Thierry Gorlia

Thierry Gorlia

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Thierry Gorlia

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Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis.

Authors:
Corinna Seliger Els Genbrugge Thierry Gorlia Olivier Chinot Roger Stupp Burt Nabors Michael Weller Peter Hau

Int J Cancer 2020 02 29;146(3):803-809. Epub 2019 Apr 29.

Department of Neurology and Wilhelm Sander-NeuroOncology Unit, Regensburg University Hospital, Regensburg, Germany.

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http://dx.doi.org/10.1002/ijc.32337DOI Listing
February 2020

Molecular Evolution of Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study.

Authors:
Kaspar Draaisma Aikaterini Chatzipli Martin Taphoorn Melissa Kerkhof Astrid Weyerbrock Marc Sanson Ann Hoeben Slávka Lukacova Giuseppe Lombardi Sieger Leenstra Monique Hanse Ruth Fleischeuer Colin Watts Joseph McAbee Nicos Angelopoulos Thierry Gorlia Vassilis Golfinopoulos Johan M Kros Roel G W Verhaak Vincent Bours Martin J van den Bent Ultan McDermott Pierre A Robe Pim J French

J Clin Oncol 2020 Jan 19;38(1):81-99. Epub 2019 Nov 19.

Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.19.00367DOI Listing
January 2020

Temporal muscle thickness is an independent prognostic marker in patients with progressive glioblastoma: translational imaging analysis of the EORTC 26101 trial.

Authors:
Julia Furtner Els Genbrugge Thierry Gorlia Martin Bendszus Martha Nowosielski Vassilis Golfinopoulos Michael Weller Martin J van den Bent Wolfgang Wick Matthias Preusser

Neuro Oncol 2019 12;21(12):1587-1594

Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917403PMC
December 2019

Symptom clusters in newly diagnosed glioma patients: which symptom clusters are independently associated with functioning and global health status?

Authors:
Marijke B Coomans Linda Dirven Neil K Aaronson Brigitta G Baumert Martin Van Den Bent Andrew Bottomley Alba A Brandes Olivier Chinot Corneel Coens Thierry Gorlia Ulrich Herrlinger Florence Keime-Guibert Annika Malmström Francesca Martinelli Roger Stupp Andrea Talacchi Michael Weller Wolfgang Wick Jaap C Reijneveld Martin J B Taphoorn

Neuro Oncol 2019 11;21(11):1447-1457

Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1093/neuonc/noz118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827824PMC
November 2019

INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFRamplified glioblastoma.

Authors:
Martin van den Bent Marica Eoli Juan Manuel Sepulveda Marion Smits Annemiek Walenkamp Jean-Sebastian Frenel Enrico Franceschi Paul M Clement Olivier Chinot Filip de Vos Nicolas Whenham Paul Sanghera Michael Weller H J Dubbink Pim French Jim Looman Jyotirmoy Dey Scott Krause Pete Ansell Sarah Nuyens Maarten Spruyt Joana Brilhante Corneel Coens Thierry Gorlia Vassilis Golfinopoulos

Neuro Oncol 2019 Nov 20. Epub 2019 Nov 20.

EORTC Headquarters, Brussels, Belgium.

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http://dx.doi.org/10.1093/neuonc/noz222DOI Listing
November 2019

Defining EGFR amplification status for clinical trial inclusion.

Authors:
Pim J French Marica Eoli Juan Manuel Sepulveda Iris de Heer Johan M Kros Annemiek Walenkamp Jean-Sebastien Frenel Enrico Franceschi Paul M Clement Michael Weller Peter Ansell Jim Looman Earle Bain Marie Morfouace Thierry Gorlia Martin van den Bent

Neuro Oncol 2019 10;21(10):1263-1272

Department of Neurology, Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands.

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http://dx.doi.org/10.1093/neuonc/noz096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784284PMC
October 2019

The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients: a meta-analysis based on individual patient data from randomised controlled trials.

Authors:
Marijke Coomans Linda Dirven Neil K Aaronson Brigitta G Baumert Martin van den Bent Andrew Bottomley Alba A Brandes Olivier Chinot Corneel Coens Thierry Gorlia Ulrich Herrlinger Florence Keime-Guibert Annika Malmström Francesca Martinelli Roger Stupp Andrea Talacchi Michael Weller Wolfgang Wick Jaap C Reijneveld Martin J B Taphoorn

Eur J Cancer 2019 Jul 13;116:190-198. Epub 2019 Jun 13.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Haaglanden Medical Center, Den Haag, the Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2019.05.012DOI Listing
July 2019

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study.

Authors:
Martha Nowosielski Thierry Gorlia Jacoline E C Bromberg Felix Sahm Inga Harting Philipp Kickingereder Alba A Brandes Martin J B Taphoorn Walter Taal Julien Domont Ahmed Idbaih Mario Campone Paul M Clement Michael Weller Michel Fabbro Emilie Le Rhun Michael Platten Vassilis Golfinopoulos Martin J van den Bent Martin Bendszus Wolfgang Wick

Neurology 2019 06 10;92(24):e2754-e2763. Epub 2019 May 10.

From the University Medical Center & German Cancer Research Center (M.N., F.S., I.H., P.K., M.P., M.B., W.W.), Heidelberg, Germany; EORTC Headquarters (T.G., V.G.), Brussels, Belgium; Brain Tumor Center at Erasmus MC Cancer Institute (J.E.C.B., W.T., M.J.v.d.B.), Rotterdam, the Netherlands; Medical Oncology Department (A.A.B.), AUSL-Bologna-IRCCS Scienze Neurologiche, Bologna, Italy; Haaglanden Medical Center (M.J.B.T.), the Hague; Leiden University Medical Center (M.J.B.T.), the Netherlands; Institut Gustave Roussy (J.D.), Villejuif; Sorbonne Université (A.I.), Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris; Institut de Cancerologie de l'Ouest (ICO)-Centre Rene Gauducheau (M.C.), Saint-Herblain, France; Leuven Cancer Institute-KU Leuven (P.M.C.), Belgium; Department of Neurology and Brain Tumor Center (M.W.), University Hospital and University of Zurich, Switzerland; Institut Régional du Cancer Montpellier (M.F.); University of Lille (E.L.R.), U-1192, Inserm; CHU Lille (E.L.R.), General and Stereotaxic Neurosurgery Service; Oscar Lambret Center (E.L.R.), Neurology, Lille, France; Department of Neurology (M.P.), Medical Faculty Mannheim, Heidelberg University, Germany; and Department of Neurology (M.N.), Medical University Innsbruck, Austria.

