mistic strategy.

Biochim Biophys Acta 2011 Aug 30;1808(8):2059-66. Epub 2011 Apr 30.

CEA, Institut de Biologie Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, F-38027 Grenoble, France.

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http://dx.doi.org/10.1016/j.bbamem.2011.04.011DOI Listing
August 2011

Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.

Biochem Pharmacol 2011 May 26;81(9):1098-105. Epub 2011 Feb 26.

Centre d'Ingénierie des Protéines, Université de Liège, Allée de la chimie, B6a, B-4000, Sart Tilman, Liège, Belgium.

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http://dx.doi.org/10.1016/j.bcp.2011.02.008DOI Listing
May 2011

Biochemical characterization of the histidine triad protein PhtD as a cell surface zinc-binding protein of pneumococcus.

Biochemistry 2011 May 11;50(17):3551-8. Epub 2011 Apr 11.

CEA, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, France.

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http://dx.doi.org/10.1021/bi200012fDOI Listing
May 2011

Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae.

J Struct Biol 2011 Apr 3;174(1):252-7. Epub 2010 Nov 3.

School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, PR China.

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http://dx.doi.org/10.1016/j.jsb.2010.10.016DOI Listing
April 2011

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.

EMBO J 2011 Apr 8;30(8):1425-32. Epub 2011 Mar 8.

Department of Chemical Biology and Organic Chemistry, Institute of Biomembranes, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2011.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102273PMC
April 2011

Large scale purification of linear plasmid DNA for efficient high throughput cloning.

Biotechnol J 2010 Sep;5(9):978-85

CEA, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, France.

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http://dx.doi.org/10.1002/biot.201000132DOI Listing
September 2010

New adhesin functions of surface-exposed pneumococcal proteins.

BMC Microbiol 2010 Jul 12;10:190. Epub 2010 Jul 12.

Institut de Biologie Structurale, UMR, Université Joseph Fourier, CNRS, CEA, Grenoble, France.

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http://dx.doi.org/10.1186/1471-2180-10-190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911433PMC
July 2010

Stability and assembly of pilus subunits of Streptococcus pneumoniae.

J Biol Chem 2010 Apr 10;285(16):12405-15. Epub 2010 Feb 10.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 (CEA, CNRS, UJF), Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M109.082776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852978PMC
April 2010

Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.

Structure 2010 Jan;18(1):106-15

Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 (CEA, CNRS, UJF), Grenoble, France.

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http://dx.doi.org/10.1016/j.str.2009.10.019DOI Listing
January 2010

Central domain of DivIB caps the C-terminal regions of the FtsL/DivIC coiled-coil rod.

J Biol Chem 2009 Oct 27;284(40):27687-700. Epub 2009 Jul 27.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale, UMR 5075, Université Joseph Fourier, CNRS, Commissariat à l'Energie Atomique, 38027 Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M109.019471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785697PMC
October 2009

Structure of the choline-binding domain of Spr1274 in Streptococcus pneumoniae.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Aug 21;65(Pt 8):757-61. Epub 2009 Jul 21.

Protein Research Institute, Tongji University, Shanghai 200092, People's Republic of China.

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http://dx.doi.org/10.1107/S1744309109025329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720326PMC
August 2009

Parallel screening and optimization of protein constructs for structural studies.

Protein Sci 2009 Feb;18(2):434-9

Institut de Biologie Structurale Jean-Pierre Ebel, Centre National de la Recherche Scientifique, Université Joseph-Fourier, Grenoble, France.

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http://dx.doi.org/10.1002/pro.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708052PMC
February 2009

Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae.

Structure 2008 Dec;16(12):1838-48

Laboratoire des Protéines Membranaires, Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 (CEA, CNRS, UJF, PSB), 41 rue Jules Horowitz, F-38027 Grenoble, France.

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http://dx.doi.org/10.1016/j.str.2008.10.007DOI Listing
December 2008

The interaction of Streptococcus pneumoniae with plasmin mediates transmigration across endothelial and epithelial monolayers by intercellular junction cleavage.

Infect Immun 2008 Nov 25;76(11):5350-6. Epub 2008 Aug 25.

Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075, Laboratoire d'Ingénierie des Macromolécules, 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1128/IAI.00184-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573366PMC
November 2008

AdcAII, a new pneumococcal Zn-binding protein homologous with ABC transporters: biochemical and structural analysis.

J Mol Biol 2008 Sep 3;381(3):594-606. Epub 2008 Jun 3.

Institut de Biologie Structurale Jean-Pierre Ebel UMR 5075 (CNRS/CEA/UJF/PSB), Laboratoire d'Ingénierie des Macromolécules, 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1016/j.jmb.2008.05.068DOI Listing
September 2008

Roles of pneumococcal DivIB in cell division.

J Bacteriol 2008 Jul 25;190(13):4501-11. Epub 2008 Apr 25.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale (Université Joseph Fourier, CNRS UMR 5075, CEA), Grenoble, France.

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http://dx.doi.org/10.1128/JB.00376-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446777PMC
July 2008

Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.

J Biochem 2008 Jun 13;143(6):821-32. Epub 2008 Mar 13.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, (CEA/CNRS, UJF), 41 rue Jules Horowitz, 38027 Grenoble Cedex, France.

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http://dx.doi.org/10.1093/jb/mvn035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798001PMC
June 2008

Penicillin-binding proteins and beta-lactam resistance.

FEMS Microbiol Rev 2008 Mar 29;32(2):361-85. Epub 2008 Jan 29.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075-CNRS, CEA, Université Joseph Fourier, Grenoble, France.

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http://dx.doi.org/10.1111/j.1574-6976.2007.00095.xDOI Listing
March 2008

The different shapes of cocci.

FEMS Microbiol Rev 2008 Mar 4;32(2):345-60. Epub 2008 Feb 4.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale (CEA/CNRS/UJF UMR5075), Grenoble, France.

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http://dx.doi.org/10.1111/j.1574-6976.2007.00098.xDOI Listing
March 2008

Common alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward beta-lactams: structural insights.

J Biol Chem 2008 Feb 30;283(8):4886-94. Epub 2007 Nov 30.

Laboratoire des Protéines Membranaires, Institut de Biologie Structurale Jean-Pierre Ebel, Université Joseph Fourier, UMR 5075-CNRS, CEA Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M706181200DOI Listing
February 2008

Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.

Infect Immun 2008 Feb 10;76(2):466-76. Epub 2007 Dec 10.

Institut de Biologie Structurale Jean-Pierre Ebel UMR 5075, Laboratoire d'Ingnierie des Macromolécules, 41 rue Jules Horowitz, CNRS, CEA, and Université Joseph Fourier, Partnership for Structural Biology, F-38027 Grenoble, France.

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http://dx.doi.org/10.1128/IAI.01261-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223458PMC
February 2008

Automated high-throughput process for site-directed mutagenesis, production, purification, and kinetic characterization of enzymes.

Anal Biochem 2006 Aug 19;355(1):110-6. Epub 2006 May 19.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale (CEA/CNRS UMR 5075/UJF), Grenoble Cedex 1 F-38027, France.

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http://dx.doi.org/10.1016/j.ab.2006.04.047DOI Listing
August 2006

Salivary apyrases of Triatoma infestans are assembled into homo-oligomers.

Biochem J 2006 Jun;396(3):509-15

Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasilia, Brazil 70.910-900.

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http://dx.doi.org/10.1042/BJ20052019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482816PMC
June 2006

Pneumococcal beta-lactam resistance due to a conformational change in penicillin-binding protein 2x.

J Biol Chem 2006 Jan 22;281(3):1771-7. Epub 2005 Nov 22.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale (Commissariat à l'Energie Atomique/CNRS UMR 5075/Université Joseph Fourrier), Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M511506200DOI Listing
January 2006

Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.

J Mol Biol 2006 Jan 9;355(4):684-96. Epub 2005 Nov 9.

Institut de Biologie Structurale Jean-Pierre Ebel (CNRS/CEA/UJF), Laboratoire de Cristallographie Macromoléculaire, 41 rue Jules Horowitz, Grenoble 38027, France.

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http://dx.doi.org/10.1016/j.jmb.2005.10.030DOI Listing
January 2006

Crystal structure of phosphorylcholine esterase domain of the virulence factor choline-binding protein e from streptococcus pneumoniae: new structural features among the metallo-beta-lactamase superfamily.

