Thibaud Lefebvre

Thibaud Lefebvre

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Thibaud Lefebvre

Publications by authors named "Thibaud Lefebvre"

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A hepcidin-based approach for iron therapy in hemodialysis patients: A pilot study.

Hemodial Int 2020 Feb 11. Epub 2020 Feb 11.

Institut National de Santé en Recherche Médicale (INSERM) U1149, Centre de recherche sur l'inflammation, Paris, France.

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http://dx.doi.org/10.1111/hdi.12823DOI Listing
February 2020

Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria).

Biochem Biophys Res Commun 2019 Dec 7;520(2):297-303. Epub 2019 Oct 7.

Laboratory of excellence, GR-Ex, Paris, France; INSERM U1035, Biothérapie des Maladies Génétiques, Inflammatoires et Cancers, France; Université de Bordeaux, 33000, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.09.141DOI Listing
December 2019

Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias.

Mol Genet Metab 2019 11 23;128(3):190-197. Epub 2019 Jan 23.

INSERM U1149, CNRS ERL 8252, Centre de Recherche sur l'inflammation, Université Paris Diderot, site Bichat, Sorbonne Paris Cité, France, 16 rue Henri Huchard, 75018 Paris, France; Laboratory of Excellence, GR-Ex, Paris, France; AP-HP, HUPNVS, Centre Français des Porphyries, Hôpital Louis Mourier, Colombes, France. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2019.01.015DOI Listing
November 2019

Extrahepatic hepcidin production: The intriguing outcomes of recent years.

World J Clin Cases 2019 Aug;7(15):1926-1936

Université Paris Diderot, Bichat site, Paris 75018, France.

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http://dx.doi.org/10.12998/wjcc.v7.i15.1926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695539PMC
August 2019

Functional erythropoietin-hepcidin axis in recombinant human erythropoietin independent haemodialysis patients.

Nephrology (Carlton) 2019 Jul 25;24(7):751-757. Epub 2019 Apr 25.

Institut National de Santé en Recherche Médicale (INSERM) U1149, centre de recherche sur l'inflammation, Centre de recherche sur l'inflammation, Paris, France.

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http://doi.wiley.com/10.1111/nep.13485
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http://dx.doi.org/10.1111/nep.13485DOI Listing
July 2019

Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria.

Am J Hum Genet 2019 02 31;104(2):341-347. Epub 2019 Jan 31.

Centre de Recherches sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale U1149, 75018 Paris, France; Université Paris Diderot, 75018 Paris, France; Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, 178 rue des Renouillers, 92701 Colombes, France; Laboratory of Excellence GR-Ex, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369449PMC
February 2019

Hepcidin: immunoanalytic characteristics.

Ann Biol Clin (Paris) 2018 Dec;76(6):705-715

CHU de Montpellier, Institut de médecine régénératrice et de biothérapies (IRMB), Laboratoire de biochimie-protéomique clinique, CCBHM, Hôpital Saint Eloi, Montpellier, France, Faculté de médecine, Université de Montpellier, France, Inserm U1040, Montpellier, France.

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http://dx.doi.org/10.1684/abc.2018.1382DOI Listing
December 2018

The R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism.

Haematologica 2018 11 12;103(11):1796-1805. Epub 2018 Jul 12.

UMR1078, INSERM, Université Bretagne Loire - Université de Bretagne Occidentale, Etablissement Français du Sang - Bretagne, Institut Brestois Santé-Agro-Matière, Brest, France

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http://dx.doi.org/10.3324/haematol.2018.189845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278975PMC
November 2018

Iron deficiency diagnosed using hepcidin on critical care discharge is an independent risk factor for death and poor quality of life at one year: an observational prospective study on 1161 patients.

Crit Care 2018 11 21;22(1):314. Epub 2018 Nov 21.

Department of Anesthesia, Université Paris Diderot ; U 942 Inserm ; APHP, Burn and Critical care, Hôpitaux Universitaires Saint louis - Lariboisiere, Paris, France.

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http://dx.doi.org/10.1186/s13054-018-2253-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249884PMC
November 2018

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.

Haematologica 2018 04 5;103(4):587-596. Epub 2018 Jan 5.

University Sorbonne Paris Cité, Paris Diderot University, Inserm U1149 / ERL 8252, Inflammation Research Center (CRI), Laboratory of Excellence GR-Ex, Paris, France

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2017.177816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865418PMC
April 2018

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.

N Engl J Med 2018 04;378(16):1479-1493

From the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.A.T., M.K.); University of California, San Francisco, Benioff Children's Hospital, Oakland (M.C.W., E.V.), Lucile Salter Packard Children's Hospital at Stanford, Palo Alto (S.S.), and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (G.J.S.) - all in California; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia (J.K., D.T.T.); Centenary Institute (J.E.J.R.), University of Sydney, Sydney Medical School (J.E.J.R., P.J.H.), and Royal Prince Alfred Hospital (J.E.J.R., P.J.H.), Camperdown, NSW, Australia; Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (J.-A.R., E.M., D.M., F.L., P.B., A.M., L.C., J.-S.D., F.S., F.M., V.B., C.B., O.H., M.D.M., S.B., M.C.), Groupe Hospitalier Universitaire Ouest (J.-A.R., A.M., L.C., M.C.), IMAGINE Institute (E.M., M.S., D.M., M.C.), Université Paris Descartes (M.S., C. Poirot, S.H.-B.-A.), Université Paris Diderot (H.P., T.L.), Pierre et Marie Curie University (C. Poirot), and Hôpital Cochin (J.-F.M.), Paris, CEA University Paris-Sud, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Hôpital Louis-Mourier, Colombes (H.P., T.L.), Centre Hospitalier Intercommunal de Créteil, Créteil (C. Pondarré), and Hôpital Bicêtre, Le Kremlin-Bicêtre (S.H.-B.-A.) - all in France; Bluebird Bio, Cambridge (J.-A.R., S.S., G.V., O.N., R.W.R., D.D., A.P., L.S., M.A.), and Harvard Medical School, Brigham and Women's Hospital, Boston (P.L.) - both in Massachusetts; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (S.H., U.A., P.L.); and the National Center for Tumor Diseases-German Cancer Research Center, Heidelberg, Germany (C.K.).

