Thierry Claudel

Thierry Claudel

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Thierry Claudel

Publications by authors named "Thierry Claudel"

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I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells.

Hepatol Commun 2019 Sep 15;3(9):1191-1204. Epub 2019 Jul 15.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria.

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http://dx.doi.org/10.1002/hep4.1395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719741PMC
September 2019

Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.

Hepatology 2019 Sep 10. Epub 2019 Sep 10.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1002/hep.30929DOI Listing
September 2019

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.

J Lipid Res 2019 Jul 2;60(7):1284-1292. Epub 2019 May 2.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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http://dx.doi.org/10.1194/jlr.M093369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602129PMC
July 2019

Thyroid hormone receptor β1 stimulates to increase biliary phosphatidylcholine excretion in mice.

J Lipid Res 2018 09 12;59(9):1610-1619. Epub 2018 Jun 12.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; and

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http://dx.doi.org/10.1194/jlr.M084145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121935PMC
September 2018

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs.

Int J Mol Sci 2018 06 15;19(6). Epub 2018 Jun 15.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3390/ijms19061777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032257PMC
June 2018

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M.

Sci Rep 2017 11 7;7(1):14661. Epub 2017 Nov 7.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-017-14557-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676689PMC
November 2017

PNPLA3 expression and its impact on the liver: current perspectives.

Hepat Med 2017 6;9:55-66. Epub 2017 Nov 6.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.

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http://dx.doi.org/10.2147/HMER.S125718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683790PMC
November 2017

FXR controls CHOP expression in steatohepatitis.

FEBS Lett 2017 10 11;591(20):3360-3368. Epub 2017 Oct 11.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1002/1873-3468.12845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698708PMC
October 2017

Impact of higher-order heme degradation products on hepatic function and hemodynamics.

J Hepatol 2017 08 12;67(2):272-281. Epub 2017 Apr 12.

Department of Anesthesiology and Intensive Care Medicine/Center for Sepsis Control and Care, Jena University Hospital, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.03.037DOI Listing
August 2017

Adiponectin regulates AQP3 via PPARα in human hepatic stellate cells.

Biochem Biophys Res Commun 2017 08 5;490(1):51-54. Epub 2017 Jun 5.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Internal Medicine III, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.06.009DOI Listing
August 2017

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.

Hepatology 2017 06 18;65(6):1875-1890. Epub 2017 Apr 18.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.29041DOI Listing
June 2017

Therapeutic Mechanisms of Bile Acids and Nor-Ursodeoxycholic Acid in Non-Alcoholic Fatty Liver Disease.

Dig Dis 2017 1;35(3):282-287. Epub 2017 Mar 1.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1159/000454853DOI Listing
May 2017

Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.

Dig Dis 2015 27;33(3):433-9. Epub 2015 May 27.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1159/000371904DOI Listing
March 2016

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.

Biochim Biophys Acta 2015 Oct 31;1853(10 Pt A):2349-60. Epub 2015 May 31.

Medical University of Vienna, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576212PMC
October 2015

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.

J Hepatol 2015 Jun 21;62(6):1398-404. Epub 2015 Jan 21.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278150001
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http://dx.doi.org/10.1016/j.jhep.2014.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451470PMC
June 2015

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients.

Metabolism 2014 Dec 6;63(12):1542-52. Epub 2014 Sep 6.

Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, 45122, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2014.09.001DOI Listing
December 2014

Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.

Trends Endocrinol Metab 2014 Nov 30;25(11):576-85. Epub 2014 Aug 30.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.08.001DOI Listing
November 2014

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).

Biochim Biophys Acta 2014 Jul 1;1842(7):959-70. Epub 2014 Mar 1.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034162PMC
July 2014

The role of canalicular ABC transporters in cholestasis.

Drug Metab Dispos 2014 Apr 28;42(4):546-60. Epub 2014 Jan 28.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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http://dmd.aspetjournals.org/content/early/2014/01/28/dmd.11
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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.056358
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http://dx.doi.org/10.1124/dmd.113.056358DOI Listing
April 2014

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.

Hepatology 2014 Mar 28;59(3):858-69. Epub 2014 Jan 28.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/hep.26732DOI Listing
March 2014

Editorial for 'randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis'.

Liver Int 2014 Mar;34(3):328-9

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1111/liv.12359DOI Listing
March 2014

Bile acid-mediated control of liver triglycerides.

Semin Liver Dis 2013 Nov 12;33(4):330-42. Epub 2013 Nov 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Hans Popper Laboratory of Molecular Hepatology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1055/s-0033-1358520DOI Listing
November 2013

Bile acid transporters and regulatory nuclear receptors in the liver and beyond.

J Hepatol 2013 Jan 8;58(1):155-68. Epub 2012 Aug 8.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.jhep.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526785PMC
January 2013

Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.

J Lipid Res 2012 Nov 28;53(11):2405-12. Epub 2012 Aug 28.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria.

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http://dx.doi.org/10.1194/jlr.M029769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466008PMC
November 2012

Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.

Hepatology 2012 Jul 29;56(1):270-80. Epub 2012 May 29.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/hep.25601DOI Listing
July 2012

FGF19 signaling cascade suppresses APOA gene expression.