J Biol Chem 2005 Aug 20;280(31):28591-600. Epub 2005 May 20.

Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean-Pierre Ebel (CEA-CNRS UMR 5075-UJF), 41 Rue Jules Horowitz 38027, Grenoble Cedex 1, France.

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http://dx.doi.org/10.1074/jbc.M502744200DOI Listing
August 2005

Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumoniae.

J Biol Chem 2005 Apr 13;280(16):15984-91. Epub 2004 Dec 13.

Laboratoire de Cristallographie Macromoléculaire and Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel (CNRS/CEA/UJF), 41 rue Jules Horowitz, Grenoble 38027, France.

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http://dx.doi.org/10.1074/jbc.M408446200DOI Listing
April 2005

The PECACE domain: a new family of enzymes with potential peptidoglycan cleavage activity in Gram-positive bacteria.

BMC Genomics 2005 Feb 17;6:19. Epub 2005 Feb 17.

Laboratoire d'Ingénierie des Macromolécules, Institute de Biologie Structurale, Jean-Pierre Ebel (CEA-CNRS UMR 5075-UJF), 41 Rue Jules Horowitz 38027 Grenoble cedex 1, France.

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http://dx.doi.org/10.1186/1471-2164-6-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC550655PMC
February 2005

Active site restructuring regulates ligand recognition in class A penicillin-binding proteins.

Proc Natl Acad Sci U S A 2005 Jan 6;102(3):577-82. Epub 2005 Jan 6.

Laboratoires de Cristallographie Macromoléculaire, Centre National de la Recherche Scientifique/Commissariat à l'Energie Atomique/Université Joseph Fourier, 41 Rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1073/pnas.0407186102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545533PMC
January 2005

In vitro reconstitution of a trimeric complex of DivIB, DivIC and FtsL, and their transient co-localization at the division site in Streptococcus pneumoniae.

Mol Microbiol 2005 Jan;55(2):413-24

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale (CEA/CNRS UMR 5075/UJF), 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1111/j.1365-2958.2004.04408.xDOI Listing
January 2005

Kinetics of expression of the salivary apyrases in Triatoma infestans.

Insect Biochem Mol Biol 2004 Oct;34(10):1051-8

Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasilia, 70910-900 Brasilia, Brazil.

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http://dx.doi.org/10.1016/j.ibmb.2004.06.016DOI Listing
October 2004

Triatoma infestans apyrases belong to the 5'-nucleotidase family.

J Biol Chem 2004 May 25;279(19):19607-13. Epub 2004 Feb 25.

Chagas' Disease Multidisciplinary Research Laboratory, Department of Pathology, Faculty of Medicine, University of Brasília, Brazil 70.910-900.

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http://dx.doi.org/10.1074/jbc.M401681200DOI Listing
May 2004

Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance.

Antimicrob Agents Chemother 2004 May;48(5):1848-55

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel (CEA-CNRS UMR 5075-UJF), 38027 Grenoble Cedex 1, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400559PMC
http://dx.doi.org/10.1128/aac.48.5.1848-1855.2004DOI Listing
May 2004

A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.

J Biol Chem 2004 Apr 20;279(16):16463-70. Epub 2004 Jan 20.

Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean-Pierre Ebel (CNRS/CEA/UJF), Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M313492200DOI Listing
April 2004

The D,D-carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae.

Mol Microbiol 2004 Mar;51(6):1641-8

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale J-P Ebel (CEA/CNRS/UJF, UMR 5075), 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03953.xDOI Listing
March 2004

The structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strains.

J Biol Chem 2003 Nov 15;278(45):44448-56. Epub 2003 Aug 15.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale J.-P. Ebel (CEA/CNRS/UJF UMR 5075), 38027 Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M305948200DOI Listing
November 2003

Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin-binding proteins during the cell cycle.

Mol Microbiol 2003 Nov;50(3):845-55

Institut de Biologie Structurale J. -P. Ebel (CEA/CNRS/UJF, UMR 5075), 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03767.xDOI Listing
November 2003

The glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae catalyzes the polymerization of murein glycan chains.