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http://dx.doi.org/10.1212/WNL.0000000000007643DOI Listing
June 2019

The RANO Leptomeningeal Metastasis Group proposal to assess response to treatment: lack of feasibility and clinical utility and a revised proposal.

Authors:
Emilie Le Rhun Patrick Devos Thomas Boulanger Marion Smits Dieta Brandsma Roberta Rudà Julia Furtner Johann-Martin Hempel Tjeerd J Postma Patrick Roth Tom J Snijders Frank Winkler Sebastian Winklhofer Antonella Castellano Elke Hattingen Jaume Capellades Thierry Gorlia Martin Van den Bent Patrick Y Wen Martin Bendszus Michael Weller

Neuro Oncol 2019 May;21(5):648-658

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/neuonc/noz024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502503PMC
May 2019

Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study.

Authors:
Philipp Kickingereder Fabian Isensee Irada Tursunova Jens Petersen Ulf Neuberger David Bonekamp Gianluca Brugnara Marianne Schell Tobias Kessler Martha Foltyn Inga Harting Felix Sahm Marcel Prager Martha Nowosielski Antje Wick Marco Nolden Alexander Radbruch Jürgen Debus Heinz-Peter Schlemmer Sabine Heiland Michael Platten Andreas von Deimling Martin J van den Bent Thierry Gorlia Wolfgang Wick Martin Bendszus Klaus H Maier-Hein

Lancet Oncol 2019 May 2;20(5):728-740. Epub 2019 Apr 2.

Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(19)30098-1DOI Listing
May 2019

Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials.

Authors:
Monika E Hegi Els Genbrugge Thierry Gorlia Roger Stupp Mark R Gilbert Olivier L Chinot L Burt Nabors Greg Jones Wim Van Criekinge Josef Straub Michael Weller

Clin Cancer Res 2019 03 4;25(6):1809-1816. Epub 2018 Dec 4.

Department of Neurology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3181DOI Listing
March 2019

Associations of anticoagulant use with outcome in newly diagnosed glioblastoma.

Authors:
Emilie Le Rhun Els Genbrugge Roger Stupp Olivier L Chinot L Burt Nabors Timothy Cloughesy David A Reardon Wolfgang Wick Thierry Gorlia Michael Weller

Eur J Cancer 2018 09 20;101:95-104. Epub 2018 Jul 20.

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ejca.2018.06.029DOI Listing
September 2018

Bevacizumab and temozolomide in patients with first recurrence of WHO grade II and III glioma, without 1p/19q co-deletion (TAVAREC): a randomised controlled phase 2 EORTC trial.

Authors:
Martin J van den Bent Martin Klein Marion Smits Jaap C Reijneveld Pim J French Paul Clement Filip Y F de Vos Antje Wick Paul J Mulholland Martin J B Taphoorn Joanne Lewis Michael Weller Olivier L Chinot Johan M Kros Iris de Heer Tina Verschuere Corneel Coens Vassilis Golfinopoulos Thierry Gorlia Ahmed Idbaih

Lancet Oncol 2018 09 13;19(9):1170-1179. Epub 2018 Aug 13.

The Brain and Spine Institute (ICM), Sorbonne Université, The National Institute of Health and Medical Research (INSERM), National Centre for Scientific Research (CNRS), Public Assistance-Paris Hospitals (AP-HP), Hôpital Pitié-Salpêtrière, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183036
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http://dx.doi.org/10.1016/S1470-2045(18)30362-0DOI Listing
September 2018

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.

Authors:
Mitsuaki Shirahata Takahiro Ono Damian Stichel Daniel Schrimpf David E Reuss Felix Sahm Christian Koelsche Annika Wefers Annekathrin Reinhardt Kristin Huang Philipp Sievers Hiroaki Shimizu Hiroshi Nanjo Yusuke Kobayashi Yohei Miyake Tomonari Suzuki Jun-Ichi Adachi Kazuhiko Mishima Atsushi Sasaki Ryo Nishikawa Melanie Bewerunge-Hudler Marina Ryzhova Oksana Absalyamova Andrey Golanov Peter Sinn Michael Platten Christine Jungk Frank Winkler Antje Wick Daniel Hänggi Andreas Unterberg Stefan M Pfister David T W Jones Martin van den Bent Monika Hegi Pim French Brigitta G Baumert Roger Stupp Thierry Gorlia Michael Weller David Capper Andrey Korshunov Christel Herold-Mende Wolfgang Wick David N Louis Andreas von Deimling

Acta Neuropathol 2018 07 23;136(1):153-166. Epub 2018 Apr 23.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1849-4
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http://dx.doi.org/10.1007/s00401-018-1849-4DOI Listing
July 2018

Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?

Authors:
Caroline Happold Thierry Gorlia L Burt Nabors Sara C Erridge David A Reardon Christine Hicking Martin Picard Roger Stupp Michael Weller

J Neurooncol 2018 May 8;138(1):163-171. Epub 2018 Feb 8.

Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://link.springer.com/10.1007/s11060-018-2786-8
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http://dx.doi.org/10.1007/s11060-018-2786-8DOI Listing
May 2018

The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.

Authors:
Pierre Bady Sebastian Kurscheid Mauro Delorenzi Thierry Gorlia Martin J van den Bent Khê Hoang-Xuan Élodie Vauléon Anja Gijtenbeek Roelien Enting Brian Thiessen Olivier Chinot Frédéric Dhermain Alba A Brandes Jaap C Reijneveld Christine Marosi Martin J B Taphoorn Wolfgang Wick Andreas von Deimling Pim French Roger Stupp Brigitta G Baumert Monika E Hegi

Acta Neuropathol 2018 04 24;135(4):601-615. Epub 2018 Jan 24.

Laboratory of Brain Tumor Biology and Genetics, Neuroscience Research Center, Lausanne University Hospital, Chemin des Boveresses 155, CLE-C306, 1066 Epalinges, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00401-018-1810-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978935PMC
April 2018

Farewell to monomodality treatment in patients with WHO lower grade glioma?

Authors:
Emilie Le Rhun Thierry Gorlia

Eur J Cancer 2018 01 24;88:109-114. Epub 2017 Nov 24.

EORTC Headquarters, Brain Tumor Group, Avenue Emmanuel Mounier 83/11, 1200 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.10.019DOI Listing
January 2018

Lomustine and Bevacizumab in Progressive Glioblastoma.