Arterioscler Thromb Vasc Biol 2012 May 19;32(5):1220-7. Epub 2012 Jan 19.

Institute of Molecular Biology and Biochemistry, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.

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http://dx.doi.org/10.1161/ATVBAHA.111.243055DOI Listing
May 2012

Targeting nuclear bile acid receptors for liver disease.

Dig Dis 2011 17;29(1):98-102. Epub 2011 Jun 17.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

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https://www.karger.com/Article/FullText/324141
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http://dx.doi.org/10.1159/000324141DOI Listing
October 2011

Farnesoid X receptor represses hepatic human APOA gene expression.

J Clin Invest 2011 Sep 1;121(9):3724-34. Epub 2011 Aug 1.

Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1172/JCI45277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163948PMC
September 2011

Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.

Biochim Biophys Acta 2011 Aug 29;1812(8):867-78. Epub 2010 Dec 29.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Austria.

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http://dx.doi.org/10.1016/j.bbadis.2010.12.021DOI Listing
August 2011

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4794-9. Epub 2011 Mar 7.

Department of Molecular Biology, National Center of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1073/pnas.1002862108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064322PMC
March 2011

New insights into autoimmune cholangitis through animal models.

Dig Dis 2010 7;28(1):99-104. Epub 2010 May 7.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1159/000282072DOI Listing
September 2010

Bile acids as regulators of hepatic lipid and glucose metabolism.

Dig Dis 2010 7;28(1):220-4. Epub 2010 May 7.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1159/000282091DOI Listing
September 2010

Plasma bile acids are not associated with energy metabolism in humans.

Nutr Metab (Lond) 2010 Sep 3;7:73. Epub 2010 Sep 3.

Dept. of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1743-7075-7-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942888PMC
September 2010

Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation.

Gut 2010 Apr;59(4):521-30

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria.

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http://dx.doi.org/10.1136/gut.2009.186528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756478PMC
April 2010

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

PLoS Biol 2009 Sep 1;7(9):e1000181. Epub 2009 Sep 1.

Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.1000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726950PMC
September 2009

Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice.

Liver Int 2008 Aug 11;28(7):948-58. Epub 2008 Apr 11.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Laboratory of Experimental and Molecular Hepatology, Medical University, Graz, Austria.

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http://dx.doi.org/10.1111/j.1478-3231.2008.01758.xDOI Listing
August 2008

Crosstalk between xenobiotics metabolism and circadian clock.

FEBS Lett 2007 Jul 17;581(19):3626-33. Epub 2007 Apr 17.

Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND-9700 RB, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2007.04.009DOI Listing
July 2007

High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.

Arterioscler Thromb Vasc Biol 2007 Apr 1;27(4):923-8. Epub 2007 Feb 1.

Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa 920-8641, Japan.

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http://dx.doi.org/10.1161/01.ATV.0000258945.76141.8aDOI Listing
April 2007

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.

Arterioscler Thromb Vasc Biol 2005 Oct 21;25(10):2020-30. Epub 2005 Jul 21.

Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000178994.21
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http://dx.doi.org/10.1161/01.ATV.0000178994.21828.a7DOI Listing
October 2005

The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism.

Rev Endocr Metab Disord 2004 Dec;5(4):319-26

Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, Academic Hospital, Groningen, The Netherlands.

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http://dx.doi.org/10.1023/B:REMD.0000045103.00467.9aDOI Listing
December 2004

The farnesoid X receptor: a novel drug target?

Expert Opin Investig Drugs 2004 Sep;13(9):1135-48

Unité de Recherche 545, Institut National de la Santé et de la Recherche Médicale, Département d'Athérosclérose, Institut Pasteur de Lille and the Faculté de Pharmacie, Université de Lille II, Lille, France.

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http://dx.doi.org/10.1517/13543784.13.9.1135DOI Listing
September 2004

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

Gastroenterology 2003 Aug;125(2):544-55

UR545 INSERM, Département d'Athérosclérose, Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1016/s0016-5085(03)00896-5DOI Listing
August 2003

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.

Gastroenterology 2003 Jun;124(7):1926-40

U545 INSERM, Department of Atherosclerosis, Faculty of Pharmacy, Lille Pasteur Institute and University of Lille II, 1 Rue du Pr Calmette, BP 245, 59019 Lille, France.

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http://dx.doi.org/10.1016/s0016-5085(03)00388-3DOI Listing
June 2003

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

Mol Endocrinol 2003 Feb;17(2):259-72

U.545 Institut National de la Santé et de la Recherche Médicale, Département d'Athérosclérose, Institut Pasteur de Lille, 59019 Lille, France.

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http://dx.doi.org/10.1210/me.2002-0120DOI Listing
February 2003

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

J Clin Invest 2002 Apr;109(7):961-71

Unité de Recherche 545, Institut National de la Santé et de la Recherche Médicale, Département d'Athérosclérose, Institut Pasteur de Lille, and the Faculté de Pharmacie, Université de Lille II, Lille, France.

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http://dx.doi.org/10.1172/JCI14505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150929PMC
April 2002