J Bacteriol 2003 Aug;185(15):4418-23

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, (CEA, CNRS, UMR5075, UJF), 38027 Grenoble cedex 1, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165775PMC
http://dx.doi.org/10.1128/jb.185.15.4418-4423.2003DOI Listing
August 2003

Expression and purification of FtsW and RodA from Streptococcus pneumoniae, two membrane proteins involved in cell division and cell growth, respectively.

Protein Expr Purif 2003 Jul;30(1):18-25

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale J.-P. Ebel (CEA/CNRS/UJF), 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1016/s1046-5928(03)00051-2DOI Listing
July 2003

Structural studies of the transpeptidase domain of PBP1a from Streptococcus pneumoniae.

Acta Crystallogr D Biol Crystallogr 2003 Jun 23;59(Pt 6):1067-9. Epub 2003 May 23.

Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean-Pierre Ebel (CEA/CNRS/UJF), 41 Rue Jules Horowitz, 38027 Grenoble, France.

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http://journals.iucr.org/d/issues/2003/06/00/cy0110/cy0110.p
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http://dx.doi.org/10.1107/s0907444903006954DOI Listing
June 2003

Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration.

J Biol Chem 2003 Apr 12;278(16):14002-12. Epub 2003 Feb 12.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, Commissariat à l'Energie Atomique/CNRS, Université Joseph Fourier, 41 rue Jules Horowitz, 38027 Grenoble Cedex, France.

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http://dx.doi.org/10.1074/jbc.M300351200DOI Listing
April 2003

Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae.

J Bacteriol 2003 Mar;185(5):1650-8

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS, UJF, UMR5075, 38027 Grenoble cedex 1, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC148077PMC
http://dx.doi.org/10.1128/jb.185.5.1650-1658.2003DOI Listing
March 2003

Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4.

J Mol Biol 2003 Feb;326(2):493-502

European Molecular Biology Laboratory, 6 rue Jules Horowitz, 38042 Grenoble, France.

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http://dx.doi.org/10.1016/s0022-2836(02)01406-7DOI Listing
February 2003

Functional mapping of conserved, surface-exposed charges of antibody variable domains.

J Mol Recognit 2002 Mar-Apr;15(2):94-103

Institut de Biologie Structurale Jean-Pierre Ebel, Laboratoire d'Ingénierie des Macromolécules, CEA/CNRS/UJF, 41 rue Jules Horowitz,-F-38027 Grenoble cedex 1, France.

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http://dx.doi.org/10.1002/jmr.562DOI Listing
August 2002

Bifunctional penicillin-binding proteins: focus on the glycosyltransferase domain and its specific inhibitor moenomycin.

Curr Pharm Biotechnol 2002 Jun;3(2):63-75

Institut de Biologie Structurale Jean-Pierre Ebel (CEA-CNRS UMR 5075-UJF), Grenoble, France.

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http://dx.doi.org/10.2174/1389201023378436DOI Listing
June 2002

Synergy between extracellular modules of vascular endothelial cadherin promotes homotypic hexameric interactions.

J Biol Chem 2002 Apr 30;277(15):12790-801. Epub 2002 Jan 30.

Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, CEA/CNRS, Université Joseph Fourier, 41 Rue Jules Horowitz, 38027 Grenoble Cedex, France.

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http://dx.doi.org/10.1074/jbc.M111597200DOI Listing
April 2002

Membrane topology of the Streptococcus pneumoniae FtsW division protein.

J Bacteriol 2002 Apr;184(7):1925-31

Institut de Biologie Structurale Jean-Pierre Ebel (CEA/CNRS/UJF), Laboratoire d'Ingénierie des Macromolécules, 38027 Grenoble Cedex 1, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134934PMC
http://dx.doi.org/10.1128/jb.184.7.1925-1931.2002DOI Listing
April 2002

Increase of the deacylation rate of PBP2x from Streptococcus pneumoniae by single point mutations mimicking the class A beta-lactamases.

Eur J Biochem 2002 Mar;269(6):1678-83

Laboratoire d'Ingénierie des Macromolécules and Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale J.-P. Ebel, Grenoble, France.

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http://dx.doi.org/10.1046/j.1432-1327.2002.02815.xDOI Listing
March 2002