Authors:
Wolfgang Wick Thierry Gorlia Martin Bendszus Martin Taphoorn Felix Sahm Inga Harting Alba A Brandes Walter Taal Julien Domont Ahmed Idbaih Mario Campone Paul M Clement Roger Stupp Michel Fabbro Emilie Le Rhun Francois Dubois Michael Weller Andreas von Deimling Vassilis Golfinopoulos Jacoline C Bromberg Michael Platten Martin Klein Martin J van den Bent

N Engl J Med 2017 11;377(20):1954-1963

From the University Medical Center and German Cancer Research Center, Heidelberg, Germany (W.W., M.B., F.S., I.H., A.D., M.P.); the European Organization for Research and Treatment of Cancer, Brussels (T.G., V.G.), and Leuven Cancer Institute-KU Leuven, Leuven (P.M.C.) - both in Belgium; Haaglanden Medical Center, The Hague (M.T.), Erasmus MC Cancer Institute, Rotterdam (W.T., J.C.B., M.J.B.), and VU University Medical Center, Amsterdam (M.K.) - all in the Netherlands; the Medical Oncology Department, Azienda Unità Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy (A.A.B.); Institut Gustave Roussy, Villejuif (J.D.), Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, INSERM Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Sorbonne Universités, University Pierre and Marie Curie 06 UMR S1127, and Institut du Cerveau et de la Moelle Épinière, Paris (A.I.), Institut de Cancerologie de l'Ouest-Centre Rene Gauducheau, Saint-Herblain (M.C.), Institut Régional du Cancer Montpellier, Montpellier (M.F.), and Centre Hospitalier Régional Universitaire de Lille, Lille (E.L.R., F.D.) - all in France; and the Departments of Oncology and Neurology, University Hospital and University of Zurich, Zurich, Switzerland (R.S., M.W.).

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http://dx.doi.org/10.1056/NEJMoa1707358DOI Listing
November 2017

Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.

Authors:
Martin J van den Bent Brigitta Baumert Sara C Erridge Michael A Vogelbaum Anna K Nowak Marc Sanson Alba Ariela Brandes Paul M Clement Jean Francais Baurain Warren P Mason Helen Wheeler Olivier L Chinot Sanjeev Gill Matthew Griffin David G Brachman Walter Taal Roberta Rudà Michael Weller Catherine McBain Jaap Reijneveld Roelien H Enting Damien C Weber Thierry Lesimple Susan Clenton Anja Gijtenbeek Sarah Pascoe Ulrich Herrlinger Peter Hau Frederic Dhermain Irene van Heuvel Roger Stupp Ken Aldape Robert B Jenkins Hendrikus Jan Dubbink Winand N M Dinjens Pieter Wesseling Sarah Nuyens Vassilis Golfinopoulos Thierry Gorlia Wolfgang Wick Johan M Kros

Lancet 2017 Oct 8;390(10103):1645-1653. Epub 2017 Aug 8.

Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(17)31442-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806535PMC
October 2017

Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG.

Authors:
Deborah T Blumenthal Thierry Gorlia Mark R Gilbert Michelle M Kim L Burt Nabors Warren P Mason Monika E Hegi Peixin Zhang Vassilis Golfinopoulos James R Perry Do Hyun Nam Sara C Erridge Benjamin W Corn René O Mirimanoff Paul D Brown Brigitta G Baumert Minesh P Mehta Martin J van den Bent David A Reardon Michael Weller Roger Stupp

Neuro Oncol 2017 Aug;19(8):1119-1126

Tel-Aviv Sourasky Medical Center, Tel-Aviv University; European Organization for Research and Treatment of Cancer, Brussels (EORTC); National Institutes of Health (M.R.M.); University of Alabama at Birmingham; Princess Margaret Cancer Centre, University of Toronto; Lausanne University Hospital; NRG Oncology Statistics and Data Management Center; Odette Cancer Centre and Sunnybrook Health Sciences Centre, University of Toronto; Samsung Medical Center, Sungkyunkwan University School of Medicine; Edinburgh Cancer Centre; Mayo Clinic; Robert-Janker Clinic at the University of Bonn Medical Centre, and MAASTRO clinic, GROW School for Oncology, Maastricht University Medical Centre; Miami Cancer Institute; Erasmus University Hospital; Dana-Farber Cancer Institute and Harvard Medical School; University of Zurich.

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http://dx.doi.org/10.1093/neuonc/nox025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570239PMC
August 2017

Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Authors:
Jaap C Reijneveld Martin J B Taphoorn Corneel Coens Jacoline E C Bromberg Warren P Mason Khê Hoang-Xuan Gail Ryan Mohamed Ben Hassel Roelien H Enting Alba A Brandes Antje Wick Olivier Chinot Michele Reni Guy Kantor Brian Thiessen Martin Klein Eugenie Verger Christian Borchers Peter Hau Michael Back Anja Smits Vassilis Golfinopoulos Thierry Gorlia Andrew Bottomley Roger Stupp Brigitta G Baumert

Lancet Oncol 2016 Nov 27;17(11):1533-1542. Epub 2016 Sep 27.

Department of Medical Oncology and Cancer Centre, University Hospital Zurich, Zurich, Switzerland; Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC) and GROW (School for Oncology), Maastricht, Netherlands; Department of Radiation-Oncology, MediClin Robert-Janker-Clinic, Clinical Cooperation Unit Neuro-oncology, University Bonn Medical Centre, Bonn, Germany.

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http://dx.doi.org/10.1016/S1470-2045(16)30305-9DOI Listing
November 2016

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Authors:
Brigitta G Baumert Monika E Hegi Martin J van den Bent Andreas von Deimling Thierry Gorlia Khê Hoang-Xuan Alba A Brandes Guy Kantor Martin J B Taphoorn Mohamed Ben Hassel Christian Hartmann Gail Ryan David Capper Johan M Kros Sebastian Kurscheid Wolfgang Wick Roelien Enting Michele Reni Brian Thiessen Frederic Dhermain Jacoline E Bromberg Loic Feuvret Jaap C Reijneveld Olivier Chinot Johanna M M Gijtenbeek John P Rossiter Nicolas Dif Carmen Balana Jose Bravo-Marques Paul M Clement Christine Marosi Tzahala Tzuk-Shina Robert A Nordal Jeremy Rees Denis Lacombe Warren P Mason Roger Stupp

Lancet Oncol 2016 Nov 27;17(11):1521-1532. Epub 2016 Sep 27.

Lausanne University Hospital, Lausanne, Switzerland; University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/S1470-2045(16)30313-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124485PMC
November 2016

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

Authors:
Wolfgang Wick Thierry Gorlia Pierre Bady Michael Platten Martin J van den Bent Martin J B Taphoorn Jonathan Steuve Alba A Brandes Marie-France Hamou Antje Wick Markus Kosch Michael Weller Roger Stupp Patrick Roth Vassilis Golfinopoulos Jean-Sebastien Frenel Mario Campone Damien Ricard Christine Marosi Salvador Villa Astrid Weyerbrock Kirsten Hopkins Krisztian Homicsko Benoit Lhermitte Gianfranco Pesce Monika E Hegi

Clin Cancer Res 2016 Oct 3;22(19):4797-4806. Epub 2016 May 3.