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http://dx.doi.org/10.1056/NEJMoa1705342DOI Listing
April 2018

Gene Therapy in a Patient with Sickle Cell Disease.

N Engl J Med 2017 03;376(9):848-855

From the Departments of Biotherapy (J.-A.R., A.M., E.M., L.C., M.C.), Clinical Pharmacy (P. Bourget), Pediatric Neuroradiology (D.G.), General Pediatrics (M.M.), and Pediatric Immunology-Hematology Unit (B.N., S.B.), Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (J.-A.R., A.M., E.M., L.C., L.W., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8258, INSERM Unité 1022, Faculté de Pharmacie de Paris, Université Paris Descartes, Chimie ParisTech (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, Hôpital Kremlin-Bicêtre, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), the Institute of Emerging Diseases and Innovative Therapies, Imagine Institute, Université Paris Descartes, Sorbonne Paris Cité University (M.S., B.N., L.W., M.C.), Mère-Enfant Clinical Investigation Center, Groupe Hospitalier Necker Cochin (M.S.), Université Paris Diderot, Sorbonne Paris Cité University, INSERM Institut National de Transfusion Sanguine, Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex (W.E.N.), and Laboratoires de Virologie, Hôpital Cochin (J.-F.M.), Paris, Atomic and Alternative Energy Commission, Université Paris-Sud, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Institut Mondor de Recherche Biomédicale, Equipe 2, Centre de Référence des Syndromes Drépanocytaires Majeurs, Centre Hospitalier Universitaire Henri Mondor, AP-HP, Laboratoire d'Excellence GR-Ex, Créteil (P. Bartolucci), and Université Paris Diderot, Sorbonne Paris Cité University, INSERM Unité 1149, Hôpital Louis-Mourier, AP-HP, Laboratoire d'Excellence GR-Ex, Colombes (H.P., T.L.) - all in France; Bluebird Bio, Cambridge (R.W.R., O.N., G.V., L.S., S.S.), and Brigham and Women's Hospital and Harvard Medical School, Boston (P.L.) - both in Massachusetts; and Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (P.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1609677
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http://dx.doi.org/10.1056/NEJMoa1609677DOI Listing
March 2017

Added value of hepcidin quantification for the diagnosis and follow-up of anemia-related diseases.

Ann Biol Clin (Paris) 2017 Feb;75(1):9-18

Institut de médecine régénératrice et de biothérapies (IRMB)-Laboratoire de biochimie-protéomique clinique-CCBHM, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France, Université de Montpellier, France, Inserm U1040, Montpellier, France.

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http://dx.doi.org/10.1684/abc.2016.1208DOI Listing
February 2017

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

J Am Soc Nephrol 2016 Mar 20;27(3):835-46. Epub 2015 Aug 20.

National Institute of Health and Medical Research (INSERM) U1149, Research Centre on inflammation, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France; Laboratory of Excellence, GR-Ex, Paris, France;

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http://dx.doi.org/10.1681/ASN.2014101035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769187PMC
March 2016

Does IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A Comparison With Healthy Volunteers.

Crit Care Med 2016 Mar;44(3):521-30

1Département Anesthésie Réanimation, CHU Angers, LUNAM Université d'Angers, Angers, France.2Service d'Anesthésie-Réanimation, AP-HP, Groupe Hospitalier Paris Nord Val de Seine, Paris, France.3INSERM, IAME, UMR 1137, Paris, France.4Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.5Service de Biostatistique, AP-HP, Groupe Hospitalier Paris Nord Val de Seine, Paris, France.6INSERM U1149, Centre de Recherche sur l'inflammation, Paris, France.7Laboratory of Excellence, GR-Ex, Paris, France.8INSERM CIC 1425, AP-HP, Groupe Hospitalier Paris Nord Val de Seine, Paris, France.9INSERM, UMR1152, Paris, France.

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http://pdfs.journals.lww.com/ccmjournal/9000/00000/Does_IV_I
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CCM.0000000000001420DOI Listing
March 2016

Acute intermittent porphyria causes hepatic mitochondrial energetic failure in a mouse model.

Int J Biochem Cell Biol 2014 Jun 13;51:93-101. Epub 2014 Apr 13.

UMR INSERM 1063, Angers, France; Centre Hospitalier Universitaire, Département de Biochimie et Génétique, Angers, France.

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http://dx.doi.org/10.1016/j.biocel.2014.03.032DOI Listing
June 2014

PXR-ALAS1: a key regulatory pathway in liver toxicity induced by isoniazid-rifampicin antituberculosis treatment.

Clin Res Hepatol Gastroenterol 2013 Nov 31;37(5):439-41. Epub 2013 Jul 31.

Université Versailles-Saint-Quentin-en-Yvelines, Guyancourt, France; Inserm U773, université Paris-Diderot, centre de recherche biomédicale Bichat-Beaujon, site Bichat, Paris, France.

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http://dx.doi.org/10.1016/j.clinre.2013.06.010DOI Listing
November 2013