Neuroscience Research Center, University Hospital Lausanne (CHUV), Lausanne, Switzerland. Department of Neurosurgery, CHUV, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-3153DOI Listing
October 2016

Reply to F. Felix et al and M.F. Fay et al.

Authors:
Caroline Happold Thierry Gorlia Oliver Chinot Mark R Gilbert L Burt Nabors Wolfgang Wick Stephanie L Pugh Monika Hegi Timothy Cloughesy Patrick Roth David A Reardon James R Perry Minesh P Mehta Roger Stupp Michael Weller

J Clin Oncol 2016 09 13;34(25):3107-8. Epub 2016 Jun 13.

University Hospital Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1200/JCO.2016.68.0926DOI Listing
September 2016

Corticosteroids compromise survival in glioblastoma.

Authors:
Kenneth L Pitter Ilaria Tamagno Kristina Alikhanyan Amira Hosni-Ahmed Siobhan S Pattwell Shannon Donnola Charles Dai Tatsuya Ozawa Maria Chang Timothy A Chan Kathryn Beal Andrew J Bishop Christopher A Barker Terreia S Jones Bettina Hentschel Thierry Gorlia Uwe Schlegel Roger Stupp Michael Weller Eric C Holland Dolores Hambardzumyan

Brain 2016 05 28;139(Pt 5):1458-71. Epub 2016 Mar 28.

2 Department of Neurosciences at the Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, 44195, USA 3 Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA

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http://brain.oxfordjournals.org/content/brain/early/2016/03/
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http://pdfs.journals.lww.com/neurosurgery/2016/10000/Do_Cort
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http://dx.doi.org/10.1093/brain/aww046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006251PMC
May 2016

Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.

Authors:
Hendrikus J Dubbink Peggy N Atmodimedjo Johan M Kros Pim J French Marc Sanson Ahmed Idbaih Pieter Wesseling Roelien Enting Wim Spliet Cees Tijssen Winand N M Dinjens Thierry Gorlia Martin J van den Bent

Neuro Oncol 2016 Mar 9;18(3):388-400. Epub 2015 Sep 9.

Department of Pathology, Rotterdam, the Netherlands (H.J.D., P.N.A., J.M.K., W.N.M.D.); Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands (P.J.F.); Groupe Hospitalier Pitie Salpetriere, Service de Neurologie Mazarin, Paris, France (M.S., A.I.); Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (P.W.); Department of Pathology, Free University Medical Center, Amsterdam, the Netherlands (P.W.); Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands (R.E.); Department of Pathology, UMCU, Utrecht, the Netherlands (W.S.); Department of Neurology, St. Elisabeth Hospital, Tilburg, the Netherlands (C.T.); European Organisation for Research and Treatment of Cancer Data Center, Brussels, Belgium (T.G.); Department of Neurology/Neuro-oncology, Erasmus MC Cancer Center, Rotterdam, the Netherlands (M.J.v.d.B.).

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http://dx.doi.org/10.1093/neuonc/nov182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767239PMC
March 2016

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.

Authors:
Caroline Happold Thierry Gorlia Olivier Chinot Mark R Gilbert L Burt Nabors Wolfgang Wick Stephanie L Pugh Monika Hegi Timothy Cloughesy Patrick Roth David A Reardon James R Perry Minesh P Mehta Roger Stupp Michael Weller

J Clin Oncol 2016 Mar 19;34(7):731-9. Epub 2016 Jan 19.

Caroline Happold, Patrick Roth, Roger Stupp, and Michael Weller, University Hospital Zurich; Monika Hegi, University Hospital Lausanne, Switzerland; Thierry Gorlia, EORTC Data Centre, Brussels, Belgium; Olivier Chinot, Aix-Marseille University, Marseille, France; Mark R. Gilbert, The University of Texas MD Anderson Cancer Center, Houston, TX; L. Burt Nabors, University of Alabama at Birmingham, Birmingham, AL; Wolfgang Wick, University of Heidelberg & German Cancer Research Center, Heidelberg, Germany; Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Timothy Cloughesy, UCLA Neuro-Oncology Program, Los Angeles, CA; David A. Reardon, Dana-Farber Cancer Institute, Boston, MA; James R. Perry, University of Toronto, Toronto, Ontario, Canada; and Minesh P. Mehta, University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2015.63.6563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070573PMC
March 2016

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome.

Authors:
Michael Weller Louis Burt Nabors Thierry Gorlia Henning Leske Elisabeth Rushing Pierre Bady Christine Hicking James Perry Yong-Kil Hong Patrick Roth Wolfgang Wick Simon L Goodman Monika E Hegi Martin Picard Holger Moch Josef Straub Roger Stupp

Oncotarget 2016 Mar;7(12):15018-32

Department of Oncology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.7588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924768PMC
March 2016

Changes in the EGFR amplification and EGFRvIII expression between paired primary and recurrent glioblastomas.

Authors:
Martin J van den Bent Ya Gao Melissa Kerkhof Johan M Kros Thierry Gorlia Kitty van Zwieten Jory Prince Sjoerd van Duinen Peter A Sillevis Smitt Martin Taphoorn Pim J French

Neuro Oncol 2015 Jul 16;17(7):935-41. Epub 2015 Feb 16.

Department of Neurology, Erasmus MC, Rotterdam, Netherlands (M.J.v.d.B., Y.G., K.v.Z., J.P., P.A.S.S., P.J.F.); Department of Pathology, Erasmus MC, Rotterdam, Netherlands (J.M.K.); Department of Neurology, Haaglanden MC, The Hague, Netherlands (M.K., M.T.); EORTC Headquarters, Brussels, Belgium (T.G.); Pathology Department, Leiden University Medical Center, Leiden, Netherlands (S.v.D.).

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http://dx.doi.org/10.1093/neuonc/nov013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762005PMC
July 2015

Evidence-Based Diagnostic Algorithm for Glioma: Analysis of the Results of Pathology Panel Review and Molecular Parameters of EORTC 26951 and 26882 Trials.

Authors:
Johan M Kros Karin Huizer Aurelio Hernández-Laín Gianluca Marucci Alex Michotte Bianca Pollo Elisabeth J Rushing Teresa Ribalta Pim French David Jaminé Nawal Bekka Denis Lacombe Martin J van den Bent Thierry Gorlia

J Clin Oncol 2015 Jun 27;33(17):1943-50. Epub 2015 Apr 27.

Johan M. Kros and Karin Huizer, Erasmus Medical Center; Pim French and Martin J. van den Bent, Dr Daniel den Hoed Cancer Center, Rotterdam, the Netherlands; Aurelio Hernández-Laín, Hospital Universitario 12 de Octubre Reseach Institute, Madrid; Teresa Ribalta, Hospital Clínic, University of Barcelona, Barcelona, Spain; Gianluca Marucci, Bellaria Hospital, University of Bologna, Bologna; Bianca Pollo, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico "C. Besta," Milano, Italy; Alex Michotte, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel; David Jaminé, Nawal Bekka, Denis Lacombe, and Thierry Gorlia, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; and Elisabeth J. Rushing, Institute for Neuropathology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1200/JCO.2014.59.0166DOI Listing
June 2015

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.

Authors:
Roger Stupp Monika E Hegi Thierry Gorlia Sara C Erridge James Perry Yong-Kil Hong Kenneth D Aldape Benoit Lhermitte Torsten Pietsch Danica Grujicic Joachim Peter Steinbach Wolfgang Wick Rafał Tarnawski Do-Hyun Nam Peter Hau Astrid Weyerbrock Martin J B Taphoorn Chiung-Chyi Shen Nalini Rao László Thurzo Ulrich Herrlinger Tejpal Gupta Rolf-Dieter Kortmann Krystyna Adamska Catherine McBain Alba A Brandes Joerg Christian Tonn Oliver Schnell Thomas Wiegel Chae-Yong Kim Louis Burt Nabors David A Reardon Martin J van den Bent Christine Hicking Andriy Markivskyy Martin Picard Michael Weller

Lancet Oncol 2014 Sep 19;15(10):1100-8. Epub 2014 Aug 19.

UniversitätsSpital Zürich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/S1470-2045(14)70379-1DOI Listing
September 2014

New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951.

Authors:
Thierry Gorlia Jean-Yves Delattre Alba A Brandes Johan M Kros Martin J B Taphoorn Mathilde C M Kouwenhoven H J J A Bernsen Marc Frénay Cees C Tijssen Denis Lacombe Martin J van den Bent

Eur J Cancer 2013 Nov 26;49(16):3477-85. Epub 2013 Jul 26.

EORTC Headquarters, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.06.039DOI Listing
November 2013

New validated prognostic models and prognostic calculators in patients with low-grade gliomas diagnosed by central pathology review: a pooled analysis of EORTC/RTOG/NCCTG phase III clinical trials.

Authors:
Thierry Gorlia Wenting Wu Meihua Wang Brigitta G Baumert Minesh Mehta Jan C Buckner Edward Shaw Paul Brown Roger Stupp Evanthia Galanis Denis Lacombe Martin J van den Bent

Neuro Oncol 2013 Nov 18;15(11):1568-79. Epub 2013 Sep 18.

Corresponding Author: M. Thierry Gorlia, The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, 83 Avenue E. Mounier, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1093/neuonc/not117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813419PMC
November 2013

MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951.

Authors:
Martin J van den Bent Lale Erdem-Eraslan Ahmed Idbaih Johan de Rooi Paul H C Eilers Wim G M Spliet Wilfred F A den Dunnen Cees Tijssen Pieter Wesseling Peter A E Sillevis Smitt Johan M Kros Thierry Gorlia Pim J French

Clin Cancer Res 2013 Oct 15;19(19):5513-22. Epub 2013 Aug 15.

Authors' Affiliations: Departments of Neurology, Biostatistics, and Pathology, Neuro-Oncology Unit Erasmus MC, Rotterdam; AP-HP, Groupe Hospitalier Pitie Salpêtrière, Service de Neurologie 2 Mazarin and Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), Paris, France; Department of Pathology, UMCU, Utrecht; Department of Pathology, UMCG, Groningen; Department of Neurology, St. Elisabeth Hospital, Tilburg; Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen; Department of Pathology, Free University Medical Center, Amsterdam, the Netherlands; and European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1157DOI Listing
October 2013

Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.

Authors:
Martin J van den Bent Alba A Brandes Martin J B Taphoorn Johan M Kros Mathilde C M Kouwenhoven Jean-Yves Delattre Hans J J A Bernsen Marc Frenay Cees C Tijssen Wolfgang Grisold László Sipos Roelien H Enting Pim J French Winand N M Dinjens Charles J Vecht Anouk Allgeier Denis Lacombe Thierry Gorlia Khê Hoang-Xuan

J Clin Oncol 2013 Jan 15;31(3):344-50. Epub 2012 Oct 15.

Neuro-Oncology Unit, Erasmus MC-Daniel den Hoed Cancer Center, PO Box 5201, 3008AE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1200/JCO.2012.43.2229DOI Listing
January 2013

Intrinsic molecular subtypes of glioma are prognostic and predict benefit from adjuvant procarbazine, lomustine, and vincristine chemotherapy in combination with other prognostic factors in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951.

Authors:
Lale Erdem-Eraslan Lonneke A Gravendeel Johan de Rooi Paul H C Eilers Ahmed Idbaih Wim G M Spliet Wilfred F A den Dunnen Johannes L Teepen Pieter Wesseling Peter A E Sillevis Smitt Johan M Kros Thierry Gorlia Martin J van den Bent Pim J French

J Clin Oncol 2013 Jan 26;31(3):328-36. Epub 2012 Dec 26.

Erasmus MC–Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1200/JCO.2012.44.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732011PMC
January 2013

EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma.

Authors:
Enrico Franceschi Roger Stupp Martin J van den Bent Carla van Herpen Florence Laigle Donadey Thierry Gorlia Monika Hegi Benoit Lhermitte Lewis C Strauss Anouk Allgeier Denis Lacombe Alba A Brandes

Neuro Oncol 2012 Dec 22;14(12):1503-10. Epub 2012 Oct 22.

Department of Medical Oncology, Bellaria-Maggiore Hospital, Azienda USL of Bologna, Italy.

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http://dx.doi.org/10.1093/neuonc/nos256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499012PMC
December 2012

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial.

Authors:
Monika E Hegi Robert-Charles Janzer Wanyu L Lambiv Thierry Gorlia Mathilde C M Kouwenhoven Christian Hartmann Andreas von Deimling Danielle Martinet Nathalie Besuchet Schmutz Annie-Claire Diserens Marie-France Hamou Pierre Bady Michael Weller Martin J van den Bent Warren P Mason René-Olivier Mirimanoff Roger Stupp Karima Mokhtari Pieter Wesseling

Acta Neuropathol 2012 Jun 15;123(6):841-52. Epub 2012 Jan 15.

Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00401-011-0938-4DOI Listing
June 2012

Prognostic value of Ki67 index in anaplastic oligodendroglial tumours--a translational study of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Authors:
Matthias Preusser Romana Hoeftberger Adelheid Woehrer Ellen Gelpi Mathilde Kouwenhoven Johan M Kros Marc Sanson Ahmed Idbaih Alba A Brandes Harald Heinzl Thierry Gorlia Johannes A Hainfellner Martin van den Bent

Histopathology 2012 May 15;60(6):885-94. Epub 2012 Feb 15.

Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1111/j.1365-2559.2011.04134.x
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http://dx.doi.org/10.1111/j.1365-2559.2011.04134.xDOI Listing
May 2012

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: a pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials.

Authors:
Thierry Gorlia Roger Stupp Alba A Brandes Roy R Rampling Pierre Fumoleau Christian Dittrich Mario M Campone Chris C Twelves Eric Raymond Monika E Hegi Denis Lacombe Martin J van den Bent

Eur J Cancer 2012 May 28;48(8):1176-84. Epub 2012 Mar 28.

EORTC Headquarters, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2012.02.004DOI Listing
May 2012

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Authors:
Sameer Agnihotri Aaron S Gajadhar Christian Ternamian Thierry Gorlia Kristin L Diefes Paul S Mischel Joanna Kelly Gail McGown Mary Thorncroft Brett L Carlson Jann N Sarkaria Geoffrey P Margison Kenneth Aldape Cynthia Hawkins Monika Hegi Abhijit Guha

J Clin Invest 2012 Jan 12;122(1):253-66. Epub 2011 Dec 12.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI59334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248301PMC
January 2012

A hypermethylated phenotype is a better predictor of survival than MGMT methylation in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951.

Authors:
Martin J van den Bent Lonneke A Gravendeel Thierry Gorlia Johan M Kros Lariesa Lapre Pieter Wesseling Johannes L Teepen Ahmed Idbaih Marc Sanson Peter A E Sillevis Smitt Pim J French

Clin Cancer Res 2011 Nov 13;17(22):7148-55. Epub 2011 Sep 13.

Neuro-Oncology Unit, Department of Neurology, Daniel den Hoed Cancer Center/Erasmus Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1274DOI Listing
November 2011

Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.

Authors:
Karima Mokhtari François Ducray Johan M Kros Thierry Gorlia Ahmed Idbaih Martin Taphoorn Pieter Wesseling Khe Hoang-Xuan Martin Van den Bent Marc Sanson

Cancer 2011 Jul 18;117(13):3014-26. Epub 2011 Jan 18.

Mixed Research Unit, UMR 975, INSERM, National Institute of Health and Medical Research-Pierre and Marie Curie University, Pitie-Salpetriere Group Hospital, Paris, France.

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http://dx.doi.org/10.1002/cncr.25827DOI Listing
July 2011

Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.

Authors:
Ahmed Idbaih Cyril Dalmasso Mathilde Kouwenhoven Judith Jeuken Catherine Carpentier Thierry Gorlia Johan M Kros Pim French Johannes Teepen Philippe Broët Olivier Delattre Karima Mokhtari Marc Sanson Jean-Yves Delattre Martin van den Bent Khê Hoang-Xuan

J Neurooncol 2011 Jun 6;103(2):221-30. Epub 2010 Sep 6.

INSERM, U975, Université Pierre & Marie Curie Paris VI, Faculté de médecine Pitié-Salpêtrière, CNRS UMR 7225, Paris, France.

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http://link.springer.com/content/pdf/10.1007/s11060-010-0380
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http://link.springer.com/10.1007/s11060-010-0380-9
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http://dx.doi.org/10.1007/s11060-010-0380-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097344PMC
June 2011

Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.

Authors:
Markus Weiler Christian Hartmann Dorothee Wiewrodt Ulrich Herrlinger Thierry Gorlia Oliver Bähr Richard Meyermann Michael Bamberg Marcos Tatagiba Andreas von Deimling Michael Weller Wolfgang Wick

Int J Radiat Oncol Biol Phys 2010 Jul 14;77(3):670-6. Epub 2009 Oct 14.

Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2009.05.031DOI Listing
July 2010

Prolonged survival for patients with newly diagnosed, inoperable glioblastoma with 3-times daily ultrafractionated radiation therapy.

Authors:
Patrick Beauchesne Valerie Bernier Charlotte Carnin Luc Taillandier Mohamed Djabri Laurent Martin Xavier Michel Jean-Philippe Maire Toufic Khalil Christine Kerr Thierry Gorlia Roger Stupp Remy Pedeux

Neuro Oncol 2010 Jun 11;12(6):595-602. Epub 2010 Feb 11.

Neuro-Oncologie - Neurologie, CHU de Nancy, Hôpital Central, CO no 34, 54035 Nancy Cedex, France.

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http://dx.doi.org/10.1093/neuonc/noq008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940649PMC
June 2010

Long-term efficacy results of EORTC genito-urinary group randomized phase 3 study 30911 comparing intravesical instillations of epirubicin, bacillus Calmette-Guérin, and bacillus Calmette-Guérin plus isoniazid in patients with intermediate- and high-risk stage Ta T1 urothelial carcinoma of the bladder.

Authors:
Richard J Sylvester Maurizio A Brausi Wim J Kirkels Wolfgang Hoeltl Fernando Calais Da Silva Philip H Powell Stephen Prescott Ziya Kirkali Cees van de Beek Thierry Gorlia Theo M de Reijke

Eur Urol 2010 May 18;57(5):766-73. Epub 2009 Dec 18.

EORTC Headquarters, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.eururo.2009.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889174PMC
May 2010

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Authors:
Martin J van den Bent Hendrikus J Dubbink Yannick Marie Alba A Brandes Martin J B Taphoorn Pieter Wesseling Marc Frenay Cees C Tijssen Denis Lacombe Ahmed Idbaih Ronald van Marion Johan M Kros Winand N M Dinjens Thierry Gorlia Marc Sanson

Clin Cancer Res 2010 Mar 16;16(5):1597-604. Epub 2010 Feb 16.

Dept Neuro-Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2902DOI Listing
March 2010

EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma.

Authors:
Alba A Brandes Roger Stupp Peter Hau Denis Lacombe Thierry Gorlia Alicia Tosoni Renè O Mirimanoff Johan M Kros Martin J van den Bent

Eur J Cancer 2010 Jan 27;46(2):348-54. Epub 2009 Nov 27.

Bellaria and Maggiore Hospitals, Bologna, Department of Medical Oncology, Italy.

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http://dx.doi.org/10.1016/j.ejca.2009.10.029DOI Listing
January 2010

Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.

Authors:
Mathilde C M Kouwenhoven Thierry Gorlia Johan M Kros Ahmed Ibdaih Alba A Brandes Jacolien E C Bromberg Karima Mokhtari Sjoerd G van Duinen Johannes L Teepen Pieter Wesseling Fanny Vandenbos Wolfgang Grisold László Sipos Rene Mirimanoff Charles J Vecht Anouk Allgeier Denis Lacombe Martin J van den Bent

Neuro Oncol 2009 Dec;11(6):737-46

Department of Neurology, Daniel den Hoed Cancer Center, Erasmus University Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1215/15228517-2009-011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802394PMC
December 2009

MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

Authors:
Martin J van den Bent Hendrikus J Dubbink Marc Sanson Cathleen R van der Lee-Haarloo Monika Hegi Judith W M Jeuken Ahmed Ibdaih Alba A Brandes Martin J B Taphoorn Marc Frenay Denis Lacombe Thierry Gorlia Winand N M Dinjens Johan M Kros

J Clin Oncol 2009 Dec 9;27(35):5881-6. Epub 2009 Nov 9.

Department of Neuro-Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2009.24.1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793037PMC
December 2009

RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study.

Authors:
Christoph P Beier Christina Schmid Thierry Gorlia Christine Kleinletzenberger Dagmar Beier Oliver Grauer Andreas Steinbrecher Birgit Hirschmann Alexander Brawanski Christopher Dietmaier Tanja Jauch-Worley Oliver Kölbl Torsten Pietsch Martin Proescholdt Petra Rümmele Armin Muigg Günther Stockhammer Monika Hegi Ulrich Bogdahn Peter Hau

BMC Cancer 2009 Sep 2;9:308. Epub 2009 Sep 2.

Department of Neurology, University of Regensburg, Universitätsstrasse 84, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1186/1471-2407-9-308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749868PMC
September 2009

Circadian rhythm in rest and activity: a biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer.

Authors:
Pasquale F Innominato Christian Focan Thierry Gorlia Thierry Moreau Carlo Garufi Jim Waterhouse Sylvie Giacchetti Bruno Coudert Stefano Iacobelli Dominique Genet Marco Tampellini Philippe Chollet Marie-Ange Lentz Marie-Christine Mormont Francis Lévi Georg A Bjarnason

Cancer Res 2009 Jun;69(11):4700-7

INSERM, U776 Biological Rhythms and Cancers, Villejuif, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690615PMC
June 2009

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.

Authors:
Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin J B Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Pieter Wesseling Salvador Villa Elizabeth Eisenhauer Thierry Gorlia Michael Weller Denis Lacombe J Gregory Cairncross René-Olivier Mirimanoff

Lancet Oncol 2009 May 9;10(5):459-66. Epub 2009 Mar 9.

Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/S1470-2045(09)70025-7DOI Listing
May 2009

Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.

Authors:
Martin J van den Bent Alba A Brandes Roy Rampling Mathilde C M Kouwenhoven Johan M Kros Antoine F Carpentier Paul M Clement Marc Frenay Mario Campone Jean-Francois Baurain Jean-Paul Armand Martin J B Taphoorn Alicia Tosoni Heidemarie Kletzl Barbara Klughammer Denis Lacombe Thierry Gorlia

J Clin Oncol 2009 Mar 9;27(8):1268-74. Epub 2009 Feb 9.

Neuro-Oncology Unit, Daniel den Hoed Cancer Center, PO Box 5201, 3008AE Rotterdam, the Netherlands.

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http://ascopubs.org/doi/10.1200/JCO.2008.17.5984
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http://dx.doi.org/10.1200/JCO.2008.17.5984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667826PMC
March 2009

Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker.

Authors:
Matthias Preusser Robert Charles Janzer Jörg Felsberg Guido Reifenberger Marie-France Hamou Annie-Claire Diserens Roger Stupp Thierry Gorlia Christine Marosi Harald Heinzl Johannes A Hainfellner Monika Hegi

Brain Pathol 2008 Oct 8;18(4):520-32. Epub 2008 Apr 8.

Department of Internal Medicine 1, Medial University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1750-3639.2008.00153.xDOI Listing
October 2008

Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study.

Authors:
Eric Raymond Alba A Brandes Christian Dittrich Pierre Fumoleau Bruno Coudert Paul M J Clement Marc Frenay Roy Rampling Roger Stupp Johan M Kros Michael C Heinrich Thierry Gorlia Denis Lacombe Martin J van den Bent

J Clin Oncol 2008 Oct;26(28):4659-65

Service Inter Hospitalier de Cancérologie, Beaujon University Hospital, Clichy.

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http://dx.doi.org/10.1200/JCO.2008.16.9235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653126PMC
October 2008

A randomized multicenter study of optimal circadian time of vinorelbine combined with chronomodulated 5-fluorouracil in pretreated metastatic breast cancer patients: EORTC trial 05971.

Authors:
Bruno Coudert Christian Focan Dominique Genet Sylvie Giacchetti Frédérique Cvickovic Alberto Zambelli Georges Fillet Philippe Chollet Domenico Amoroso Jaak Van Der Auwera Marie Ange Lentz Sandrine Marreaud Benoit Baron Thierry Gorlia Fabienne Biville Francis Lévi

Chronobiol Int 2008 Sep;25(5):680-96

Centre Georges Francois Leclerc and IFR100, Dijon, France.

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http://dx.doi.org/10.1080/07420520802384036DOI Listing
September 2008

Chromosome 1p loss evaluation in anaplastic oligodendrogliomas.

Authors:
Ahmed Idbaih Mathilde Kouwenhoven Judith Jeuken Catherine Carpentier Thierry Gorlia Johan M Kros Pim French Johannes L Teepen Olivier Delattre Jean-Yves Delattre Martin van den Bent Khê Hoang-Xuan

Neuropathology 2008 Aug 26;28(4):440-3. Epub 2008 Feb 26.

INSERM, Unité 711, Paris, France.

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http://dx.doi.org/10.1111/j.1440-1789.2008.00863.xDOI Listing
August 2008

Adjuvant dibromodulcitol and BCNU chemotherapy in anaplastic astrocytoma: results of a randomised European Organisation for Research and Treatment of Cancer phase III study (EORTC study 26882).

Authors:
Jerzy Hildebrand Thierry Gorlia Johan M Kros Dénes Afra Marc Frenay Antonio Omuro Roger Stupp Denis Lacombe Anouk Allgeier Martin J van den Bent

Eur J Cancer 2008 Jun 14;44(9):1210-6. Epub 2008 Jan 14.

Hopital Universitaire Erasme, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2007.12.005DOI Listing
June 2008

Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.

Authors:
Anastasia Murat Eugenia Migliavacca Thierry Gorlia Wanyu L Lambiv Tal Shay Marie-France Hamou Nicolas de Tribolet Luca Regli Wolfgang Wick Mathilde C M Kouwenhoven Johannes A Hainfellner Frank L Heppner Pierre-Yves Dietrich Yitzhak Zimmer J Gregory Cairncross Robert-Charles Janzer Eytan Domany Mauro Delorenzi Roger Stupp Monika E Hegi

J Clin Oncol 2008 Jun;26(18):3015-24

Laboratory of Tumor Biology and Genetics, Centre Universitaire Romand de Neurochirurgie, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne 1011, Switzerland.

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http://dx.doi.org/10.1200/JCO.2007.15.7164DOI Listing
June 2008

Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study.

Authors:
Leida M Lamers Roger Stupp Martin J van den Bent Maiwenn J Al Thierry Gorlia Jean-Blaise Wasserfallen Nicole Mittmann Soo Jin Seung Ralph Crott Carin A Uyl-de Groot

Cancer 2008 Mar;112(6):1337-44

Institute for Medical Technology Assessment bv, Erasmus University Medical Center, Rotterdam, Netherlands.

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http://doi.wiley.com/10.1002/cncr.23297
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http://dx.doi.org/10.1002/cncr.23297DOI Listing
March 2008

Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3.

Authors:
Thierry Gorlia Martin J van den Bent Monika E Hegi René O Mirimanoff Michael Weller J Gregory Cairncross Elizabeth Eisenhauer Karl Belanger Alba A Brandes Anouk Allgeier Denis Lacombe Roger Stupp

Lancet Oncol 2008 Jan 21;9(1):29-38. Epub 2007 Dec 21.

EORTC Data Centre, Brussels, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(07)70384-4DOI Listing
January 2008

Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer.

Authors:
Jan B Vermorken Eva Remenar Carla van Herpen Thierry Gorlia Ricard Mesia Marian Degardin John S Stewart Svetislav Jelic Jan Betka Joachim H Preiss Danielle van den Weyngaert Ahmad Awada Didier Cupissol Heinz R Kienzer Augustin Rey Isabelle Desaunois Jacques Bernier Jean-Louis Lefebvre

N Engl J Med 2007 Oct;357(17):1695-704

Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium.

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http://dx.doi.org/10.1056/NEJMoa071028DOI Listing
October 2007

Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome.

Authors:
Johan M Kros Thierry Gorlia Mathilde C Kouwenhoven Ping-Pin Zheng V Peter Collins Dominique Figarella-Branger Felice Giangaspero Caterina Giannini Karima Mokhtari Sverre J Mørk Anders Paetau Guido Reifenberger Martin J van den Bent

J Neuropathol Exp Neurol 2007 Jun;66(6):545-51

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/01.jnen.0000263869.84188.72DOI Listing
June 2007

Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group.

Authors:
Sylvie Giacchetti Georg Bjarnason Carlo Garufi Dominique Genet Stefano Iacobelli Marco Tampellini Rune Smaaland Christian Focan Bruno Coudert Yves Humblet Jean Luc Canon Antoine Adenis Giovanni Lo Re Carlos Carvalho Johannes Schueller Nicole Anciaux Marie-Ange Lentz Benoît Baron Thierry Gorlia Francis Lévi

J Clin Oncol 2006 Aug;24(22):3562-9

Hopital Paul Brousse and INSERM, Villejuif, France.

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http://ascopubs.org/doi/10.1200/JCO.2006.06.1440
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http://dx.doi.org/10.1200/JCO.2006.06.1440DOI Listing
August 2006

Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Authors:
Matthias Preusser Harald Heinzl Ellen Gelpi Katharina Schonegger Christine Haberler Peter Birner Christine Marosi Monika Hegi Thierry Gorlia Johannes A Hainfellner

Cancer 2006 Jul;107(1):162-70

Institute of Neurology, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/cncr.21973DOI Listing
July 2006

Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.

Authors:
René-Olivier Mirimanoff Thierry Gorlia Warren Mason Martin J Van den Bent Rolf-Dieter Kortmann Barbara Fisher Michele Reni Alba A Brandes Jüergen Curschmann Salvador Villa Gregory Cairncross Anouk Allgeier Denis Lacombe Roger Stupp

J Clin Oncol 2006 Jun;24(16):2563-9

Department of Radiation Oncology, University Hospital Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1200/JCO.2005.04.5963DOI Listing
June 2006

Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial.

Authors:
Martin J van den Bent Antoine F Carpentier Alba A Brandes Marc Sanson Martin J B Taphoorn Hans J J A Bernsen Marc Frenay Cees C Tijssen Wolfgang Grisold Laslo Sipos Hanny Haaxma-Reiche Johannes M Kros Mathilde C M van Kouwenhoven Charles J Vecht Anouk Allgeier Denis Lacombe Thierry Gorlia

J Clin Oncol 2006 Jun;24(18):2715-22

Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1200/JCO.2005.04.6078DOI Listing
June 2006

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

Authors:
Roger Stupp Warren P Mason Martin J van den Bent Michael Weller Barbara Fisher Martin J B Taphoorn Karl Belanger Alba A Brandes Christine Marosi Ulrich Bogdahn Jürgen Curschmann Robert C Janzer Samuel K Ludwin Thierry Gorlia Anouk Allgeier Denis Lacombe J Gregory Cairncross Elizabeth Eisenhauer René O Mirimanoff

N Engl J Med 2005 Mar;352(10):987-96

Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa043330
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http://dx.doi.org/10.1056/NEJMoa043330DOI Listing
March 2005

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Authors:
Monika E Hegi Annie-Claire Diserens Thierry Gorlia Marie-France Hamou Nicolas de Tribolet Michael Weller Johan M Kros Johannes A Hainfellner Warren Mason Luigi Mariani Jacoline E C Bromberg Peter Hau René O Mirimanoff J Gregory Cairncross Robert C Janzer Roger Stupp

N Engl J Med 2005 Mar;352(10):997-1003

Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1056/NEJMoa043331DOI Listing
March 2005

Cost effectiveness of paclitaxel/cisplatin compared with cyclophosphamide/cisplatin in the treatment of advanced ovarian cancer in Belgium.

Authors:
Niels Neymark Thierry Gorlia Ines Adriaenssen Benoit Baron Martine Piccart

Pharmacoeconomics 2002 ;20(7):485-97

European Organization for Research and Treatment of Cancer (EORTC) Data Center, Health Economics Unit, bte. 11, Avenue E. Mounier 83, B-1200 Brussels, Belgium.

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http://dx.doi.org/10.2165/00019053-200220070-00006DOI Listing
August 2002